3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential von Younis, Yassir, Douelle, Frederic, Feng, Tzu-Shean, Cabrera, Diego González, Manach, Claire Le, Nchinda, Aloysius T, Duffy, Sandra, White, Karen L, Shackleford, David M, Morizzi, Julia, Mannila, Janne, Katneni, Kasiram, Bhamidipati, Ravi, Zabiulla, K. Mohammed, Joseph, Jayan T, Bashyam, Sridevi, Waterson, David, Witty, Michael J, Hardick, David, Wittlin, Sergio, Avery, Vicky, Charman, Susan A, Chibale, Kelly

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Medicinal Chemistry Optimization of Antiplasmodial Imidazopyridazine Hits from High Throughput Screening of a SoftFocus Kinase Library: Part 1 von Le Manach, Claire, Gonzàlez Cabrera, Diego, Douelle, Frederic, Nchinda, Aloysius T, Younis, Yassir, Taylor, Dale, Wiesner, Lubbe, White, Karen L, Ryan, Eileen, March, Corinne, Duffy, Sandra, Avery, Vicky M, Waterson, David, Witty, Michael J, Wittlin, Sergio, Charman, Susan A, Street, Leslie J, Chibale, Kelly

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Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum von Le Manach, Claire, Scheurer, Christian, Sax, Sibylle, Schleiferböck, Sarah, Cabrera, Diego Gonzalez, Younis, Yassir, Paquet, Tanya, Street, Leslie, Smith, Peter, Ding, Xavier C, Waterson, David, Witty, Michael J, Leroy, Didier, Chibale, Kelly, Wittlin, Sergio

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Alternative solid-state forms of a potent antimalarial aminopyridine: X-ray crystallographic, thermal and solubility aspects von Cruickshank, Dyanne L, Younis, Yassir, Njuguna, Nicholas M, Ongarora, Dennis SB, Chibale, Kelly, Caira, Mino R

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Synthesis and structure–activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2 von Sharma, Rajni Kant, Younis, Yassir, Mugumbate, Grace, Njoroge, Mathew, Gut, Jiri, Rosenthal, Philip J., Chibale, Kelly

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Identification of a Potential Antimalarial Drug Candidate from a Series of 2‑Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle von Le Manach, Claire, Nchinda, Aloysius T, Paquet, Tanya, Gonzàlez Cabrera, Diego, Younis, Yassir, Han, Ze, Bashyam, Sridevi, Zabiulla, Mohammed, Taylor, Dale, Lawrence, Nina, White, Karen L, Charman, Susan A, Waterson, David, Witty, Michael J, Wittlin, Sergio, Botha, Mariëtte E, Nondaba, Sindisiswe H, Reader, Janette, Birkholtz, Lyn-Marie, Jiménez-Díaz, María Belén, Martínez, María Santos, Ferrer, Santiago, Angulo-Barturen, Iñigo, Meister, Stephan, Antonova-Koch, Yevgeniya, Winzeler, Elizabeth A, Street, Leslie J, Chibale, Kelly

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Novel Orally Active Antimalarial Thiazoles von González Cabrera, Diego, Douelle, Frederic, Feng, Tzu-Shean, Nchinda, Aloysius T, Younis, Yassir, White, Karen L, Wu, Quoc, Ryan, Eileen, Burrows, Jeremy N, Waterson, David, Witty, Michael J, Wittlin, Sergio, Charman, Susan A, Chibale, Kelly

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Medicinal Chemistry Optimization of Antiplasmodial Imidazopyridazine Hits from High Throughput Screening of a SoftFocus Kinase Library: Part 2 von Le Manach, Claire, Paquet, Tanya, Gonzàlez Cabrera, Diego, Younis, Yassir, Taylor, Dale, Wiesner, Lubbe, Lawrence, Nina, Schwager, Sylva, Waterson, David, Witty, Michael J, Wittlin, Sergio, Street, Leslie J, Chibale, Kelly

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Cell-based medicinal chemistry optimization of high throughput screening hits for orally active antimalarials. Part 2: hits from SoftFocus kinase and other libraries von Younis, Yassir, Street, Leslie J, Waterson, David, Witty, Michael J, Chibale, Kelly

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Structure–Activity-Relationship Studies around the 2‑Amino Group and Pyridine Core of Antimalarial 3,5-Diarylaminopyridines Lead to a Novel Series of Pyrazine Analogues with Oral i... von Younis, Yassir, Douelle, Frederic, González Cabrera, Diego, Le Manach, Claire, Nchinda, Aloysius T, Paquet, Tanya, Street, Leslie J, White, Karen L, Zabiulla, K. Mohammed, Joseph, Jayan T, Bashyam, Sridevi, Waterson, David, Witty, Michael J, Wittlin, Sergio, Charman, Susan A, Chibale, Kelly

