Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron von Shuai, Huiping, Chan, Jasper Fuk-Woo, Hu, Bingjie, Chai, Yue, Yuen, Terrence Tsz-Tai, Yin, Feifei, Huang, Xiner, Yoon, Chaemin, Hu, Jing-Chu, Liu, Huan, Shi, Jialu, Liu, Yuanchen, Zhu, Tianrenzheng, Zhang, Jinjin, Hou, Yuxin, Wang, Yixin, Lu, Lu, Cai, Jian-Piao, Zhang, Anna Jinxia, Zhou, Jie, Yuan, Shuofeng, Brindley, Melinda A., Zhang, Bao-Zhong, Huang, Jian-Dong, To, Kelvin Kai-Wang, Yuen, Kwok-Yung, Chu, Hin

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Host and viral determinants for efficient SARS-CoV-2 infection of the human lung von Chu, Hin, Hu, Bingjie, Huang, Xiner, Chai, Yue, Zhou, Dongyan, Wang, Yixin, Shuai, Huiping, Yang, Dong, Hou, Yuxin, Zhang, Xi, Yuen, Terrence Tsz-Tai, Cai, Jian-Piao, Zhang, Anna Jinxia, Zhou, Jie, Yuan, Shuofeng, To, Kelvin Kai-Wang, Chan, Ivy Hau-Yee, Sit, Ko-Yung, Foo, Dominic Chi-Chung, Wong, Ian Yu-Hong, Ng, Ada Tsui-Lin, Cheung, Tan To, Law, Simon Ying-Kit, Au, Wing-Kuk, Brindley, Melinda A., Chen, Zhiwei, Kok, Kin-Hang, Chan, Jasper Fuk-Woo, Yuen, Kwok-Yung

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Emerging SARS-CoV-2 variants expand species tropism to murines von Shuai, Huiping, Chan, Jasper Fuk-Woo, Yuen, Terrence Tsz-Tai, Yoon, Chaemin, Hu, Jing-Chu, Wen, Lei, Hu, Bingjie, Yang, Dong, Wang, Yixin, Hou, Yuxin, Huang, Xiner, Chai, Yue, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Lu, Lu, Zhang, Rui-Qi, Chan, Wan-Mui, Ip, Jonathan Daniel, Chu, Allen Wing-Ho, Hu, Ye-Fan, Cai, Jian-Piao, Chan, Kwok-Hung, Zhou, Jie, Sridhar, Siddharth, Zhang, Bao-Zhong, Yuan, Shuofeng, Zhang, Anna Jinxia, Huang, Jian-Dong, To, Kelvin Kai-Wang, Yuen, Kwok-Yung, Chu, Hin

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Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2 von Hu, Bingjie, Chan, Jasper Fuk-Woo, Liu, Huan, Liu, Yuanchen, Chai, Yue, Shi, Jialu, Shuai, Huiping, Hou, Yuxin, Huang, Xiner, Yuen, Terrence Tsz-Tai, Yoon, Chaemin, Zhu, Tianrenzheng, Zhang, Jinjin, Li, Wenjun, Zhang, Anna Jinxia, Zhou, Jie, Yuan, Shuofeng, Zhang, Bao-Zhong, Yuen, Kwok-Yung, Chu, Hin

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Lineage-specific pathogenicity, immune evasion, and virological features of SARS-CoV-2 BA.2.86/JN.1 and EG.5.1/HK.3 von Liu, Yuanchen, Zhao, Xiaoyu, Shi, Jialu, Wang, Yajie, Liu, Huan, Hu, Ye-Fan, Hu, Bingjie, Shuai, Huiping, Yuen, Terrence Tsz-Tai, Chai, Yue, Liu, Feifei, Gong, Hua-Rui, Li, Jiayan, Wang, Xun, Jiang, Shujun, Zhang, Xiang, Zhang, Yanliang, Li, Xiangnan, Wang, Lei, Hartnoll, Madeline, Zhu, Tianrenzheng, Hou, Yuxin, Huang, Xiner, Yoon, Chaemin, Wang, Yang, He, Yixin, Zhou, Minmin, Du, Lianzhao, Zhang, Xiaojuan, Chan, Wan-Mui, Chen, Lin-Lei, Cai, Jian-Piao, Yuan, Shuofeng, Zhou, Jie, Huang, Jian-Dong, Yuen, Kwok-Yung, To, Kelvin Kai-Wang, Chan, Jasper Fuk-Woo, Zhang, Bao-Zhong, Sun, Lei, Wang, Pengfei, Chu, Hin

