60 Development of a gene signature to predict the anti-tumor response of the salt-inducible kinase (SIK) inhibitor OMX-0407 von Maser, Ilona-Petra, Lacher, Sonja, Stebegg, Marisa, Piras, Vincent, Kracher, Barbara, Quirin, Kai, Yule, Murray, Loferer, Hannes, Bissinger, Stefan

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Metabolism and pharmacokinetics of oxazaphosphorines von Boddy, A V, Yule, S M

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A Randomized Phase II Pharmacokinetic and Pharmacodynamic Study of Indisulam as Second-Line Therapy in Patients with Advanced Non–Small Cell Lung Cancer von TALBOT, Denis C, VON PAWEL, Joachim, RECK, Martin, CATTELL, Emma, YULE, S. Murray, JOHNSTON, Claire, ZANDVLIET, Anthe S, HUITEMA, Alwin D. R, NORBURY, Chris J, ELLIS, Paul, BOSQUEE, Leon

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Cyclophosphamide Metabolism in Children with Non-Hodgkin’s Lymphoma von YULE, S. Murray, PRICE, Lisa, MCMAHON, Alex D, PEARSON, Andrew D. J, BODDY, Alan V

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Phase I and Pharmacokinetic Study of E7070, a Chloroindolyl-Sulfonamide Anticancer Agent, Administered on a Weekly Schedule to Patients with Solid Tumors von DITTRICH, Christian, DUMEZ, Herlinde, CALVERT, Hilary, HANAUSKE, Axel, FABER, Marije, WANDERS, Jantien, YULE, Murray, RAVIC, Miroslav, FUMOLEAU, Pierre

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First-in-human phase I dose escalation study of a second-generation non-ansamycin HSP90 inhibitor, AT13387, in patients with advanced solid tumors von Shapiro, Geoffrey I, Kwak, Eunice, Dezube, Bruce J, Yule, Murray, Ayrton, John, Lyons, John, Mahadevan, Daruka

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Semi-physiological model describing the hematological toxicity of the anti-cancer agent indisulam von van Kesteren, Charlotte, Zandvliet, Anthe S, Karlsson, Mats O, Mathôt, Ron A A, Punt, Cornelis J A, Armand, Jean-Pierre, Raymond, Eric, Huitema, Alwin D R, Dittrich, Christian, Dumez, Herlinde, Roché, Henri H, Droz, Jean-Pierre, Ravic, Miroslav, Yule, S Murray, Wanders, Jantien, Beijnen, Jos H, Fumoleau, Pierre, Schellens, Jan H M

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Identification of predictive and pharmacodynamic biomarkers associated with the first-in-class selective axl inhibitor bemcentinib across multiple phase II clinical trials von Holt, Robert J, Micklem, David, Brown, Anthony, Yule, Murray, Loges, Sonja, Lorens, James

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The SPEARHEAD-1 trial of afamitresgene autoleucel (afami-cel [formerly ADP-A2M4]): Pooled analysis of cytokine release syndrome across cohorts in patients with advanced synovial sa... von D'Angelo, Sandra P., Ganjoo, Kristen N., Blay, Jean-Yves, Valverde, Claudia, Araujo, Dejka M., Abdul Razak, Albiruni Ryan, Le Cesne, Axel, Schuetze, Scott, Wagner, Michael J, Attia, Steven, Forcade, Edouard, Druta, Mihaela, Pollack, Seth, Bai, Jane, Lunt, Colin, Sun, Amy, Yule, Murray, McAlpine, Cheryl, Williams, Dennis, Van Tine, Brian Andrew

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AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3β activation and RNA polymerase II inhibition von Santo, L, Vallet, S, Hideshima, T, Cirstea, D, Ikeda, H, Pozzi, S, Patel, K, Okawa, Y, Gorgun, G, Perrone, G, Calabrese, E, Yule, M, Squires, M, Ladetto, M, Boccadoro, M, Richardson, P G, Munshi, N C, Anderson, K C, Raje, N

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Abstract 953: Development of a predictive biomarker signature for the highly potent SIK3 inhibitor OMX-0407 von Maser, Ilona-Petra, Lacher, Sonja, Piras, Vincent, Kracher, Barbara, Zanziger, Kai, Yule, Murray, Loferer, Hannes, Bissinger, Stefan

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Human metabolism of [(14)C]indisulam following i.v. infusion in cancer patients von Beumer, Jan-Hendrik, Hillebrand, Michel J X, Pluim, Dick, Rosing, Hilde, Foley, Karen, Yule, S Murray, Schellens, Jan H M, Beijnen, Jos H

