Evaluation of the Therapeutic Index of a Novel Phosphodiesterase 4B– Selective Inhibitor Over Phosphodiesterase 4D in Mice von Suzuki, Osamu, Mizukami, Kiyoshi, Etori, Maki, Sogawa, Yoshitaka, Takagi, Nana, Tsuchida, Hiroshi, Morimoto, Kiyoshi, Goto, Taiji, Yoshino, Toshiharu, Mikkaichi, Tsuyoshi, Hirahara, Kazuki, Nakamura, Satoshi, Maeda, Hiroaki

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Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors von Goto, Taiji, Shiina, Akiko, Yoshino, Toshiharu, Mizukami, Kiyoshi, Hirahara, Kazuki, Suzuki, Osamu, Sogawa, Yoshitaka, Takahashi, Tomoko, Mikkaichi, Tsuyoshi, Nakao, Naoki, Takahashi, Mizuki, Hasegawa, Masashi, Sasaki, Shigeki

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Identification of the 5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives as highly selective PDE4B inhibitors von Goto, Taiji, Shiina, Akiko, Murata, Takeshi, Tomii, Masato, Yamazaki, Takanori, Yoshida, Ken-ichi, Yoshino, Toshiharu, Suzuki, Osamu, Sogawa, Yoshitaka, Mizukami, Kiyoshi, Takagi, Nana, Yoshitomi, Tomomi, Etori, Maki, Tsuchida, Hiroshi, Mikkaichi, Tsuyoshi, Nakao, Naoki, Takahashi, Mizuki, Takahashi, Hisashi, Sasaki, Shigeki

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Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors von Goto, Taiji, Shiina, Akiko, Yoshino, Toshiharu, Mizukami, Kiyoshi, Hirahara, Kazuki, Suzuki, Osamu, Sogawa, Yoshitaka, Takahashi, Tomoko, Mikkaichi, Tsuyoshi, Nakao, Naoki, Takahashi, Mizuki, Hasegawa, Masashi, Sasaki, Shigeki

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The role of phosphodiesterase 4B in IL-8/LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase 4B inhibitor von Suzuki, Osamu, Goto, Taiji, Yoshino, Toshiharu, Nakamura, Satoshi, Maeda, Hiroaki

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Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: Exploration of 6–6 fused rings as alternative S1 moieties von Yoshikawa, Kenji, Kobayashi, Shozo, Nakamoto, Yumi, Haginoya, Noriyasu, Komoriya, Satoshi, Yoshino, Toshiharu, Nagata, Tsutomu, Mochizuki, Akiyoshi, Watanabe, Kengo, Suzuki, Makoto, Kanno, Hideyuki, Ohta, Toshiharu

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Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: Exploration of 5–6 fused rings as alternative S1 moieties von Yoshikawa, Kenji, Yokomizo, Aki, Naito, Hiroyuki, Haginoya, Noriyasu, Kobayashi, Shozo, Yoshino, Toshiharu, Nagata, Tsutomu, Mochizuki, Akiyoshi, Osanai, Ken, Watanabe, Kengo, Kanno, Hideyuki, Ohta, Toshiharu

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Discovery of N-[(1 R,2 S,5 S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4- c]pyridine-2-carboxamide hydrochlori... von Nagata, Tsutomu, Yoshino, Toshiharu, Haginoya, Noriyasu, Yoshikawa, Kenji, Nagamochi, Masatoshi, Kobayashi, Syozo, Komoriya, Satoshi, Yokomizo, Aki, Muto, Ryo, Yamaguchi, Mitsuhiro, Osanai, Ken, Suzuki, Makoto, Kanno, Hideyuki

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Total synthesis of an enantiomeric pair of FR900482. 1. Synthetic and end-game strategies von Katoh, Tadashi, Itoh, Etsuko, Yoshino, Toshiharu, Terashima, Shiro

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A Total Synthesis of Xestodecalactone A and Proof of Its Absolute Stereochemistry:  Interesting Observations on Dienophilic Control with 1,3-Disubstituted Nonequivalent Allenes von Yoshino, Toshiharu, Ng, Fay, Danishefsky, Samuel J

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Total synthesis of an enantiomeric pair of FR900482. 2. Syntheses of the aromatic and the optically active aliphatic segments von Yoshino, Toshiharu, Nagata, Yuriko, Itoh, Etsuko, Hashimoto, Masaru, Katoh, Tadashi, Terashima, Shiro

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A novel enantioselective synthesis of the key intermediate of (−)-huperzine a employing asymmetric palladium-catalyzed bicycloannulation von Kaneko, Satoru, Yoshino, Toshiharu, Katoh, Tadashi, Terashima, Shiro

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Total synthesis of natural (+)-FR900482. 1. Synthetic and end-game strategies von Katoh, Tadashi, Itoh, Etsuko, Yoshino, Toshiharu, Terashima, Shiro

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Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors von Nagata, Tsutomu, Yoshino, Toshiharu, Haginoya, Noriyasu, Yoshikawa, Kenji, Isobe, Yumiko, Furugohri, Taketoshi, Kanno, Hideyuki

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A New Method for Synthesis of 7-Deoxytaxane Analogues by Hydrogenation of Δ6,7-Taxane Derivatives von Takeda, Yasuyuki, Yoshino, Toshiharu, Uoto, Kouichi, Terasawa, Hirofumi, Soga, Tsunehiko

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Design, synthesis and SAR of novel ethylenediamine and phenylenediamine derivatives as factor Xa inhibitors von Yoshikawa, Kenji, Yoshino, Toshiharu, Yokomizo, Yoshihiro, Uoto, Kouichi, Naito, Hiroyuki, Kawakami, Katsuhiro, Mochizuki, Akiyoshi, Nagata, Tsutomu, Suzuki, Makoto, Kanno, Hideyuki, Takemura, Makoto, Ohta, Toshiharu

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The role of phosphodiesterase 4B in IL-8/LTB 4 -induced human neutrophil chemotaxis evaluated with a phosphodiesterase 4B inhibitor von Suzuki, Osamu, Goto, Taiji, Yoshino, Toshiharu, Nakamura, Satoshi, Maeda, Hiroaki

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Synthesis and Evaluation of Water-Soluble Non-Prodrug Analogs of Docetaxel Bearing sec-Aminoethyl Group at the C-10 Position von UOTO, Kouichi, TAKENOSHITA, Haruhiro, YOSHINO, Toshiharu, HIROTA, Yasuhide, ANDO, Shuichi, MITSUI, Ikuo, TERASAWA, Hirofumi, SOGA, Tsunehiko

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Stereoselective synthesis and biological evaluation of 3,4-diaminocyclohexanecarboxylic acid derivatives as factor Xa inhibitors von Nagata, Tsutomu, Nagamochi, Masatoshi, Kobayashi, Shozo, Komoriya, Satoshi, Yoshino, Toshiharu, Kanno, Hideyuki

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Synthesis and Conformational Analysis of a Non-Amidine Factor Xa Inhibitor That Incorporates 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 Binding Element von Haginoya, Noriyasu, Kobayashi, Syozo, Komoriya, Satoshi, Yoshino, Toshiharu, Suzuki, Makoto, Shimada, Takashi, Watanabe, Kengo, Hirokawa, Yumiko, Furugori, Taketoshi, Nagahara, Takayasu

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