RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes von Xin, Yurong, Kim, Jinrang, Okamoto, Haruka, Ni, Min, Wei, Yi, Adler, Christina, Murphy, Andrew J., Yancopoulos, George D., Lin, Calvin, Gromada, Jesper

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Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial von Bachert, Claus, Mannent, Leda, Naclerio, Robert M, Mullol, Joaquim, Ferguson, Berrylin J, Gevaert, Philippe, Hellings, Peter, Jiao, Lixia, Wang, Lin, Evans, Robert R, Pirozzi, Gianluca, Graham, Neil M, Swanson, Brian, Hamilton, Jennifer D, Radin, Allen, Gandhi, Namita A, Stahl, Neil, Yancopoulos, George D, Sutherland, E. Rand

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REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters von Baum, Alina, Ajithdoss, Dharani, Copin, Richard, Zhou, Anbo, Lanza, Kathryn, Negron, Nicole, Ni, Min, Wei, Yi, Mohammadi, Kusha, Musser, Bret, Atwal, Gurinder S, Oyejide, Adelekan, Goez-Gazi, Yenny, Dutton, John, Clemmons, Elizabeth, Staples, Hilary M, Bartley, Carmen, Klaffke, Benjamin, Alfson, Kendra, Gazi, Michal, Gonzalez, Olga, Dick, Jr, Edward, Carrion, Jr, Ricardo, Pessaint, Laurent, Porto, Maciel, Cook, Anthony, Brown, Renita, Ali, Vaneesha, Greenhouse, Jack, Taylor, Tammy, Andersen, Hanne, Lewis, Mark G, Stahl, Neil, Murphy, Andrew J, Yancopoulos, George D, Kyratsous, Christos A

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Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma von Rabe, Klaus F, Nair, Parameswaran, Brusselle, Guy, Maspero, Jorge F, Castro, Mario, Sher, Lawrence, Zhu, Hongjie, Hamilton, Jennifer D, Swanson, Brian N, Khan, Asif, Chao, Jingdong, Staudinger, Heribert, Pirozzi, Gianluca, Antoni, Christian, Amin, Nikhil, Ruddy, Marcella, Akinlade, Bolanle, Graham, Neil M.H, Stahl, Neil, Yancopoulos, George D, Teper, Ariel

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Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies von Baum, Alina, Fulton, Benjamin O, Wloga, Elzbieta, Copin, Richard, Pascal, Kristen E, Russo, Vincenzo, Giordano, Stephanie, Lanza, Kathryn, Negron, Nicole, Ni, Min, Wei, Yi, Atwal, Gurinder S, Murphy, Andrew J, Stahl, Neil, Yancopoulos, George D, Kyratsous, Christos A

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Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised d... von Wenzel, Sally, Prof, Castro, Mario, MD, Corren, Jonathan, MD, Maspero, Jorge, MD, Wang, Lin, PhD, Zhang, Bingzhi, PhD, Pirozzi, Gianluca, MD, Sutherland, E Rand, MD, Evans, Robert R, PharmD, Joish, Vijay N, PhD, Eckert, Laurent, PhD, Graham, Neil M H, MD, Stahl, Neil, PhD, Yancopoulos, George D, MD, Louis-Tisserand, Mariana, MD, Teper, Ariel, MD

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Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial von Stratigos, Alexander J, Sekulic, Aleksandar, Peris, Ketty, Bechter, Oliver, Prey, Sorilla, Kaatz, Martin, Lewis, Karl D, Basset-Seguin, Nicole, Chang, Anne Lynn S, Dalle, Stèphane, Orland, Almudena Fernandez, Licitra, Lisa, Robert, Caroline, Ulrich, Claas, Hauschild, Axel, Migden, Michael R, Dummer, Reinhard, Li, Siyu, Yoo, Suk-Young, Mohan, Kosalai, Coates, Ebony, Jankovic, Vladimir, Fiaschi, Nathalie, Okoye, Emmanuel, Bassukas, Ioannis D, Loquai, Carmen, De Giorgi, Vincenzo, Eroglu, Zeynep, Gutzmer, Ralf, Ulrich, Jens, Puig, Susana, Seebach, Frank, Thurston, Gavin, Weinreich, David M, Yancopoulos, George D, Lowy, Israel, Bowler, Timothy, Fury, Matthew G

