Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody-Drug Conjugates von Caculitan, Niña G, Dela Cruz Chuh, Josefa, Ma, Yong, Zhang, Donglu, Kozak, Katherine R, Liu, Yichin, Pillow, Thomas H, Sadowsky, Jack, Cheung, Tommy K, Phung, Qui, Haley, Benjamin, Lee, Byoung-Chul, Akita, Robert W, Sliwkowski, Mark X, Polson, Andrew G

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Molecular Mechanisms of Alzheimer Disease Protection by the A673T Allele of Amyloid Precursor Protein von Maloney, Janice A., Bainbridge, Travis, Gustafson, Amy, Zhang, Shuo, Kyauk, Roxanne, Steiner, Pascal, van der Brug, Marcel, Liu, Yichin, Ernst, James A., Watts, Ryan J., Atwal, Jasvinder K.

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Quantitative Determination of Protein–Ligand Affinity by Size Exclusion Chromatography Directly Coupled to High-Resolution Native Mass Spectrometry von Ren, Chengfeng, Bailey, Aaron O, VanderPorten, Erica, Oh, Angela, Phung, Wilson, Mulvihill, Melinda M, Harris, Seth F, Liu, Yichin, Han, Guanghui, Sandoval, Wendy

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High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers von Ohri, Rachana, Bhakta, Sunil, Fourie-O’Donohue, Aimee, dela Cruz-Chuh, Josefa, Tsai, Siao Ping, Cook, Ryan, Wei, Binqing, Ng, Carl, Wong, Athena W, Bos, Aaron B, Farahi, Farzam, Bhakta, Jiten, Pillow, Thomas H, Raab, Helga, Vandlen, Richard, Polakis, Paul, Liu, Yichin, Erickson, Hans, Junutula, Jagath R, Kozak, Katherine R

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Automated Affinity Capture and On-Tip Digestion to Accurately Quantitate in Vivo Deamidation of Therapeutic Antibodies von Tran, John C, Tran, Daniel, Hilderbrand, Amy, Andersen, Nisana, Huang, Tao, Reif, Karin, Hotzel, Isidro, Stefanich, Eric G, Liu, Yichin, Wang, Jianyong

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Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors von Meininger, David, Zalameda, Leeanne, Liu, Yichin, Stepan, Lara P., Borges, Luis, McCarter, John D., Sutherland, Claire L.

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Membrane-associated farnesylated UCH-L1 promotes α-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease von Liu, Zhihua, Meray, Robin K, Grammatopoulos, Tom N, Fredenburg, Ross A, Cookson, Mark R, Liu, Yichin, Logan, Todd, Lansbury, Peter T. Jr

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Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase von Fauber, Benjamin P., Dragovich, Peter S., Chen, Jinhua, Corson, Laura B., Ding, Charles Z., Eigenbrot, Charles, Giannetti, Anthony M., Hunsaker, Thomas, Labadie, Sharada, Liu, Yichin, Liu, Yingchun, Malek, Shiva, Peterson, David, Pitts, Keith, Sideris, Steve, Ultsch, Mark, VanderPorten, Erica, Wang, Jing, Wei, BinQing, Yen, Ivana, Yue, Qin

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Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase von Dragovich, Peter S., Fauber, Benjamin P., Corson, Laura B., Ding, Charles Z., Eigenbrot, Charles, Ge, HongXiu, Giannetti, Anthony M., Hunsaker, Thomas, Labadie, Sharada, Liu, Yichin, Malek, Shiva, Pan, Borlan, Peterson, David, Pitts, Keith, Purkey, Hans E., Sideris, Steve, Ultsch, Mark, VanderPorten, Erica, Wei, BinQing, Xu, Qing, Yen, Ivana, Yue, Qin, Zhang, Huihui, Zhang, Xuying

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Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies von Liang, Jun, Zhang, Birong, Labadie, Sharada, Ortwine, Daniel F., Vinogradova, Maia, Kiefer, James R., Gehling, Victor S., Harmange, Jean-Christophe, Cummings, Richard, Lai, Tommy, Liao, Jiangpeng, Zheng, Xiaoping, Liu, Yichin, Gustafson, Amy, Van der Porten, Erica, Mao, Weifeng, Liederer, Bianca M., Deshmukh, Gauri, Classon, Marie, Trojer, Patrick, Dragovich, Peter S., Murray, Lesley

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Improved translation of stability for conjugated antibodies using an in vitro whole blood assay von Fourie-O'Donohue, Aimee, Chu, Phillip Y., Chuh, Josefa dela Cruz, Tchelepi, Robert, Tsai, Siao Ping, Tran, John C., Sawyer, William S., Su, Dian, Ng, Carl, Xu, Keyang, Yu, Shang-Fan, Pillow, Thomas H., Sadowsky, Jack, Dragovich, Peter S., Liu, Yichin, Kozak, Katherine R.

