Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis von Ganapathy, Vidya, Ge, Rongrong, Grazioli, Alison, Xie, Wen, Banach-Petrosky, Whitney, Kang, Yibin, Lonning, Scott, McPherson, John, Yingling, Jonathan M, Biswas, Swati, Mundy, Gregory R, Reiss, Michael

Volltext

TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma von Anido, Judit, Sáez-Borderías, Andrea, Gonzàlez-Juncà, Alba, Rodón, Laura, Folch, Gerard, Carmona, Maria A, Prieto-Sánchez, Rosa M, Barba, Ignasi, Martínez-Sáez, Elena, Prudkin, Ludmila, Cuartas, Isabel, Raventós, Carolina, Martínez-Ricarte, Francisco, Poca, M Antonia, García-Dorado, David, Lahn, Michael M, Yingling, Jonathan M, Rodón, Jordi, Sahuquillo, Juan, Baselga, José, Seoane, Joan

Volltext

Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases von KONICEK, Bruce W, STEPHENS, Jennifer R, MCCANN, Denis J, PELLETIER, Jerry, FURIC, Luc, YINGLING, Jonathan M, STANCATO, Louis F, SONENBERG, Nahum, GRAFF, Jeremy R, MCNULTY, Ann M, ROBICHAUD, Nathaniel, PEERY, Robert B, DUMSTORF, Chad A, DOWLESS, Michele S, IVERSEN, Philip W, PARSONS, Stephen, ELLIS, Karen E

Volltext

Development of TGF-β signalling inhibitors for cancer therapy von Yingling, Jonathan M, Blanchard, Kerry L, Sawyer, J. Scott

Volltext

Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-β receptor type I inhibitor von Yingling, Jonathan M, McMillen, William T, Yan, Lei, Huang, Huocong, Sawyer, J Scott, Graff, Jeremy, Clawson, David K, Britt, Karen S, Anderson, Bryan D, Beight, Douglas W, Desaiah, Durisala, Lahn, Michael M, Benhadji, Karim A, Lallena, Maria J, Holmgaard, Rikke B, Xu, Xiaohong, Zhang, Faming, Manro, Jason R, Iversen, Philip W, Iyer, Chandrasekar V, Brekken, Rolf A, Kalos, Michael D, Driscoll, Kyla E

Volltext

Defining a therapeutic window for the novel TGF‐β inhibitor LY2157299 monohydrate based on a pharmacokinetic/pharmacodynamic model von Gueorguieva, Ivelina, Cleverly, Ann L., Stauber, Anja, Pillay, N. Sada, Rodon, Jordi A., Miles, Colin P., Yingling, Jonathan M., Lahn, Michael M.

Volltext

Reduced SMAD7 Leads to Overactivation of TGF-β Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-β Receptor I Kinase von LI ZHOU, MCMAHON, Christine, YONGKAI MO, SHEN, Wa, WICKREMA, Amittha, GUANGHUI KONG, FRIEDMAN, Ellen, SOKOL, Lubomir, MANTZARIS, Giannis, PELLAGATTI, Andrea, BOULTWOOD, Jacqueline, PLATANIAS, Leonidas C, BHAGAT, Tushar, STEIDL, Ulrich, LEI YAN, YINGLING, Jonathan M, LAHN, Michael M, LIST, Alan, BITZER, Markus, VERMA, Amit, ALENCAR, Cristina, YITING YU, FAZZARI, Melissa, SOHAL, Davendra, HEUCK, Christoph, GUNDABOLU, Krishna, NG, Chun

Volltext

Outgrowth of Drug-Resistant Carcinomas Expressing Markers of Tumor Aggression after Long-term TβRI/II Kinase Inhibition with LY2109761 von CONNOLLY, Erin C, SAUNIER, Elise F, QUIGLEY, David, THU LUU, Minh, DE SAPIO, Angela, HANN, Byron, YINGLING, Jonathan M, AKHURST, Rosemary J

Volltext

Cancer-Associated Transforming Growth Factor β Type II Receptor Gene Mutant Causes Activation of Bone Morphogenic Protein-Smads and Invasive Phenotype von BHARATHY, Savita, WEN XIE, YINGLING, Jonathan M, REISS, Michael

Volltext

Effect of transforming growth factor beta (TGF-β) receptor I kinase inhibitor on prostate cancer bone growth von Wan, Xinhai, Li, Zhi-Gang, Yingling, Jonathan M, Yang, Jun, Starbuck, Michael W, Ravoori, Murali K, Kundra, Vikas, Vazquez, Elba, Navone, Nora M