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Bacillus Calmette-Guérin-induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 mice von Zhang, Bao-Zhong, Shuai, Huiping, Gong, Hua-Rui, Hu, Jing-Chu, Yan, Bingpeng, Yuen, Terrence Tsz-Tai, Hu, Ye-Fan, Yoon, Chaemin, Wang, Xiao-Lei, Hou, Yuxin, Lin, Xuansheng, Huang, Xiner, Li, Renhao, Au-Yeung, Yee Man, Li, Wenjun, Hu, Bingjie, Chai, Yue, Yue, Ming, Cai, Jian-Piao, Ling, Guang Sheng, Hung, Ivan Fan-Ngai, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo, Huang, Jian-Dong, Chu, Hin

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Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination von Zhao, Xiaoyu, Qiu, Tianyi, Huang, Xiner, Mao, Qiyu, Wang, Yajie, Qiao, Rui, Li, Jiayan, Mao, Tiantian, Wang, Yuan, Cun, Yewei, Wang, Caicui, Luo, Cuiting, Yoon, Chaemin, Wang, Xun, Li, Chen, Cui, Yuchen, Zhao, Chaoyue, Li, Minghui, Chen, Yanjia, Cai, Guonan, Geng, Wenye, Hu, Zixin, Cao, Jinglei, Zhang, Wenhong, Cao, Zhiwei, Chu, Hin, Sun, Lei, Wang, Pengfei

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STAT2-dependent restriction of Zika virus by human macrophages but not dendritic cells von Yang, Dong, Chu, Hin, Lu, Gang, Shuai, Huiping, Wang, Yixin, Hou, Yuxin, Zhang, Xi, Huang, Xiner, Hu, Bingjie, Chai, Yue, Yuen, Terrence Tsz-Tai, Zhao, Xiaoyu, Lee, Andrew Chak-Yiu, Ye, Ziwei, Li, Cun, Chik, Kenn Ka-Heng, Zhang, Anna Jinxia, Zhou, Jie, Yuan, Shuofeng, Chan, Jasper Fuk-Woo

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Comparative Replication and Immune Activation Profiles of SARS-CoV-2 and SARS-CoV in Human Lungs: An Ex Vivo Study With Implications for the Pathogenesis of COVID-19 von Chu, Hin, Chan, Jasper Fuk-Woo, Wang, Yixin, Yuen, Terrence Tsz-Tai, Chai, Yue, Hou, Yuxin, Shuai, Huiping, Yang, Dong, Hu, Bingjie, Huang, Xiner, Zhang, Xi, Cai, Jian-Piao, Zhou, Jie, Yuan, Shuofeng, Kok, Kin-Hang, To, Kelvin Kai-Wang, Chan, Ivy Hau-Yee, Zhang, Anna Jinxia, Sit, Ko-Yung, Au, Wing-Kuk, Yuen, Kwok-Yung

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Attenuated Interferon and Proinflammatory Response in SARS-CoV-2–Infected Human Dendritic Cells Is Associated With Viral Antagonism of STAT1 Phosphorylation von Yang, Dong, Chu, Hin, Hou, Yuxin, Chai, Yue, Shuai, Huiping, Lee, Andrew Chak-Yiu, Zhang, Xi, Wang, Yixin, Hu, Bingjie, Huang, Xiner, Yuen, Terrence Tsz-Tai, Cai, Jian-Piao, Zhou, Jie, Yuan, Shuofeng, Zhang, Anna Jinxia, Chan, Jasper Fuk-Woo, Yuen, Kwok-Yung

