MiR-21-mediated Metabolic Alteration of Cancer-associated Fibroblasts and Its Effect on Pancreatic Cancer Cell Behavior von Chen, Shuo, Chen, Xi, Shan, Tao, Ma, Jiancang, Lin, Wanrun, Li, Wei, Kang, Ya'an

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Cancer-associated fibroblasts enhance pancreatic cancer cell invasion by remodeling the metabolic conversion mechanism von Shan, Tao, Chen, Shuo, Chen, Xi, Lin, Wan Run, Li, Wei, Ma, Jiancang, Wu, Tao, Cui, Xijuan, Ji, Hong, Li, Yiming, Kang, Ya'An

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SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy von Wang, Feng, Xia, Xiaojun, Yang, Chunying, Shen, Jianliang, Mai, Junhua, Kim, Han-Cheon, Kirui, Dickson, Kang, Ya'an, Fleming, Jason B, Koay, Eugene J, Mitra, Sankar, Ferrari, Mauro, Shen, Haifa

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Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation von Wang, Yan, Hsu, Jung-Mao, Kang, Ya'an, Wei, Yongkun, Lee, Pei-Chih, Chang, Shing-Jyh, Hsu, Yi-Hsin, Hsu, Jennifer L, Wang, Hung-Ling, Chang, Wei-Chao, Li, Chia-Wei, Liao, Hsin-Wei, Chang, Shih-Shin, Xia, Weiya, Ko, How-Wen, Chou, Chao-Kai, Fleming, Jason B, Wang, Huamin, Hwang, Rosa F, Chen, Yue, Qin, Jun, Hung, Mien-Chie

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Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS-Dependent Pancreatic Ductal Adenocarcinoma von Mottini, Carla, Tomihara, Hideo, Carrella, Diego, Lamolinara, Alessia, Iezzi, Manuela, Huang, Justin K, Amoreo, Carla A, Buglioni, Simonetta, Manni, Isabella, Robinson, Frederick S, Minelli, Rosalba, Kang, Ya'an, Fleming, Jason B, Kim, Michael P, Bristow, Christopher A, Trisciuoglio, Daniela, Iuliano, Antonella, Del Bufalo, Donatella, Di Bernardo, Diego, Melisi, Davide, Draetta, Giulio F, Ciliberto, Gennaro, Carugo, Alessandro, Cardone, Luca

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SMAD4 regulates cell motility through transcription of N-cadherin in human pancreatic ductal epithelium von Kang, Ya'an, Ling, Jianhua, Suzuki, Rei, Roife, David, Chopin-Laly, Xavier, Truty, Mark J, Chatterjee, Deyali, Wang, Huamin, Thomas, Ryan M, Katz, Matthew H, Chiao, Paul J, Fleming, Jason B

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Deciphering the Mechanisms of Tumorigenesis in Human Pancreatic Ductal Epithelial Cells von ZHE CHANG, ZHONGKUI LI, ABBRUZZESE, James L, CHIAO, Paul J, XIAOYANG WANG, YA'AN KANG, YUHUI YUAN, JIANGONG NIU, HUAMIN WANG, CHATTERJEE, Deyali, FLEMING, Jason B, MIN LI

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IGFBP2 promotes tumor progression by inducing alternative polarization of macrophages in pancreatic ductal adenocarcinoma through the STAT3 pathway von Sun, Longhao, Zhang, Xuebin, Song, Qianqian, Liu, Liang, Forbes, Elizabeth, Tian, Weijun, Zhang, Zhixiang, Kang, Ya'an, Wang, Huamin, Fleming, Jason B., Pasche, Boris C., Zhang, Wei

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CES2 sustains HNF4α expression to promote pancreatic adenocarcinoma progression through an epoxide hydrolase-dependent regulatory loop von Chen, Yihui, Capello, Michela, Rios Perez, Mayrim V., Vykoukal, Jody V., Roife, David, Kang, Ya'an, Prakash, Laura R., Katayama, Hiroyuki, Irajizad, Ehsan, Fleury, Alia, Ferri-Borgogno, Sammy, Baluya, Dodge L., Dennison, Jennifer B., Do, Kim-Anh, Fiehn, Oliver, Maitra, Anirban, Wang, Huamin, Chiao, Paul J., Katz, Matthew H.G., Fleming, Jason B., Hanash, Samir M., Fahrmann, Johannes F.