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Dose-escalation study of a second-generation non-ansamycin HSP90 inhibitor, onalespib (AT13387), in combination with imatinib in patients with metastatic gastrointestinal stromal t... von Wagner, Andrew J, Agulnik, Mark, Heinrich, Michael C, Mahadevan, Daruka, Riedel, Richard F, von Mehren, Margaret, Trent, Jonathan, Demetri, George D, Corless, Christopher L, Yule, Murray, Lyons, John F, Oganesian, Aram, Keer, Harold

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A phase I trial of AT9283 (a selective inhibitor of aurora kinases) in children and adolescents with solid tumors: a Cancer Research UK study von Moreno, Lucas, Marshall, Lynley V, Pearson, Andrew D J, Morland, Bruce, Elliott, Martin, Campbell-Hewson, Quentin, Makin, Guy, Halford, Sarah E R, Acton, Gary, Ross, Philip, Kazmi-Stokes, Shamim, Lock, Victoria, Rodriguez, Ana, Lyons, John F, Boddy, Alan V, Griffin, Melanie J, Yule, Murray, Hargrave, Darren

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Final Analysis of the Dose Escalation, Expansion and Biomarker Correlations in the Ph I/II Trial BGBC003 with the Selective Oral AXL Inhibitor Bemcentinib (BGB324) in Relapsed/Refr... von Loges, Sonja, Heuser, Michael, Chromik, Joerg, Vigil, Carlos E, Paschka, Peter, Ben-Batalla, Isabel, Akyüz, Nuray, Micklem, David, Holt, Robert, Brown, Anthony, Lorens, James, Yule, Murray, Kebenko, Maxim, Janning, Melanie, Binder, Mascha, Fiedler, Walter, Cortes, Jorge E., Gjertsen, Bjorn

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A phase 1/2 dose escalation and expansion study of bemcentinib (BGB324), a first-in-class, selective AXL inhibitor, with docetaxel in patients with previously treated non-squamous... von Rashdan, Sawsan, Williams, Jessica N., Currykosky, Penny, Fattah, Farjana, Padro, Jonathan, Wnuk-Lipinska, Katarzyna, Gausdal, Gro, Brown, Anthony, Micklem, David, Holt, Robert J, Lorens, James, Yule, Murray, Gerber, David E.

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Combination of bemcentinib (BGB324): A first-in-class selective oral AXL inhibitor, with pembrolizumab in patients with triple negative breast cancer and adenocarcinoma of the lung von Yule, Murray, Davidsen, Kjersti, Bloe, Magnus, Hodneland, Linn, Engelsen, Agnete, Lie, Maria, Bougnaud, Sebastien, D'Mello, Stacey, Aguilera, Kristina, Ahmed, Lavina, Rybika, Agata, Milde Naeval, Eline, Boniecka, Anna, Thiery, Jean Paul, Chouaib, Salem, Brekken, Rolf A., Gausdal, Gro, Lorens, James

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The Orally Available Selective Axl Inhibitor BGB324 Induces Diversification of the Immune Repertoire and Specific Changes in Plasma Biomarker Profiles von Loges, Sonja, Gjertsen, Bjørn Tore, Heuser, Michael, Chromik, Joerg, Ben-Batalla, Isabel, Akyüz, Nuray, Micklem, David, Brown, Anthony, Lorens, James, Yule, Murray, Kebenko, Maxim, Janning, Melanie, Binder, Mascha, Fiedler, Walter, Cortes, Jorge E.

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Axl blockade in vitro and in patients with high-risk MDS by the small molecule inhibitor BGB324 von Loges, Sonja, Ben Batalla, Isabel, Heuser, Michael, Berenbrok, Nikolas, Schroeder, Thomas, Geyh, Stefanie, Micklem, David, Chromik, Jörg, Kebenko, Maxim, Fiedler, Walter M., Yule, Murray, Cortes, Jorge E., Gjertsen, Bjorn T.

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A Phase I and Pharmacodynamic Study of AT9283, a Small-Molecule Inhibitor of Aurora Kinases in Patients With Relapsed/Refractory Leukemia or Myelofibrosis von Foran, James, Ravandi, Farhad, Wierda, William, Garcia-Manero, Guillermo, Verstovsek, Srdan, Kadia, Tapan, Burger, Jan, Yule, Murray, Langford, Gillian, Lyons, John, Ayrton, John, Lock, Victoria, Borthakur, Gautham, Cortes, Jorge, Kantarjian, Hagop

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