Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models von Kim, Hyoung, Xu, Haineng, George, Erin, Hallberg, Dorothy, Kumar, Sushil, Jagannathan, Veena, Medvedev, Sergey, Kinose, Yasuto, Devins, Kyle, Verma, Priyanka, Ly, Kevin, Wang, Yifan, Greenberg, Roger A., Schwartz, Lauren, Johnson, Neil, Scharpf, Robert B., Mills, Gordon B., Zhang, Rugang, Velculescu, Victor E., Brown, Eric J., Simpkins, Fiona

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PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma von Liu, Tianrun, Ma, Wenjuan, Xu, Haineng, Huang, Menggui, Zhang, Duo, He, Zhenqiang, Zhang, Lin, Brem, Steven, O’Rourke, Donald M., Gong, Yanqing, Mou, Yonggao, Zhang, Zhenfeng, Fan, Yi

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Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α von Wang, Qirui, He, Zhenqiang, Huang, Menggui, Liu, Tianrun, Wang, Yanling, Xu, Haineng, Duan, Hao, Ma, Peihong, Zhang, Lin, Zamvil, Scott S., Hidalgo, Juan, Zhang, Zhenfeng, O’Rourke, Donald M., Dahmane, Nadia, Brem, Steven, Mou, Yonggao, Gong, Yanqing, Fan, Yi

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Circulating Glioma Cells Exhibit Stem Cell-like Properties von Liu, Tianrun, Xu, Haineng, Huang, Menggui, Ma, Wenjuan, Saxena, Deeksha, Lustig, Robert A, Alonso-Basanta, Michelle, Zhang, Zhenfeng, O'Rourke, Donald M, Zhang, Lin, Gong, Yanqing, Kao, Gary D, Dorsey, Jay F, Fan, Yi

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Stage IV colon cancer patients without DENND2D expression benefit more from neoadjuvant chemotherapy von Ma, Wen-juan, Chen, Yukun, Peng, Jian-hong, Tang, Chaoming, Zhang, Ling, Liu, Min, Hu, Shanshan, Xu, Haineng, Tan, Hua, Gu, Yangkui, Pan, Zhi-zhong, Chen, Gong, Zhou, Zhong-guo, Zhang, Rong-xin

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Effect of the mRNA decapping enzyme scavenger (DCPS) inhibitor RG3039 on glioblastoma von Duan, Hao, Xie, Yuan, Wu, Suwen, Zhao, Guangyin, Zeng, Zhen, Hu, Hongrong, Yu, Yanjiao, Hu, Wanming, Yang, Yuanzhong, Chen, Yukun, Xie, Haoqun, Chen, Zexin, Zhang, Gao, Flaherty, Keith T, Hu, Shanshan, Xu, Haineng, Ma, Wenjuan, Mou, Yonggao

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CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models von Xu, Haineng, George, Erin, Kinose, Yasuto, Kim, Hyoung, Shah, Jennifer B., Peake, Jasmine D., Ferman, Benjamin, Medvedev, Sergey, Murtha, Thomas, Barger, Carter J., Devins, Kyle M., D’Andrea, Kurt, Wubbenhorst, Bradley, Schwartz, Lauren E., Hwang, Wei-Ting, Mills, Gordon B., Nathanson, Katherine L., Karpf, Adam R., Drapkin, Ronny, Brown, Eric J., Simpkins, Fiona

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CHK1 inhibitor SRA737 is active in PARP inhibitor resistant and CCNE1 amplified ovarian cancer von Xu, Haineng, Gitto, Sarah B., Ho, Gwo-Yaw, Medvedev, Sergey, Shield-Artin, Kristy, Kim, Hyoung, Beard, Sally, Kinose, Yasuto, Wang, Xiaolei, Barker, Holly E., Ratnayake, Gayanie, Hwang, Wei-Ting, Hansen, Ryan J., Strouse, Bryan, Milutinovic, Snezana, Hassig, Christian, Wakefield, Matthew J., Vandenberg, Cassandra J., Scott, Clare L., Simpkins, Fiona

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Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer von MU, JIASHENG, XU, HAINENG, YANG, YU, HUANG, WEIDAN, XIAO, JING, LI, MAOLAN, TAN, ZHUJUN, DING, QICHEN, ZHANG, LIN, LU, JIANHUA, WU, XIANGSONG, LIU, YINGBIN

