Targeting Notch to overcome radiation resistance von Yahyanejad, Sanaz, Theys, Jan, Vooijs, Marc

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The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to γ-secretase inhibition von Hounjet, Judith, Habets, Roger, Schaaf, Marco B., Hendrickx, Tessa C., Barbeau, Lydie M. O., Yahyanejad, Sanaz, Rouschop, Kasper M., Groot, Arjan J., Vooijs, Marc

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Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins von Groot, Arjan J., Habets, Roger, Yahyanejad, Sanaz, Hodin, Caroline M., Reiss, Karina, Saftig, Paul, Theys, Jan, Vooijs, Marc

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High NOTCH activity induces radiation resistance in non small cell lung cancer von Theys, Jan, Yahyanejad, Sanaz, Habets, Roger, Span, Paul, Dubois, Ludwig, Paesmans, Kim, Kattenbeld, Bo, Cleutjens, Jack, Groot, Arjan J, Schuurbiers, Olga C.J, Lambin, Philippe, Bussink, Jan, Vooijs, Marc

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Transcriptome-wide analysis reveals insight into tumor suppressor functions of 1B3, a novel synthetic miR-193a-3p mimic von van den Bosch, Marion T.J., Yahyanejad, Sanaz, Alemdehy, Mir Farshid, Telford, Bryony J., de Gunst, Thijs, den Boer, Harm C., Vos, Rogier M., Stegink, Marieke, van Pinxteren, Laurens A.H., Schaapveld, Roel Q.J., Janicot, Michel

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The tumor suppressor 5A2, a synthetic miR-7-5p mimic, targets oncogenic and metabolic pathways, as revealed by transcriptome-wide analysis von van den Bosch, Marion T. J., Telford, Bryony J., Yahyanejad, Sanaz, de Gunst, Thijs, den Boer, Harm C., Vos, Rogier M., Duurland, Chantal L., Biemans, Rianne, Dubois, Ludwig J., van Pinxteren, Laurens A. H., Schaapveld, Roel Q. J., Janicot, Michel

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P422: TARGETING THE WT1MUT‐MIR‐193A TRANSCRIPTIONAL AXIS WITH INT‐1B3, A NOVEL LIPID NANOPARTICLE‐FORMULATED MIR‐193A‐3P MIMIC IN ACUTE MYELOID LEUKEMIA von Yang, Xining, Krowiorz, Kathrin, Buelow, Daelynn, Bhayadia, Raj, Kohlschmidt, Jessica, Nicolet, Deedra, Maetzig, Tobias, Pabst, Caroline, Hui, Jeremy, Shad, Arshia, Gao, Sharon, Stephenson, Maria, Wei Wu, Si, Bosch, Marion, Escano, Leo, Lock, Frances, Panahi, Afsaneh, Macphee, Liam, Maksakova, Irina, Amoah, Amanda, Döhner, Konstanze, Fogelstrand, Linda, Eisfeld, Ann‐Kathrin, Yahyanejad, Sanaz, Janicot, Michel, Klusmann, Jan‐Henning, Baker, Sharyn, Oakes, Christopher, Rouhi, Arefeh, Kuchenbauer, Florian

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Complementary Use of Bioluminescence Imaging and Contrast-Enhanced Micro—Computed Tomography in an Orthotopic Brain Tumor Model von Yahyanejad, Sanaz, Granton, Patrick V., Lieuwes, Natasja G., Gilmour, Lesley, Dubois, Ludwig, Theys, Jan, Chalmers, Anthony J., Verhaegen, Frank, Vooijs, Marc

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The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to [gamma]-secretase inhibition von Hounjet, Judith, Habets, Roger, Schaaf, Marco B, Hendrickx, Tessa C, Barbeau, Lydie M. O, Yahyanejad, Sanaz, Rouschop, Kasper M

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Phase I/Ib study with INT-1B3, a novel LNP-formulated micro-RNA (miR-193a-3p mimic) therapeutic for patients with advanced solid cancer von Kotecki, Nuria, Opdam, Frans, Robbrecht, Debbie, Strijbos, Michiel, Kroon, Karlijn, Janicot, Michel, Yahyanejad, Sanaz, Telford, Bryony, van den Bosch, Marion, Alemdehy, Farshid, de Gunst, Thijs, den Boer, Harm, Vos, Rogier M., van Pinxteren, Laurens, Schaapveld, Roel

