Targeting phosphoinositide 3-kinase—Moving towards therapy von Marone, Romina, Cmiljanovic, Vladimir, Giese, Bernd, Wymann, Matthias P.

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5‑(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)­pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Ca... von Beaufils, Florent, Cmiljanovic, Natasa, Cmiljanovic, Vladimir, Bohnacker, Thomas, Melone, Anna, Marone, Romina, Jackson, Eileen, Zhang, Xuxiao, Sele, Alexander, Borsari, Chiara, Mestan, Jürgen, Hebeisen, Paul, Hillmann, Petra, Giese, Bernd, Zvelebil, Marketa, Fabbro, Doriano, Williams, Roger L, Rageot, Denise, Wymann, Matthias P

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Targeting Phosphoinositide 3-Kinase - Five Decades of Chemical Space Exploration von Borsari, Chiara, Wymann, Matthias P.

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Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention von Bohnacker, Thomas, Prota, Andrea E., Beaufils, Florent, Burke, John E., Melone, Anna, Inglis, Alison J., Rageot, Denise, Sele, Alexander M., Cmiljanovic, Vladimir, Cmiljanovic, Natasa, Bargsten, Katja, Aher, Amol, Akhmanova, Anna, Díaz, J. Fernando, Fabbro, Doriano, Zvelebil, Marketa, Williams, Roger L., Steinmetz, Michel O., Wymann, Matthias P.

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New molecular and therapeutic insights into canine diffuse large B-cell lymphoma elucidates the role of the dog as a model for human disease von Aresu, Luca, Ferraresso, Serena, Marconato, Laura, Cascione, Luciano, Napoli, Sara, Gaudio, Eugenio, Kwee, Ivo, Tarantelli, Chiara, Testa, Andrea, Maniaci, Chiara, Ciulli, Alessio, Hillmann, Petra, Bohnacker, Thomas, Wymann, Matthias P, Comazzi, Stefano, Milan, Massimo, Riondato, Fulvio, Rovere, Giulia Dalla, Giantin, Mery, Giannuzzi, Diana, Bertoni, Francesco

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Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology von Takeda, Andrew J., Maher, Timothy J., Zhang, Yu, Lanahan, Stephen M., Bucklin, Molly L., Compton, Susan R., Tyler, Paul M., Comrie, William A., Matsuda, Makoto, Olivier, Kenneth N., Pittaluga, Stefania, McElwee, Joshua J., Long Priel, Debra A., Kuhns, Douglas B., Williams, Roger L., Mustillo, Peter J., Wymann, Matthias P., Koneti Rao, V., Lucas, Carrie L.

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Lipid signalling in disease von Wymann, Matthias P, Schneiter, Roger

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Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation von Barthwal, Manoj K, Anzinger, Joshua J, Xu, Qing, Bohnacker, Thomas, Wymann, Matthias P, Kruth, Howard S

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Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ von Perino, Alessia, Ghigo, Alessandra, Ferrero, Enrico, Morello, Fulvio, Santulli, Gaetano, Baillie, George S, Damilano, Federico, Dunlop, Allan J, Pawson, Catherine, Walser, Romy, Levi, Renzo, Altruda, Fiorella, Silengo, Lorenzo, Langeberg, Lorene K, Neubauer, Gitte, Heymans, Stephane, Lembo, Giuseppe, Wymann, Matthias P, Wetzker, Reinhard, Houslay, Miles D, Iaccarino, Guido, Scott, John D, Hirsch, Emilio

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Disease-related mutations in PI3K gamma disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors von Rathinaswamy, Manoj K., Gaieb, Zied, Fleming, Kaelin D., Borsari, Chiara, Harris, Noah J., Moeller, Brandon E., Wymann, Matthias P., Amaro, Rommie E., Burke, John E.

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Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature von Reichel, Christoph A, Lerchenberger, Max, Uhl, Bernd, Rehberg, Markus, Berberich, Nina, Zahler, Stefan, Wymann, Matthias P, Krombach, Fritz

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The Chemical Biology of Phosphoinositide 3-Kinases von Wymann, Matthias P., Schultz, Carsten

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PI3K gamma Regulatory Protein p84 Determines Mast Cell Sensitivity to Ras Inhibition-Moving Towards Cell Specific PI3K Targeting? von Jin, Julie R., Gogvadze, Elena, Xavier, Ana R., Bohnacker, Thomas, Voelzmann, Jan, Wymann, Matthias P.

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Nuclear and cytosolic fractions of SOX2 synergize as transcriptional and translational co-regulators of cell fate von Schaefer, Thorsten, Mittal, Nitish, Wang, Hui, Ataman, Meric, Candido, Silvia, Lötscher, Jonas, Velychko, Sergiy, Tintignac, Lionel, Bock, Thomas, Börsch, Anastasiya, Baßler, Jochen, Rao, Tata Nageswara, Zmajkovic, Jakub, Roffeis, Sarah, Löliger, Jordan, Jacob, Francis, Dumlin, Alain, Schürch, Christoph, Schmidt, Alexander, Skoda, Radek C., Wymann, Matthias P., Hess, Christoph, Schöler, Hans R., Zaehres, Holm, Hurt, Ed, Zavolan, Mihaela, Lengerke, Claudia

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Cell-Permeant and Photocleavable Chemical Inducer of Dimerization von Zimmermann, Mirjam, Cal, Ruben, Janett, Elia, Hoffmann, Viktor, Bochet, Christian G., Constable, Edwin, Beaufils, Florent, Wymann, Matthias P.

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Two-drug trick to target the brain blocks toxicity in the body von Wymann, Matthias P., Borsari, Chiara

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Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy von Collmann, Emilie, PhD, Bohnacker, Thomas, PhD, Marone, Romina, PhD, Dawson, Janet, PhD, Rehberg, Markus, PhD, Stringer, Rowan, PhD, Krombach, Fritz, PhD, Burkhart, Christoph, PhD, Hirsch, Emilio, PhD, Hollingworth, Gregory J., PhD, Thomas, Matthew, PhD, Wymann, Matthias P., PhD

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C-C motif chemokine CCL3 and canonical neutrophil attractants promote neutrophil extravasation through common and distinct mechanisms von Reichel, Christoph A., Puhr-Westerheide, Daniel, Zuchtriegel, Gabriele, Uhl, Bernd, Berberich, Nina, Zahler, Stefan, Wymann, Matthias P., Luckow, Bruno, Krombach, Fritz

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The Forkhead Transcription Factor FOXO3a Increases Phosphoinositide-3 Kinase/Akt Activity in Drug-Resistant Leukemic Cells through Induction of PIK3CA Expression von Hui, Rosaline C.-Y., Gomes, Ana R., Constantinidou, Demetra, Costa, Joana R., Karadedou, Christina T., Fernandez de Mattos, Silvia, Wymann, Matthias P., Brosens, Jan J., Schulze, Almut, Lam, Eric W.-F.

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The role of PI3Kγ in the immune system: new insights and translational implications von Lanahan, Stephen M., Wymann, Matthias P., Lucas, Carrie L.

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