Cell-based high-throughput screening for the evaluation of reactive metabolite formation potential von Harada, Kosuke, Kohara, Hiroshi, Yukawa, Tomoya, Matsumiya, Kouta, Shinozawa, Tadahiro

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Allylcyanation of Alkynes:  Regio- and Stereoselective Access to Functionalized Di- or Trisubstituted Acrylonitriles von Nakao, Yoshiaki, Yukawa, Tomoya, Hirata, Yasuhiro, Oda, Shinichi, Satoh, Jun, Hiyama, Tamejiro

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Nickel/Lewis Acid-Catalyzed Carbocyanation of Alkynes Using Acetonitrile and Substituted Acetonitriles von Yada, Akira, Yukawa, Tomoya, Idei, Hiroaki, Nakao, Yoshiaki, Hiyama, Tamejiro

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Utility of Physicochemical Properties for the Prediction of Toxicological Outcomes: Takeda Perspective von Yukawa, Tomoya, Naven, Russell

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Practical application of 3-substituted-2,6-difluoropyridines in drug discovery: Facile synthesis of novel protein kinase C theta inhibitors von Katoh, Taisuke, Tomata, Yoshihide, Setoh, Masaki, Sasaki, Satoshi, Takai, Takafumi, Yoshitomi, Yayoi, Yukawa, Tomoya, Nakagawa, Hideyuki, Fukumoto, Shoji, Tsukamoto, Tetsuya, Nakada, Yoshihisa

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Nickel-Catalyzed Carbocyanation of Alkynes with Allyl Cyanides von Hirata, Yasuhiro, Yukawa, Tomoya, Kashihara, Natsuko, Nakao, Yoshiaki, Hiyama, Tamejiro

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In Vitro Human Ion Channel Assays Predictive of Drug Induced Seizure von Cohen, Jennifer D, You, Dahea, Sharma, Ashok K, Takai, Takafumi, Hara, Hideto, Sales, Vicencia T, Yukawa, Tomoya, Cai, Beibei

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Freshly isolated primary human proximal tubule cells as an in vitro model for the detection of renal tubular toxicity von Bajaj, Piyush, Chung, Git, Pye, Keith, Yukawa, Tomoya, Imanishi, Akio, Takai, Yuichi, Brown, Colin, Wagoner, Matthew P.

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Stannylative Cycloaddition of Enynes Catalyzed by Palladium−Iminophosphine von Nakao, Yoshiaki, Hirata, Yasuhiro, Ishihara, Shinjiro, Oda, Shinichi, Yukawa, Tomoya, Shirakawa, Eiji, Hiyama, Tamejiro

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Small-Scale Panel Comprising Diverse Gene Family Targets To Evaluate Compound Promiscuity von Sameshima, Tomoya, Yukawa, Tomoya, Hirozane, Yoshihiko, Yoshikawa, Masato, Katoh, Taisuke, Hara, Hideto, Yogo, Takatoshi, Miyahisa, Ikuo, Okuda, Teruaki, Miyamoto, Makoto, Naven, Russell

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Discovery of [cis-3-({(5R)‑5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro‑1H‑inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5H)‑yl}carbonyl)­cyclobutyl]­acetic Acid (TAK-828... von Kono, Mitsunori, Ochida, Atsuko, Oda, Tsuneo, Imada, Takashi, Banno, Yoshihiro, Taya, Naohiro, Masada, Shinichi, Kawamoto, Tetsuji, Yonemori, Kazuko, Nara, Yoshi, Fukase, Yoshiyuki, Yukawa, Tomoya, Tokuhara, Hidekazu, Skene, Robert, Sang, Bi-Ching, Hoffman, Isaac D, Snell, Gyorgy P, Uga, Keiko, Shibata, Akira, Igaki, Keiko, Nakamura, Yoshiki, Nakagawa, Hideyuki, Tsuchimori, Noboru, Yamasaki, Masashi, Shirai, Junya, Yamamoto, Satoshi

