Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor von FENWICK, Craig, AMAD, Ma'an, FADER, Lee D, FAUCHER, Anne-Marie, GARNEAU, Michel, JAKALIAN, Araz, KAWAI, Stephen, LAMORTE, Louie, LAPLANTE, Steven, LAIBIN LUO, MASON, Steve, POUPART, Marc-André, BAILEY, Murray D, RIOUX, Nathalie, SCHROEDER, Patricia, SIMONEAU, Bruno, TREMBLAY, Sonia, TSANTRIZOS, Youla, WITVROUW, Myriam, YOAKIM, Christiane, BETHELL, Richard, BÖS, Michael, BONNEAU, Pierre, CORDINGLEY, Michael, COULOMBE, René, DUAN, Jianmin, EDWARDS, Paul

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Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein von LEMKE, Christopher T, TITOLO, Steve, GAGNON, Alexandre, KAWAI, Stephen H, RANCOURT, Jean, TREMBLAY, Martin, YOAKIM, Christiane, SIMONEAU, Bruno, ARCHAMBAULT, Jacques, SUNDQUIST, Wesley I, MASON, Stephen W, VON SCHWEDLER, Uta, GOUDREAU, Nathalie, MERCIER, Jean-François, WARDROP, Elizabeth, FAUCHER, Anne-Marie, COULOMBE, Rene, BANIK, Soma S. R, FADER, Lee

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Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly von Fader, Lee D., Bethell, Richard, Bonneau, Pierre, Bös, Michael, Bousquet, Yves, Cordingley, Michael G., Coulombe, René, Deroy, Patrick, Faucher, Anne-Marie, Gagnon, Alexandre, Goudreau, Nathalie, Grand-Maître, Chantal, Guse, Ingrid, Hucke, Oliver, Kawai, Stephen H., Lacoste, Jean-Eric, Landry, Serge, Lemke, Christopher T., Malenfant, Eric, Mason, Stephen, Morin, Sébastien, O’Meara, Jeff, Simoneau, Bruno, Titolo, Steve, Yoakim, Christiane

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Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole sca... von Tremblay, Martin, Bonneau, Pierre, Bousquet, Yves, DeRoy, Patrick, Duan, Jianmin, Duplessis, Martin, Gagnon, Alexandre, Garneau, Michel, Goudreau, Nathalie, Guse, Ingrid, Hucke, Oliver, Kawai, Stephen H., Lemke, Christopher T., Mason, Stephen W., Simoneau, Bruno, Surprenant, Simon, Titolo, Steve, Yoakim, Christiane

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Efficient Nucleophilic Aromatic Substitution between Aryl Nitrofluorides and Alkynes von DeRoy, Patrick L, Surprenant, Simon, Bertrand-Laperle, Megan, Yoakim, Christiane

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Crystal Structure of the E2 Transactivation Domain of Human Papillomavirus Type 11 Bound to a Protein Interaction Inhibitor von Wang, Yong, Coulombe, René, Cameron, Dale R., Thauvette, Louise, Massariol, Marie-Josée, Amon, Lynn M., Fink, Dominique, Titolo, Steve, Welchner, Ewald, Yoakim, Christiane, Archambault, Jacques, White, Peter W.

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Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV von Fader, Lee D, Carson, Rebekah, Morin, Sébastien, Bilodeau, François, Chabot, Catherine, Halmos, Ted, Bailey, Murray D, Kawai, Stephen H, Coulombe, René, Laplante, Steven, Mekhssian, Kevork, Jakalian, Araz, Garneau, Michel, Duan, Jianmin, Mason, Stephen W, Simoneau, Bruno, Fenwick, Craig, Tsantrizos, Youla, Yoakim, Christiane

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Inhibition of Human Papillomavirus DNA Replication by Small Molecule Antagonists of the E1-E2 Protein Interaction von White, Peter W., Titolo, Steve, Brault, Karine, Thauvette, Louise, Pelletier, Alex, Welchner, Ewald, Bourgon, Lise, Doyon, Louise, Ogilvie, William W., Yoakim, Christiane, Cordingley, Michael G., Archambault, Jacques

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Characterization of the Binding Site for Inhibitors of the HPV11 E1−E2 Protein Interaction on the E2 Transactivation Domain by Photoaffinity Labeling and Mass Spectrometry von Davidson, Walter, McGibbon, Graham A, White, Peter W, Yoakim, Christiane, Hopkins, Jerry L, Guse, Ingrid, Hambly, David M, Frego, Lee, Ogilvie, William W, Lavallée, Pierre, Archambault, Jacques