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Structure–Activity Relationship Studies of Orally Active Antimalarial 3,5-Substituted 2‑Aminopyridines von González Cabrera, Diego, Douelle, Frederic, Younis, Yassir, Feng, Tzu-Shean, Le Manach, Claire, Nchinda, Aloysius T, Street, Leslie J, Scheurer, Christian, Kamber, Jolanda, White, Karen L, Montagnat, Oliver D, Ryan, Eileen, Katneni, Kasiram, Zabiulla, K. Mohammed, Joseph, Jayan T, Bashyam, Sridevi, Waterson, David, Witty, Michael J, Charman, Susan A, Wittlin, Sergio, Chibale, Kelly

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Cell-Based Medicinal Chemistry Optimization of High Throughput Screening Hits for Orally Active Antimalarials. Part 2: Hits from SoftFocus Kinase and other Libraries: Miniperspecti... von Younis, Yassir, Street, Leslie J, Waterson, David, Witty, Michael J, Chibale, Kelly

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Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics von Ghidelli-Disse, Sonja, Lafuente-Monasterio, Maria Jose, Waterson, David, Witty, Michael, Younis, Yassir, Paquet, Tanya, Street, Leslie J, Chibale, Kelly, Gamo-Benito, Francisco Javier, Bantscheff, Marcus, Drewes, Gerard

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[d4U]-Spacer-[HI-236] double-drug inhibitors of HIV-1 reverse-transcriptase von Younis, Yassir, Hunter, Roger, Muhanji, Clare I., Hale, Ian, Singh, Rajinder, Bailey, Christopher M., Sullivan, Todd J., Anderson, Karen S.

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C-2-Aryl O-substituted HI-236 derivatives as non-nucleoside HIV-1 reverse-transcriptase inhibitors von Hunter, Roger, Younis, Yassir, Muhanji, Clare I., Curtin, Tanith-lea, Naidoo, Kevin J., Petersen, Melissa, Bailey, Christopher M., Basavapathruni, Aravind, Anderson, Karen S.

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2,4-Diaminothienopyrimidines as Orally Active Antimalarial Agents von González Cabrera, Diego, Le Manach, Claire, Douelle, Frederic, Younis, Yassir, Feng, Tzu-Shean, Paquet, Tanya, Nchinda, Aloysius T, Street, Leslie J, Taylor, Dale, de Kock, Carmen, Wiesner, Lubbe, Duffy, Sandra, White, Karen L, Zabiulla, K. Mohammed, Sambandan, Yuvaraj, Bashyam, Sridevi, Waterson, David, Witty, Michael J, Charman, Susan A, Avery, Vicky M, Wittlin, Sergio, Chibale, Kelly

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Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum von Le Manach, Claire, Scheurer, Christian, Sax, Sibylle, Schleiferböck, Sarah, Cabrera, Diego Gonzalez, Younis, Yassir, Paquet, Tanya, Street, Leslie, Smith, Peter, Ding, Xavier C, Waterson, David, Witty, Michael J, Leroy, Didier, Chibale, Kelly, Wittlin, Sergio

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Alternative solid-state forms of a potent antimalarial aminopyridine: X-ray crystallographic, thermal and solubility aspectsElectronic supplementary information (ESI) available: Th... von Cruickshank, Dyanne L, Younis, Yassir, Njuguna, Nicholas M, Ongarora, Dennis S. B, Chibale, Kelly, Caira, Mino R

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C-2-Aryl 0-substituted HI-236 derivatives as non-nucleoside HIV-1 reverse-transcriptase inhibitors von HUNTER, Roger, YOUNIS, Yassir, MUHANJI, Clare I, CURTIN, Tanith-Lea, NAIDOO, Kevin J, PETERSEN, Melissa, BAILEY, Christopher M, BASAVAPATHRUNI, Aravind, ANDERSON, Karen S

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TASPASE1 INHIBITORS AND USES THEREOF von ROMAINE, Ian, M, DUTTA, Shubhankar, WATERSON, Alex, G, JANA, Somnath, LAMERS, Alexander, P, RENSLO, Adam, R, REPELLIN, Claire, BRYANT, Clifford, MOORE, William, J, HSIEH, James, ADAM, Yassir, Younis, ARKIN, Michelle, R, SAMBUCETTI, Lidia, NEITZ, R., Jeffrey

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