C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists von Chao, Jianhua, Taveras, Arthur G., Chao, Jianping, Aki, Cynthia, Dwyer, Michael, Yu, Younong, Purakkattle, Biju, Rindgen, Diane, Jakway, James, Hipkin, William, Fosetta, James, Fan, Xuedong, Lundell, Daniel, Fine, Jay, Minnicozzi, Michael, Phillips, Jonathan, Merritt, J. Robert

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Chemoselective Peptide Modification via Photocatalytic Tryptophan β‑Position Conjugation von Yu, Younong, Zhang, Li-Kang, Buevich, Alexei V, Li, Guoqing, Tang, Haiqun, Vachal, Petr, Colletti, Steven L, Shi, Zhi-Cai

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Substituted dibenzo[c, h]cinnolines: Topoisomerase I-targeting anticancer agents von YOUNONG YU, SINGH, Sudhir K, LIU, Angela, LI, Tsai-Kun, LIU, Leroy F, LAVOIE, Edmond J

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Discovery of 2-Hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123):  A Potent, Orally Bioavailable CXCR2/CXCR1... von Dwyer, Michael P, Yu, Younong, Chao, Jianping, Aki, Cynthia, Chao, Jianhua, Biju, Purakkattle, Girijavallabhan, Viyyoor, Rindgen, Diane, Bond, Richard, Mayer-Ezel, Rosemary, Jakway, James, Hipkin, R. William, Fossetta, James, Gonsiorek, Waldemar, Bian, Hong, Fan, Xuedong, Terminelli, Carol, Fine, Jay, Lundell, Daniel, Merritt, J. Robert, Rokosz, Laura L, Kaiser, Bernd, Li, Ge, Wang, Wei, Stauffer, Tara, Ozgur, Lynne, Baldwin, John, Taveras, Arthur G

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Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation von Yu, Wensheng, Liu, Jian, Yu, Younong, Zhang, Vivian, Clausen, Dane, Kelly, Joseph, Wolkenberg, Scott, Beshore, Douglas, Duffy, Joseph L., Chung, Christine C., Myers, Robert W., Klein, Daniel J., Fells, James, Holloway, Kate, Wu, Jin, Wu, Guoxin, Howell, Bonnie J., Barnard, Richard J.O., Kozlowski, Joseph

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Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity von Yu, Wensheng, Liu, Jian, Clausen, Dane, Yu, Younong, Duffy, Joseph L, Wang, Ming, Xu, Shouning, Deng, Lin, Suzuki, Takao, Chung, Christine C, Myers, Robert W, Klein, Daniel J, Fells, James I, Holloway, M. Katharine, Wu, Jin, Wu, Guoxin, Howell, Bonnie J, Barnard, Richard J. O, Kozlowski, Joseph

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Discovery of Highly Selective and Potent HDAC3 Inhibitors Based on a 2‑Substituted Benzamide Zinc Binding Group von Liu, Jian, Yu, Younong, Kelly, Joseph, Sha, Deyou, Alhassan, Abdul-Basit, Yu, Wensheng, Maletic, Milana M, Duffy, Joseph L, Klein, Daniel J, Holloway, M. Katharine, Carroll, Steve, Howell, Bonnie J, Barnard, Richard J. O, Wolkenberg, Scott, Kozlowski, Joseph A

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Identification of Oxidation Products of (−)-Epigallocatechin Gallate and (−)-Epigallocatechin with H2O2 von Zhu, Nanqun, Huang, Tzou-Chi, Yu, Younong, LaVoie, Edmond J, Yang, Chung S, Ho, Chi-Tang

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Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes von Liu, Jian, Guiadeen, Deodial, Krikorian, Arto, Gao, Xiaolei, Wang, James, Babu Boga, Sobhana, Alhassan, Abdul-Basit, Yu, Wensheng, Selyutin, Oleg, Yu, Younong, Anand, Rajan, Xu, Jiayi, Kelly, Joseph, Duffy, Joseph L., Liu, Shilan, Yang, Chundao, Wu, Hao, Cai, Jiaqiang, Bennett, Chad, Maloney, Kevin M., Tyagarajan, Sriram, Gao, Ying-Duo, Fischmann, Thierry O., Presland, Jeremy, Mansueto, My, Xu, Zangwei, Leccese, Erica, Zhang-Hoover, Jie, Knemeyer, Ian, Garlisi, Charles G., Stivers, Peter, Brandish, Philip E., Hicks, Alexandra, Kim, Ronald, Kozlowski, Joseph A.

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Rapid Affinity and Microsomal Stability Ranking of Crude Mixture Libraries of Histone Deacetylase Inhibitors von Tyagarajan, Sriram, Andrews, Christine L., Beshore, Douglas C., Buevich, Alexei V., Curran, Patrick J., Dandliker, Peter, Greshock, Thomas J., Hoar, Jason, Kim, Alex, Karnachi, Prabha, Knemeyer, Ian, Kozlowski, Joseph, Liu, Jian, Maletic, Milana, Myers, Robert, Rada, Vanessa, Sha, Deyou, Sauvagnat, Berengere, Vachal, Petr, Wolkenberg, Scott, Yu, Wensheng, Yu, Younong, Krska, Shane W.

