Free Drug Theory – No Longer Just a Hypothesis? von Summerfield, Scott G., Yates, James W. T., Fairman, David A.

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Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent von Foote, Kevin M, Nissink, J. Willem M, McGuire, Thomas, Turner, Paul, Guichard, Sylvie, Yates, James W. T, Lau, Alan, Blades, Kevin, Heathcote, Dan, Odedra, Rajesh, Wilkinson, Gary, Wilson, Zena, Wood, Christine M, Jewsbury, Philip J

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Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity von Ballard, Peter, Yates, James W T, Yang, Zhenfan, Kim, Dong-Wan, Yang, James Chih-Hsin, Cantarini, Mireille, Pickup, Kathryn, Jordan, Angela, Hickey, Mike, Grist, Matthew, Box, Matthew, Johnström, Peter, Varnäs, Katarina, Malmquist, Jonas, Thress, Kenneth S, Jänne, Pasi A, Cross, Darren

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The ATR Inhibitor AZD6738 Synergizes with Gemcitabine In Vitro and In Vivo to Induce Pancreatic Ductal Adenocarcinoma Regression von Wallez, Yann, Dunlop, Charles R, Johnson, Timothy Isaac, Koh, Siang-Boon, Fornari, Chiara, Yates, James W T, Bernaldo de Quirós Fernández, Sandra, Lau, Alan, Richards, Frances M, Jodrell, Duncan I

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Osimertinib for Patients With Leptomeningeal Metastases Associated With EGFR T790M-Positive Advanced NSCLC: The AURA Leptomeningeal Metastases Analysis von Ahn, Myung-Ju, Chiu, Chao-Hua, Cheng, Ying, Han, Ji-Youn, Goldberg, Sarah B., Greystoke, Alastair, Crawford, Jeffrey, Zhao, Yanqiu, Huang, Xiangning, Johnson, Martin, Vishwanathan, Karthick, Yates, James W.T., Brown, Andrew P., Mendoza-Naranjo, Ariadna, Mok, Tony

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Integrated pharmacokinetic-pharmacodynamic and agent-based modelling in drug development: Current status and future perspectives von Yates, James W.T.

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Ancient DNA data hold insights into past organisms and ecosystems — handle them with more care von Bergström, Anders, Fellows Yates, James A., Warinner, Christina

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Quantitative Systems Pharmacology and Machine Learning: A Match Made in Heaven or Hell? von Tindall, Marcus John, Cucurull-Sanchez, Lourdes, Mistry, Hitesh, Yates, James W.T.

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REPLY TO BEN-DOR ET AL: Oral bacteria of Neanderthals and modern humans exhibit evidence of starch adaptation von Warinner, Christina, Velsko, Irina M., Yates, James A. Fellows

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Ecology, Not Host Phylogeny, Shapes the Oral Microbiome in Closely Related Species von Moraitou, Markella, Forsythe, Adrian, Fellows Yates, James A, Brealey, Jaelle C, Warinner, Christina, Guschanski, Katerina

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Skipping a pillar does not make for strong foundations: Pharmacokinetic‐pharmacodynamic reasoning behind the shape of dose–response relationships in oncology von Yates, James W. T., Mistry, Hitesh B.

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A Robust Framework for Microbial Archaeology von Warinner, Christina, Herbig, Alexander, Mann, Allison, Fellows Yates, James A, Weiß, Clemens L, Burbano, Hernán A, Orlando, Ludovic, Krause, Johannes

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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: Comparative assessement of prediction methods of human clearance von Ring, Barbara J., Chien, Jenny Y., Adkison, Kimberly K., Jones, Hannah M., Rowland, Malcolm, Jones, Rhys Do, Yates, James W.T., Ku, M. Sherry, Gibson, Christopher R., He, Handan, Vuppugalla, Ragini, Marathe, Punit, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K., Björnsson, Thorir, Lavé, Thierry, Poulin, Patrick

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The ingredients for an antimicrobial mathematical modelling broth von Tindall, Marcus, Chappell, Michael J., Yates, James W.T.

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PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmaco... von Poulin, Patrick, Jones, Rhys D.O., Jones, Hannah M., Gibson, Christopher R., Rowland, Malcolm, Chien, Jenny Y., Ring, Barbara J., Adkison, Kimberly K., Ku, M. Sherry, He, Handan, Vuppugalla, Ragini, Marathe, Punit, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K., Björnsson, Thorir, Lavé, Thierry, Yates, James W.T.

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Microbial differences between dental plaque and historic dental calculus are related to oral biofilm maturation stage von Velsko, Irina M, Fellows Yates, James A, Aron, Franziska, Hagan, Richard W, Frantz, Laurent A F, Loe, Louise, Martinez, Juan Bautista Rodriguez, Chaves, Eros, Gosden, Chris, Larson, Greger, Warinner, Christina

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AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous Schedules von Guichard, Sylvie M, Curwen, Jon, Bihani, Teeru, D'Cruz, Celina M, Yates, James W T, Grondine, Michael, Howard, Zoe, Davies, Barry R, Bigley, Graham, Klinowska, Teresa, Pike, Kurt G, Pass, Martin, Chresta, Christine M, Polanska, Urszula M, McEwen, Robert, Delpuech, Oona, Green, Stephen, Cosulich, Sabina C

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In situ solid-state nanopore fabrication von Fried, Jasper P, Swett, Jacob L, Nadappuram, Binoy Paulose, Mol, Jan A, Edel, Joshua B, Ivanov, Aleksandar P, Yates, James R

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Differential preservation of endogenous human and microbial DNA in dental calculus and dentin von Mann, Allison E., Sabin, Susanna, Ziesemer, Kirsten, Vågene, Åshild J., Schroeder, Hannes, Ozga, Andrew T., Sankaranarayanan, Krithivasan, Hofman, Courtney A., Fellows Yates, James A., Salazar-García, Domingo C., Frohlich, Bruno, Aldenderfer, Mark, Hoogland, Menno, Read, Christopher, Milner, George R., Stone, Anne C., Lewis, Cecil M., Krause, Johannes, Hofman, Corinne, Bos, Kirsten I., Warinner, Christina

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Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals von Martin, Emma C., Aarons, Leon, Yates, James W. T.

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