Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial von Yuen, Man-Fung, Heo, Jeong, Jang, Jeong-Won, Yoon, Jung-Hwan, Kweon, Young-Oh, Park, Sung-Jae, Tami, Yvonne, You, Shihyun, Yates, Phillip, Tao, Yu, Cremer, Jennifer, Campbell, Fiona, Elston, Robert, Theodore, Dickens, Paff, Melanie, Bennett, C. Frank, Kwoh, T. Jesse

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3′ RNA Elements in Hepatitis C Virus Replication: Kissing Partners and Long Poly(U) von YOU, Shihyun, RICE, Charles M

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Stimulator of interferon genes (STING) is an essential proviral host factor for human rhinovirus species A and C von McKnight, Kevin L., Swanson, Karen V., Austgen, Kathryn, Richards, Cindy, Mitchell, Jonathan K., McGivern, David R., Fritch, Ethan, Johnson, John, Remlinger, Katja, Magid-Slav, Michal, Kapustina, Maryna, You, Shihyun, Lemon, Stanley M.

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ZAP's stress granule localization is correlated with its antiviral activity and induced by virus replication von Law, Lok Man John, Razooky, Brandon S, Li, Melody M H, You, Shihyun, Jurado, Andrea, Rice, Charles M, MacDonald, Margaret R

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Gene Expression Profiling Indicates the Roles of Host Oxidative Stress, Apoptosis, Lipid Metabolism, and Intracellular Transport Genes in the Replication of Hepatitis C Virus von Blackham, Samantha, Baillie, Andrew, Al-Hababi, Fadel, Remlinger, Katja, You, Shihyun, Hamatake, Robert, McGarvey, Michael J

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The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors von Wood, Edgar R., Bledsoe, Randy, Chai, Jing, Daka, Philias, Deng, Hongfeng, Ding, Yun, Harris-Gurley, Sarah, Kryn, Luz Helena, Nartey, Eldridge, Nichols, James, Nolte, Robert T., Prabhu, Ninad, Rise, Cecil, Sheahan, Timothy, Shotwell, J. Brad, Smith, Danielle, Tai, Vince, Taylor, J. David, Tomberlin, Ginger, Wang, Liping, Wisely, Bruce, You, Shihyun, Xia, Bing, Dickson, Hamilton

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Studying hepatitis C virus: Making the best of a bad virus von TELLINGHUISEN, Timothy L, EVANS, Matthew J, VON HAHN, Thomas, SHIHYUN YOU, RICE, Charles M

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Preclinical Characterization of GSK2336805, a Novel Inhibitor of Hepatitis C Virus Replication That Selects for Resistance in NS5A von WALKER, Jill, CROSBY, Renae, HAMATAKE, Robert, AMY WANG, WOLDU, Ermias, VAMATHEVAN, Jessica, VOITENLEITNER, Christian, SHIHYUN YOU, REMLINGER, Katja, MAOSHANG DUAN, KAZMIERSKI, Wieslaw

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A cis-Acting Replication Element in the Sequence Encoding the NS5B RNA-Dependent RNA Polymerase Is Required for Hepatitis C Virus RNA Replication von YOU, Shihyun, STUMP, Decherd D, BRANCH, Andrea D, RICE, Charles M

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In Vitro Characterization of GSK2485852, a Novel Hepatitis C Virus Polymerase Inhibitor von VOITENLEITNER, Christian, CROSBY, Renae, HORTON, Joseph, CREECH, Katrina, SHOTWELL, J. Brad, ZHI HONG, HAMATAKE, Robert, WALKER, Jill, REMLINGER, Katja, VAMATHEVAN, Jessica, WANG, Amy, SHIHYUN YOU, JOHNSON, John, WOLDU, Ermias, VAN HORN, Stephanie

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De Novo Synthesis of Negative-Strand RNA by Dengue Virus RNA-Dependent RNA Polymerase In Vitro: Nucleotide, Primer, and Template Parameters von Nomaguchi, Masako, Ackermann, Matt, Yon, Changsuek, You, Shihyun, Padmanabhan, R, Padmanbhan, R

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The Serine Protease and RNA-Stimulated Nucleoside Triphosphatase and RNA Helicase Functional Domains of Dengue Virus Type 2 NS3 Converge within a Region of 20 Amino Acids von Li, H, Clum, S, You, S, Ebner, K E, Padmanabhan, R

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Reply to: “Bepirovirsen/GSK3389404: Antisense or TLR9 agonists?” von You, Shihyun, Elston, Robert, Yuen, Man-Fung

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Multi-Modal Imaging with a Toolbox of Influenza AReporter Viruses von Tran, Vy, Poole, Daniel S, Jeffery, Justin J, Sheahan, Timothy P, Creech, Donald, Yevtodiyenko, Aleksey, Peat, Andrew J, Francis, Kevin P, You, Shihyun, Mehle, Andrew

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End game: Getting the most out of microRNAs von You, Shihyun, Murray, Catherine L, Luna, Joseph M, Rice, Charles M

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SAT-196 - Cell-mediated immunity analysis to assess the characteristics of immune response to bepirovirsen: Examples from the B-Clear study von Singh, Jenn, Salaun, Bruno, You, Shihyun, Corson, Stephen, Paff, Melanie, Theodore, Dickens

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Cell-mediated immunity analysis to assess the characteristics of immune response to bepirovirsen: Examples from the B-Clear study von Singh, Jenn, Salaun, Bruno, You, Shihyun, Corson, Stephen, Paff, Melanie, Theodore, Dickens

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SAT-390 Nonclinical phenotypic evaluation of clinically identified baseline and treatment-emergent hepatitis B Virus variants that contain single nucleotide polymorphisms in the be... von Koenig, Alexander, Savarese, Michael, Turk, Elise, Lau, Chi, Galwey, Nicholas, Bouquet, Jerome, Elston, Robert, Theodore, Dickens, Paff, Melanie, You, Shihyun, Livingston, Christine

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Combination treatment of a PAPD5/7 inhibitor with an antisense oligonucleotide bepirovirsen with concurrent dosing shows additive HBsAg decreases in the AAV-HBV mouse model von Delahaye, Jared, Long, Edward, Lau, Chi, Parsons, Jacob, Wen, Bo, Cui, Zhiyi, Paff, Melanie, You, Shihyun, Leivers, Martin

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Bepirovirsen, antisense oligonucleotide (ASO) against hepatitis B virus (HBV), harbors intrinsic immunostimulatory activity via Toll-like receptor 8 (TLR8) preclinically, correlati... von You, Shihyun, Delahaye, Jared, Ermler, Megan, Singh, Jennifer, Jordan, William, Ray, Avijit, Galwey, Nicholas, Austin, Daren, Theodore, Dickens, Paff, Melanie

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