Strategies for designing synthetic immune agonists von Wu, Tom Y.‐H.

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Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6‑Azaindole Derivative GNF2133 von Liu, Yahu A, Jin, Qihui, Zou, Yefen, Ding, Qiang, Yan, Shanshan, Wang, Zhicheng, Hao, Xueshi, Nguyen, Bao, Zhang, Xiaoyue, Pan, Jianfeng, Mo, Tingting, Jacobsen, Kate, Lam, Thanh, Wu, Tom Y.-H, Petrassi, H. Michael, Bursulaya, Badry, DiDonato, Michael, Gordon, W. Perry, Liu, Bo, Baaten, Janine, Hill, Robert, Nguyen-Tran, Vân, Qiu, Minhua, Zhang, You-Qing, Kamireddy, Anwesh, Espinola, Sheryll, Deaton, Lisa, Ha, Sukwon, Harb, George, Jia, Yong, Li, Jing, Shen, Weijun, Schumacher, Andrew M, Colman, Karyn, Glynne, Richard, Pan, Shifeng, McNamara, Peter, Laffitte, Bryan, Meeusen, Shelly, Molteni, Valentina, Loren, Jon

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Incorporation of Phosphonate into Benzonaphthyridine Toll-like Receptor 7 Agonists for Adsorption to Aluminum Hydroxide von Cortez, Alex, Li, Yongkai, Miller, Andrew T, Zhang, Xiaoyue, Yue, Kathy, Maginnis, Jillian, Hampton, Janice, Hall, De Shon, Shapiro, Michael, Nayak, Bishnu, D’Oro, Ugo, Li, Chun, Skibinski, David, Mbow, M. Lamine, Singh, Manmohan, O’Hagan, Derek T, Cooke, Michael P, Valiante, Nicholas M, Wu, Tom Y.-H

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A Dual Inhibitor of DYRK1A and GSK3β for β‐Cell Proliferation: Aminopyrazine Derivative GNF4877 von Liu, Yahu A., Jin, Qihui, Ding, Qiang, Hao, Xueshi, Mo, Tingting, Yan, Shanshan, Zou, Yefen, Huang, Zhihong, Zhang, Xiaoyue, Gao, Wenqi, Wu, Tom Y.‐H., Li, Chun, Bursalaya, Badry, Di Donato, Michael, Zhang, You‐Qing, Deaton, Lisa, Shen, Weijun, Taylor, Brandon, Kamireddy, Anwesh, Harb, George, Li, Jing, Jia, Yong, Schumacher, Andrew M., Laffitte, Bryan, Glynne, Richard, Pan, Shifeng, McNamara, Peter, Molteni, Valentina, Loren, Jon

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Development and Characterization of Nonpeptidic Small Molecule Inhibitors of the XIAP/Caspase-3 Interaction von Wu, Tom Y.H, Wagner, Klaus W, Bursulaya, Badry, Schultz, Peter G, Deveraux, Quinn L

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Synthetic Small Molecules That Control Stem Cell Fate von Ding, Sheng, Tom Y. H. Wu, Brinker, Achim, Peters, Eric C., Hur, Wooyoung, Gray, Nathanael S., Schultz, Peter G.

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Stable Nanoemulsions for the Delivery of Small Molecule Immune Potentiators von Lodaya, Rushit N., Brito, Luis A., Wu, Tom Y.H., Miller, Andrew T., Otten, Gillis R., Singh, Manmohan, O'Hagan, Derek T.

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Liver‐Targeted Toll‐Like Receptor 7 Agonist Combined With Entecavir Promotes a Functional Cure in the Woodchuck Model of Hepatitis B Virus von Korolowizc, Kyle E., Li, Bin, Huang, Xu, Yon, Changsuek, Rodrigo, Evelyn, Corpuz, Manny, Plouffe, David M., Kallakury, Bhaskar V., Suresh, Manasa, Wu, Tom Y.‐H., Miller, Andrew T., Menne, Stephan

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Pancreas-Specific Delivery of β-Cell Proliferating Small Molecules von Hao, Xueshi, Jin, Qihui, Va, Porino, Li, Chun, Shen, Weijun, Laffitte, Bryan, Wu, Tom Y.-H.

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Biarylimidazoles as inhibitors of microsomal prostaglandin E 2 synthase-1 von Wu, Tom Y.H., Juteau, Hélène, Ducharme, Yves, Friesen, Richard W., Guiral, Sébastien, Dufresne, Lynn, Poirier, Hugo, Salem, Myriam, Riendeau, Denis, Mancini, Joseph, Brideau, Christine

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Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1 von WU, Tom Y. H, JUTEAU, Hélène, BRIDEAU, Christine, DUCHARME, Yves, FRIESEN, Richard W, GUIRAL, Sébastien, DUFRESNE, Lynn, POIRIER, Hugo, SALEM, Myriam, RIENDEAU, Denis, MANCINI, Joseph

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Discovery of 5‑(3,4-Difluorophenyl)-3-(pyrazol-4-yl)-7-azaindole (GNF3809) for β‑Cell Survival in Type 1 Diabetes von Huang, Zhihong, Tremblay, Matthew S, Wu, Tom Y.-H, Ding, Qiang, Hao, Xueshi, Baaten, Janine, Hill, Robert, Liu, Bo, Meeusen, Shelly, Zou, Yefen, Yan, Shanshan, Jia, Yong, Nguyen-Tran, Van, Shen, Weijun, Bhat, Ganesh, Glynne, Richard, Laffitte, Bryan, Li, Jing, Molteni, Valentina, Liu, Yahu A

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A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells von Santone, Melissa, Aprea, Susanna, Wu, Tom Y H, Cooke, Michael P, Mbow, M Lamine, Valiante, Nicholas M, Rush, James S, Dougan, Stephanie, Avalos, Ana, Ploegh, Hidde, De Gregorio, Ennio, Buonsanti, Cecilia, D'Oro, Ugo

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One-Pot Two-Step Microwave-Assisted Reaction in Constructing 4,5-Disubstituted Pyrazolopyrimidines von Wu, Tom Y. H, Schultz, Peter G, Ding, Sheng

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Topical SMIP-7.7, a Toll–Like Receptor 7 Agonist, Protects against Genital Herpes Simplex Virus Type-2 Disease in the Guinea Pig Model of Genital Herpes von Bernstein, David I, Cardin, Rhonda D, Bravo, Fernando J, Earwood, Julie, Clark, Jennifer R, Li, Yongkai, Mishra, Pranab, Li, Chun, Nayak, Bishnu P, Miller, Andrew T, Wu, Tom Y-H, Cooke, Michael P, Valiante, Nicholas M

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Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group von Wu, Tom Y.H., Hassig, Christian, Wu, Yiqin, Ding, Sheng, Schultz, Peter G.

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A Genome-Wide Overexpression Screen in Yeast for Small-Molecule Target Identification von Luesch, Hendrik, Wu, Tom Y.H., Ren, Pingda, Gray, Nathanael S., Schultz, Peter G., Supek, Frantisek

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Solid-Phase Synthesis of 2,3,5-Trisubstituted Indoles von Wu, Tom Y. H, Ding, Sheng, Gray, Nathanael S, Schultz, Peter G

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A Versatile Linkage Strategy for Solid-Phase Synthesis of N,N-Dimethyltryptamines and β-Carbolines von Wu, Tom Y. H, Schultz, Peter G

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Applying chemical tools to the discovery of novel regenerative medicine von Wu, Tom Y.H., Ding, Sheng

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