TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury von Balakrishna, Shrilatha, Song, Weifeng, Achanta, Satyanarayana, Doran, Stephen F, Liu, Boyi, Kaelberer, Melanie M, Yu, Zhihong, Sui, Aiwei, Cheung, Mui, Leishman, Emma, Eidam, Hilary S, Ye, Guosen, Willette, Robert N, Thorneloe, Kevin S, Bradshaw, Heather B, Matalon, Sadis, Jordt, Sven-Eric

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Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4 von Cheung, Mui, Bao, Weike, Behm, David J, Brooks, Carl A, Bury, Michael J, Dowdell, Sarah E, Eidam, Hilary S, Fox, Ryan M, Goodman, Krista B, Holt, Dennis A, Lee, Dennis, Roethke, Theresa J, Willette, Robert N, Xu, Xiaoping, Ye, Guosen, Thorneloe, Kevin S

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Development of Dihydropyridone Indazole Amides as Selective Rho-Kinase Inhibitors von Goodman, Krista B, Cui, Haifeng, Dowdell, Sarah E, Gaitanopoulos, Dimitri E, Ivy, Robert L, Sehon, Clark A, Stavenger, Robert A, Wang, Gren Z, Viet, Andrew Q, Xu, Weiwei, Ye, Guosen, Semus, Simon F, Evans, Christopher, Fries, Harvey E, Jolivette, Larry J, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Jung, David K, Wright, Lois L, Smith, Gary K, Behm, David J, Bentley, Ross, Doe, Christopher P, Hu, Erding, Lee, Dennis

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Observation on the ice crystal formation process of large yellow croaker (Pseudosciaena crocea) and the effect of multiple cryoprotectants pre-soaking treatments on frozen quality von Yang, Zhikang, Ye, Guosen, Yang, Dazhang, Xie, Jing, Huo, Yilin

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Design of amidobenzimidazole STING receptor agonists with systemic activity von Ramanjulu, Joshi M., Pesiridis, G. Scott, Yang, Jingsong, Concha, Nestor, Singhaus, Robert, Zhang, Shu-Yun, Tran, Jean-Luc, Moore, Patrick, Lehmann, Stephanie, Eberl, H. Christian, Muelbaier, Marcel, Schneck, Jessica L., Clemens, Jim, Adam, Michael, Mehlmann, John, Romano, Joseph, Morales, Angel, Kang, James, Leister, Lara, Graybill, Todd L., Charnley, Adam K., Ye, Guosen, Nevins, Neysa, Behnia, Kamelia, Wolf, Amaya I., Kasparcova, Viera, Nurse, Kelvin, Wang, Liping, Puhl, Ana C., Li, Yue, Klein, Michael, Hopson, Christopher B., Guss, Jeffrey, Bantscheff, Marcus, Bergamini, Giovanna, Reilly, Michael A., Lian, Yiqian, Duffy, Kevin J., Adams, Jerry, Foley, Kevin P., Gough, Peter J., Marquis, Robert W., Smothers, James, Hoos, Axel, Bertin, John

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Research on the progress of particle-bubble transport von Liang, Zihao, Wang, Jinfeng, Sun, Weihua, Ye, Guosen, Jiang, Jilin, Han, Xinrong

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Optimization of zero superheat control at the evaporator outlet: Application of EXV and pressure regulation valve von Ma, Xingxing, Wang, Jinfeng, Xie, Jing, Xu, Hao, Ye, Guosen, Jiang, Jilin, Han, Xinrong

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Discovery of Aminofurazan-azabenzimidazoles as Inhibitors of Rho-Kinase with High Kinase Selectivity and Antihypertensive Activity von Stavenger, Robert A, Cui, Haifeng, Dowdell, Sarah E, Franz, Robert G, Gaitanopoulos, Dimitri E, Goodman, Krista B, Hilfiker, Mark A, Ivy, Robert L, Leber, Jack D, Marino, Joseph P, Oh, Hye-Ja, Viet, Andrew Q, Xu, Weiwei, Ye, Guosen, Zhang, Daohua, Zhao, Yongdong, Jolivette, Larry J, Head, Martha S, Semus, Simon F, Elkins, Patricia A, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Jung, David K, Wright, Lois L, Smith, Gary K, Behm, David J, Doe, Christopher P, Bentley, Ross, Chen, Zunxuan X, Hu, Erding, Lee, Dennis

