Animals models of gastrointestinal and liver diseases. Animal models of alcohol-induced liver disease: pathophysiology, translational relevance, and challenges von Mathews, Stephanie, Xu, Mingjiang, Wang, Hua, Bertola, Adeline, Gao, Bin

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Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression von Cimmino, Luisa, Dolgalev, Igor, Wang, Yubao, Yoshimi, Akihide, Martin, Gaëlle H., Wang, Jingjing, Ng, Victor, Xia, Bo, Witkowski, Matthew T., Mitchell-Flack, Marisa, Grillo, Isabella, Bakogianni, Sofia, Ndiaye-Lobry, Delphine, Martín, Miguel Torres, Guillamot, Maria, Banh, Robert S., Xu, Mingjiang, Figueroa, Maria E., Dickins, Ross A., Abdel-Wahab, Omar, Park, Christopher Y., Tsirigos, Aristotelis, Neel, Benjamin G., Aifantis, Iannis

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Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice von Li, Hongliang, Xu, Mingjiang, Lee, Jiyeon, He, Chaoyong, Xie, Zhonglin

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Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies von Li, Zhe, Cai, Xiaoqiang, Cai, Chen-Leng, Wang, Jiapeng, Zhang, Wenyong, Petersen, Bruce E., Yang, Feng-Chun, Xu, Mingjiang

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Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies von Yang, Hui, Kurtenbach, Stefan, Guo, Ying, Lohse, Ines, Durante, Michael A., Li, Jianping, Li, Zhaomin, Al-Ali, Hassan, Li, Lingxiao, Chen, Zizhen, Field, Matthew G., Zhang, Peng, Chen, Shi, Yamamoto, Shohei, Li, Zhuo, Zhou, Yuan, Nimer, Stephen D., Harbour, J. William, Wahlestedt, Claes, Xu, Mingjiang, Yang, Feng-Chun

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RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells von Guallar, Diana, Bi, Xianju, Pardavila, Jose Angel, Huang, Xin, Saenz, Carmen, Shi, Xianle, Zhou, Hongwei, Faiola, Francesco, Ding, Junjun, Haruehanroengra, Phensinee, Yang, Fan, Li, Dan, Sanchez-Priego, Carlos, Saunders, Arven, Pan, Feng, Valdes, Victor Julian, Kelley, Kevin, Blanco, Miguel G., Chen, Lingyi, Wang, Huayan, Sheng, Jia, Xu, Mingjiang, Fidalgo, Miguel, Shen, Xiaohua, Wang, Jianlong

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The presence of JAK2V617F mutation in the liver endothelial cells of patients with Budd-Chiari syndrome von Sozer, Selcuk, Fiel, Maria Isabel, Schiano, Thomas, Xu, Mingjiang, Mascarenhas, John, Hoffman, Ronald

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Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies von He, Yonghan, Khan, Sajid, Huo, Zhiguang, Lv, Dongwen, Zhang, Xuan, Liu, Xingui, Yuan, Yaxia, Hromas, Robert, Xu, Mingjiang, Zheng, Guangrong, Zhou, Daohong

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Hepatocytes and neutrophils cooperatively suppress bacterial infection by differentially regulating lipocalin‐2 and neutrophil extracellular traps von Li, Hongjie, Feng, Dechun, Cai, Yan, Liu, Yudong, Xu, Mingjiang, Xiang, Xiaogang, Zhou, Zhou, Xia, Qiang, Kaplan, Mariana J., Kong, Xiaoni, Gao, Bin

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Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis von Li, Xuekun, Yao, Bing, Chen, Li, Kang, Yunhee, Li, Yujing, Cheng, Ying, Li, Liping, Lin, Li, Wang, Zhiqin, Wang, Mengli, Pan, Feng, Dai, Qing, Zhang, Wei, Wu, Hao, Shu, Qiang, Qin, Zhaohui, He, Chuan, Xu, Mingjiang, Jin, Peng

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HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia von Zhu, Ganqian, Luo, Huacheng, Feng, Yang, Guryanova, Olga A., Xu, Jianfeng, Chen, Shi, Lai, Qian, Sharma, Arati, Xu, Bing, Zhao, Zhigang, Feng, Ru, Ni, Hongyu, Claxton, David, Guo, Ying, Mesa, Ruben A., Qiu, Yi, Yang, Feng-Chun, Li, Wei, Nimer, Stephen D., Huang, Suming, Xu, Mingjiang

