Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase von Huang, Wei-Sheng, Liu, Shuangying, Zou, Dong, Thomas, Mathew, Wang, Yihan, Zhou, Tianjun, Romero, Jan, Kohlmann, Anna, Li, Feng, Qi, Jiwei, Cai, Lisi, Dwight, Timothy A, Xu, Yongjin, Xu, Rongsong, Dodd, Rory, Toms, Angela, Parillon, Lois, Lu, Xiaohui, Anjum, Rana, Zhang, Sen, Wang, Frank, Keats, Jeffrey, Wardwell, Scott D, Ning, Yaoyu, Xu, Qihong, Moran, Lauren E, Mohemmad, Qurish K, Jang, Hyun Gyung, Clackson, Tim, Narasimhan, Narayana I, Rivera, Victor M, Zhu, Xiaotian, Dalgarno, David, Shakespeare, William C

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Surface mercapto engineered magnetic Fe₃O₄ nanoadsorbent for the removal of mercury from aqueous solutions von Pan, Shengdong, Shen, Haoyu, Xu, Qihong, Luo, Jian, Hu, Meiqin

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Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance von Zhou, Tianjun, Commodore, Lois, Huang, Wei-Sheng, Wang, Yihan, Thomas, Mathew, Keats, Jeff, Xu, Qihong, Rivera, Victor M, Shakespeare, William C, Clackson, Tim, Dalgarno, David C, Zhu, Xiaotian

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9-(Arenethenyl)purines as Dual Src/Abl Kinase Inhibitors Targeting the Inactive Conformation: Design, Synthesis, and Biological Evaluation von Huang, Wei-Sheng, Zhu, Xiaotian, Wang, Yihan, Azam, Mohammad, Wen, David, Sundaramoorthi, Raji, Thomas, R. Mathew, Liu, Shuangying, Banda, Geetha, Lentini, Scott P, Das, Sasmita, Xu, Qihong, Keats, Jeff, Wang, Frank, Wardwell, Scott, Ning, Yaoyu, Snodgrass, Joseph T, Broudy, Marc I, Russian, Karin, Daley, George Q, Iuliucci, John, Dalgarno, David C, Clackson, Tim, Sawyer, Tomi K, Shakespeare, William C

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Adsorption Studies on Phosphate by Amino-functionalized Nano-size Composite Materials von Zhang, Yun, Xi, Xiaoqing, Xu, Shanni, Zhou, Junchen, Zhou, Jinjin, Xu, Qihong, Shen, Haoyu

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Simultaneous determination of 11 quinolone residues in freshwater fish samples by magnetic solid‐extraction coupled to liquid chromatography‐tandem mass spectrometry von Pan, Shengdong, Xu, Qihong, Guo, Yanbo, Wang, Li

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Identification, synthesis, and biological evaluation of novel pyrazoles as low molecular weight luteinizing hormone receptor agonists von Jorand-Lebrun, Catherine, Brondyk, Bill, Lin, Jing, Magar, Sharad, Murray, Robert, Reddy, Adulla, Shroff, Hitesh, Wands, Greg, Weiser, Weishui, Xu, Qihong, McKenna, Sean, Brugger, Nadia

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Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR–ABL including the T315I gatekeeper mutant von Thomas, Mathew, Huang, Wei-Sheng, Wen, David, Zhu, Xiaotian, Wang, Yihan, Metcalf, Chester A., Liu, Shuangying, Chen, Ingrid, Romero, Jan, Zou, Dong, Sundaramoorthi, Raji, Li, Feng, Qi, Jiwei, Cai, Lisi, Zhou, Tianjun, Commodore, Lois, Xu, Qihong, Keats, Jeff, Wang, Frank, Wardwell, Scott, Ning, Yaoyu, Snodgrass, Joseph T., Broudy, Marc I., Russian, Karin, Iuliucci, John, Rivera, Victor M., Sawyer, Tomi K., Dalgarno, David C., Clackson, Tim, Shakespeare, William C.

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Enhancing flotation separation of chalcopyrite and galena by the surface synergism between sodium sulfite and sodium lignosulfonate von Liu, Mengfei, Zhang, Chenyang, Hu, Bo, Sun, Zhongmei, Xu, Qihong, Wen, Jian, Xiao, Jun, Dong, Yanhong, Gan, Min, Sun, Wei, Zhu, Jianyu, Chen, Daixiong

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Abstract 1555: Enhanced HER2-dependent immune activation by margetuximab, an investigational Fc-engineered anti-HER2 mAb, supports combination with checkpoint blockade von Zhang, Xiaoyu, Li, Haiquan, Yang, Yinhua, Xu, Qihong, Kaufman, Tom, Smith, Doug, Nordstrom, Jeffrey, Bonvini, Ezio, Moore, Paul

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B-cell delivered gene transfer of human S-Ag-Ig fusion protein protects from experimental autoimmune uveitis von Liang, Wei, Karabekian, Zaruhi, Xu, Qihong, Viley, Angelia M., Scott, David W.