Volltext

Smad7 Regulates the Adult Neural Stem/Progenitor Cell Pool in a Transforming Growth Factor β- and Bone Morphogenetic Protein-Independent Manner von Krampert, Monika, Chirasani, Sridhar Reddy, Wachs, Frank-Peter, Aigner, Robert, Bogdahn, Ulrich, Yingling, Jonathan M., Heldin, Carl-Henrik, Aigner, Ludwig, Heuchel, Rainer

Volltext

Synthesis and Activity of New Aryl- and Heteroaryl-Substituted Pyrazole Inhibitors of the Transforming Growth Factor-β Type I Receptor Kinase Domain von Sawyer, J. Scott, Anderson, Bryan D, Beight, Douglas W, Campbell, Robert M, Jones, Michael L, Herron, David K, Lampe, John W, McCowan, Jefferson R, McMillen, William T, Mort, Nicholas, Parsons, Stephen, Smith, Edward C. R, Vieth, Michal, Weir, Leonard C, Yan, Lei, Zhang, Faming, Yingling, Jonathan M

Volltext

Developing and applying a gene functional association network for anti-angiogenic kinase inhibitor activity assessment in an angiogenesis co-culture model von Chen, Yuefeng, Wei, Tao, Yan, Lei, Lawrence, Frank, Qian, Hui-Rong, Burkholder, Timothy P, Starling, James J, Yingling, Jonathan M, Shou, Jianyong

Volltext

Epithelial/mesenchymal interactions and branching morphogenesis of the lung von Hogan, Brigid LM, Yingling, Jonathan M

Volltext

Optimization of a Dihydropyrrolopyrazole Series of Transforming Growth Factor-β Type I Receptor Kinase Domain Inhibitors: Discovery of an Orally Bioavailable Transforming Growth Fa... von Li, Hong-yu, McMillen, William T, Heap, Charles R, McCann, Denis J, Yan, Lei, Campbell, Robert M, Mundla, Sreenivasa R, King, Chi-Hsin R, Dierks, Elizabeth A, Anderson, Bryan D, Britt, Karen S, Huss, Karen L, Voss, Matthew D, Wang, Yan, Clawson, David K, Yingling, Jonathan M, Sawyer, J. Scott

Volltext

Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain von SAWYER, J. Scott, BEIGHT, Douglas W, PARSONS, Stephen, SMITH, Edward C. R, WAGNER, Jill R, LEI YAN, FAMING ZHANG, YINGLING, Jonathan M, BRITT, Karen S, ANDERSON, Bryan D, CAMPBELL, Robert M, GOODSON, Theodore JR, HERRON, David K, LI, Hong-Yu, MCMILLEN, William T, MORT, Nicholas

Volltext

Kinetic Characterization of Novel Pyrazole TGF-β Receptor I Kinase Inhibitors and Their Blockade of the Epithelial−Mesenchymal Transition von Peng, Sheng-Bin, Yan, Lei, Xia, Xiaoling, Watkins, Scott A, Brooks, Harold B, Beight, Douglas, Herron, David K, Jones, Michael L, Lampe, John W, McMillen, William T, Mort, Nicholas, Sawyer, J. Scott, Yingling, Jonathan M

Volltext

Smad4-dependent Regulation of Urokinase Plasminogen Activator Secretion and RNA Stability Associated with Invasiveness by Autocrine and Paracrine Transforming Growth Factor-β von Shiou, Sheng-Ru, Datta, Pran K., Dhawan, Punita, Law, Brian K., Yingling, Jonathan M., Dixon, Dan A., Beauchamp, R. Daniel

Volltext

Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development von Weaver, M, Yingling, J M, Dunn, N R, Bellusci, S, Hogan, B L

Volltext

TGF-β signalling-related markers in cancer patients with bone metastasis von Baselga, Jose, Rothenberg, Mace L., Tabernero, Josep, Seoane, Joan, Daly, Thomas, Cleverly, Ann, Berry, Brandi, Rhoades, Susanne K., Ray, Chad A., Fill, Jeffrey, Farrington, Daphne L., Anne Wallace, Lisa, Yingling, Jonathan M., Lahn, Michael, Arteaga, Carlos, Carducci, Michael

Volltext