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Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma von Li, Xinqun, Lee, Yeonju, Kang, Ya'an, Dai, Bingbing, Perez, Mayrim Rios, Pratt, Michael, Koay, Eugene J, Kim, Michael, Brekken, Rolf A, Fleming, Jason B

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Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis von Kim, Michael P., Li, Xinqun, Deng, Jenying, Zhang, Yun, Dai, Bingbing, Allton, Kendra L., Hughes, Tara G., Siangco, Christian, Augustine, Jithesh J., Kang, Ya'an, McDaniel, Joy M., Xiong, Shunbin, Koay, Eugene J., McAllister, Florencia, Bristow, Christopher A., Heffernan, Timothy P., Maitra, Anirban, Liu, Bin, Barton, Michelle C., Wasylishen, Amanda R., Fleming, Jason B., Lozano, Guillermina

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Clinical significance of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in pancreatic ductal adenocarcinoma von Waragai, Yuichi, Suzuki, Rei, Takagi, Tadayuki, Sugimoto, Mitsuru, Asama, Hiroyuki, Watanabe, Ko, Kikuchi, Hitomi, Hikichi, Takuto, Masamune, Atsushi, Kang, Ya'an, Fleming, Jason B, Ohira, Hiromasa

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Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition von Yan, Liang, Tu, Bo, Yao, Jun, Gong, Jing, Carugo, Alessandro, Bristow, Christopher A., Wang, Qiuyun, Zhu, Cihui, Dai, Bingbing, Kang, Ya'an, Han, Leng, Feng, Ningping, Jin, Yanqing, Fleming, Jason, Heffernan, Timothy P., Yao, Wantong, Ying, Haoqiang

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Clinical candidate and genistein analogue AXP107‐11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein‐coupled estrogen receptor signaling von Mesmar, Fahmi, Dai, Bingbing, Ibrahim, Ahmed, Hases, Linnea, Jafferali, Mohammed Hakim, Jose Augustine, Jithesh, DiLorenzo, Sebastian, Kang, Ya'an, Zhao, Yang, Wang, Jing, Kim, Michael, Lin, Chin‐Yo, Berkenstam, Anders, Fleming, Jason, Williams, Cecilia

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Antineoplastic effects of auranofin in human pancreatic adenocarcinoma preclinical models von Rios Perez, Mayrim V., Roife, David, Dai, Bingbing, Pratt, Michael, Dobrowolski, Ryszard, Kang, Ya'an, Li, Xinqun, Augustine, Jithesh J., Zielinski, Rafal, Priebe, Waldemar, Fleming, Jason B.

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Defective feedback regulation of NF-κB underlies Sjögren's syndrome in mice with mutated κB enhancers of the IκBα promoter von Peng, Bailu, Ling, Jianhua, Lee, Andrew Joon, Wang, Zilai, Chang, Zhe, Jin, Wei, Kang, Ya'an, Zhang, Richard, Shim, David, Wang, Huamin, Fleming, Jason B, Zheng, Hui, Sun, Shao-Cong, Chiao, Paul J

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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway von Son, Jaekyoung, Lyssiotis, Costas A., Ying, Haoqiang, Wang, Xiaoxu, Hua, Sujun, Ligorio, Matteo, Perera, Rushika M., Ferrone, Cristina R., Mullarky, Edouard, Shyh-Chang, Ng, Kang, Ya’an, Fleming, Jason B., Bardeesy, Nabeel, Asara, John M., Haigis, Marcia C., DePinho, Ronald A., Cantley, Lewis C., Kimmelman, Alec C.

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Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function von Viale, Andrea, Pettazzoni, Piergiorgio, Lyssiotis, Costas A., Ying, Haoqiang, Sánchez, Nora, Marchesini, Matteo, Carugo, Alessandro, Green, Tessa, Seth, Sahil, Giuliani, Virginia, Kost-Alimova, Maria, Muller, Florian, Colla, Simona, Nezi, Luigi, Genovese, Giannicola, Deem, Angela K., Kapoor, Avnish, Yao, Wantong, Brunetto, Emanuela, Kang, Ya’an, Yuan, Min, Asara, John M., Wang, Y. Alan, Heffernan, Timothy P., Kimmelman, Alec C., Wang, Huamin, Fleming, Jason B., Cantley, Lewis C., DePinho, Ronald A., Draetta, Giulio F.

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Silencing thioredoxin induces liver cancer cell senescence under hypoxia von Zhang, Ti, Liu, Heping, Zhu, Cihui, Briggs, Katrina, Kang, Ya'an, Fleming, Jason A., Curley, Steven A.

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KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma von Ling, Jianhua, Kang, Ya'an, Zhao, Ruiying, Xia, Qianghua, Lee, Dung-Fang, Chang, Zhe, Li, Jin, Peng, Bailu, Fleming, Jason B., Wang, Huamin, Liu, Jinsong, Lemischka, Ihor R., Hung, Mien-Chie, Chiao, Paul J.

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