Targeting phosphoinositide 3-kinase—Moving towards therapy von Marone, Romina, Cmiljanovic, Vladimir, Giese, Bernd, Wymann, Matthias P.

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5‑(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)­pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Ca... von Beaufils, Florent, Cmiljanovic, Natasa, Cmiljanovic, Vladimir, Bohnacker, Thomas, Melone, Anna, Marone, Romina, Jackson, Eileen, Zhang, Xuxiao, Sele, Alexander, Borsari, Chiara, Mestan, Jürgen, Hebeisen, Paul, Hillmann, Petra, Giese, Bernd, Zvelebil, Marketa, Fabbro, Doriano, Williams, Roger L, Rageot, Denise, Wymann, Matthias P

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Targeting Phosphoinositide 3-Kinase - Five Decades of Chemical Space Exploration von Borsari, Chiara, Wymann, Matthias P.

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Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention von Bohnacker, Thomas, Prota, Andrea E., Beaufils, Florent, Burke, John E., Melone, Anna, Inglis, Alison J., Rageot, Denise, Sele, Alexander M., Cmiljanovic, Vladimir, Cmiljanovic, Natasa, Bargsten, Katja, Aher, Amol, Akhmanova, Anna, Díaz, J. Fernando, Fabbro, Doriano, Zvelebil, Marketa, Williams, Roger L., Steinmetz, Michel O., Wymann, Matthias P.

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New molecular and therapeutic insights into canine diffuse large B-cell lymphoma elucidates the role of the dog as a model for human disease von Aresu, Luca, Ferraresso, Serena, Marconato, Laura, Cascione, Luciano, Napoli, Sara, Gaudio, Eugenio, Kwee, Ivo, Tarantelli, Chiara, Testa, Andrea, Maniaci, Chiara, Ciulli, Alessio, Hillmann, Petra, Bohnacker, Thomas, Wymann, Matthias P, Comazzi, Stefano, Milan, Massimo, Riondato, Fulvio, Rovere, Giulia Dalla, Giantin, Mery, Giannuzzi, Diana, Bertoni, Francesco

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Lipid signalling in disease von Wymann, Matthias P, Schneiter, Roger

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Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology von Takeda, Andrew J., Maher, Timothy J., Zhang, Yu, Lanahan, Stephen M., Bucklin, Molly L., Compton, Susan R., Tyler, Paul M., Comrie, William A., Matsuda, Makoto, Olivier, Kenneth N., Pittaluga, Stefania, McElwee, Joshua J., Long Priel, Debra A., Kuhns, Douglas B., Williams, Roger L., Mustillo, Peter J., Wymann, Matthias P., Koneti Rao, V., Lucas, Carrie L.

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Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ von Perino, Alessia, Ghigo, Alessandra, Ferrero, Enrico, Morello, Fulvio, Santulli, Gaetano, Baillie, George S, Damilano, Federico, Dunlop, Allan J, Pawson, Catherine, Walser, Romy, Levi, Renzo, Altruda, Fiorella, Silengo, Lorenzo, Langeberg, Lorene K, Neubauer, Gitte, Heymans, Stephane, Lembo, Giuseppe, Wymann, Matthias P, Wetzker, Reinhard, Houslay, Miles D, Iaccarino, Guido, Scott, John D, Hirsch, Emilio

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Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors von Rathinaswamy, Manoj K, Gaieb, Zied, Fleming, Kaelin D, Borsari, Chiara, Harris, Noah J, Moeller, Brandon E, Wymann, Matthias P, Amaro, Rommie E, Burke, John E

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The Chemical Biology of Phosphoinositide 3-Kinases von Wymann, Matthias P., Schultz, Carsten

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Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation von Barthwal, Manoj K, Anzinger, Joshua J, Xu, Qing, Bohnacker, Thomas, Wymann, Matthias P, Kruth, Howard S

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Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature von Reichel, Christoph A, Lerchenberger, Max, Uhl, Bernd, Rehberg, Markus, Berberich, Nina, Zahler, Stefan, Wymann, Matthias P, Krombach, Fritz

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PI3K γ Regulatory Protein p84 Determines Mast Cell Sensitivity to Ras Inhibition-Moving Towards Cell Specific PI3K Targeting? von Jin, Julie R, Gogvadze, Elena, Xavier, Ana R, Bohnacker, Thomas, Voelzmann, Jan, Wymann, Matthias P

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Nuclear and cytosolic fractions of SOX2 synergize as transcriptional and translational co-regulators of cell fate von Schaefer, Thorsten, Mittal, Nitish, Wang, Hui, Ataman, Meric, Candido, Silvia, Lötscher, Jonas, Velychko, Sergiy, Tintignac, Lionel, Bock, Thomas, Börsch, Anastasiya, Baßler, Jochen, Rao, Tata Nageswara, Zmajkovic, Jakub, Roffeis, Sarah, Löliger, Jordan, Jacob, Francis, Dumlin, Alain, Schürch, Christoph, Schmidt, Alexander, Skoda, Radek C., Wymann, Matthias P., Hess, Christoph, Schöler, Hans R., Zaehres, Holm, Hurt, Ed, Zavolan, Mihaela, Lengerke, Claudia

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Cell-Permeant and Photocleavable Chemical Inducer of Dimerization von Zimmermann, Mirjam, Cal, Ruben, Janett, Elia, Hoffmann, Viktor, Bochet, Christian G., Constable, Edwin, Beaufils, Florent, Wymann, Matthias P.

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Two-drug trick to target the brain blocks toxicity in the body von Wymann, Matthias P., Borsari, Chiara

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The role of PI3Kγ in the immune system: new insights and translational implications von Lanahan, Stephen M., Wymann, Matthias P., Lucas, Carrie L.

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Specific Requirement of the p84/p110γ Complex of PI3Kγ for Antibody‐Activated, Inducible Cross‐Presentation in Murine Type 2 DCs von Koumantou, Despoina, Adiko, Aimé Cézaire, Bourdely, Pierre, Nugue, Mathilde, Boedec, Erwan, El‐Benna, Jamel, Monteiro, Renato, Saveanu, Cosmin, Laffargue, Muriel, Wymann, Matthias P., Dalod, Marc, Guermonprez, Pierre, Saveanu, Loredana

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Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy von Collmann, Emilie, PhD, Bohnacker, Thomas, PhD, Marone, Romina, PhD, Dawson, Janet, PhD, Rehberg, Markus, PhD, Stringer, Rowan, PhD, Krombach, Fritz, PhD, Burkhart, Christoph, PhD, Hirsch, Emilio, PhD, Hollingworth, Gregory J., PhD, Thomas, Matthew, PhD, Wymann, Matthias P., PhD

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C-C motif chemokine CCL3 and canonical neutrophil attractants promote neutrophil extravasation through common and distinct mechanisms von Reichel, Christoph A., Puhr-Westerheide, Daniel, Zuchtriegel, Gabriele, Uhl, Bernd, Berberich, Nina, Zahler, Stefan, Wymann, Matthias P., Luckow, Bruno, Krombach, Fritz

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