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Differential immune activation profile of SARS-CoV-2 and SARS-CoV infection in human lung and intestinal cells: Implications for treatment with IFN-β and IFN inducer von Shuai, Huiping, Chu, Hin, Hou, Yuxin, Yang, Dong, Wang, Yixin, Hu, Bingjie, Huang, Xiner, Zhang, Xi, Chai, Yue, Cai, Jian-Piao, Chan, Jasper Fuk-Woo, Yuen, Kwok-Yung

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Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory stud... von Chu, Hin, Chan, Jasper Fuk-Woo, Yuen, Terrence Tsz-Tai, Shuai, Huiping, Yuan, Shuofeng, Wang, Yixin, Hu, Bingjie, Yip, Cyril Chik-Yan, Tsang, Jessica Oi-Ling, Huang, Xiner, Chai, Yue, Yang, Dong, Hou, Yuxin, Chik, Kenn Ka-Heng, Zhang, Xi, Fung, Agnes Yim-Fong, Tsoi, Hoi-Wah, Cai, Jian-Piao, Chan, Wan-Mui, Ip, Jonathan Daniel, Chu, Allen Wing-Ho, Zhou, Jie, Lung, David Christopher, Kok, Kin-Hang, To, Kelvin Kai-Wang, Tsang, Owen Tak-Yin, Chan, Kwok-Hung, Yuen, Kwok-Yung

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Coronaviruses exploit a host cysteine-aspartic protease for replication von Chu, Hin, Hou, Yuxin, Yang, Dong, Wen, Lei, Shuai, Huiping, Yoon, Chaemin, Shi, Jialu, Chai, Yue, Yuen, Terrence Tsz-Tai, Hu, Bingjie, Li, Cun, Zhao, Xiaoyu, Wang, Yixin, Huang, Xiner, Lee, Kin Shing, Luo, Cuiting, Cai, Jian-Piao, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Zhang, Anna Jinxia, Yuan, Shuofeng, Sit, Ko-Yung, Foo, Dominic Chi-Chung, Au, Wing-Kuk, Wong, Kenneth Kak-Yuen, Zhou, Jie, Kok, Kin-Hang, Jin, Dong-Yan, Chan, Jasper Fuk-Woo, Yuen, Kwok-Yung

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Low Environmental Temperature Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Golden Syrian Hamsters von Chan, Jasper Fuk Woo, Poon, Vincent Kwok Man, Chan, Chris Chung Sing, Chik, Kenn Ka Heng, Tsang, Jessica Oi Ling, Zou, Zijiao, Chan, Chris Chun Yiu, Lee, Andrew Chak Yiu, Li, Can, Liang, Ronghui, Cao, Jianli, Tang, Kaiming, Yuen, Terrence Tsz Tai, Hu, Bingjie, Huang, Xiner, Chai, Yue, Shuai, Huiping, Luo, Cuiting, Cai, Jian Piao, Chan, Kwok Hung, Sridhar, Siddharth, Yin, Feifei, Kok, Kin Hang, Chu, Hin, Zhang, Anna Jinxia, Yuan, Shuofeng, Yuen, Kwok Yung

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Conditional gene inactivation by combining tetracycline-mediated transcriptional repression and auxin-inducible degron-mediated degradation von Ng, Lau Yan, Ma, Hoi Tang, Liu, Julio C.Y., Huang, Xiner, Lee, Nelson, Poon, Randy Y.C.