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Loss of Asxl1 leads to myelodysplastic syndrome–like disease in mice von Wang, Jiapeng, Li, Zhaomin, He, Yongzheng, Pan, Feng, Chen, Shi, Rhodes, Steven, Nguyen, Lihn, Yuan, Jin, Jiang, Li, Yang, Xianlin, Weeks, Ophelia, Liu, Ziyue, Zhou, Jiehao, Ni, Hongyu, Cai, Chen-Leng, Xu, Mingjiang, Yang, Feng-Chun

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TET1 plays an essential oncogenic role in MLL-rearranged leukemia von Huang, Hao, Jiang, Xi, Li, Zejuan, Li, Yuanyuan, Song, Chun-Xiao, He, Chunjiang, Sun, Miao, Chen, Ping, Gurbuxani, Sandeep, Wang, Jiapeng, Hong, Gia-Ming, Elkahloun, Abdel G., Arnovitz, Stephen, Wang, Jinhua, Szulwach, Keith, Lin, Li, Street, Craig, Wunderlich, Mark, Dawlaty, Meelad, Neilly, Mary Beth, Jaenisch, Rudolf, Yang, Feng-Chun, Mulloy, James C., Jin, Peng, Liu, Paul P., Rowley, Janet D., Xu, Mingjiang, He, Chuan, Chen, Jianjun

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Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells von Pan, Feng, Wingo, Thomas S., Zhao, Zhigang, Gao, Rui, Makishima, Hideki, Qu, Guangbo, Lin, Li, Yu, Miao, Ortega, Janice R., Wang, Jiapeng, Nazha, Aziz, Chen, Li, Yao, Bing, Liu, Can, Chen, Shi, Weeks, Ophelia, Ni, Hongyu, Phillips, Brittany Lynn, Huang, Suming, Wang, Jianlong, He, Chuan, Li, Guo-Min, Radivoyevitch, Tomas, Aifantis, Iannis, Maciejewski, Jaroslaw P., Yang, Feng-Chun, Jin, Peng, Xu, Mingjiang

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Upregulation of a Disintegrin and Metalloproteinase With Thrombospondin Motifs-7 by miR-29 Repression Mediates Vascular Smooth Muscle Calcification von Du, Yaoyao, Gao, Cheng, Liu, Ziyi, Wang, Li, Liu, Bo, He, Fan, Zhang, Tao, Wang, Yue, Wang, Xiujie, Xu, Mingjiang, Luo, Guan-Zheng, Zhu, Yi, Xu, Qingbo, Wang, Xian, Kong, Wei

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Macrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses von Huang, Zhuqi, Shen, Sirui, Han, Xue, Li, Weixin, Luo, Wu, Lin, Liming, Xu, Mingjiang, Wang, Yi, Huang, Weijian, Wu, Gaojun, Liang, Guang

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Six1 regulates leukemia stem cell maintenance in acute myeloid leukemia von Chu, Yajing, Chen, Yangpeng, Li, Mengke, Shi, Deyang, Wang, Bichen, Lian, Yu, Cheng, Xuelian, Wang, Xiaomin, Xu, Mingjiang, Cheng, Tao, Shi, Jun, Yuan, Weiping

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Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice von Zhao, Zhigang, Chen, Li, Dawlaty, Meelad M., Pan, Feng, Weeks, Ophelia, Zhou, Yuan, Cao, Zeng, Shi, Hui, Wang, Jiapeng, Lin, Li, Chen, Shi, Yuan, Weiping, Qin, Zhaohui, Ni, Hongyu, Nimer, Stephen D., Yang, Feng-Chun, Jaenisch, Rudolf, Jin, Peng, Xu, Mingjiang

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Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo von Guo, Ying, Yang, Hui, Chen, Shi, Zhang, Peng, Li, Rong, Nimer, Stephen D., Harbour, J. William, Xu, Mingjiang, Yang, Feng-Chun

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Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy von Zhang, Peng, He, Fuhong, Bai, Jie, Yamamoto, Shohei, Chen, Shi, Zhang, Lin, Sheng, Mengyao, Zhang, Lei, Guo, Ying, Man, Na, Yang, Hui, Wang, Suyun, Cheng, Tao, Nimer, Stephen D, Zhou, Yuan, Xu, Mingjiang, Wang, Qian-Fei, Yang, Feng-Chun

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