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Genomic and Genetic Analysis of Bordetella Bacteriophages Encoding Reverse Transcriptase-Mediated Tropism-Switching Cassettes von MINGHSUN LIU, GINGERY, Mari, QUAIL, Michael A, PRESTON, Andrew, HARVILL, Eric T, MASKELL, Duncan J, EISERLING, Frederick A, PARKHILL, Julian, MILLER, Jeff F, DOULATOV, Sergei R, YICHIN LIU, HODES, Asher, BAKER, Stephen, DAVIS, Paul, SIMMONDS, Mark, CHURCHER, Carol, MUNGALL, Karen

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High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry von Sawyer, William S., Srikumar, Neha, Carver, Joseph, Chu, Phillip Y., Shen, Amy, Xu, Ankai, Williams, Ambrose J., Spiess, Christoph, Wu, Cong, Liu, Yichin, Tran, John C.

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An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells von Vinogradova, Maia, Gehling, Victor S, Gustafson, Amy, Arora, Shilpi, Tindell, Charles A, Wilson, Catherine, Williamson, Kaylyn E, Guler, Gulfem D, Gangurde, Pranoti, Manieri, Wanda, Busby, Jennifer, Flynn, E Megan, Lan, Fei, Kim, Hyo-jin, Odate, Shobu, Cochran, Andrea G, Liu, Yichin, Wongchenko, Matthew, Yang, Yibin, Cheung, Tommy K, Maile, Tobias M, Lau, Ted, Costa, Michael, Hegde, Ganapati V, Jackson, Erica, Pitti, Robert, Arnott, David, Bailey, Christopher, Bellon, Steve, Cummings, Richard T, Albrecht, Brian K, Harmange, Jean-Christophe, Kiefer, James R, Trojer, Patrick, Classon, Marie

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Allosteric inhibition of BACE1 by an exosite-binding antibody von Wang, Weiru, Liu, Yichin, Lazarus, Robert A

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline von Jonsson, Thorlakur, Atwal, Jasvinder K., Steinberg, Stacy, Snaedal, Jon, Jonsson, Palmi V., Bjornsson, Sigurbjorn, Stefansson, Hreinn, Sulem, Patrick, Gudbjartsson, Daniel, Maloney, Janice, Hoyte, Kwame, Gustafson, Amy, Liu, Yichin, Lu, Yanmei, Bhangale, Tushar, Graham, Robert R., Huttenlocher, Johanna, Bjornsdottir, Gyda, Andreassen, Ole A., Jönsson, Erik G., Palotie, Aarno, Behrens, Timothy W., Magnusson, Olafur T., Kong, Augustine, Thorsteinsdottir, Unnur, Watts, Ryan J., Stefansson, Kari

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Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry von Park, Hae-Min, Winton, Valerie J, Drader, Jared J, Manalili Wheeler, Sheri, Lazar, Greg A, Kelleher, Neil L, Liu, Yichin, Tran, John C, Compton, Philip D

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Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer’s Disease von Patel, Snahel, Meilandt, William J, Erickson, Rebecca I, Chen, Jinhua, Deshmukh, Gauri, Estrada, Anthony A, Fuji, Reina N, Gibbons, Paul, Gustafson, Amy, Harris, Seth F, Imperio, Jose, Liu, Wendy, Liu, Xingrong, Liu, Yichin, Lyssikatos, Joseph P, Ma, Changyou, Yin, Jianping, Lewcock, Joseph W, Siu, Michael

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Modulating Antibody–Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification von Su, Dian, Kozak, Katherine R, Sadowsky, Jack, Yu, Shang-Fan, Fourie-O’Donohue, Aimee, Nelson, Christopher, Vandlen, Richard, Ohri, Rachana, Liu, Luna, Ng, Carl, He, Jintang, Davis, Helen, Lau, Jeff, Del Rosario, Geoffrey, Cosino, Ely, Cruz-Chuh, Josefa dela, Ma, Yong, Zhang, Donglu, Darwish, Martine, Cai, Wenwen, Chen, Chunjiao, Zhou, Hongxiang, Lu, Jiawei, Liu, Yichin, Kaur, Surinder, Xu, Keyang, Pillow, Thomas H

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Translatability of In Vitro Stress for Predicting Deamidation and Oxidation Biotransformation on Biotherapeutics von Chu, Phillip Y., Wang, Hui, Ross, Emily, Stephens, Nicole, Zhang, Hui-Min, Andersen, Nisana, Chan, Wayman, Shivva, Vittal, Crowell, Susan R., Spiess, Christoph, Holder, Patrick G., Agard, Nicholas J., Ji, Chengjie, Chen, John, Sreedhara, Alavattam, Wang, Jianyong, Wu, Cong, Liu, Yichin, Tran, John C.

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