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Evaluation of GSK2789917-induced TRPV4 inhibition in animal models of fluid induced lung injury von Bihari, Shailesh, Costell, Melissa H., Bouchier, Tara, Behm, David J., Burgert, Mark, Ye, Guosen, Bersten, Andrew D., Puukila, Stephanie, Cavallaro, Elena, Sprecher, Dennis L., Dixon, Dani-Louise

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Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions von Patterson, Jaclyn R, Terrell, Lamont R, Donatelli, Carla A, Holt, Dennis A, Jolivette, Larry J, Rivero, Ralph A, Roethke, Theresa J, Shu, Arthur, Stoy, Patrick, Ye, Guosen, Youngman, Mark, Lawhorn, Brian G

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Discovery of Pyrrolidine Sulfonamides as Selective and Orally Bioavailable Antagonists of Transient Receptor Potential Vanilloid‑4 (TRPV4) von Brnardic, Edward J, Ye, Guosen, Brooks, Carl, Donatelli, Carla, Barton, Linda, McAtee, Jeff, Sanchez, Robert M, Shu, Arthur, Erhard, Karl, Terrell, Lamont, Graczyk-Millbrandt, Grazyna, He, Yanan, Costell, Melissa H, Behm, David J, Roethke, Theresa, Stoy, Patrick, Holt, Dennis A, Lawhorn, Brian G

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Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) von Brooks, Carl A, Barton, Linda S, Behm, David J, Eidam, Hilary S, Fox, Ryan M, Hammond, Marlys, Hoang, Tram H, Holt, Dennis A, Hilfiker, Mark A, Lawhorn, Brian G, Patterson, Jaclyn R, Stoy, Patrick, Roethke, Theresa J, Ye, Guosen, Zhao, Steve, Thorneloe, Kevin S, Goodman, Krista B, Cheung, Mui

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Discovery of 6‑Phenylpyrimido[4,5‑b][1,4]oxazines as Potent and Selective Acyl CoA:Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors with in Vivo Efficacy in Rodents von Fox, Brian M, Sugimoto, Kazuyuki, Iio, Kiyosei, Yoshida, Atsuhito, Zhang, Jian (Ken), Li, Kexue, Hao, Xiaolin, Labelle, Marc, Smith, Marie-Louise, Rubenstein, Steven M, Ye, Guosen, McMinn, Dustin, Jackson, Simon, Choi, Rebekah, Shan, Bei, Ma, Ji, Miao, Shichang, Matsui, Takuya, Ogawa, Nobuya, Suzuki, Masahiro, Kobayashi, Akio, Ozeki, Hidekazu, Okuma, Chihiro, Ishii, Yukihito, Tomimoto, Daisuke, Furakawa, Noboru, Tanaka, Masahiro, Matsushita, Mutsuyoshi, Takahashi, Mitsuru, Inaba, Takashi, Sagawa, Shoichi, Kayser, Frank

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Author Correction: Design of amidobenzimidazole STING receptor agonists with systemic activity von Ramanjulu, Joshi M., Pesiridis, G. Scott, Yang, Jingsong, Concha, Nestor, Singhaus, Robert, Zhang, Shu-Yun, Tran, Jean-Luc, Moore, Patrick, Lehmann, Stephanie, Eberl, H. Christian, Muelbaier, Marcel, Schneck, Jessica L., Clemens, Jim, Adam, Michael, Mehlmann, John, Romano, Joseph, Morales, Angel, Kang, James, Leister, Lara, Graybill, Todd L., Charnley, Adam K., Ye, Guosen, Nevins, Neysa, Behnia, Kamelia, Wolf, Amaya I., Kasparcova, Viera, Nurse, Kelvin, Wang, Liping, Puhl, Ana C., Li, Yue, Klein, Michael, Hopson, Christopher B., Guss, Jeffrey, Bantscheff, Marcus, Bergamini, Giovanna, Reilly, Michael A., Lian, Yiqian, Duffy, Kevin J., Adams, Jerry, Foley, Kevin P., Gough, Peter J., Marquis, Robert W., Smothers, James, Hoos, Axel, Bertin, John

