MHCEpitopeEnergy, a Flexible Rosetta-Based Biotherapeutic Deimmunization Platform von Yachnin, Brahm J, Mulligan, Vikram Khipple, Khare, Sagar D, Bailey-Kellogg, Chris

Volltext

Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5′ leader regions von Steinberger, Jutta, Shen, Leo, J. Kiniry, Stephen, Naineni, Sai Kiran, Cencic, Regina, Amiri, Mehdi, Aboushawareb, Sarah A E, Chu, Jennifer, Maïga, Rayelle Itoua, Yachnin, Brahm J, Robert, Francis, Sonenberg, Nahum, Baranov, Pavel V, Pelletier, Jerry

Volltext

The Substrate-Bound Crystal Structure of a Baeyer–Villiger Monooxygenase Exhibits a Criegee-like Conformation von Yachnin, Brahm J, Sprules, Tara, McEvoy, Michelle B, Lau, Peter C. K, Berghuis, Albert M

Volltext

Computational Design of a Photocontrolled Cytosine Deaminase von Blacklock, Kristin M, Yachnin, Brahm J, Woolley, G. Andrew, Khare, Sagar D

Volltext

A Bis(imidazole)-based cysteine labeling tool for metalloprotein assembly von Ahmad, Raheel, Tyryshkin, Alexei M., Xie, Lingjun, Hansen, William A., Yachnin, Brahm J., Emge, Thomas J., Mashrai, Ashraf, Khare, Sagar D., Knapp, Spencer

Volltext

Crystal Structures of Cyclohexanone Monooxygenase Reveal Complex Domain Movements and a Sliding Cofactor von Mirza, I. Ahmad, Yachnin, Brahm J, Wang, Shaozhao, Grosse, Stephan, Bergeron, Hélène, Imura, Akihiro, Iwaki, Hiroaki, Hasegawa, Yoshie, Lau, Peter C. K, Berghuis, Albert M

Volltext

Massively parallel, computationally guided design of a proenzyme von Yachnin, Brahm J, Azouz, Laura R, White, 3rd, Ralph E, Minetti, Conceição A S A, Remeta, David P, Tan, Victor M, Drake, Justin M, Khare, Sagar D

Volltext

The role of conformational flexibility in Baeyer-Villiger monooxygenase catalysis and structure von Yachnin, Brahm J., Lau, Peter C.K., Berghuis, Albert M.

Volltext

Engineering carboxypeptidase G2 circular permutations for the design of an autoinhibited enzyme von Yachnin, Brahm J., Khare, Sagar D.

Volltext

Comprehensive characterization of ligand‐induced plasticity changes in a dimeric enzyme von Baettig, Oliver M., Shi, Kun, Yachnin, Brahm J., Burk, David L., Berghuis, Albert M.

Volltext

Lactone-Bound Structures of Cyclohexanone Monooxygenase Provide Insight into the Stereochemistry of Catalysis von Yachnin, Brahm J, McEvoy, Michelle B, MacCuish, Roderick J. D, Morley, Krista L, Lau, Peter C. K, Berghuis, Albert M

Volltext

Multiple Conformers in Active Site of Human Dihydrofolate Reductase F31R/Q35E Double Mutant Suggest Structural Basis for Methotrexate Resistance von Volpato, Jordan P., Yachnin, Brahm J., Blanchet, Jonathan, Guerrero, Vanessa, Poulin, Lucie, Fossati, Elena, Berghuis, Albert M., Pelletier, Joelle N.

Volltext

Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues von Toulouse, Jacynthe L, Yachnin, Brahm J, Ruediger, Edward H, Deon, Daniel, Gagnon, Marc, Saint-Jacques, Kévin, Ebert, Maximilian C. C. J. C, Forge, Delphine, Bastien, Dominic, Colin, Damien Y, Vanden Eynde, Jean Jacques, Marinier, Anne, Berghuis, Albert M, Pelletier, Joelle N

Volltext

A Bis(imidazole)-based cysteine labeling tool for metalloprotein assembly von Ahmad, Raheel, Tyryshkin, Alexei M., Xie, Lingjun, Hansen, William A., Yachnin, Brahm J., Emge, Thomas J., Mashrai, Ashraf, Khare, Sagar D., Knapp, Spencer

Volltext

Massively Parallel Protein Design to Develop Enzymes for Next‐Generation Chemotherapy von Yachnin, Brahm Jonathan, White, Ralph, Azouz, Laura, Drake, Justin M., Khare, Sagar D

Volltext

Computational Design of a Photo-controlled Cytosine Deaminase von Blacklock, Kristin M., Yachnin, Brahm J., Woolley, G. Andrew, Khare, Sagar D.

Volltext

Novel crystallization conditions for tandem variant R67 DHFR yield a wild-type crystal structure von Yachnin, Brahm J., Colin, Damien Y., Volpato, Jordan P., Ebert, Maximilian, Pelletier, Joelle N., Berghuis, Albert M.

Volltext

Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks von Koehler Leman, Julia, Lyskov, Sergey, Lewis, Steven M., Adolf-Bryfogle, Jared, Alford, Rebecca F., Barlow, Kyle, Ben-Aharon, Ziv, Farrell, Daniel, Fell, Jason, Hansen, William A., Harmalkar, Ameya, Jeliazkov, Jeliazko, Kuenze, Georg, Krys, Justyna D., Ljubetič, Ajasja, Loshbaugh, Amanda L., Maguire, Jack, Moretti, Rocco, Mulligan, Vikram Khipple, Nance, Morgan L., Nguyen, Phuong T., Ó Conchúir, Shane, Roy Burman, Shourya S., Samanta, Rituparna, Smith, Shannon T., Teets, Frank, Tiemann, Johanna K. S., Watkins, Andrew, Woods, Hope, Yachnin, Brahm J., Bahl, Christopher D., Bailey-Kellogg, Chris, Baker, David, Das, Rhiju, DiMaio, Frank, Khare, Sagar D., Kortemme, Tanja, Labonte, Jason W., Lindorff-Larsen, Kresten, Meiler, Jens, Schief, William, Schueler-Furman, Ora, Siegel, Justin B., Stein, Amelie, Yarov-Yarovoy, Vladimir, Kuhlman, Brian, Leaver-Fay, Andrew, Gront, Dominik, Gray, Jeffrey J., Bonneau, Richard

Volltext

The Structural Basis for BVMO Substrate Profile and Stereospecificity von Yachnin, Brahm, McEvoy, Michelle, MacCuish, Roderick, Morley, Krista, Mittermaier, Anthony, Lau, Peter, Berghuis, Albert

Volltext

Characterization of the Redox and Metal Binding Activity of BsSco, a Protein Implicated in the Assembly of Cytochrome c Oxidase von Imriskova-Sosova, Iveta, Andrews, Diann, Yam, Katherine, Davidson, David, Yachnin, Brahm, Hill, Bruce C

Volltext