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Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV‑1 von Fader, Lee D, Malenfant, Eric, Parisien, Mathieu, Carson, Rebekah, Bilodeau, François, Landry, Serge, Pesant, Marc, Brochu, Christian, Morin, Sébastien, Chabot, Catherine, Halmos, Ted, Bousquet, Yves, Bailey, Murray D, Kawai, Stephen H, Coulombe, René, LaPlante, Steven, Jakalian, Araz, Bhardwaj, Punit K, Wernic, Dominik, Schroeder, Patricia, Amad, Ma’an, Edwards, Paul, Garneau, Michel, Duan, Jianmin, Cordingley, Michael, Bethell, Richard, Mason, Stephen W, Bös, Michael, Bonneau, Pierre, Poupart, Marc-André, Faucher, Anne-Marie, Simoneau, Bruno, Fenwick, Craig, Yoakim, Christiane, Tsantrizos, Youla

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Investigation on the role of the tetrazole in the binding of thiotetrazolylacetanilides with HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases von Gagnon, Alexandre, Landry, Serge, Coulombe, René, Jakalian, Araz, Guse, Ingrid, Thavonekham, Bounkham, Bonneau, Pierre R., Yoakim, Christiane, Simoneau, Bruno

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Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs von Fader, Lee D, Bailey, Murray, Beaulieu, Eric, Bilodeau, François, Bonneau, Pierre, Bousquet, Yves, Carson, Rebekah J, Chabot, Catherine, Coulombe, René, Duan, Jianmin, Fenwick, Craig, Garneau, Michel, Halmos, Ted, Jakalian, Araz, James, Clint, Kawai, Stephen H, Landry, Serge, LaPlante, Steven R, Mason, Stephen W, Morin, Sebastien, Rioux, Nathalie, Simoneau, Bruno, Surprenant, Simon, Thavonekham, Bounkham, Thibeault, Carl, Trinh, Thao, Tsantrizos, Youla, Tsoung, Jennifer, Yoakim, Christiane, Wernic, Dominik

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Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors von O’Meara, Jeff A., Jakalian, Araz, LaPlante, Steven, Bonneau, Pierre R., Coulombe, René, Faucher, Anne-Marie, Guse, Ingrid, Landry, Serge, Racine, Jennifer, Simoneau, Bruno, Thavonekham, Bounkham, Yoakim, Christiane

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Regiocontrolled opening of cyclic ethers using dimethylboron bromide von Guindon, Yvan, Therien, Michel, Girard, Yves, Yoakim, Christiane

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Discovery of Potent, Orally Bioavailable Inhibitors of Human Cytomegalovirus von Fader, Lee, Brault, Martine, Desjardins, Jessica, Dansereau, Nathalie, Lamorte, Louie, Tremblay, Sonia, Bilodeau, François, Bordeleau, Josée, Duplessis, Martin, Gorys, Vida, Gillard, James, Gleason, James L, James, Clint, Joly, Marc-André, Kuhn, Cyrille, Llinas-Brunet, Montse, Luo, Laibin, Morency, Louis, Morin, Sébastien, Parisien, Mathieu, Poirier, Maude, Thibeault, Carl, Trinh, Thao, Sturino, Claudio, Srivastava, Sanjay, Yoakim, Christiane, Franti, Michael

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Practical Synthesis of A Benzophenone-Based NNRT Inhibitor of HIV-1 von Wang, Xiao-jun, Zhang, Li, Sun, Xiufeng, Lee, Heewon, Krishnamurthy, Dhileepkumar, O’Meara, Jeff A, Landry, Serge, Yoakim, Christiane, Simoneau, Bruno, Yee, Nathan K, Senanayake, Chris H

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Optimization and determination of the absolute configuration of a series of potent inhibitors of human papillomavirus type-11 E1–E2 protein–protein interaction: A combined medicina... von Goudreau, Nathalie, Cameron, Dale R., Déziel, Robert, Haché, Bruno, Jakalian, Araz, Malenfant, Eric, Naud, Julie, Ogilvie, William W., O’Meara, Jeff, White, Peter W., Yoakim, Christiane

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Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1–E2–Origin DNA complex von Yoakim, Christiane, Ogilvie, William W., Goudreau, Nathalie, Naud, Julie, Haché, Bruno, O'Meara, Jeff A., Cordingley, Michael G., Archambault, Jacques, White, Peter W.

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Novel 8-Substituted Dipyridodiazepinone Inhibitors with a Broad-Spectrum of Activity against HIV-1 Strains Resistant to Non-nucleoside Reverse Transcriptase Inhibitors von O'Meara, Jeff A, Yoakim, Christiane, Bonneau, Pierre R, Bös, Michael, Cordingley, Michael G, Déziel, Robert, Doyon, Louise, Duan, Jianmin, Garneau, Michel, Guse, Ingrid, Landry, Serge, Malenfant, Eric, Naud, Julie, Ogilvie, William W, Thavonekham, Bounkham, Simoneau, Bruno

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Removable Phosphine Reagents for the Mitsunobu Reaction von Yoakim, Christiane, Guse, I., O’Meara, J. A., Thavonekham, B.

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