Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators von Aird, Daniel, Teng, Teng, Huang, Chia-Ling, Pazolli, Ermira, Banka, Deepti, Cheung-Ong, Kahlin, Eifert, Cheryl, Furman, Craig, Wu, Zhenhua Jeremy, Seiler, Michael, Buonamici, Silvia, Fekkes, Peter, Karr, Craig, Palacino, James, Park, Eunice, Smith, Peter G., Yu, Lihua, Mizui, Yoshiharu, Warmuth, Markus, Chicas, Agustin, Corson, Laura, Zhu, Ping

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Splicing factor SF3b as a target of the antitumor natural product pladienolide von Mizui, Yoshiharu, Kotake, Yoshihiko, Sagane, Koji, Owa, Takashi, Mimori-Kiyosue, Yuko, Shimizu, Hajime, Uesugi, Mai, Ishihama, Yasushi, Iwata, Masao

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Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex von Teng, Teng, Tsai, Jennifer HC, Puyang, Xiaoling, Seiler, Michael, Peng, Shouyong, Prajapati, Sudeep, Aird, Daniel, Buonamici, Silvia, Caleb, Benjamin, Chan, Betty, Corson, Laura, Feala, Jacob, Fekkes, Peter, Gerard, Baudouin, Karr, Craig, Korpal, Manav, Liu, Xiang, T. Lowe, Jason, Mizui, Yoshiharu, Palacino, James, Park, Eunice, Smith, Peter G., Subramanian, Vanitha, Wu, Zhenhua Jeremy, Zou, Jian, Yu, Lihua, Chicas, Agustin, Warmuth, Markus, Larsen, Nicholas, Zhu, Ping

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Total Synthesis of the Potent Antitumor Macrolides Pladienolide B and D von Kanada, Regina M., Itoh, Daisuke, Nagai, Mitsuo, Niijima, Jun, Asai, Naoki, Mizui, Yoshiharu, Abe, Shinya, Kotake, Yoshihiko

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E6201 [(3S,4R,5Z,8S,9S,11E)-14-(Ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a Novel Kinase Inhibitor of Mitogen-Act... von Goto, Masaki, Chow, Jesse, Muramoto, Kenzo, Chiba, Ken-ichi, Yamamoto, Satoshi, Fujita, Masanori, Obaishi, Hiroshi, Tai, Kenji, Mizui, Yoshiharu, Tanaka, Isao, Young, Donna, Yang, Hua, Wang, Yuan J, Shirota, Hiroshi, Gusovsky, Fabian

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Pladienolides, New Substances from Culture of Streptomyces platensis Mer-11107: III. In Vitro and In Vivo Antitumor Activities von MIZUI, YOSHIHARU, SAKAI, TAKASHI, IWATA, MASAO, UENAKA, TOSHIMITSU, OKAMOTO, KIYOSHI, SHIMIZU, HAJIME, YAMORI, TAKAO, YOSHIMATSU, KENTARO, ASADA, MAKOTO

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Pladienolides, New Substances from Culture of Streptomyces platensis Mer-11107: I. Taxonomy, Fermentation, Isolation and Screening von SAKAI, TAKASHI, SAMESHIMA, TOMOHIRO, MATSUFUJI, MOTOKO, KAWAMURA, NAOTO, DOBASHI, KAZUYUKI, MIZUI, YOSHIHARU

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Pladienolides, New Substances from Culture of Streptomyces platensis Mer-11107: II. Physico-chemical Properties and Structure Elucidation von SAKAI, TAKASHI, ASAI, NAOKI, OKUDA, AKIFUMI, KAWAMURA, NAOTO, MIZUI, YOSHIHARU

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H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers von Seiler, Michael, Yoshimi, Akihide, Darman, Rachel, Chan, Betty, Keaney, Gregg, Thomas, Michael, Agrawal, Anant A, Caleb, Benjamin, Csibi, Alfredo, Sean, Eckley, Fekkes, Peter, Karr, Craig, Klimek, Virginia, Lai, George, Lee, Linda, Kumar, Pavan, Lee, Stanley Chun-Wei, Liu, Xiang, Mackenzie, Crystal, Meeske, Carol, Mizui, Yoshiharu, Padron, Eric, Park, Eunice, Pazolli, Ermira, Peng, Shouyong, Prajapati, Sudeep, Taylor, Justin, Teng, Teng, Wang, John, Warmuth, Markus, Yao, Huilan, Yu, Lihua, Zhu, Ping, Abdel-Wahab, Omar, Smith, Peter G, Buonamici, Silvia

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Microregional antitumor activity of a small-molecule hypoxia-inducible factor 1 inhibitor von OKAMOTO, KIYOSHI, ITO, DAISUKE, MIYAZAKI, KAZUKI, WATANABE, SAORI, TOHYAMA, OSAMU, YOKOI, AKIRA, OZAWA, YOICHI, ASANO, MAKOTO, KAWAMURA, TAKANORI, YAMANE, YOSHINOBU, NAGAO, SATOSHI, FUNASAKA, SETSUO, KAMATA, JUNICHI, KOTAKE, YOSHIHIKO, AOKI, MIKA, TSUKAHARA, NAOKO, MIZUI, YOSHIHARU, TANAKA, ISAO, SAWADA, KOHEI

