Comparison and optimization of hiPSC forebrain cortical differentiation protocols von Muratore, Christina R, Srikanth, Priya, Callahan, Dana G, Young-Pearse, Tracy L

Volltext

Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease von Terzioglu, Gizem, Young-Pearse, Tracy L

Volltext

APC Is an RNA-Binding Protein, and Its Interactome Provides a Link to Neural Development and Microtubule Assembly von Preitner, Nicolas, Quan, Jie, Nowakowski, Dan W., Hancock, Melissa L., Shi, Jianhua, Tcherkezian, Joseph, Young-Pearse, Tracy L., Flanagan, John G.

Volltext

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons von Muratore, Christina R, Rice, Heather C, Srikanth, Priya, Callahan, Dana G, Shin, Taehwan, Benjamin, Lawrence N P, Walsh, Dominic M, Selkoe, Dennis J, Young-Pearse, Tracy L

Volltext

Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia von Yu, Lei, Petyuk, Vladislav A., Gaiteri, Chris, Mostafavi, Sara, Young‐Pearse, Tracy, Shah, Raj C., Buchman, Aron S., Schneider, Julie A., Piehowski, Paul D., Sontag, Ryan L., Fillmore, Thomas L., Shi, Tujin, Smith, Richard D., Jager, Philip L., Bennett, David A.

Volltext

Making kin: Exploring new philosophical and pedagogical openings in sustainability education in higher education von Malone, Karen, Young, Tracy

Volltext

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins von Corbett, Grant T., Wang, Zemin, Hong, Wei, Colom-Cadena, Marti, Rose, Jamie, Liao, Meichen, Asfaw, Adhana, Hall, Tia C., Ding, Lai, DeSousa, Alexandra, Frosch, Matthew P., Collinge, John, Harris, David A., Perkinton, Michael S., Spires-Jones, Tara L., Young-Pearse, Tracy L., Billinton, Andrew, Walsh, Dominic M.

Volltext

Magnetic resonance elastography to study the effect of amyloid plaque accumulation in a mouse model von Palotai, Miklos, Schregel, Katharina, Nazari, Navid, Merchant, Julie P., Taylor, Walter M., Guttmann, Charles R. G., Sinkus, Ralph, Young‐Pearse, Tracy L., Patz, Samuel

Volltext

Person‐specific differences in ubiquitin‐proteasome mediated proteostasis in human neurons von Hsieh, Yi‐Chen, Augur, Zachary M., Arbery, Mason, Ashour, Nancy, Barrett, Katharine, Pearse, Richard V., Tio, Earvin S., Duong, Duc M., Felsky, Daniel, De Jager, Philip L., Bennett, David A., Seyfried, Nicholas T., Young‐Pearse, Tracy L.

Volltext

Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate von Srikanth, Priya, Han, Karam, Callahan, Dana G., Makovkina, Eugenia, Muratore, Christina R., Lalli, Matthew A., Zhou, Honglin, Boyd, Justin D., Kosik, Kenneth S., Selkoe, Dennis J., Young-Pearse, Tracy L.

Volltext

Human neural cell type‐specific extracellular vesicle proteome defines disease‐related molecules associated with activated astrocytes in Alzheimer's disease brain von You, Yang, Muraoka, Satoshi, Jedrychowski, Mark P., Hu, Jianqiao, McQuade, Amanda K., Young‐Pearse, Tracy, Aslebagh, Roshanak, Shaffer, Scott A., Gygi, Steven P., Blurton‐Jones, Mathew, Poon, Wayne W., Ikezu, Tsuneya

Volltext

Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy von Spangler, Jamie B, Trotta, Eleonora, Tomala, Jakub, Peck, Ariana, Young, Tracy A, Savvides, Christina S, Silveria, Stephanie, Votavova, Petra, Salafsky, Joshua, Pande, Vijay S, Kovar, Marek, Bluestone, Jeffrey A, Garcia, K Christopher

Volltext

Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing von Nguyen, Lien D., Wei, Zhiyun, Silva, M. Catarina, Barberán-Soler, Sergio, Zhang, Jiarui, Rabinovsky, Rosalia, Muratore, Christina R., Stricker, Jonathan M. S., Hortman, Colin, Young-Pearse, Tracy L., Haggarty, Stephen J., Krichevsky, Anna M.

Volltext

INPP5D regulates inflammasome activation in human microglia von Chou, Vicky, Pearse, Richard V., Aylward, Aimee J., Ashour, Nancy, Taga, Mariko, Terzioglu, Gizem, Fujita, Masashi, Fancher, Seeley B., Sigalov, Alina, Benoit, Courtney R., Lee, Hyo, Lam, Matti, Seyfried, Nicholas T., Bennett, David A., De Jager, Philip L., Menon, Vilas, Young-Pearse, Tracy L.

Volltext

Somatic mosaicism of sex chromosomes in the blood and brain von Graham, Emma J., Vermeulen, Michael, Vardarajan, Badri, Bennett, David, De Jager, Phil, Pearse, Richard V., Young-Pearse, Tracy L., Mostafavi, Sara

Volltext

A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy von Pei, Shanshan, Shelton, Ian T, Gillen, Austin E, Stevens, Brett M, Gasparetto, Maura, Wang, Yanan, Liu, Lina, Liu, Jun, Brunetti, Tonya M, Engel, Krysta, Staggs, Sarah, Showers, William, Sheth, Anagha Inguva, Amaya, Maria L, Minhajuddin, Mohammad, Winters, Amanda, Patel, Sweta B, Tolison, Hunter, Krug, Anna E, Young, Tracy N, Schowinsky, Jeffrey, McMahon, Christine M, Smith, Clayton A, Pollyea, Daniel A, Jordan, Craig T

Volltext

Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation von Wong, Joyce J. W., Young, Tracy A., Zhang, Jiayan, Liu, Shiheng, Leser, George P., Komives, Elizabeth A., Lamb, Robert A., Zhou, Z. Hong, Salafsky, Joshua, Jardetzky, Theodore S.

Volltext

Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids von Srikanth, Priya, Lagomarsino, Valentina N., Muratore, Christina R., Ryu, Steven C., He, Amy, Taylor, Walter M., Zhou, Constance, Arellano, Marlise, Young-Pearse, Tracy L.

Volltext

Mosaic loss of Chromosome Y in aged human microglia von Vermeulen, Michael C, Pearse, Richard, Young-Pearse, Tracy, Mostafavi, Sara

Volltext

Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1 von Lee, Hyo, Aylward, Aimee J., Pearse, Richard V., Lish, Alexandra M., Hsieh, Yi-Chen, Augur, Zachary M., Benoit, Courtney R., Chou, Vicky, Knupp, Allison, Pan, Cheryl, Goberdhan, Srilakshmi, Duong, Duc M., Seyfried, Nicholas T., Bennett, David A., Taga, Mariko F., Huynh, Kevin, Arnold, Matthias, Meikle, Peter J., De Jager, Philip L., Menon, Vilas, Young, Jessica E., Young-Pearse, Tracy L.

Volltext