Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study von Xu, Jianlin, Xu, Xuankuo, Huang, Chao, Angelo, James, Oliveira, Christopher L, Xu, Mengmeng, Xu, Xia, Temel, Deniz, Ding, Julia, Ghose, Sanchayita, Borys, Michael C, Li, Zheng Jian

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Emerging biomaterials for downstream manufacturing of therapeutic proteins von Li, Yi, Stern, David, Lock, Lye Lin, Mills, Jason, Ou, Shih-Hao, Morrow, Marina, Xu, Xuankuo, Ghose, Sanchayita, Li, Zheng Jian, Cui, Honggang

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Protein aggregation and mitigation strategy in low pH viral inactivation for monoclonal antibody purification von Jin, Weixin, Xing, Zizhuo, Song, Yuanli, Huang, Chao, Xu, Xuankuo, Ghose, Sanchayita, Li, Zheng Jian

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Model assisted comparison of Protein A resins and multi-column chromatography for capture processes von Baur, Daniel, Angelo, James M., Chollangi, Srinivas, Xu, Xuankuo, Müller-Späth, Thomas, Zhang, Na, Ghose, Sanchayita, Li, Zheng Jian, Morbidelli, Massimo

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Metabolic understanding of disulfide reduction during monoclonal antibody production von Cura, Anthony J., Xu, Xuankuo, Egan, Susan, Aron, Kathryn, Jenkins, Lauren, Hageman, Tyler, Huang, Yunping, Chollangi, Srinivas, Borys, Michael, Ghose, Sanchayita, Li, Zheng Jian

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Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics von Chen, Zhiqiang, Qian, Yueming, Song, Yuanli, Xu, Xuankuo, Tao, Li, Mussa, Nesredin, Ghose, Sanchayita, Li, Zheng Jian

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Untargeted proteomics reveals upregulation of stress response pathways during CHO-based monoclonal antibody manufacturing process leading to disulfide bond reduction von Park, Seo-Young, Egan, Susan, Cura, Anthony J, Aron, Kathryn L, Xu, Xuankuo, Zheng, Mengyuan, Borys, Michael, Ghose, Sanchayita, Li, Zhengjian, Lee, Kyongbum

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Adaptation of the pore diffusion model to describe multi-addition batch uptake high-throughput screening experiments von Traylor, Steven J., Xu, Xuankuo, Li, Yi, Jin, Mi, Li, Zheng Jian

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Binary adsorption of globular proteins on ion-exchange media von Xu, Xuankuo, Lenhoff, Abraham M.

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Shrinking-core modeling of binary chromatographic breakthrough von Traylor, Steven J., Xu, Xuankuo, Lenhoff, Abraham M.

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Chromatography of proteins on charge-variant ion exchangers and implications for optimizing protein uptake rates von Langford, John F., Xu, Xuankuo, Yao, Yan, Maloney, Sean F., Lenhoff, Abraham M.

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Disaggregation of high-molecular weight species during downstream processing to recover functional monomer von Xu, Xuankuo, Didio, David M., Leister, Kirk J., Ghose, Sanchayita

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Effect of solution condition on the binding behaviors of monoclonal antibody and fusion protein therapeutics in Protein A chromatography von Guo, Jing, Noyes, Steven, Jin, Weixin, Curtis, Harris, Xu, Xuankuo, Ghose, Sanchayita

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Modeling and techno-economic analysis of downstream manufacturing process intensification strategies for existing biopharmaceutical facilities von Romero, Juan J., Angelo, James, Xu, Xuankuo, Husson, Scott M., Ghose, Sanchayita

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Experimental Design of the Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) Unit for the Separation of PEGylated Proteins von Kim, Tae Keun, Botti, Chiara, Angelo, James, Xu, Xuankuo, Ghose, Sanchayita, Li, Zheng Jian, Morbidelli, Massimo, Sponchioni, Mattia

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Role of the gradient slope during the product internal recycling for the multicolumn countercurrent solvent gradient purification of PEGylated proteins von Kim, Tae Keun, Bham, Abdallah Ayub, Fioretti, Ismaele, Angelo, James, Xu, Xuankuo, Ghose, Sanchayita, Morbidelli, Massimo, Sponchioni, Mattia

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Hydrophobic property of cation-exchange resins affects monoclonal antibody aggregation von Huang, Chao, Wang, Yiran, Xu, Xuankuo, Mills, Jason, Jin, Weixin, Ghose, Sanchayita, Li, Zheng Jian

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Predictive mechanistic modeling of loading and elution in protein A chromatography von Bhoyar, Soumitra, Kumar, Vijesh, Foster, Max, Xu, Xuankuo, Traylor, Steven J., Guo, Jing, Lenhoff, Abraham M.

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Design and economic investigation of a Multicolumn Countercurrent Solvent Gradient Purification unit for the separation of an industrially relevant PEGylated protein von Kim, Tae Keun, Sechi, Benedetta, Romero Conde, Juan Jose, Angelo, James, Xu, Xuankuo, Ghose, Sanchayita, Morbidelli, Massimo, Sponchioni, Mattia

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Engineering protein A ligands to mitigate antibody loss during high-pH washes in protein A chromatography von Bhoyar, Soumitra, Foster, Max, Oh, Young Hoon, Xu, Xuankuo, Traylor, Steven J., Guo, Jing, Ghose, Sanchayita, Lenhoff, Abraham M.

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