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Type‐II IFN inhibits SARS‐CoV‐2 replication in human lung epithelial cells and ex vivo human lung tissues through indoleamine 2,3‐dioxygenase‐mediated pathways von Yang, Dong, Chan, Jasper Fuk‐Woo, Yoon, Chaemin, Luk, Tsz‐Yat, Shuai, Huiping, Hou, Yuxin, Huang, Xiner, Hu, Bingjie, Chai, Yue, Yuen, Terrence Tsz‐Tai, Liu, Yuanchen, Zhu, Tianrenzheng, Liu, Huan, Shi, Jialu, Wang, Yang, He, Yixin, Sit, Ko‐Yung, Au, Wing‐Kuk, Zhang, Anna Jinxia, Yuan, Shuofeng, Zhang, Bao‐Zhong, Huang, Yao‐Wei, Chu, Hin

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The viral fitness and intrinsic pathogenicity of dominant SARS-CoV-2 Omicron sublineages BA.1, BA.2, and BA.5 von Shuai, Huiping, Chan, Jasper Fuk-Woo, Hu, Bingjie, Chai, Yue, Yoon, Chaemin, Liu, Huan, Liu, Yuanchen, Shi, Jialu, Zhu, Tianrenzheng, Hu, Jing-Chu, Hu, Ye-fan, Hou, Yuxin, Huang, Xiner, Yuen, Terrence Tsz-Tai, Wang, Yang, Zhang, Jinjin, Xia, Yao, Chen, Lin-Lei, Cai, Jian-Piao, Zhang, Anna Jinxia, Yuan, Shuofeng, Zhou, Jie, Zhang, Bao-Zhong, Huang, Jian-Dong, Yuen, Kwok-Yung, To, Kelvin Kai-Wang, Chu, Hin

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Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity von Chu, Hin, Shuai, Huiping, Hou, Yuxin, Zhang, Xi, Wen, Lei, Huang, Xiner, Hu, Bingjie, Yang, Dong, Wang, Yixin, Yoon, Chaemin, Wong, Bosco Ho-Yin, Li, Cun, Zhao, Xiaoyu, Poon, Vincent Kwok-Man, Cai, Jian-Piao, Wong, Kenneth Kak-Yuen, Yeung, Man-Lung, Zhou, Jie, Au-Yeung, Rex Kwok-Him, Yuan, Shuofeng, Jin, Dong-Yan, Kok, Kin-Hang, Perlman, Stanley, Chan, Jasper Fuk-Woo, Yuen, Kwok-Yung

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Virological features and pathogenicity of SARS-CoV-2 Omicron BA.2 von Fuk-Woo Chan, Jasper, Hu, Bingjie, Chai, Yue, Shuai, Huiping, Liu, Huan, Shi, Jialu, Liu, Yuanchen, Yoon, Chaemin, Zhang, Jinjin, Hu, Jing-Chu, Hou, Yuxin, Huang, Xiner, Tsz-Tai Yuen, Terrence, Zhu, Tianrenzheng, Li, Wenjun, Cai, Jian-Piao, Luo, Cuiting, Chik-Yan Yip, Cyril, Zhang, Anna Jinxia, Zhou, Jie, Yuan, Shuofeng, Zhang, Bao-Zhong, Huang, Jian-Dong, Kai-Wang To, Kelvin, Yuen, Kwok-Yung, Chu, Hin

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SARS-CoV-2 Induces a More Robust Innate Immune Response and Replicates Less Efficiently Than SARS-CoV in the Human Intestines: An Ex Vivo Study With Implications on Pathogenesis of... von Chu, Hin, Chan, Jasper Fuk-Woo, Wang, Yixin, Yuen, Terrence Tsz-Tai, Chai, Yue, Shuai, Huiping, Yang, Dong, Hu, Bingjie, Huang, Xiner, Zhang, Xi, Hou, Yuxin, Cai, Jian-Piao, Zhang, Anna Jinxia, Zhou, Jie, Yuan, Shuofeng, To, Kelvin Kai-Wang, Hung, Ivan Fan-Ngai, Cheung, Tan To, Ng, Ada Tsui-Lin, Hau-Yee Chan, Ivy, Wong, Ian Yu-Hong, Law, Simon Ying-Kit, Foo, Dominic Chi-Chung, Leung, Wai-Keung, Yuen, Kwok-Yung

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