Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles von Verbanck, Marie, Canouil, Mickaël, Leloire, Audrey, Dhennin, Véronique, Coumoul, Xavier, Yengo, Loïc, Froguel, Philippe, Poulain-Godefroy, Odile

Volltext

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human von Ichimura, Atsuhiko, Hirasawa, Akira, Poulain-Godefroy, Odile, Bonnefond, Amélie, Hara, Takafumi, Yengo, Loïc, Kimura, Ikuo, Leloire, Audrey, Liu, Ning, Iida, Keiko, Choquet, Hélène, Besnard, Philippe, Lecoeur, Cécile, Vivequin, Sidonie, Ayukawa, Kumiko, Takeuchi, Masato, Ozawa, Kentaro, Tauber, Maithé, Maffeis, Claudio, Morandi, Anita, Buzzetti, Raffaella, Elliott, Paul, Pouta, Anneli, Jarvelin, Marjo-Riitta, Körner, Antje, Kiess, Wieland, Pigeyre, Marie, Caiazzo, Roberto, Van Hul, Wim, Van Gaal, Luc, Horber, Fritz, Balkau, Beverley, Lévy-Marchal, Claire, Rouskas, Konstantinos, Kouvatsi, Anastasia, Hebebrand, Johannes, Hinney, Anke, Scherag, Andre, Pattou, François, Meyre, David, Koshimizu, Taka-aki, Wolowczuk, Isabelle, Tsujimoto, Gozoh, Froguel, Philippe

Volltext

Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals von Okbay, Aysu, Wu, Yeda, Wang, Nancy, Jayashankar, Hariharan, Bennett, Michael, Nehzati, Seyed Moeen, Sidorenko, Julia, Kweon, Hyeokmoon, Goldman, Grant, Gjorgjieva, Tamara, Jiang, Yunxuan, Hicks, Barry, Tian, Chao, Hinds, David A., Ahlskog, Rafael, Magnusson, Patrik K. E., Oskarsson, Sven, Hayward, Caroline, Campbell, Archie, Porteous, David J., Freese, Jeremy, Herd, Pamela, Watson, Chelsea, Jala, Jonathan, Conley, Dalton, Koellinger, Philipp D., Johannesson, Magnus, Laibson, David, Meyer, Michelle N., Lee, James J., Kong, Augustine, Yengo, Loic, Cesarini, David, Turley, Patrick, Visscher, Peter M., Beauchamp, Jonathan P., Benjamin, Daniel J., Young, Alexander I.

Volltext

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes von Bonnefond, Amélie, Clément, Nathalie, Fawcett, Katherine, Yengo, Loïc, Vaillant, Emmanuel, Guillaume, Jean-Luc, Dechaume, Aurélie, Payne, Felicity, Roussel, Ronan, Czernichow, Sébastien, Hercberg, Serge, Hadjadj, Samy, Balkau, Beverley, Marre, Michel, Lantieri, Olivier, Langenberg, Claudia, Bouatia-Naji, Nabila, Charpentier, Guillaume, Vaxillaire, Martine, Rocheleau, Ghislain, Wareham, Nicholas J, Sladek, Robert, McCarthy, Mark I, Dina, Christian, Barroso, Inês, Jockers, Ralf, Froguel, Philippe

Volltext

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes von Abderrahmani, Amar, Yengo, Loïc, Caiazzo, Robert, Canouil, Mickaël, Cauchi, Stéphane, Raverdy, Violeta, Plaisance, Valérie, Pawlowski, Valérie, Lobbens, Stéphane, Maillet, Julie, Rolland, Laure, Boutry, Raphael, Queniat, Gurvan, Kwapich, Maxime, Tenenbaum, Mathie, Bricambert, Julien, Saussenthaler, Sophie, Anthony, Elodie, Jha, Pooja, Derop, Julien, Sand, Olivier, Rabearivelo, Iandry, Leloire, Audrey, Pigeyre, Marie, Daujat-Chavanieu, Martine, Gerbal-Chaloin, Sabine, Dayeh, Tasnim, Lassailly, Guillaume, Mathurin, Philippe, Staels, Bart, Auwerx, Johan, Schürmann, Annette, Postic, Catherine, Schafmayer, Clemens, Hampe, Jochen, Bonnefond, Amélie, Pattou, François, Froguel, Philippe

Volltext

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations von Wang, Ying, Guo, Jing, Ni, Guiyan, Yang, Jian, Visscher, Peter M., Yengo, Loic

Volltext

Improved polygenic prediction by Bayesian multiple regression on summary statistics von Lloyd-Jones, Luke R., Zeng, Jian, Sidorenko, Julia, Yengo, Loïc, Moser, Gerhard, Kemper, Kathryn E., Wang, Huanwei, Zheng, Zhili, Magi, Reedik, Esko, Tõnu, Metspalu, Andres, Wray, Naomi R., Goddard, Michael E., Yang, Jian, Visscher, Peter M.

Volltext

Disruption of a Novel Krüppel-like Transcription Factor p300-regulated Pathway for Insulin Biosynthesis Revealed by Studies of the c.-331 INS Mutation Found in Neonatal Diabetes Me... von Bonnefond, Amélie, Lomberk, Gwen, Buttar, Navtej, Busiah, Kanetee, Vaillant, Emmanuel, Lobbens, Stéphane, Yengo, Loïc, Dechaume, Aurélie, Mignot, Brigitte, Simon, Albane, Scharfmann, Raphaël, Neve, Bernadette, Tanyolaç, Sinan, Hodoglugil, Ugur, Pattou, François, Cavé, Hélène, Iovanna, Juan, Stein, Roland, Polak, Michel, Vaxillaire, Martine, Froguel, Philippe, Urrutia, Raul

Volltext

Genome-wide association study of medication-use and associated disease in the UK Biobank von Wu, Yeda, Byrne, Enda M., Zheng, Zhili, Kemper, Kathryn E., Yengo, Loic, Mallett, Andrew J., Yang, Jian, Visscher, Peter M., Wray, Naomi R.