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Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1 von Kallander, Lara S., Washburn, David, Hilfiker, Mark A., Eidam, Hilary Schenck, Lawhorn, Brian G., Prendergast, Joanne, Fox, Ryan, Dowdell, Sarah, Manns, Sharada, Hoang, Tram, Zhao, Steve, Ye, Guosen, Hammond, Marlys, Holt, Dennis A., Roethke, Theresa, Hong, Xuan, Reid, Robert A., Gampe, Robert, Zhang, Hong, Diaz, Elsie, Rendina, Alan R., Quinn, Amy M., Willette, Bob

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Discovery of INT131: A selective PPARγ modulator that enhances insulin sensitivity von Taygerly, Joshua P., McGee, Lawrence R., Rubenstein, Steven M., Houze, Jonathan B., Cushing, Timothy D., Li, Yang, Motani, Alykhan, Chen, Jin-Long, Frankmoelle, Walter, Ye, Guosen, Learned, Marc R., Jaen, Juan, Miao, Shichang, Timmermans, Pieter B., Thoolen, Martin, Kearney, Patrick, Flygare, John, Beckmann, Holger, Weiszmann, Jennifer, Lindstrom, Michelle, Walker, Nigel, Liu, Jinsong, Biermann, Donna, Wang, Zhulun, Hagiwara, Atsushi, Iida, Tetsuya, Aramaki, Hisateru, Kitao, Yuki, Shinkai, Hisashi, Furukawa, Noboru, Nishiu, Jun, Nakamura, Motonao

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Discovery of INT131: A selective PPARI3 modulator that enhances insulin sensitivity von Taygerly, Joshua, McGee, Lawrence, Rubenstein, Steven, Houze, Jonathan, Cushing, Timothy, Li, Yang, Motani, Alykhan, Chen, Jin-Long, Frankmoelle, Walter, Ye, Guosen, Learned, Marc, Jaen, Juan, Miao, Shichang, Timmermans, Pieter, Thoolen, Martin, Kearney, Patrick, Flygare, John, Beckmann, Holger, Weiszmann, Jennifer, Lindstrom, Michelle, Walker, Nigel, Liu, Jinsong, Biermann, Donna, Wang, Zhulun, Hagiwara, Atsushi, Iida, Tetsuya, Aramaki, Hisateru, Kitao, Yuki, Shinkai, Hisashi, Furukawa, Noboru, Nishiu, Jun, Nakamura, Motonao

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Discovery of INT131: A selective PPAR[gamma] modulator that enhances insulin sensitivity von Taygerly, Joshua P, McGee, Lawrence R, Rubenstein, Steven M, Houze, Jonathan B, Cushing, Timothy D, Li, Yang, Motani, Alykhan, Chen, Jin-Long, Frankmoelle, Walter, Ye, Guosen, Learned, Marc R, Jaen, Juan, Miao, Shichang, Timmermans, Pieter B, Thoolen, Martin, Kearney, Patrick, Flygare, John, Beckmann, Holger, Weiszmann, Jennifer, Lindstrom, Michelle, Walker, Nigel, Liu, Jinsong, Biermann, Donna, Wang, Zhulun, Hagiwara, Atsushi, Iida, Tetsuya, Aramaki, Hisateru, Kitao, Yuki, Shinkai, Hisashi, Furukawa, Noboru, Nishiu, Jun, Nakamura, Motonao

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TRPV4 antagonist von Stoy, Patrick, Brooks, Carl A, Ye, Guosen

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TRPV4 antagonist von Stoy, Patrick, Brooks, Carl A, Ye, Guosen

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