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Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells von Wang, Yanling, Xu, Haineng, Liu, Tianrun, Huang, Menggui, Butter, Param-Puneet, Li, Chunsheng, Zhang, Lin, Kao, Gary D., Gong, Yanqing, Maity, Amit, Koumenis, Constantinos, Fan, Yi

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Capitalizing on the absence of TP53 mutations in low-grade serous and clear cell ovarian cancer with XPO1 inhibition von Nasioudis, Dimitrios, Wang, Xiaolei, Xu, Haineng, Medvedev, Sergey, Anderson, Matthew, Xiaoyin, Shan, Kim, Hyoung, Schwartz, Lauren, Simpkins, Fiona

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Design, synthesis and QSAR study of novel isatin analogues inspired Michael acceptor as potential anticancer compounds von Wang, Jiabing, Yun, Di, Yao, Jiali, Fu, Weitao, Huang, Fangyan, Chen, Liping, Wei, Tao, Yu, Cuijuan, Xu, Haineng, Zhou, Xiaoou, Huang, Yanqing, Wu, Jianzhang, Qiu, Peihong, Li, Wulan

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The Traditional Chinese Medicine Baicalein Potently Inhibits Gastric Cancer Cells von Mu, Jiasheng, Liu, Tianrun, Jiang, Lin, Wu, Xiangsong, Cao, Yang, Li, Maolan, Dong, Qian, Liu, Yingbin, Xu, Haineng

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Design and optimize N‐substituted EF24 as effective and low toxicity NF‐κB inhibitor for lung cancer therapy via apoptosis‐to‐pyroptosis switch von Chen, Liping, Li, Qian, Zheng, Zhiwei, Xie, Jingwen, Lin, Xiaoming, Jiang, Chengxi, Xu, Haineng, Wu, Xiaoping, Wu, Jianzhang, Zhang, Huajie

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An autologous humanized patient-derived-xenograft platform to evaluate immunotherapy in ovarian cancer von Gitto, Sarah B., Kim, Hyoung, Rafail, Stavros, Omran, Dalia K., Medvedev, Sergey, Kinose, Yasuto, Rodriguez-Garcia, Alba, Flowers, Ahron J., Xu, Haineng, Schwartz, Lauren E., Powell, Daniel J., Simpkins, Fiona

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Abstract GMM-060: A NOVEL TREATMENT APPROACH FOR TARGETING CYCLIN E OVER-EXPRESSING OVARIAN CANCERS von Xu, Haineng, Kinose, Yasuto, Kim, Hyoung, Medvedev, Sergey, George, Erin, Drapkin, Ronny, Brown, Eric, Mills, Gordon, Simpkins, Fiona

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Abstract AP31: ATR INHIBITION TARGETS TREATMENT RESISTANT OVARIAN CANCER von Kim, Hyoung, George, Erin, Xu, Haineng, Medvedev, Sergey, Jagannathan, Veena, Morgan, Mark, Mills, Gordon, Brown, Eric, Simpkins, Fiona

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Altered β1,6‐GlcNAc branched N‐glycans impair TGF‐β‐mediated Epithelial‐to‐Mesenchymal Transition through Smad signalling pathway in human lung cancer von Li, Na, Xu, Haineng, Fan, Kun, Liu, Xijun, Qi, Jingjing, Zhao, Chao, Yin, Peng, Wang, Liying, Li, Zengxia, Zha, Xiliang

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Targeting lung cancer stem‐like cells with TRAIL gene armed oncolytic adenovirus von Yang, Yu, Xu, Haineng, Huang, Weidan, Ding, Miao, Xiao, Jing, Yang, Dongmei, Li, Huaguang, Liu, Xin‐Yuan, Chu, Liang

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Synthesis and anti-tumor activity of EF24 analogues as IKKβ inhibitors von Jin, Rong, Chen, Qiuxiang, Yao, Song, Bai, Encheng, Fu, Weitao, Wang, Ledan, Wang, Jiabing, Du, Xiaojing, Wei, Tao, Xu, Haineng, Jiang, Chengxi, Qiu, Peihong, Wu, Jianzhang, Li, Wulan, Liang, Guang

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