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Cemiplimab plus chemotherapy versus chemotherapy alone in non-small cell lung cancer: a randomized, controlled, double-blind phase 3 trial von Gogishvili, Miranda, Melkadze, Tamar, Makharadze, Tamta, Giorgadze, Davit, Dvorkin, Mikhail, Penkov, Konstantin, Laktionov, Konstantin, Nemsadze, Gia, Nechaeva, Marina, Rozhkova, Irina, Kalinka, Ewa, Gessner, Christian, Moreno-Jaime, Brizio, Passalacqua, Rodolfo, Li, Siyu, McGuire, Kristina, Kaul, Manika, Paccaly, Anne, Quek, Ruben G. W., Gao, Bo, Seebach, Frank, Weinreich, David M., Yancopoulos, George D., Lowy, Israel, Gullo, Giuseppe, Rietschel, Petra

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Cemiplimab monotherapy for first-line treatment of advanced non-small-cell lung cancer with PD-L1 of at least 50%: a multicentre, open-label, global, phase 3, randomised, controlle... von Sezer, Ahmet, Kilickap, Saadettin, Gümüş, Mahmut, Bondarenko, Igor, Özgüroğlu, Mustafa, Gogishvili, Miranda, Turk, Haci M, Cicin, Irfan, Bentsion, Dmitry, Gladkov, Oleg, Clingan, Philip, Sriuranpong, Virote, Rizvi, Naiyer, Gao, Bo, Li, Siyu, Lee, Sue, McGuire, Kristina, Chen, Chieh-I, Makharadze, Tamta, Paydas, Semra, Nechaeva, Marina, Seebach, Frank, Weinreich, David M, Yancopoulos, George D, Gullo, Giuseppe, Lowy, Israel, Rietschel, Petra

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Targeting key proximal drivers of type 2 inflammation in disease von Gandhi, Namita A., Bennett, Brandy L., Graham, Neil M. H., Pirozzi, Gianluca, Stahl, Neil, Yancopoulos, George D.

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ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia von Gaudet, Daniel, Gipe, Daniel A, Pordy, Robert, Ahmad, Zahid, Cuchel, Marina, Shah, Prediman K, Chyu, Kuang-Yuh, Sasiela, William J, Chan, Kuo-Chen, Brisson, Diane, Khoury, Etienne, Banerjee, Poulabi, Gusarova, Viktoria, Gromada, Jesper, Stahl, Neil, Yancopoulos, George D, Hovingh, G. Kees

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REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19 von Weinreich, David M, Sivapalasingam, Sumathi, Norton, Thomas, Ali, Shazia, Gao, Haitao, Bhore, Rafia, Musser, Bret J, Soo, Yuhwen, Rofail, Diana, Im, Joseph, Perry, Christina, Pan, Cynthia, Hosain, Romana, Mahmood, Adnan, Davis, John D, Turner, Kenneth C, Hooper, Andrea T, Hamilton, Jennifer D, Baum, Alina, Kyratsous, Christos A, Kim, Yunji, Cook, Amanda, Kampman, Wendy, Kohli, Anita, Sachdeva, Yessica, Graber, Ximena, Kowal, Bari, DiCioccio, Thomas, Stahl, Neil, Lipsich, Leah, Braunstein, Ned, Herman, Gary, Yancopoulos, George D

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ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion von Gusarova, Viktoria, Alexa, Corey A., Na, Erqian, Stevis, Panayiotis E., Xin, Yurong, Bonner-Weir, Susan, Cohen, Jonathan C., Hobbs, Helen H., Murphy, Andrew J., Yancopoulos, George D., Gromada, Jesper

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Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab von Papadopoulos, Nicholas, Martin, Joel, Ruan, Qin, Rafique, Ashique, Rosconi, Michael P., Shi, Ergang, Pyles, Erica A., Yancopoulos, George D., Stahl, Neil, Wiegand, Stanley J.

