A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation von Cui, Xiao-Long, Nie, Ji, Ku, Jeremy, Dougherty, Urszula, West-Szymanski, Diana C., Collin, Francois, Ellison, Christopher K., Sieh, Laura, Ning, Yuhong, Deng, Zifeng, Zhao, Carolyn W. T., Bergamaschi, Anna, Pekow, Joel, Wei, Jiangbo, Beadell, Alana V., Zhang, Zhou, Sharma, Geeta, Talwar, Raman, Arensdorf, Patrick, Karpus, Jason, Goel, Ajay, Bissonnette, Marc, Zhang, Wei, Levy, Samuel, He, Chuan

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Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA von Guler, Gulfem D., Ning, Yuhong, Ku, Chin-Jen, Phillips, Tierney, McCarthy, Erin, Ellison, Christopher K., Bergamaschi, Anna, Collin, Francois, Lloyd, Paul, Scott, Aaron, Antoine, Michael, Wang, Wendy, Chau, Kim, Ashworth, Alan, Quake, Stephen R., Levy, Samuel

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A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines von Hollenbach, Paul W, Nguyen, Aaron N, Brady, Helen, Williams, Michelle, Ning, Yuhong, Richard, Normand, Krushel, Leslie, Aukerman, Sharon L, Heise, Carla, MacBeth, Kyle J

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Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G1–S Checkpoint von Zhu, Dan, Xu, Shuichan, Deyanat-Yazdi, Gordafaried, Peng, Sophie X., Barnes, Leo A., Narla, Rama Krishna, Tran, Tam, Mikolon, David, Ning, Yuhong, Shi, Tao, Jiang, Ning, Raymon, Heather K., Riggs, Jennifer R., Boylan, John F.

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Plasma cell-free DNA hydroxymethylation profiling reveals anti-PD-1 treatment response and resistance biology in non-small cell lung cancer von Guler, Gulfem D, Ning, Yuhong, Coruh, Ceyda, Mognol, Giuliana P, Phillips, Tierney, Nabiyouni, Maryam, Hazen, Kyle, Scott, Aaron, Volkmuth, Wayne, Levy, Samuel

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Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase... von Gandhi, Anita K, Kang, Jian, Havens, Courtney G, Conklin, Thomas, Ning, Yuhong, Wu, Lei, Ito, Takumi, Ando, Hideki, Waldman, Michelle F, Thakurta, Anjan, Klippel, Anke, Handa, Hiroshi, Daniel, Thomas O, Schafer, Peter H, Chopra, Rajesh

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FarView: An in-situ manufactured lunar far side radio array concept for 21-cm Dark Ages cosmology von Polidan, Ronald S., Burns, Jack O., Ignatiev, Alex, Hegedus, Alex, Pober, Jonathan, Mahesh, Nivedita, Chang, Tzu-Ching, Hallinan, Gregg, Ning, Yuhong, Bowman, Judd

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Epigenomic Blood-Based Early Detection of Pancreatic Cancer Employing Cell-Free DNA von Haan, David, Bergamaschi, Anna, Friedl, Verena, Guler, Gulfem D., Ning, Yuhong, Reggiardo, Roman, Kesling, Michael, Collins, Micah, Gibb, Bill, Hazen, Kyle, Bates, Steve, Antoine, Michael, Fraire, Carolina, Lopez, Vanessa, Malta, Roger, Nabiyouni, Maryam, Nguyen, Albert, Phillips, Tierney, Riviere, Michael, Leighton, Anna, Ellison, Christopher, McCarthy, Erin, Scott, Aaron, Gigliotti, Lauren, Nilson, Eric, Sheard, Judith, Peters, Melissa, Bethel, Kelly, Chowdhury, Shimul, Volkmuth, Wayne, Levy, Samuel

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The 5-Hydroxymethylcytosine Landscape of Prostate Cancer von Sjöström, Martin, Zhao, Shuang G, Levy, Samuel, Zhang, Meng, Ning, Yuhong, Shrestha, Raunak, Lundberg, Arian, Herberts, Cameron, Foye, Adam, Aggarwal, Rahul, Hua, Junjie T, Li, Haolong, Bergamaschi, Anna, Maurice-Dror, Corinne, Maheshwari, Ashutosh, Chen, Sujun, Ng, Sarah W S, Ye, Wenbin, Petricca, Jessica, Fraser, Michael, Chesner, Lisa, Perry, Marc D, Moreno-Rodriguez, Thaidy, Chen, William S, Alumkal, Joshi J, Chou, Jonathan, Morgans, Alicia K, Beer, Tomasz M, Thomas, George V, Gleave, Martin, Lloyd, Paul, Phillips, Tierney, McCarthy, Erin, Haffner, Michael C, Zoubeidi, Amina, Annala, Matti, Reiter, Robert E, Rettig, Matthew B, Witte, Owen N, Fong, Lawrence, Bose, Rohit, Huang, Franklin W, Luo, Jianhua, Bjartell, Anders, Lang, Joshua M, Mahajan, Nupam P, Lara, Primo N, Evans, Christopher P, Tran, Phuoc T, Posadas, Edwin M, He, Chuan, Cui, Xiao-Long, Huang, Jiaoti, Zwart, Wilbert, Gilbert, Luke A, Maher, Christopher A, Boutros, Paul C, Chi, Kim N, Ashworth, Alan, Small, Eric J, He, Housheng H, Wyatt, Alexander W, Quigley, David A, Feng, Felix Y

