Inhibition of Autophagosome Formation by the Benzoporphyrin Derivative Verteporfin von Donohue, Elizabeth, Tovey, Andrew, Vogl, A. Wayne, Arns, Steve, Sternberg, Ethan, Young, Robert N., Roberge, Michel

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The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K von Gauthier, Jacques Yves, Chauret, Nathalie, Cromlish, Wanda, Desmarais, Sylvie, Duong, Le T., Falgueyret, Jean-Pierre, Kimmel, Donald B., Lamontagne, Sonia, Léger, Serge, LeRiche, Tammy, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Nicoll-Griffith, Deborah A., Oballa, Renata M., Palmer, James T., Percival, M. David, Riendeau, Denis, Robichaud, Joel, Rodan, Gideon A., Rodan, Sevgi B., Seto, Carmai, Thérien, Michel, Truong, Vouy-Linh, Venuti, Michael C., Wesolowski, Gregg, Young, Robert N., Zamboni, Robert, Black, W. Cameron

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Novel EP4 Receptor Agonist‐Bisphosphonate Conjugate Drug (C1) Promotes Bone Formation and Improves Vertebral Mechanical Properties in the Ovariectomized Rat Model of Postmenopausal... von Liu, Careesa C, Hu, Sally, Chen, Gang, Georgiou, John, Arns, Steve, Kumar, Nag S, Young, Robert N, Grynpas, Marc D

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Design and synthesis of novel bone-targeting dual-action pro-drugs for the treatment and reversal of osteoporosis von Arns, Steve, Gibe, Romelo, Moreau, Anne, Monzur Morshed, M., Young, Robert N.

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Design, Synthesis, and Pharmacokinetics of a Bone-Targeting Dual-Action Prodrug for the Treatment of Osteoporosis von Xie, Haibo, Chen, Gang, Young, Robert N

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Design and synthesis of an all-in-one 3-(1,1-difluoroprop-2-ynyl)-3H-diazirin-3-yl functional group for photo-affinity labeling von KUMAR, Nag S, YOUNG, Robert N

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A protocol for identifying the binding sites of small molecules on the cystic fibrosis transmembrane conductance regulator (CFTR) protein von Laselva, Onofrio, Petrotchenko, Evgeniy V., Hamilton, C. Michael, Qureshi, Zafar, Borchers, Christoph H., Young, Robert N., Bear, Christine E.

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Identification of Pyruvate Kinase in Methicillin-Resistant Staphylococcus aureus as a Novel Antimicrobial Drug Target von ZORAGHI, Roya, SEE, Raymond H, AMANDORON, Emily, TIAN LIAN, JACKSON, Linda, JIHONG JIANG, THORSON, Lisa, LABRIERE, Christophe, FOSTER, Leonard, BRUNHAM, Robert C, MCMASTER, William R, FINLAY, B. Brett, AXERIO-CILIES, Peter, STRYNADKA, Natalie C, CHERKASOV, Artem, YOUNG, Robert N, REINER, Neil E, KUMAR, Nag S, HUANSHENG GONG, MOREAU, Anne, HSING, Michael, KAUR, Sukhbir, SWAYZE, Richard D, WORRALL, Liam

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The promise and peril of chemical probes von Arrowsmith, Cheryl H, Audia, James E, Austin, Christopher, Baell, Jonathan, Bennett, Jonathan, Blagg, Julian, Bountra, Chas, Brennan, Paul E, Brown, Peter J, Bunnage, Mark E, Buser-Doepner, Carolyn, Campbell, Robert M, Carter, Adrian J, Cohen, Philip, Copeland, Robert A, Cravatt, Ben, Dahlin, Jayme L, Dhanak, Dashyant, Edwards, Aled M, Frederiksen, Mathias, Frye, Stephen V, Gray, Nathanael, Grimshaw, Charles E, Hepworth, David, Howe, Trevor, Huber, Kilian V M, Jin, Jian, Knapp, Stefan, Kotz, Joanne D, Kruger, Ryan G, Lowe, Derek, Mader, Mary M, Marsden, Brian, Mueller-Fahrnow, Anke, Müller, Susanne, O'Hagan, Ronan C, Overington, John P, Owen, Dafydd R, Rosenberg, Saul H, Ross, Ruth, Roth, Bryan, Schapira, Matthieu, Schreiber, Stuart L, Shoichet, Brian, Sundström, Michael, Superti-Furga, Giulio, Taunton, Jack, Toledo-Sherman, Leticia, Walpole, Chris, Walters, Michael A, Willson, Timothy M, Workman, Paul, Young, Robert N, Zuercher, William J