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Efficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma von Wechsler, Michael E, Ruddy, Marcella K, Pavord, Ian D, Israel, Elliot, Rabe, Klaus F, Ford, Linda B, Maspero, Jorge F, Abdulai, Raolat M, Hu, Chih-Chi, Martincova, Renata, Jessel, Andreas, Nivens, Michael C, Amin, Nikhil, Weinreich, David M, Yancopoulos, George D, Goulaouic, Helene

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Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, rando... von Bachert, Claus, Han, Joseph K, Desrosiers, Martin, Hellings, Peter W, Amin, Nikhil, Lee, Stella E, Mullol, Joaquim, Greos, Leon S, Bosso, John V, Laidlaw, Tanya M, Cervin, Anders U, Maspero, Jorge F, Hopkins, Claire, Olze, Heidi, Canonica, G Walter, Paggiaro, Pierluigi, Cho, Seong H, Fokkens, Wytske J, Fujieda, Shigeharu, Zhang, Mei, Lu, Xin, Fan, Chunpeng, Draikiwicz, Steven, Kamat, Siddhesh A, Khan, Asif, Pirozzi, Gianluca, Patel, Naimish, Graham, Neil M H, Ruddy, Marcella, Staudinger, Heribert, Weinreich, David, Stahl, Neil, Yancopoulos, George D, Mannent, Leda P

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Effect of a Monoclonal Antibody to PCSK9 on LDL Cholesterol von Stein, Evan A, Mellis, Scott, Yancopoulos, George D, Stahl, Neil, Logan, Douglas, Smith, William B, Lisbon, Eleanor, Gutierrez, Maria, Webb, Cheryle, Wu, Richard, Du, Yunling, Kranz, Therese, Gasparino, Evelyn, Swergold, Gary D

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Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging p... von Thaçi, Diamant, Prof, Simpson, Eric L, MD, Beck, Lisa A, Prof, Bieber, Thomas, Prof, Blauvelt, Andrew, MD, Papp, Kim, MD, Soong, Weily, MD, Worm, Margitta, Univ-Prof, Szepietowski, Jacek C, Prof, Sofen, Howard, MD, Kawashima, Makoto, Prof, Wu, Richard, PhD, Weinstein, Steven P, MD, Graham, Neil M H, MD, Pirozzi, Gianluca, MD, Teper, Ariel, MD, Sutherland, E Rand, MD, Mastey, Vera, MS, Stahl, Neil, PhD, Yancopoulos, George D, MD, Ardeleanu, Marius, MD

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Intravitreal Aflibercept for Diabetic Macular Edema von Korobelnik, Jean-François, MD, Do, Diana V., MD, Schmidt-Erfurth, Ursula, MD, Boyer, David S., MD, Holz, Frank G., MD, Heier, Jeffrey S., MD, Midena, Edoardo, MD, Kaiser, Peter K., MD, Terasaki, Hiroko, MD, Marcus, Dennis M., MD, Nguyen, Quan D., MD, Jaffe, Glenn J., MD, Slakter, Jason S., MD, Simader, Christian, MD, Soo, Yuhwen, PhD, Schmelter, Thomas, PhD, Yancopoulos, George D., MD, PhD, Stahl, Neil, PhD, Vitti, Robert, MD, Berliner, Alyson J., MD, PhD, Zeitz, Oliver, MD, Metzig, Carola, MD, Brown, David M., MD

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Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes von Macdonald, Lynn E., Karow, Margaret, Stevens, Sean, Auerbach, Wojtek, Poueymirou, William T., Yasenchak, Jason, Frendewey, David, Valenzuela, David M., Giallourakis, Cosmas C., Alt, Frederick W., Yancopoulos, George D., Murphy, Andrew J.

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