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Targeting the WT1mut-Mir-193a Transcriptional Axis with INT-1B3, a Novel Lipid Nanoparticle-Formulated Mir-193a-3p Mimic in Acute Myeloid Leukemia von Yang, Xining, Krowiorz, Kathrin, Bhayadia, Raj, Kohlschmidt, Jessica, Nicolet, Deedra, Maetzig, Tobias, Pabst, Caroline, Hui, Jeremy, Shad, Arshia, Gao, Sharon, Stephenson, Maria, Wu, Si Wei, Bosch, Marion van den, Buelow, Daelynn, Baker, Sharyn, Escano, Leo, Lock, Frances E, Panahi, Afsaneh, MacPhee, Liam, Maksakova, Irina, Amoah, Amanda, Döhner, Konstanze, Fogelstrand, Linda, Eisfeld, Ann-Kathrin, Yahyanejad, Sanaz, Janicot, Michel, Oakes, Christopher C., Klusmann, Jan-Henning, Rouhi, Arefeh, Kuchenbauer, Florian

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Targeting the WT1mut -M ir-193a Transcriptional Axis with INT-1B3, a Novel Lipid Nanoparticle-Formulated Mir -193a-3p Mimic in Acute Myeloid Leukemia von Yang, Xining, Krowiorz, Kathrin, Bhayadia, Raj, Kohlschmidt, Jessica, Nicolet, Deedra, Maetzig, Tobias, Pabst, Caroline, Hui, Jeremy, Shad, Arshia, Gao, Sharon, Stephenson, Maria, Wu, Si Wei, Bosch, Marion van den, Buelow, Daelynn, Baker, Sharyn, Escano, Leo, Lock, Frances E, Panahi, Afsaneh, MacPhee, Liam, Maksakova, Irina, Amoah, Amanda, Döhner, Konstanze, Fogelstrand, Linda, Eisfeld, Ann-Kathrin, Yahyanejad, Sanaz, Janicot, Michel, Oakes, Christopher C., Klusmann, Jan-Henning, Rouhi, Arefeh, Kuchenbauer, Florian

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NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma von Yahyanejad, Sanaz, King, Henry, Iglesias, Venus Sosa, Granton, Patrick V, Barbeau, Lydie M O, van Hoof, Stefan J, Groot, Arjan J, Habets, Roger, Prickaerts, Jos, Chalmers, Anthony J, Eekers, Daniëlle B P, Theys, Jan, Short, Susan C, Verhaegen, Frank, Vooijs, Marc

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Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology von Telford, Bryony J, Yahyanejad, Sanaz, de Gunst, Thijs, den Boer, Harm C, Vos, Rogier M, Stegink, Marieke, van den Bosch, Marion T J, Alemdehy, Mir Farshid, van Pinxteren, Laurens A H, Schaapveld, Roel Q J, Janicot, Michel

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Abstract 4405: Pharmacologic profile of INT-1B3: A novel synthetic microRNA 193a-3p mimic for therapeutic intervention in oncology von Yahyanejad, Sanaz, Gunst, Thijs de, Schultz, Iman, Boer, Harm den, Raimo, Monica, Telford, Bryony, Vos, Rogier, Pinxteren, Laurens van, Schaapveld, Roel, Janicot, Michel

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INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction... von Duurland, Chantal L, Gunst, Thijs de, Boer, Harm C den, Bosch, Marion T J van den, Telford, Bryony J, Vos, Rogier M, Xie, Xiaolei, Zang, Mingfa, Wang, Fang, Shao, Yingying, An, Xiaoyu, Wang, Jingjing, Cai, Jie, Bourré, Ludovic, Pinxteren, Laurens A H van, Schaapveld, Roel Q J, Janicot, Michel, Yahyanejad, Sanaz

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Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17 von Habets, Roger A.J., Groot, Arjan J., Yahyanejad, Sanaz, Tiyanont, Kittichoat, Blacklow, Stephen C., Vooijs, Marc

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Abstract 3243: Notch inhibitors and chemoradiation in an orthotopic glioblastoma model von Yahyanejad, Sanaz, Granton, Patrick, van Hoof, Stefan, Barbeau, Lydie, Theys, Jan, Verhaegen, Frank, Vooijs, Marc

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An image guided small animal radiation therapy platform (SmART) to monitor glioblastoma progression and therapy response von Yahyanejad, Sanaz, van Hoof, Stefan J, Theys, Jan, Barbeau, Lydie M.O, Granton, Patrick V, Paesmans, Kim, Verhaegen, Frank, Vooijs, Marc

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SmART-ER imaging and treatment of glioblastoma von Granton, Patrick V., Yahyanejad, Sanaz, Vooijs, Marc A.

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