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AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance von O'Hare, Thomas, Shakespeare, William C., Zhu, Xiaotian, Eide, Christopher A., Rivera, Victor M., Wang, Frank, Adrian, Lauren T., Zhou, Tianjun, Huang, Wei-Sheng, Xu, Qihong, Metcalf, Chester A., Tyner, Jeffrey W., Loriaux, Marc M., Corbin, Amie S., Wardwell, Scott, Ning, Yaoyu, Keats, Jeffrey A., Wang, Yihan, Sundaramoorthi, Raji, Thomas, Mathew, Zhou, Dong, Snodgrass, Joseph, Commodore, Lois, Sawyer, Tomi K., Dalgarno, David C., Deininger, Michael W.N., Druker, Brian J., Clackson, Tim

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Discovery of 3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent, Orally Active Pan-I... von Huang, Wei-Sheng, Metcalf, Chester A, Sundaramoorthi, Raji, Wang, Yihan, Zou, Dong, Thomas, R. Mathew, Zhu, Xiaotian, Cai, Lisi, Wen, David, Liu, Shuangying, Romero, Jan, Qi, Jiwei, Chen, Ingrid, Banda, Geetha, Lentini, Scott P, Das, Sasmita, Xu, Qihong, Keats, Jeff, Wang, Frank, Wardwell, Scott, Ning, Yaoyu, Snodgrass, Joseph T, Broudy, Marc I, Russian, Karin, Zhou, Tianjun, Commodore, Lois, Narasimhan, Narayana I, Mohemmad, Qurish K, Iuliucci, John, Rivera, Victor M, Dalgarno, David C, Sawyer, Tomi K, Clackson, Tim, Shakespeare, William C

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Novel N9-arenethenyl purines as potent dual Src/Abl tyrosine kinase inhibitors von Wang, Yihan, Shakespeare, William C., Huang, Wei-Sheng, Sundaramoorthi, Raji, Lentini, Scott, Das, Sasmita, Liu, Shuangying, Banda, Geeta, Wen, David, Zhu, Xiaotian, Xu, Qihong, Keats, Jeffrey, Wang, Frank, Wardwell, Scott, Ning, Yaoyu, Snodgrass, Joseph T., Broudy, Mark I., Russian, Karin, Dalgarno, David, Clackson, Tim, Sawyer, Tomi K.

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Abstract 554: Tumor-antigen 5T4-dependent activation of the CD137 costimulatory pathway by bispecific 5T4 x CD137 x CD137 TRIDENT™ molecules von Liu, Liqin, Huang, Ling, Long, Vatana, Yang, Yinhua, Burns, Robert, Li, Jonathan, DiChiara, Jennifer, Xu, Qihong, Whiddon, Arin, Lam, Chia-Ying K, Tamura, Jim, Ciccarone, Valentina, Johnson, Syd, Bonvini, Ezio, Moore, Paul

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Functionally Biased D2R Antagonists: Targeting the β‑Arrestin Pathway to Improve Antipsychotic Treatment von Weïwer, Michel, Xu, Qihong, Gale, Jennifer P, Lewis, Michael, Campbell, Arthur J, Schroeder, Frederick A, Van de Bittner, Genevieve C, Walk, Michelle, Amaya, Aldo, Su, Ping, D̵ordevic, Luka, Sacher, Joshua R, Skepner, Adam, Fei, David, Dennehy, Kelly, Nguyen, Shannon, Faloon, Patrick W, Perez, Jose, Cottrell, Jeffrey R, Liu, Fang, Palmer, Michelle, Pan, Jen Q, Hooker, Jacob M, Zhang, Yan-Ling, Scolnick, Edward, Wagner, Florence F, Holson, Edward B

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Crystal Structure of the T315I Mutant of Abl Kinase von Zhou, Tianjun, Parillon, Lois, Li, Feng, Wang, Yihan, Keats, Jeff, Lamore, Sarah, Xu, Qihong, Shakespeare, William, Dalgarno, David, Zhu, Xiaotian

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Crystal structure of the T315I mutant of AbI kinase von Zhou, Tianjun, Parillon, Lois, Li, Feng, Wang, Yihan, Keats, Jeff, Lamore, Sarah, Xu, Qihong, Shakespeare, William, Dalgarno, David, Zhu, Xiaotian

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Surface mercapto engineered magnetic Fe 3O 4 nanoadsorbent for the removal of mercury from aqueous solutions von Pan, Shengdong, Shen, Haoyu, Xu, Qihong, Luo, Jian, Hu, Meiqin

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Surface mercapto engineered magnetic Fe sub(3O) sub(4) nanoadsorbent for the removal of mercury from aqueous solutions von Pan, Shengdong, Shen, Haoyu, Xu, Qihong, Luo, Jian, Hu, Meiqin

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