The Functional Landscape of Patient-Derived RNF43 Mutations Predicts Sensitivity to Wnt Inhibition von Yu, Jia, Yusoff, Permeen A. Mohamed, Woutersen, Danielle T. J., Goh, Pamela, Harmston, Nathan, Smits, Ron, Epstein, David M., Virshup, David M., Madan, Babita

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Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase von Choy, Meng S., Yusoff, Permeen, Lee, Irene C., Newton, Jocelyn C., Goh, Catherine W., Page, Rebecca, Shenolikar, Shirish, Peti, Wolfgang

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Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration von Goh, Catherine Wenhui, Lee, Irene Chengjie, Sundaram, Jeyapriya Rajameenakshi, George, Simi Elizabeth, Yusoff, Permeen, Brush, Matthew Hayden, Sze, Newman Siu Kwan, Shenolikar, Shirish

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Evolution of IgA nephropathy in Singapore over four decades and a comparison of two cohorts from the first and fourth decade von Woo, Keng Thye, Chan, Choong Meng, Foo, Marjorie, Lim, Cynthia, Choo, Jason, Chin, Yok Mooi, Teng, Esther Wei Ling, Yusoff, Permeen A. Mohamed, Mok, Irene, Kwek, Jia Liang, Tan, Hui Zhuan, Loh, Alwin H. L., Choong, Hui Lin, Tan, Han Khim, Wong, Kok Seng, Lee, Grace S. L., Lee, Evan, Tan, Puay Hoon, Tan, Chieh Suai

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Sprouty-related Ena/Vasodilator-stimulated Phosphoprotein Homology 1-Domain-containing Protein (SPRED1), a Tyrosine-Protein Phosphatase Non-receptor Type 11 (SHP2) Substrate in the... von Quintanar-Audelo, Martina, Yusoff, Permeen, Sinniah, Saravanan, Chandramouli, Sumana, Guy, Graeme R.

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Sprouty 2, an inhibitor of mitogen-activated protein kinase signaling, is down-regulated in hepatocellular carcinoma von CHEE WAI FONG, CHUA, Mei-Sze, GUY, Graeme R, MCKIE, Arthur B, HEE MING LING, Sharon, MASON, Veronica, RUI LI, YUSOFF, Permeen, TING LING LO, LEUNG, Hing Y, SO, Samuel K. S

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The Ras/mitogen-activated protein kinase pathway inhibitor and likely tumor suppressor proteins, sprouty 1 and sprouty 2 are deregulated in breast cancer von TING LING LO, YUSOFF, Permeen, CHOUDARY PUTTI, Thomas, GUY, Graeme R, CHEE WAI FONG, KE GUO, MCCAW, Ben J, PHILLIPS, Wayne A, HE YANG, SOOK MIIN WONG, Esther, HWEI FEN LEONG, QI ZENG

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Sprouty2 Inhibits the Ras/MAP Kinase Pathway by Inhibiting the Activation of Raf von Yusoff, Permeen, Lao, Dieu-Hung, Ong, Siew Hwa, Wong, Esther Sook Miin, Lim, Jormay, Lo, Ting Ling, Leong, Hwei Fen, Fong, Chee Wai, Guy, Graeme R.

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Tyrosine Phosphorylation of Sprouty2 Enhances Its Interaction with c-Cbl and Is Crucial for Its Function von Fong, Chee Wai, Leong, Hwei Fen, Wong, Esther Sook Miin, Lim, Jormay, Yusoff, Permeen, Guy, Graeme R.

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A functional network of gastric-cancer-associated splicing events controlled by dysregulated splicing factors von Cheng, Shanshan, Ray, Debleena, Lee, Raymond Teck Ho, Naripogu, Kishore Babu, Yusoff, Permeen Akhtar Bt Mohamed, Goh, Pamela Bee Leng, Liu, Yujing, Suzuki, Yuka, Das, Kakoli, Chan, Hsiang Sui, Wong, Wai Keong, Chan, Weng Hoong, Chow, Pierce Kah-Hoe, Ong, Hock Soo, Raj, Prema, Soo, Khee Chee, Tan, Patrick, Epstein, David M, Rozen, Steven G

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A Src Homology 3-binding Sequence on the C Terminus of Sprouty2 Is Necessary for Inhibition of the Ras/ERK Pathway Downstream of Fibroblast Growth Factor Receptor Stimulation von Lao, Dieu-Hung, Chandramouli, Sumana, Yusoff, Permeen, Fong, Chee Wai, Saw, Tzuen Yih, Tai, Lai Peng, Yu, Chye Yun, Leong, Hwei Fen, Guy, Graeme R.