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A new synthesis of 3,4-disubstituted 1,2,5-thiadiazoles von Biju, Purakkattle, Yu, Younong

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Synthesis of HDAC Inhibitor Libraries via Microscale Workflow von Dykstra, Kevin D, Streckfuss, Eric, Liu, Min, Liu, Jian, Yu, Younong, Wang, Ming, Kozlowski, Joseph A, Myers, Robert W, Buevich, Alexei V, Maletic, Milana M, Vachal, Petr, Krska, Shane W

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Discovery of novel BTK inhibitors with carboxylic acids von Gao, Xiaolei, Wang, James, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto, Boga, Sobhana Babu, Alhassan, Abdul-Basit, Selyutin, Oleg, Yu, Wensheng, Yu, Younong, Anand, Rajan, Liu, Shilan, Yang, Chundao, Wu, Hao, Cai, Jiaqiang, Cooper, Alan, Zhu, Hugh, Maloney, Kevin, Gao, Ying-Duo, Fischmann, Thierry O., Presland, Jeremy, Mansueto, My, Xu, Zangwei, Leccese, Erica, Zhang-Hoover, Jie, Knemeyer, Ian, Garlisi, Charles G., Bays, Nathan, Stivers, Peter, Brandish, Philip E., Hicks, Alexandra, Kim, Ronald, Kozlowski, Joeseph A.

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Use of molecular modeling aided design to dial out hERG liability in adenosine A(2A) receptor antagonists von Deng, Qiaolin, Lim, Yeon-Hee, Anand, Rajan, Yu, Younong, Kim, Jae-hun, Zhou, Wei, Zheng, Junying, Tempest, Paul, Levorse, Dorothy, Zhang, Xiaoping, Greene, Scott, Mullins, Deborra, Culberson, Chris, Sherborne, Brad, Parker, Eric M, Stamford, Andrew, Ali, Amjad

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Use of molecular modeling aided design to dial out hERG liability in adenosine A2A receptor antagonists von Deng, Qiaolin, Lim, Yeon-Hee, Anand, Rajan, Yu, Younong, Kim, Jae-hun, Zhou, Wei, Zheng, Junying, Tempest, Paul, Levorse, Dorothy, Zhang, Xiaoping, Greene, Scott, Mullins, Deborra, Culberson, Chris, Sherborne, Brad, Parker, Eric M., Stamford, Andrew, Ali, Amjad

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Quality by design (QbD) of amide isosteres: 5,5-Disubstituted isoxazolines as potent CRTh2 antagonists with favorable pharmacokinetic and drug-like properties von Xiao, Dong, Zhu, Xiaohong, Yu, Younong, Shao, Ning, Wu, Jie, McCormick, Kevin D., Dhondi, Pawan, Qin, Jun, Mazzola, Robert, Tang, Haiqun, Rao, Ashwin, Siliphaivanh, Phieng, Qiu, Hongchen, Yang, Xiaoxin, Rivelli, Maria, Garlisi, Charles G., Eckel, Steve, Mukhopadhyay, Gitali, Correll, Craig, Rindgen, Diane, Aslanian, Robert, Palani, Anandan

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Quality by design (QbD) of amide isosteres: 5,5-Disubstituted isoxazolines as potent CRTh sub(2) antagonists with favorable pharmacokinetic and drug-like properties von Xiao, Dong, Zhu, Xiaohong, Yu, Younong, Shao, Ning, Wu, Jie, McCormick, Kevin D, Dhondi, Pawan, Qin, Jun, Mazzola, Robert, Tang, Haiqun, Rao, Ashwin, Siliphaivanh, Phieng, Qiu, Hongchen, Yang, Xiaoxin, Rivelli, Maria, Garlisi, Charles G, Eckel, Steve, Mukhopadhyay, Gitali, Correll, Craig, Rindgen, Diane, Aslanian, Robert, Palani, Anandan

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3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists von Biju, Purakkattle, Taveras, Arthur G., Yu, Younong, Zheng, Junying, Hipkin, R. William, Fossetta, James, Fan, Xuedong, Fine, Jay, Lundell, Daniel

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INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION von Yu, Younong, Clausen, Dane James, Liu, Jian, Yu, Wensheng, Wang, Ming, Kozlowski, Joseph, Li, Bing

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ADENOSINE A2A AND A2B RECEPTOR DUAL ANTAGONISTS FOR IMMUNO-ONCOLOGY von Swaminathan, Uma, Hennessy, Elisabeth T, Mansoor, Umar Faruk, Wu, Heping, Ye, Yingchun, Kelly, Joseph M, Yu, Younong, Lo, Michael Man-Chu, Cumming, Jared N, Ali, Amjad, DeMong, Duane, Kuang, Rongze, Graham, Thomas H, Moreno, Jesus, De Lera Ruiz, Manuel

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