A phase 1 trial of ibrutinib plus palbociclib in previously treated mantle cell lymphoma von Martin, Peter, Bartlett, Nancy L., Blum, Kristie A., Park, Steven, Maddocks, Kami, Ruan, Jia, Ridling, LeAnn, Dittus, Christopher, Chen, Zhengming, Huang, Xiangao, Inghirami, Giorgio, DiLiberto, Maurizio, Chen-Kiang, Selina, Leonard, John P.

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Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance von Li, Fei, Wang, Yizhe, Hwang, Inah, Jang, Ja-Young, Xu, Libo, Deng, Zhong, Yu, Eun Young, Cai, Yiming, Wu, Caizhi, Han, Zhenbo, Huang, Yu-Han, Huang, Xiangao, Zhang, Ling, Yao, Jun, Lue, Neal F., Lieberman, Paul M., Ying, Haoqiang, Paik, Jihye, Zheng, Hongwu

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A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase function von Liu, Yaobin, Huang, Xiangao, He, Xian, Zhou, Yanqing, Jiang, Xiaogang, Chen‐Kiang, Selina, Jaffrey, Samie R., Xu, Guoqiang

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A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas von Jang, Ja-Young, Hwang, Inah, Pan, Heng, Yao, Jun, Alinari, Lapo, Imada, Eddie, Zanettini, Claudio, Kluk, Michael J, Wang, Yizhe, Lee, Yunkyoung, Lin, Hua V, Huang, Xiangao, Di Liberto, Maurizio, Chen, Zhengming, Ballman, Karla V, Cantley, Lewis C, Marchionni, Luigi, Inghirami, Giorgio, Elemento, Olivier, Baiocchi, Robert A, Chen-Kiang, Selina, Belvedere, Sandro, Zheng, Hongwu, Paik, Jihye

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Prolonged early G1 arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle–coupled loss of IRF4 von Huang, Xiangao, Di Liberto, Maurizio, Jayabalan, David, Liang, Jun, Ely, Scott, Bretz, Jamieson, Shaffer, Arthur L., Louie, Tracey, Chen, Isan, Randolph, Sophia, Hahn, William C., Staudt, Louis M., Niesvizky, Ruben, Moore, Malcolm A.S., Chen-Kiang, Selina

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A novel therapeutic combination using PD 0332991 and bortezomib: study in the 5T33MM myeloma model von Menu, Eline, Garcia, Josefina, Huang, Xiangao, Di Liberto, Maurizio, Toogood, Peter L, Chen, Isan, Vanderkerken, Karin, Chen-Kiang, Selina

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MAGE-A Inhibits Apoptosis in Proliferating Myeloma Cells through Repression of Bax and Maintenance of Survivin von NARDIELLO, Tricia, JUNGBLUTH, Achim A, PEARSE, Roger, COLEMAN, Morton, JAYABALAN, David S, BHARDWAJ, Nina, OLD, Lloyd J, CHEN-KIANG, Selina, HEARN JAY CHO, MEI, Anna, DILIBERTO, Maurizio, XIANGAO HUANG, DABROWSKI, Ania, ANDRADE, Valéria C. C, WASSERSTRUM, Rebecca, ELY, Scott, NIESVIZKY, Ruben

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Caspase-8 Inhibition Prevents the Cleavage and Degradation of E3 Ligase Substrate Receptor Cereblon and Potentiates Its Biological Function von Zhou, Liang, Yu, Wenjun, Jayabalan, David S, Niesvizky, Ruben, Jaffrey, Samie R, Huang, Xiangao, Xu, Guoqiang

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Caspase-8 Regulates the Antimyeloma Activity of Bortezomib and Lenalidomide von Zhou, Liang, Huang, Xiangao, Niesvizky, Ruben, Pu, Zhongjian, Xu, Guoqiang