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Biological validation that SF3b is a target of the antitumor macrolide pladienolide von Yokoi, Akira, Kotake, Yoshihiko, Takahashi, Kentaro, Kadowaki, Tadashi, Matsumoto, Yoshiko, Minoshima, Yukinori, Sugi, Naoko H., Sagane, Koji, Hamaguchi, Makoto, Iwata, Masao, Mizui, Yoshiharu

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Phase I Pharmacokinetic and Pharmacodynamic Study of the First-in-Class Spliceosome Inhibitor E7107 in Patients with Advanced Solid Tumors von ESKENS, Ferry A. L. M, RAMOS, Francisco J, TABERNERO, Josep, BURGER, Herman, O'BRIEN, James P, PIERA, Adelaida, DE JONGE, Maja J. A, MIZUI, Yoshiharu, WIEMER, Erik A. C, CARRERAS, Maria Josepa, BASELGA, José

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Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point von Darman, Rachel B., Seiler, Michael, Agrawal, Anant A., Lim, Kian H., Peng, Shouyong, Aird, Daniel, Bailey, Suzanna L., Bhavsar, Erica B., Chan, Betty, Colla, Simona, Corson, Laura, Feala, Jacob, Fekkes, Peter, Ichikawa, Kana, Keaney, Gregg F., Lee, Linda, Kumar, Pavan, Kunii, Kaiko, MacKenzie, Crystal, Matijevic, Mark, Mizui, Yoshiharu, Myint, Khin, Park, Eun Sun, Puyang, Xiaoling, Selvaraj, Anand, Thomas, Michael P., Tsai, Jennifer, Wang, John Y., Warmuth, Markus, Yang, Hui, Zhu, Ping, Garcia-Manero, Guillermo, Furman, Richard R., Yu, Lihua, Smith, Peter G., Buonamici, Silvia

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Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23 von Sagane, Koji, Yamazaki, Kazuto, Mizui, Yoshiharu, Tanaka, Isao

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Total Synthesis of the Potent Antitumor Macrolides Pladienolide B and D von Kanada, Regina M, Itoh, Daisuke, Nagai, Mitsuo, Niijima, Jun, Asai, Naoki, Mizui, Yoshiharu, Abe, Shinya, Kotake, Yoshihiko

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Altered Expression of HES-1, BETA2/NeuroD, and PDX-1 Is Involved in Impaired Insulin Synthesis Induced by Glucocorticoids in HIT-T15 Cells von Shinozuka, Yoriko, Okada, Masayuki, Oki, Tohru, Sagane, Koji, Mizui, Yoshiharu, Tanaka, Isao, Katayama, Kouichi, Murakami-Murofushi, Kimiko

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Abstract 281: Sensitivity to splicing modulation of BCL2 family genes reveals cancer therapeutic strategies for splicing modulators von Aird, Daniel, Teng, Teng, Huang, Chia-Ling, Pazolli, Ermira, Banka, Deepti, Cheung-Ong, Kahlin, Eifert, Cheryl, Furman, Craig, Wu, Jeremy, Seiler, Michael, Buonamici, Silvia, Fekkes, Peter, Karr, Craig, Palacino, James, Park, Eunice, Smith, Peter, Yu, Lihua, Mizui, Yoshiharu, Warmuth, Markus, Chicas, Agustin, Corson, Laura, Zhu, Ping

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Abstract 3013: Identification of PHF5A as a common cellular target of splicing-modulating chemical probes von Teng, Teng, Puyang, Xiaoling, Peng, Shouyong, Feala, Jacob, Chan, Betty, Tsai, Jennifer, Caleb, Benjamin, Karr, Craig, Park, Eunice, Corson, Laura, Mizui, Yoshiharu, Smith, Peter, Larsen, Nicholas, Yu, Lihua, Warmuth, Markus, Zhu, Ping, Chicas, Agustin

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Abstract 126: A chemogenomic approach reveals the action of splicing modulators at the branch point adenosine binding pocket defined by the PHF5A/SF3b complex von Teng, Teng, Tsai, Jennifer, Puyang, Xiaoling, Seiler, Michael, Peng, Shouyong, Aird, Daniel, Buonamici, Silvia, Caleb, Benjamin, Chan, Betty, Corson, Laura, Feala, Jacob, Fekkes, Peter, Karr, Craig, Korpal, Manav, Mizui, Yoshiharu, Park, Eunice, Palacino, James, Smith, Peter, Subramanian, Vanitha, Wu, Jeremy, Yu, Lihua, Chicas, Agustin, Warmuth, Markus, Larsen, Nicholas, Zhu, Ping

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H3B-8800, an Orally Bioavailable Modulator of the SF3b Complex, Shows Efficacy in Spliceosome-Mutant Myeloid Malignancies von Buonamici, Silvia, Yoshimi, Akihide, Thomas, Michael, Seiler, Michael, Chan, Betty, Caleb, Benjamin, Darman, Rachel, Fekkes, Peter, Karr, Craig, Keaney, Gregg F., Klimek, Virginia M., Kunii, Kaiko, Lee, Linda, Lee, Stanley Chun-Wei, Liu, Xiang, Meeske, Carol, Mizui, Yoshiharu, Padron, Eric, Park, Eunice, Pazolli, Ermira, Prajapati, Sudeep, Taylor, Justin, Wang, John, Warmuth, Markus, Yu, Lihua, Zhu, Ping, Abdel-Wahab, Omar, Smith, Peter G

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