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TAK-994 Mechanistic Investigation into Drug-Induced Liver Injury von Shinozawa, Tadahiro, Miyamoto, Kazumasa, Baker, Kevin S, Faber, Samantha C, Flores, Ramon, Uetrecht, Jack, von Hehn, Christian, Yukawa, Tomoya, Tohyama, Kimio, Kadali, Harisha, von Grotthuss, Marcin, Sudo, Yusuke, Smith, Erin N, Diogo, Dorothée, Zhu, Andy Z X, Dragan, Yvonne, Cebers, Gvido, Wagoner, Matthew P

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Nickel/AlMe2Cl-catalysed carbocyanation of alkynes using arylacetonitriles von Yada, Akira, Yukawa, Tomoya, Nakao, Yoshiaki, Hiyama, Tamejiro

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New phenotypic cytotoxicity assay for ROS-inducing compounds using rat renal epithelial cells von Uchiyama, Noriko, Yukawa, Tomoya, Dragan, Yvonne P., Wagoner, Matthew P., Naven, Russell T.

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Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Invers... von Yukawa, Tomoya, Nara, Yoshi, Kono, Mitsunori, Sato, Ayumu, Oda, Tsuneo, Takagi, Terufumi, Sato, Takayuki, Banno, Yoshihiro, Taya, Naohiro, Imada, Takashi, Shiokawa, Zenyu, Negoro, Nobuyuki, Kawamoto, Tetsuji, Koyama, Ryokichi, Uchiyama, Noriko, Skene, Robert, Hoffman, Isaac, Chen, Chien-Hung, Sang, BiChing, Snell, Gyorgy, Katsuyama, Ryosuke, Yamamoto, Satoshi, Shirai, Junya

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Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives von Kono, Mitsunori, Oda, Tsuneo, Tawada, Michiko, Imada, Takashi, Banno, Yoshihiro, Taya, Naohiro, Kawamoto, Tetsuji, Tokuhara, Hidekazu, Tomata, Yoshihide, Ishii, Naoki, Ochida, Atsuko, Fukase, Yoshiyuki, Yukawa, Tomoya, Fukumoto, Shoji, Watanabe, Hiroyuki, Uga, Keiko, Shibata, Akira, Nakagawa, Hideyuki, Shirasaki, Mikio, Fujitani, Yasushi, Yamasaki, Masashi, Shirai, Junya, Yamamoto, Satoshi

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Assessment of a 3D neural spheroid model to detect pharmaceutical-induced neurotoxicity von Wang, Qin, Cohen, Jennifer D, Yukawa, Tomoya, Estrella, Heather, Leonard, Chris, Nunes, Jairo, Choi, Colin, Mishra, Nibha, Lewis, Lauren, Baker, Kevin S, Kuga, Kazuhiro, Dragan, Yvonne P, Wagoner, Matthew P

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Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors – Part 3 von Yukawa, Tomoya, Nakada, Yoshihisa, Sakauchi, Nobuki, Kamei, Taku, Yamada, Masami, Ohba, Yusuke, Fujimori, Ikuo, Ueno, Hiroyuki, Takiguchi, Maiko, Kuno, Masako, Kamo, Izumi, Nakagawa, Hideyuki, Fujioka, Yasushi, Igari, Tomoko, Ishichi, Yuji, Tsukamoto, Tetsuya

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Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors—Part 2 von Yukawa, Tomoya, Fujimori, Ikuo, Kamei, Taku, Nakada, Yoshihisa, Sakauchi, Nobuki, Yamada, Masami, Ohba, Yusuke, Ueno, Hiroyuki, Takiguchi, Maiko, Kuno, Masako, Kamo, Izumi, Nakagawa, Hideyuki, Fujioka, Yasushi, Igari, Tomoko, Ishichi, Yuji, Tsukamoto, Tetsuya

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Design, synthesis and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitor von Fujimori, Ikuo, Yukawa, Tomoya, Kamei, Taku, Nakada, Yoshihisa, Sakauchi, Nobuki, Yamada, Masami, Ohba, Yusuke, Takiguchi, Maiko, Kuno, Masako, Kamo, Izumi, Nakagawa, Hideyuki, Hamada, Teruki, Igari, Tomoko, Okuda, Teruaki, Yamamoto, Satoshi, Tsukamoto, Tetsuya, Ishichi, Yuji, Ueno, Hiroyuki

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