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Effects of treatment with a bone-targeted prostaglandin E2 receptor 4 agonist C3 (Mes-1007) in a mouse model of severe osteogenesis imperfecta von Boraschi-Diaz, Iris, Chen, Gang, Polak-Nachumow, Jonathan, Young, Robert N., Rauch, Frank

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Targeting therapeutics to bone by conjugation with bisphosphonates von Young, Robert N, Grynpas, Marc D

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In Vivo Bone Effects of a Novel Bisphosphonate‐EP4a Conjugate Drug (C3) for Reversing Osteoporotic Bone Loss in an Ovariectomized Rat Model von Sheikh, Zeeshan, Chen, Gang, Al‐Jaf, Faik, Thévenin, Marion, Banks, Kate, Glogauer, Michael, Young, Robert N, Grynpas, Marc D

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E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis von Patankar, Jay V., Müller, Tanja M., Kantham, Srinivas, Acera, Miguel Gonzalez, Mascia, Fabrizio, Scheibe, Kristina, Mahapatro, Mousumi, Heichler, Christina, Yu, Yuqiang, Li, Wei, Ruder, Barbara, Günther, Claudia, Leppkes, Moritz, Mathew, Mano J., Wirtz, Stefan, Neufert, Clemens, Kühl, Anja A., Paquette, Jay, Jacobson, Kevan, Atreya, Raja, Zundler, Sebastian, Neurath, Markus F., Young, Robert N., Becker, Christoph

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Determination of the Rat in Vivo Pharmacokinetic Profile of a Bone-Targeting Dual-Action Pro-Drug for Treatment of Osteoporosis von Chen, Gang, Arns, Steven, Young, Robert N

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Lipid nanoparticle-mediated silencing of osteogenic suppressor GNAS leads to osteogenic differentiation of mesenchymal stem cells in vivo von Basha, Genc, Cottle, Andrew G., Pretheeban, Thavaneetharajah, Chan, Karen YT, Witzigmann, Dominik, Young, Robert N., Rossi, Fabio MV, Cullis, Pieter R.

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Large-Scale Virtual Screening for the Discovery of SARS-CoV‑2 Papain-like Protease (PLpro) Non-covalent Inhibitors von Garland, Olivia, Ton, Anh-Tien, Moradi, Shoeib, Smith, Jason R., Kovacic, Suzana, Ng, Kurtis, Pandey, Mohit, Ban, Fuqiang, Lee, Jaeyong, Vuckovic, Marija, Worrall, Liam J., Young, Robert N., Pantophlet, Ralph, Strynadka, Natalie C. J., Cherkasov, Artem

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Lipophilicity of the Cystic Fibrosis Drug, Ivacaftor (VX-770), and Its Destabilizing Effect on the Major CF-causing Mutation: F508del von Chin, Stephanie, Hung, Maurita, Won, Amy, Wu, Yu-Sheng, Ahmadi, Saumel, Yang, Donghe, Elmallah, Salma, Toutah, Krimo, Hamilton, C. Michael, Young, Robert N., Viirre, Russell D., Yip, Christopher M., Bear, Christine E.

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Further investigation of inhibitors of MRSA pyruvate kinase: Towards the conception of novel antimicrobial agents von Labrière, Christophe, Gong, Huansheng, Finlay, B. Brett, Reiner, Neil E., Young, Robert N.

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Achieving enhanced bone regeneration using monetite granules with bone anabolic drug conjugates (C3 and C6) in rat mandibular defects von Sheikh, Zeeshan, Abdallah, Mohamed‐Nur, Al‐Jaf, Faik, Chen, Gang, Hamdan, Nader, Young, Robert N., Grynpas, Marc D., Glogauer, Michael

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Improved bone regeneration using bone anabolic drug conjugates (C3 and C6) with deproteinized bovine bone mineral as a carrier in rat mandibular defects von Sheikh, Zeeshan, Abdallah, Mohamed‐Nur, Al‐Jaf, Faik, Chen, Gang, Hamdan, Nader, Young, Robert N., Grynpas, Marc D., Glogauer, Michael

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