HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma von Pei, Yanxin, Liu, Kun-Wei, Wang, Jun, Garancher, Alexandra, Tao, Ran, Esparza, Lourdes A., Maier, Donna L., Udaka, Yoko T., Murad, Najiba, Morrissy, Sorana, Seker-Cin, Huriye, Brabetz, Sebastian, Qi, Lin, Kogiso, Mari, Schubert, Simone, Olson, James M., Cho, Yoon-Jae, Li, Xiao-Nan, Crawford, John R., Levy, Michael L., Kool, Marcel, Pfister, Stefan M., Taylor, Michael D., Wechsler-Reya, Robert J.

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Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key β-Cell-Specific Disease Genes von Fang, Zhou, Weng, Chen, Li, Haiyan, Tao, Ran, Mai, Weihua, Liu, Xiaoxiao, Lu, Leina, Lai, Sisi, Duan, Qing, Alvarez, Carlos, Arvan, Peter, Wynshaw-Boris, Anthony, Li, Yun, Pei, Yanxin, Jin, Fulai, Li, Yan

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MYC Drives Group 3 Medulloblastoma through Transformation of Sox2 + Astrocyte Progenitor Cells von Tao, Ran, Murad, Najiba, Xu, Zhenhua, Zhang, Peng, Okonechnikov, Konstantin, Kool, Marcel, Rivero-Hinojosa, Samuel, Lazarski, Christopher, Zheng, Pan, Liu, Yang, Eberhart, Charles G, Rood, Brian R, Packer, Roger, Pei, Yanxin

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Differential Immune Microenvironments and Response to Immune Checkpoint Blockade among Molecular Subtypes of Murine Medulloblastoma von Pham, Christina D, Flores, Catherine, Yang, Changlin, Pinheiro, Elaine M, Yearley, Jennifer H, Sayour, Elias J, Pei, Yanxin, Moore, Colin, McLendon, Roger E, Huang, Jianping, Sampson, John H, Wechsler-Reya, Robert, Mitchell, Duane A

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WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum von Pei, Yanxin, Brun, Sonja N, Markant, Shirley L, Lento, William, Gibson, Paul, Taketo, Makoto M, Giovannini, Marco, Gilbertson, Richard J, Wechsler-Reya, Robert J

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Medulloblastoma rendered susceptible to NK-cell attack by TGFβ neutralization von Powell, Allison B, Yadavilli, Sridevi, Saunders, Devin, Van Pelt, Stacey, Chorvinsky, Elizabeth, Burga, Rachel A, Albihani, Shuroug, Hanley, Patrick J, Xu, Zhenhua, Pei, Yanxin, Yvon, Eric S, Hwang, Eugene I, Bollard, Catherine M, Nazarian, Javad, Cruz, Conrad Russell Y

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EXTH-07. UNRAVELING THE ROLE OF SHH SIGNALING PATHWAY IN RETINOBLASTOMA von Pei, Yanxin, Liu, Xiao

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ERK Inhibitor Ulixertinib Inhibits High-Risk Neuroblastoma Growth In Vitro and In Vivo von Yu, Yang, Zhao, Yanling, Choi, Jongmin, Shi, Zhongcheng, Guo, Linjie, Elizarraras, John, Gu, Andy, Cheng, Feng, Pei, Yanxin, Lu, Dai, Fabbri, Muller, Agarwal, Saurabh, Zhang, Chunchao, Jung, Sung Yun, Foster, Jennifer H, Yang, Jianhua

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A Proteogenomic Approach to Understanding MYC Function in Metastatic Medulloblastoma Tumors von Staal, Jerome A, Pei, Yanxin, Rood, Brian R

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MODL-30. AN ENGINEERED TRANSGENIC MOUSE MODEL OF RETINOBLASTOMA von Liu, Xiao, Pei, Yanxin

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Abstract 3569: An animal model of GLI2-amplified medulloblastoma von Pei, Yanxin

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Subtypes of medulloblastoma have distinct developmental origins von GIBSON, Paul, YIAI TONG, FINKELSTEIN, David, POUNDS, Stanley, WEISS, Aaron, PATAY, Zoltan, SCOGGINS, Matthew, OGG, Robert, YANXIN PEI, YANG, Zeng-Jie, BRUN, Sonja, LEE, Youngsoo, ROBINSON, Giles, ZINDY, Frederique, LINDSEY, Janet C, TAKETO, Makoto M, BOOP, Frederick A, SANFORD, Robert A, GAJJAR, Amar, CLIFFORD, Steven C, ROUSSEL, Martine F, MCKINNON, Peter J, GUTMANN, David H, THOMPSON, Margaret C, ELLISON, David W, WECHSLER-REYA, GILBERTSON, Richard J, CURRLE, D. Spencer, EDEN, Christopher, KRANENBURG, Tanya A, HOGG, Twala, POPPLETON, Helen, MARTIN, Julie

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Modulating native GABAA receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death von Kallay, Laura, Keskin, Havva, Ross, Alexandra, Rupji, Manali, Moody, Olivia A., Wang, Xin, Li, Guanguan, Ahmed, Taukir, Rashid, Farjana, Stephen, Michael Rajesh, Cottrill, Kirsten A., Nuckols, T. Austin, Xu, Maxwell, Martinson, Deborah E., Tranghese, Frank, Pei, Yanxin, Cook, James M., Kowalski, Jeanne, Taylor, Michael D., Jenkins, Andrew, Pomeranz Krummel, Daniel A., Sengupta, Soma

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STEM-06. THE ROLE OF SHH SIGNALING PATHWAY IN RETINOBLASTOMA INITIATION AND PROGRESSION von Liu, Xiao, Murad, Najiba, Pei, Yanxin, Micklye, McKayla Bridgette

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MODL-33. AN ANIMAL MODEL OF GLI2-AMPLIFIED MEDULLOBLASTOMA von Murad, Najiba, Liu, Xiao, Tao, Ran, Pei, Yanxin

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Direct stimulation of de novo nucleotide synthesis by O-GlcNAcylation von Chen, Lulu, Zhou, Qi, Zhang, Pingfeng, Tan, Wei, Li, Yingge, Xu, Ziwen, Ma, Junfeng, Kupfer, Gary M., Pei, Yanxin, Song, Qibin, Pei, Huadong

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MDB-110. A NOVEL TRANSGENIC MOUSE MODEL FOR GLI2-AMPLIFIED MEDULLOBLASTOMA von Murad, Najiba, Xu, Zhenhua, Liu, Xiao, Rivero-Hinojosa, Samuel, Ramawickrama, Prathibhani Gamachchige, Pei, Yanxin

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MDB-99. SPATIAL AND TEMPORAL DEVELOPMENT OF GLI2-DRIVEN MEDULLOBLASTOMA von Murad, Najiba, Xu, Zhenhua, Zhang, Jiao, Gamachchige, Prathibhani Ramawickrama, Schoof, Melanie, Schüller, Ulrich, Dlugosz, Andrzej, Taylor, Michael D, Pei, Yanxin

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ETMR-25. UNRAVELING THE ROLE OF SHH SIGNALING PATHWAY IN RETINOBLASTOMA von Liu, Xiao, Zhang, Jiao, Xu, Zhenhua, Dlugosz, Andrzej, Frank, Stephan, Meyer, Peter, Suzuki, Hiromichi, Nakashima, Taakuma, Pei, Yanxin

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MEDB-39. Oncogenic mechanisms underlying GLI2-amplified medulloblastoma von Murad, Najiba, Zhang, Jiao, Liu, Xiao, Tao, Ran, Taylor, Michael, Pei, Yanxin

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