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Noxa mediates p18INK4c cell-cycle control of homeostasis in B cells and plasma cell precursors von Bretz, Jamieson, Garcia, Josefina, Huang, Xiangao, Kang, Lin, Zhang, Yang, Toellner, Kai-Michael, Chen-Kiang, Selina

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Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma von Chiron, David, Di Liberto, Maurizio, Martin, Peter, Huang, Xiangao, Sharman, Jeff, Blecua, Pedro, Mathew, Susan, Vijay, Priyanka, Eng, Ken, Ali, Siraj, Johnson, Amy, Chang, Betty, Ely, Scott, Elemento, Olivier, Mason, Christopher E, Leonard, John P, Chen-Kiang, Selina

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Combined Inhibition of CDK2 and BCL2 Overrides Resistance to Targeting BTK and CDK4/6 in Mantle Cell Lymphoma Therapy von Al-Ansari, Haya Y., Bashir, Saira, Cui, Adrienne, Huang, Xiangao, Hu, Yang, Martin, Peter, Elemento, Olivier, Di Liberto, Maurizio, Chen-Kiang, Selina

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Disrupting GRINL1A Association with Cereblon Accelerates IKZF1/3 Degradation and IMiD Killing of Mantle Cell Lymphoma Cells By CDK4/6 Inhibition von Zhao, Nicole, Di Liberto, Maurizio, Elemento, Olivier, Chen-Kiang, Selina, Huang, Xiangao

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Harnessing Btki Therapy By CDK4/6i Control of T Effector Memory Cells and T Cell Surveillance in Mantle Cell Lymphoma von Di Liberto, Maurizio, Hu, Yang, Huang, Xiangao, Inghirami, Giorgio, Wang, Kevin, Lee, Christina, Maddocks, Kami J., Blum, Kristie A., Ruan, Jia, Leonard, John P., Bartlett, Nancy L., Martin, Peter, Elemento, Olivier, Chen-Kiang, Selina

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Dynamic Immune Surveillance in Durable Clinical Response to Combined BTK and BCL2 Inhibition in MCL at Longitudinal Single-Cell Resolution von Wang, Kevin, Di Liberto, Maurizio, Hu, Yang, Huang, Xiangao, Koldej, Rachel M, Ritchie, David, Martin, Peter, Inghirami, Giorgio, Elemento, Olivier, Tam, Constantine S., Chen-Kiang, Selina

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Cooperative Repression of IRF4 and Induction of IRF7 By CDK4/6 Inhibition Sensitizes Mantle Cell Lymphoma Cells to IMiD-Mediated Apoptosis Independent of p16 Deletion or c-Myc Over... von Humos, Basel A, Di Liberto, Maurizio, Huang, Xiangao, Elemento, Olivier, Chen-Kiang, Selina

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FOXO1 Dependent Transcription Network Is a Targetable Vulnerability of Mantle Cell Lymphoma von Jang, Ja-Young, Hwang, Inah, Pan, Heng, Kluk, Michael, Yao, Jun, Huang, Xiangao, Di Liberto, Maurizio, Chen, Zhengming, Ballman, Karla V, Cantley, Lewis C, Inghirami, Giorgio, Elemento, Olivier, Baiocchi, Robert, Chen-Kiang, Selina, Belvedere, Sandro, Zheng, Hongwu, Paik, Jihye

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Cooperative Supression of MEIS2 Mediates Dexamethasone Enhancement of Lenalidomide Killing in Myeloma Cells von Allouch, Sonia, Jayabalan, David S, Rossi, Adriana C, Niesvizky, Ruben, Huang, Xiangao, Chen-Kiang, Selina

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Blind reconnaissance of the pseudo-random sequence in DS/SS signal with negative SNR von Huang, Xiangao, Huang, Wei, Wang, Chao, Lu, Zejun, Hu, Yanhua

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Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1 von Chiron, David, Martin, Peter, Di Liberto, Maurizio, Huang, Xiangao, Ely, Scott, Lannutti, Brian J., Leonard, John P., Mason, Christopher E., Chen-Kiang, Selina

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