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Monitoring immunotherapy response in non-small cell lung cancer patients using 5-hydroxymethylcytosine signatures in circulating cell free DNA von Guler, Gulfem, Haan, David, Ning, Yuhong, Ku, Jeremy, McCarthy, Erin, Phillips, Tierney, Antoine, Michael, Bergamaschi, Anna, Lloyd, Paul, Scott, Aaron, Ellison, Chris, Levy, Samuel

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Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G 1 -S Checkpoint von Zhu, Dan, Xu, Shuichan, Deyanat-Yazdi, Gordafaried, Peng, Sophie X, Barnes, Leo A, Narla, Rama Krishna, Tran, Tam, Mikolon, David, Ning, Yuhong, Shi, Tao, Jiang, Ning, Raymon, Heather K, Riggs, Jennifer R, Boylan, John F

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Pancreatic cancer detection using EpiDetect signatures in plasma-derived cell free DNA in high-risk patients with new onset diabetes von Guler, Gulfem, Bergamaschi, Anna, Haan, David, Kesling, Michael, Ning, Yuhong, Ellison, Chris, Gibb, William, Antoine, Michael, Nguyen, Albert, Malta, Roger, Fraire, Carolina, Woldeyohanne, Samuel, Scott, Aaron, Hazen, Kyle, Peters, Melissa, Sheard, Judy, Volkmuth, Wayne, Bethel, Kelly, Levy, Samuel

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Genome-wide 5hmC profiles to enable cancer detection and tissue of origin classification in breast, colorectal, lung, ovarian, and pancreatic cancers von Haan, David, Bergamaschi, Anna, Ning, Yuhong, Gibb, William, Kesling, Michael, Pitea, Adriana, Nabiyouni, Maryam, Ellison, Chris, Malta, Roger, Nguyen, Albert, Guler, Gulfem, McCarthy, Erin, Phillips, Tierney, Scott, Aaron, Hazen, Kyle, Sheard, Judy, Peters, Melissa, Bethel, Kelly, Volkmuth, Wayne, Levy, Samuel

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Abstract 1372: Detection of early stage pancreatic cancer using 5–hydroxymethylcytosine signatures in circulating cell free DNA von Collin, Francois, Ning, Yuhong, Guler, Gulfem D., Phillips, Tierney, McCarthy, Erin, Scott, Aaron, Ellison, Chris, Ku, Chin-Jen, Chau, Kim, Ashworth, Alan, Quake, Stephen R., Levy, Samuel

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Changes in DNA hydroxymethylation for the detection of multiple cancers in plasma cell-free DNA von Bergamaschi, Anna, Collins, Francois, Ellison, Chris, Ning, Yuhong, Guler, Gulfem, Phillips, Tierney, McCarthy, Erin, Wang, Wendy, Antoine, Michael, Ku, Jeremy, Scott, Aaron, Lloyd, Paul, Ashworth, Alan, Levy, Samuel

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Abstract 783: Epigenomic detection of multiple cancers in plasma derived cell free DNA von Bergamaschi, Anna, Ku, Jeremy, Ning, Yuhong, Collin, Francois, Ellison, Chris, Phillips, Tierney, McCarthy, Erin, Wang, Wendy, Antoine, Michael, Haan, David, Scott, Aaron, Lloyd, Paul, Guler, Gulfem, Ashworth, Alan, Quake, Stephen, Levy, Samuel

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Effect of detection of epigenomic changes in plasma-derived cell-free DNA on multicancer classification von Bergamaschi, Anna, Haan, David, Ku, Jeremy, Ning, Yuhong, Ellison, Chris, Guler, Gulfem, Phillips, Tierney, McCarthy, Erin, Antoine, Michael, Nguyen, Albert, Scott, Aaron, Lloyd, Paul, Ashworth, Alan, Bethel, Kelly, Levy, Samuel

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Pomalidomide in combination with dexamethasone results in synergistic anti‐tumour responses in pre‐clinical models of lenalidomide‐resistant multiple myeloma von Rychak, Emily, Mendy, Derek, Shi, Tao, Ning, Yuhong, Leisten, Jim, Lu, Ling, Miller, Karen, Narla, Rama K., Orlowski, Robert Z., Raymon, Heather K., Bjorklund, Chad C., Thakurta, Anjan, Gandhi, Anita K., Cathers, Brian E., Chopra, Rajesh, Daniel, Thomas O., Lopez‐Girona, Antonia

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5-hydroxymethylcytosine as a liquid biopsy biomarker in mCRPC von Sjöström, Martin, Zhao, Shuang, Small, Eric Jay, Ning, Yuhong, Maurice-Dror, Corinne, Foye, Adam, Hua, Jun Jie T., Li, Haolong, Beer, Tomasz M., Evans, Christopher P., Rettig, Matthew, Chi, Kim N., Alumkal, Joshi J., Aggarwal, Rahul Raj, Ashworth, Alan, Levy, Samuel, He, Housheng H., Wyatt, Alexander W., Quigley, David A., Feng, Felix Y

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7 Anti-PD1 treatment response prediction and monitoring in non-small cell lung cancer patients using plasma cell-free DNA hydroxymethylation von Guler, Gulfem, Ning, Yuhong, Haan, David, Kesling, Michael, Coruh, Ceyda, Mognol, Giuliana, Phillips, Tierney, Hazen, Kyle, Volkmuth, Wayne, Levy, Samuel

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