Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing br... von Xia, Wenle, Gerard, Catherine M, Liu, Leihua, Baudson, Nathalie M, Ory, Thierry L, Spector, Neil L

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An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models von Xia, Wenle, Petricoin, 3rd, Emanual F, Zhao, Sumin, Liu, Leihua, Osada, Takuya, Cheng, Qing, Wulfkuhle, Julia D, Gwin, William R, Yang, Xiaoyi, Gallagher, Rosa I, Bacus, Sarah, Lyerly, H Kim, Spector, Neil L

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Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways von Xia, Wenle, Mullin, Robert J, Keith, Barry R, Liu, Lei-Hua, Ma, Hong, Rusnak, David W, Owens, Gary, Alligood, Krystal J, Spector, Neil L

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A Model of Acquired Autoresistance to a Potent ErbB2 Tyrosine Kinase Inhibitor and a Therapeutic Strategy to Prevent Its Onset in Breast Cancer von Xia, Wenle, Bacus, Sarah, Hegde, Priti, Husain, Intisar, Strum, Jay, Liu, Leihua, Paulazzo, Georgina, Lyass, Ljuba, Trusk, Patricia, Hill, Jason, Harris, Jennifer, Spector, Neil L.

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Acquired Resistance to Small Molecule ErbB2 Tyrosine Kinase Inhibitors von CHEN, Franklin L, WENLE XIA, SPECTOR, Neil L

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Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers von WENLE XIA, HUSAIN, Intisar, LEIHUA LIU, BACUS, Sarah, SAINI, Shermini, SPOHN, Janice, PRY, Karen, WESTLUND, Ron, STEIN, Steven H, SPECTOR, Neil L

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Truncated ErbB2 receptor (p95 ) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR ErbB2 kinase inhibitor GW572016 von Xia, Wenle, Liu, Lei-Hua, Ho, Peter, Spector, Neil L

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Study of the Biologic Effects of Lapatinib, a Reversible Inhibitor of ErbB1 and ErbB2 Tyrosine Kinases, on Tumor Growth and Survival Pathways in Patients With Advanced Malignancies von Spector, Neil L, Xia, Wenle, Burris, 3rd, Howard, Hurwitz, Herbert, Dees, E Claire, Dowlati, Afshin, O'Neil, Bert, Overmoyer, Beth, Marcom, Paul K, Blackwell, Kimberly L, Smith, Deborah A, Koch, Kevin M, Stead, Andrew, Mangum, Steven, Ellis, Matthew J, Liu, Leihua, Man, Albert K, Bremer, Troy M, Harris, Jennifer, Bacus, Sarah

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X-Ray Psoralen Activated Cancer Therapy (X-PACT) von Oldham, Mark, Yoon, Paul, Fathi, Zak, Beyer, Wayne F, Adamson, Justus, Liu, Leihua, Alcorta, David, Xia, Wenle, Osada, Takuya, Liu, Congxiao, Yang, Xiao Y, Dodd, Rebecca D, Herndon, 2nd, James E, Meng, Boyu, Kirsch, David G, Lyerly, H Kim, Dewhirst, Mark W, Fecci, Peter, Walder, Harold, Spector, Neil L

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A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53 von Kurokawa, Manabu, Kim, Jiyeon, Geradts, Joseph, Matsuura, Kenkyo, Liu, Liu, Ran, Xu, Xia, Wenle, Ribar, Thomas J, Henao, Ricardo, Dewhirst, Mark W, Kim, Wun-Jae, Lucas, Joseph E, Wang, Shaomeng, Spector, Neil L, Kornbluth, Sally

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Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells von Spector, Neil L, Yarden, Yosef, Smith, Bradley, Lyass, Ljuba, Trusk, Patricia, Pry, Karen, Hill, Jason E, Xia, Wenle, Seger, Rony, Bacus, Sarah S

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Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis von Xia, Wenle, Gooden, David, Liu, Leihua, Zhao, Sumin, Soderblom, Erik J, Toone, Eric J, Beyer, Jr, Wayne F, Walder, Harold, Spector, Neil L

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Regulation of survivin by ErbB2 signaling : Therapeutic implications for ErbB2-overexpressing breast cancers von WENLE XIA, BISI, John, WESTLUND, Ron E, SUMIN ZHAO, BACUS, Sarah, SPECTOR, Neil L, STRUM, Jay, LEIHUA LIU, CARRICK, Kevin, GRAHAM, Katherine M, TREECE, Amanda L, HARDWICKE, Mary Ann, DUSH, Michael, QIAOYIN LIAO

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Luminescent Gold Nanoparticles with Controllable Hydrophobic Interactions von Tang, Bing, Xia, Wenle, Cai, Wei, Liu, Jinbin

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Resistance to ErbB2 tyrosine kinase inhibitors in breast cancer is mediated by calcium-dependent activation of RelA von Xia, Wenle, Bacus, Sarah, Husain, Intisar, Liu, Leihua, Zhao, Sumin, Liu, Zuguo, Moseley, 3rd, M Arthur, Thompson, J Will, Chen, Franklin L, Koch, Kevin M, Spector, Neil L

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A ratiometric detection of heparin with high sensitivity based on aggregation-enhanced emission of gold nanoclusters triggered by silicon nanoparticles von Qu, Fei, Xia, Wenle, Xia, Lian, You, Jinmao, Han, Wenli

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Hyperphosphorylation of Heat Shock Transcription Factor 1 Is Correlated with Transcriptional Competence and Slow Dissociation of Active Factor Trimers von Xia, Wenle, Voellmy, Richard

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Tumor Selective G2/M Cell Cycle Arrest and Apoptosis of Epithelial and Hematological Malignancies by BBL22, a Benzazepine von Xia, Wenle, Spector, Sydney, Hardy, Lys, Zhao, Sumin, Saluk, Alan, Alemane, Lourdes, Spector, Neil L.

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HER2 therapy. Small molecule HER-2 tyrosine kinase inhibitors von Spector, Neil, Xia, Wenle, El-Hariry, Iman, Yarden, Yossi, Bacus, Sarah

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Induction of autophagy across multiple tumor types through irreversible HER tyrosine kinase blockade von Gwin, William Rayford, Liu, Leihua, Zhao, Sumin, Xia, Wenle, Spector, Neil

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