Design and Synthesis of Orexin 1 Receptor-Selective Agonists von Iio, Keita, Hashimoto, Kao, Nagumo, Yasuyuki, Amezawa, Mao, Hasegawa, Taisei, Yamamoto, Naoshi, Kutsumura, Noriki, Takeuchi, Katsuhiko, Ishikawa, Yukiko, Yamamoto, Hikari, Tokuda, Akihisa, Sato, Tetsu, Uchida, Yasuo, Inoue, Asuka, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi, Saitoh, Tsuyoshi

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Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring von Iio, Keita, Saitoh, Tsuyoshi, Ohshita, Ryuichiro, Hino, Tsubasa, Amezawa, Mao, Takayama, Yoshiaki, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ishikawa, Yukiko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi

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Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton von Hino, Tsubasa, Saitoh, Tsuyoshi, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ishikawa, Yukiko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi

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Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives von Katoh, Koki, Kutsumura, Noriki, Yamamoto, Naoshi, Nagumo, Yasuyuki, Saitoh, Tsuyoshi, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi

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Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands von Iio, Keita, Kutsumura, Noriki, Nagumo, Yasuyuki, Saitoh, Tsuyoshi, Tokuda, Akihisa, Hashimoto, Kao, Yamamoto, Naoshi, Kise, Ryoji, Inoue, Asuka, Mizoguchi, Hirokazu, Nagase, Hiroshi

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ZnCl2-Promoted Intramolecular Hetero-Diels–Alder Reaction of o-Alkynylphenylcarbodiimides for Synthesis of Dihydrodibenzo[b,g][1,8]naphthyridines von Kutsumura, Noriki, Koyama, Yasuaki, Tateno, Kotaro, Yamamoto, Naoshi, Nagase, Hiroshi, Saito, Takao

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Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors von Katoh, Koki, Yamamoto, Naoshi, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Tanimura, Ryuji, Saitoh, Tsuyoshi, Nagumo, Yasuyuki, Kutsumura, Noriki, Yanagisawa, Masashi, Nagase, Hiroshi

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Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library von Saitoh, Tsuyoshi, Amezawa, Mao, Horiuchi, Jumpei, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Ohshita, Ryuichiro, Tokuda, Akihisa, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Hasegawa, Emi, Sakurai, Takeshi, Uchida, Yasuo, Sato, Tetsu, Gouda, Hiroaki, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi

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The application of a specific morphinan template to the synthesis of galanthamine von Yamamoto, Naoshi, Okada, Takahiro, Harada, Yukimasa, Kutsumura, Noriki, Imaide, Satomi, Saitoh, Tsuyoshi, Fujii, Hideaki, Nagase, Hiroshi

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Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group von Saitoh, Tsuyoshi, Seki, Kazunori, Nakajima, Ryo, Yamamoto, Naoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Yanagisawa, Masashi, Nagase, Hiroshi

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Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity von Saitoh, Tsuyoshi, Seki, Kazunori, Nakajima, Ryo, Yamamoto, Naoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi

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Synthesis of heterocyclic compounds with adamantane-like cage structures consisting of phosphorus, sulfur, and carbon von Kutsumura, Noriki, Ohshita, Ryuichiro, Horiuchi, Jumpei, Tateno, Kotaro, Yamamoto, Naoshi, Saitoh, Tsuyoshi, Nagumo, Yasuyuki, Kawai, Hidetoshi, Nagase, Hiroshi

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Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity von Ohrui, Sayaka, Yamamoto, Naoshi, Saitoh, Tsuyoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Watanabe, Yurie, Hayakawa, Daichi, Gouda, Hiroaki, Yanagisawa, Masashi, Nagase, Hiroshi

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Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti- Plasmodium falciparum Activities von Kutsumura, Noriki, Koyama, Yasuaki, Saitoh, Tsuyoshi, Yamamoto, Naoshi, Nagumo, Yasuyuki, Miyata, Yoshiyuki, Hokari, Rei, Ishiyama, Aki, Iwatsuki, Masato, Otoguro, Kazuhiko, Ōmura, Satoshi, Nagase, Hiroshi

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Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-... von Yamamoto, Naoshi, Ohrui, Sayaka, Okada, Takahiro, Saitoh, Tsuyoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Watanabe, Yurie, Hayakawa, Daichi, Gouda, Hiroaki, Yanagisawa, Masashi, Nagase, Hiroshi

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Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism von Nagase, Hiroshi, Nakajima, Ryo, Yamamoto, Naoshi, Hirayama, Shigeto, Iwai, Takashi, Nemoto, Toru, Gouda, Hiroaki, Hirono, Shuichi, Fujii, Hideaki

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Synthesis of (−)-Homogalanthamine from Naltrexone von Yamamoto, Naoshi, Fujii, Hideaki, Imaide, Satomi, Hirayama, Shigeto, Nemoto, Toru, Inokoshi, Junji, Tomoda, Hiroshi, Nagase, Hiroshi

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Synthesis of a Stable Iminium Salt and Propellane Derivatives von Nagase, Hiroshi, Yamamoto, Naoshi, Nemoto, Toru, Yoza, Kenji, Kamiya, Kenshu, Hirono, Shuichi, Momen, Shinobu, Izumimoto, Naoki, Hasebe, Ko, Mochizuki, Hidenori, Fujii, Hideaki

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Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5‑trioxazatriquinane skeleton von Amezawa, Mao, Yamamoto, Naoshi, Nagumo, Yasuyuki, Kutsumura, Noriki, Ishikawa, Yukiko, Yanagisawa, Masashi, Nagase, Hiroshi, Saitoh, Tsuyoshi

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Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton von Maeda, Kenta, Ohrui, Sayaka, Tokuda, Akihisa, Nagumo, Yasuyuki, Yamamoto, Naoshi, Tanimura, Ryuji, Saitoh, Tsuyoshi, Kutsumura, Noriki, Nagase, Hiroshi

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