Volltext

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry von Pulit, Sara L, Stoneman, Charli, Morris, Andrew P, Wood, Andrew R, Glastonbury, Craig A, Tyrrell, Jessica, Yengo, Loïc, Ferreira, Teresa, Marouli, Eirini, Ji, Yingjie, Yang, Jian, Jones, Samuel, Beaumont, Robin, Croteau-Chonka, Damien C, Winkler, Thomas W, Hattersley, Andrew T, Loos, Ruth J F, Hirschhorn, Joel N, Visscher, Peter M, Frayling, Timothy M, Yaghootkar, Hanieh, Lindgren, Cecilia M

Volltext

Assortative mating biases marker-based heritability estimators von Border, Richard, O’Rourke, Sean, de Candia, Teresa, Goddard, Michael E., Visscher, Peter M., Yengo, Loic, Jones, Matt, Keller, Matthew C.

Volltext

Risk in Relatives, Heritability, SNP-Based Heritability, and Genetic Correlations in Psychiatric Disorders: A Review von Baselmans, Bart M.L., Yengo, Loïc, van Rheenen, Wouter, Wray, Naomi R.

Volltext

Widespread signatures of natural selection across human complex traits and functional genomic categories von Zeng, Jian, Xue, Angli, Jiang, Longda, Lloyd-Jones, Luke R., Wu, Yang, Wang, Huanwei, Zheng, Zhili, Yengo, Loic, Kemper, Kathryn E., Goddard, Michael E., Wray, Naomi R., Visscher, Peter M., Yang, Jian

Volltext

Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals von Liu, Ching-Ti, Merino, Jordi, Rybin, Denis, DiCorpo, Daniel, Benke, Kelly S., Bragg-Gresham, Jennifer L., Canouil, Mickaël, Corre, Tanguy, Grallert, Harald, Isaacs, Aaron, Kutalik, Zoltan, Lahti, Jari, Marullo, Letizia, Marzi, Carola, Rasmussen-Torvik, Laura J., Rocheleau, Ghislain, Rueedi, Rico, Scapoli, Chiara, Verweij, Niek, Vogelzangs, Nicole, Willems, Sara M., Yengo, Loïc, Bakker, Stephan J. L., Beilby, John, Hui, Jennie, Kajantie, Eero, Müller-Nurasyid, Martina, Rathmann, Wolfgang, Balkau, Beverley, Bergmann, Sven, Eriksson, Johan G., Florez, Jose C., Froguel, Philippe, Harris, Tamara, Hung, Joseph, James, Alan L., Kavousi, Maryam, Miljkovic, Iva, Musk, Arthur W., Palmer, Lyle J., Peters, Annette, Roussel, Ronan, van der harst, Pim, van Duijn, Cornelia M., Vollenweider, Peter, Barroso, Inês, Prokopenko, Inga, Dupuis, Josée, Meigs, James B., Bouatia-Naji, Nabila

Volltext

Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization von Pathak, Gita A., Singh, Kritika, Miller-Fleming, Tyne W., Wendt, Frank R., Ehsan, Nava, Hou, Kangcheng, Johnson, Ruth, Lu, Zeyun, Gopalan, Shyamalika, Yengo, Loic, Mohammadi, Pejman, Pasaniuc, Bogdan, Polimanti, Renato, Davis, Lea K., Mancuso, Nicholas

Volltext

Detection of human adaptation during the past 2000 years von Field, Yair, Boyle, Evan A, Telis, Natalie, Gao, Ziyue, Gaulton, Kyle J., Golan, David, Yengo, Loic, Rocheleau, Ghislain, Froguel, Philippe, McCarthy, Mark I., Pritchard, Jonathan K.

Volltext

The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation von Favennec, Marie, Hennart, Benjamin, Caiazzo, Robert, Leloire, Audrey, Yengo, Loïc, Verbanck, Marie, Arredouani, Abdelilah, Marre, Michel, Pigeyre, Marie, Bessede, Alban, Guillemin, Gilles J., Chinetti, Giulia, Staels, Bart, Pattou, François, Balkau, Beverley, Allorge, Delphine, Froguel, Philippe, Poulain‐Godefroy, Odile

Volltext

Phenotypic covariance across the entire spectrum of relatedness for 86 billion pairs of individuals von Kemper, Kathryn E., Yengo, Loic, Zheng, Zhili, Abdellaoui, Abdel, Keller, Matthew C., Goddard, Michael E., Wray, Naomi R., Yang, Jian, Visscher, Peter M.

Volltext

Signatures of negative selection in the genetic architecture of human complex traits von Zeng, Jian, de Vlaming, Ronald, Wu, Yang, Robinson, Matthew R., Lloyd-Jones, Luke R., Yengo, Loic, Yap, Chloe X., Xue, Angli, Sidorenko, Julia, McRae, Allan F., Powell, Joseph E., Montgomery, Grant W., Metspalu, Andres, Esko, Tonu, Gibson, Greg, Wray, Naomi R., Visscher, Peter M., Yang, Jian

Volltext

Early metabolic markers identify potential targets for the prevention of type 2 diabetes von Peddinti, Gopal, Cobb, Jeff, Yengo, Loic, Froguel, Philippe, Kravić, Jasmina, Balkau, Beverley, Tuomi, Tiinamaija, Aittokallio, Tero, Groop, Leif

Volltext