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Direct Binding of PP2A to Sprouty2 and Phosphorylation Changes Are a Prerequisite for ERK Inhibition Downstream of Fibroblast Growth Factor Receptor Stimulation von Lao, Dieu-Hung, Yusoff, Permeen, Chandramouli, Sumana, Philp, Robin J., Fong, Chee Wai, Jackson, Rebecca A., Saw, Tzuen Yih, Yu, Chye Yun, Guy, Graeme R.

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Tesk1 Interacts with Spry2 to Abrogate Its Inhibition of ERK Phosphorylation Downstream of Receptor Tyrosine Kinase Signaling von Chandramouli, Sumana, Yu, Chye Yun, Yusoff, Permeen, Lao, Dieu-Hung, Leong, Hwei Fen, Mizuno, Kensaku, Guy, Graeme R.

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Sprouty: how does the branch manager work? von Guy, Graeme R, Wong, Esther S M, Yusoff, Permeen, Chandramouli, Sumana, Lo, Ting Ling, Lim, Jormay, Fong, Chee Wai

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The Cysteine-Rich Sprouty Translocation Domain Targets Mitogen-Activated Protein Kinase Inhibitory Proteins to Phosphatidylinositol 4,5-Bisphosphate in Plasma Membranes von Lim, Jormay, Yusoff, Permeen, Wong, Esther Sook Miin, Chandramouli, Sumana, Lao, Dieu-Hung, Fong, Chee Wai, Guy, Graeme R.

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Genome-Wide CRISPR Screen Identifies an NF2-Adherens Junction Mechanistic Dependency for Cardiac Lineage von Lee, Chang Jie Mick, Autio, Matias I, Zheng, Wenhao, Song, Yoohyun, Wang, Shyi Chyi, Wong, Darren Chen Pei, Xiao, Jingwei, Zhu, Yike, Yusoff, Permeen, Yei, Xi, Chock, Wan Kee, Low, Boon Chuan, Sudol, Marius, Foo, Roger S-Y

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Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function von Lee, Irene Chengjie, Ho, Xue Yan, George, Simi Elizabeth, Goh, Catherine Wenhui, Sundaram, Jeyapriya Rajameenakshi, Pang, Karen Ka Lam, Luo, Weiwei, Yusoff, Permeen, Sze, Newman Siu Kwan, Shenolikar, Shirish

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Phosphorylation at Tyrosine 262 Promotes GADD34 Protein Turnover von Zhou, Wei, Jeyaraman, Krishna, Yusoff, Permeen, Shenolikar, Shirish

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Wars2 is a determinant of angiogenesis von Wang, Mao, Sips, Patrick, Khin, Ester, Rotival, Maxime, Sun, Ximing, Ahmed, Rizwan, Widjaja, Anissa Anindya, Schafer, Sebastian, Yusoff, Permeen, Choksi, Pervinder Kaur, Ko, Nicole Shi Jie, Singh, Manvendra K., Epstein, David, Guan, Yuguang, Houštěk, Josef, Mracek, Tomas, Nuskova, Hana, Mikell, Brittney, Tan, Jessie, Pesce, Francesco, Kolar, Frantisek, Bottolo, Leonardo, Mancini, Massimiliano, Hubner, Norbert, Pravenec, Michal, Petretto, Enrico, MacRae, Calum, Cook, Stuart A

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Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin von Mukherjee, Manjeet, Chow, Soah Yee, Yusoff, Permeen, Seetharaman, J, Ng, Cherlyn, Sinniah, Saravanan, Koh, Xiao Woon, Asgar, Nur Farehan M, Li, Dan, Yim, Daniel, Jackson, Rebecca A, Yew, Jingxi, Qian, Jingru, Iyu, Audrey, Lim, Yoon Pin, Zhou, Xingding, Sze, Siu Kwan, Guy, Graeme R, Sivaraman, J

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