Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1 von Choi, Michael Y, Widhopf, George F, Wu, Christina C.N, Cui, Bing, Lao, Fitzgerald, Sadarangani, Anil, Cavagnaro, Joy, Prussak, Charles, Carson, Dennis A, Jamieson, Catriona, Kipps, Thomas J

Volltext

A FZD7-specific Antibody-Drug Conjugate Induces Ovarian Tumor Regression in Preclinical Models von Do, Myan, Wu, Christina C N, Sonavane, Pooja R, Juarez, Edwin F, Adams, Stephen R, Ross, Jason, Rodriguez Y Baena, Alessandra, Patel, Charmi, Mesirov, Jill P, Carson, Dennis A, Advani, Sunil J, Willert, Karl

Volltext

Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand von Wu, Christina C.N, Hayashi, Tomoko, Takabayashi, Kenji, Sabet, Mojgan, Smee, Donald F, Guiney, Donald D, Cottam, Howard B, Carson, Dennis A

Volltext

Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists von Jin, Guangyi, Wu, Christina C.N., Tawatao, Rommel I., Chan, Michael, Carson, Dennis A., Cottam, Howard B.

Volltext

Ovarian cancer stem cells express ROR1, which can be targeted for anti–cancer-stem-cell therapy von Zhang, Suping, Cui, Bing, Lai, Hsien, Liu, Grace, Ghia, Emanuela M., Widhopf, George F., Zhang, Zhuhong, Wu, Christina C. N., Chen, Liguang, Wu, Rongrong, Schwab, Richard, Carson, Dennis A., Kipps, Thomas J.

Volltext

Abstract 489: Buoyant targeted microbubble technology provides efficient and superior quality of hematopoietic stem cells isolated from umbilical cord blood von Shi, Guixin, Wu, Christina C.N., Darmadi, Sean, Wang, Zhiyong, Carson, Dennis, Liu, Yu-Tsueng, Liu, Yu-Tsueng

Volltext

Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44 von Zhang, Suping, Wu, Christina C. N., Fecteau, Jessie-F., Cui, Bing, Chen, Liguang, Zhang, Ling, Wu, Rongrong, Rassenti, Laura, Lao, Fitzgerald, Weigand, Stefan, Kipps, Thomas J.

Volltext

Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia von Wu, Raymond P., Hayashi, Tomoko, Cottam, Howard B., Jin, Guangyi, Yao, Shiyin, Wu, Christina C. N., Rosenbach, Michael D., Corr, Maripat, Schwab, Richard B., Carson, Dennis A.

Volltext

Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells von Gumber, Diana, Do, Myan, Kumar, Neya Suresh, Sonavane, Pooja R., Wu, Christina C. N., Cruz, Luisjesus S., Grainger, Stephanie, Carson, Dennis, Gaasterland, Terry, Willert, Karl

Volltext

Novel Dormancy Mechanism of Castration Resistance in Bone Metastatic Prostate Cancer Organoids von Lee, Sanghee, Mendoza, Theresa R, Burner, Danielle N, Muldong, Michelle T, Wu, Christina C N, Arreola-Villanueva, Catalina, Zuniga, Abril, Greenburg, Olga, Zhu, William Y, Murtadha, Jamillah, Koutouan, Evodie, Pineda, Naomi, Pham, Hao, Kang, Sung-Gu, Kim, Hyun Tae, Pineda, Gabriel, Lennon, Kathleen M, Cacalano, Nicholas A, Jamieson, Catriona H M, Kane, Christopher J, Kulidjian, Anna A, Gaasterland, Terry, Jamieson, Christina A M

Volltext

Antitumor effect and mechanism of FZD7 polypeptide vaccine von Hua, Zhongke, Han, Yu, Liu, Kan, Yang, Hua, Zhou, Cai, Chen, Fengyi, Nie, Shenglan, Li, Mengqing, Yu, Qinyao, Wei, Yunpeng, Wu, Christina C. N., Wang, Xiaomei

Volltext

Synthesis and Immunological Characterization of Toll-Like Receptor 7 Agonistic Conjugates von Chan, Michael, Hayashi, Tomoko, Kuy, Crystal S, Gray, Christine S, Wu, Christina C. N, Corr, Maripat, Wrasidlo, Wolfgang, Cottam, Howard B, Carson, Dennis A

Volltext

Activation of Anti-Hepatitis C Virus Responses via Toll-like Receptor 7 von Lee, Jongdae, Wu, Christina C. N., Lee, Ki Jeong, Chuang, Tsung-Hsien, Katakura, Kyoko, Liu, Yu-Tsueng, Chan, Michael, Tawatao, Rommel, Chung, Michelle, Shen, Carol, Cottam, Howard B., Lai, Michael M. C., Raz, Eyal, Carson, Dennis A.

Volltext

Synthetic and immunological studies on the OCT4 immunodominant motif antigen-based anti-cancer vaccine von Chen, Tingting, Liu, Kan, Xu, Jiangyao, Zhan, Tianying, Liu, Maixian, Li, Li, Yang, Zhiwen, Yuan, Shuping, Zou, Wenyi, Lin, Guimiao, Carson, Dennis A., Wu, Christina C. N., Wang, Xiaomei

Volltext

Inhibition of Wnt Signaling By Dimethyl Fumarate Results in in Vitro and in Vivo Clearance of Chronic Lymphocytic Leukemia Cells and Has Additive Activity with Ibrutinib von Wu, Christina C.N., Lao, Fitzgerald, Li, Hongying, Rassenti, Laura, Kipps, Thomas J., Messer, Karen, Carson, Dennis A., Choi, Michael Y.

Volltext

Inhibition Of Wnt Signaling In Chronic Lymphocytic Leukemia Has Synergistic Cytotoxicity With Ibrutinib von Wu, Christina C.N., Choi, Michael Y., Lao, Fitzgerald, Kipps, Thomas J., Carson, Dennis A.

Volltext

Amide derivatives of ethacrynic acid: Synthesis and evaluation as antagonists of Wnt/β-catenin signaling and CLL cell survival von Jin, Guangyi, Lu, Desheng, Yao, Shiyin, Wu, Christina C.N., Liu, Jerry X., Carson, Dennis A., Cottam, Howard B.

Volltext

Cirmtuzumab Vedotin (UC-961ADC3), An Anti-ROR1-Monomethyl Auristatin E Antibody-Drug Conjugate, Is a Potential Treatment For ROR1-Positive Leukemia and Solid Tumors von Cui, Bing, Widhopf, George F., Prussak, Charles E., Wu, Christina C.N., Sadarangani, Anil, Zhang, Suping, Lao, Fitzgerald, Jamieson, Catriona HM, Carson, Dennis A., Kipps, Thomas J.

Volltext

Necessity of Oligonucleotide Aggregation for Toll-like Receptor 9 Activation von Wu, Christina C.N., Lee, Jongdae, Raz, Eyal, Corr, Maripat, Carson, Dennis A.

Volltext

Increased Activity of Aldehyde Dehydrogenase, a Stem/Progenitor Cell Marker, in Chronic Lymphocytic Leukemia von Wu, Raymond P., Wu, Christina C.N., Hayashi, Tomoko, Rassenti, Laura Z., Kipps, Thomas J., Carson, Dennis A.

Volltext