Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs von Hadi, Kevin, Yao, Xiaotong, Behr, Julie M, Deshpande, Aditya, Xanthopoulakis, Charalampos, Tian, Huasong, Kudman, Sarah, Rosiene, Joel, Darmofal, Madison, DeRose, Joseph, Mortensen, Rick, Adney, Emily M, Shaiber, Alon, Gajic, Zoran, Sigouros, Michael, Eng, Kenneth, Wala, Jeremiah A, Wrzeszczyński, Kazimierz O, Arora, Kanika, Shah, Minita, Emde, Anne-Katrin, Felice, Vanessa, Frank, Mayu O, Darnell, Robert B, Ghandi, Mahmoud, Huang, Franklin, Dewhurst, Sally, Maciejowski, John, de Lange, Titia, Setton, Jeremy, Riaz, Nadeem, Reis-Filho, Jorge S, Powell, Simon, Knowles, David A, Reznik, Ed, Mishra, Bud, Beroukhim, Rameen, Zody, Michael C, Robine, Nicolas, Oman, Kenji M, Sanchez, Carissa A, Kuhner, Mary K, Smith, Lucian P, Galipeau, Patricia C, Paulson, Thomas G, Reid, Brian J, Li, Xiaohong, Wilkes, David, Sboner, Andrea, Mosquera, Juan Miguel, Elemento, Olivier, Imielinski, Marcin

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The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes von Basturk, Olca, Tan, Marcus, Bhanot, Umesh, Allen, Peter, Adsay, Volkan, Scott, Sasinya N, Shah, Ronak, Berger, Michael F, Askan, Gokce, Dikoglu, Esra, Jobanputra, Vaidehi, Wrzeszczynski, Kazimierz O, Sigel, Carlie, Iacobuzio-Donahue, Christine, Klimstra, David S

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Identification of tumor suppressors and oncogenes from genomic and epigenetic features in ovarian cancer von Wrzeszczynski, Kazimierz O, Varadan, Vinay, Byrnes, James, Lum, Elena, Kamalakaran, Sitharthan, Levine, Douglas A, Dimitrova, Nevenka, Zhang, Michael Q, Lucito, Robert

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Loss of DOK2 induces carboplatin resistance in ovarian cancer via suppression of apoptosis von Lum, Elena, Vigliotti, Michele, Banerjee, Nilanjana, Cutter, Noelle, Wrzeszczynski, Kazimierz O, Khan, Sohail, Kamalakaran, Sitharthan, Levine, Douglas A, Dimitrova, Nevenka, Lucito, Robert

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A quantitative proteomics-based signature of platinum sensitivity in ovarian cancer cell lines von Fan, Gaofeng, Wrzeszczynski, Kazimierz O, Fu, Cexiong, Su, Gang, Pappin, Darryl J, Lucito, Robert, Tonks, Nicholas K

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Multiregional genetic evolution of metastatic uveal melanoma von Rodriguez, Daniel A., Yang, Jessica, Durante, Michael A., Shoushtari, Alexander N., Moschos, Stergios J., Wrzeszczynski, Kazimierz O., Harbour, J. William, Carvajal, Richard D.

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Physical protein–protein interactions predicted from microarrays von Soong, Ta-tsen, Wrzeszczynski, Kazimierz O., Rost, Burkhard

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A recurrent novel MGA-NUTM1 fusion identifies a new subtype of high-grade spindle cell sarcoma von Diolaiti, Daniel, Dela Cruz, Filemon S, Gundem, Gunes, Bouvier, Nancy, Boulad, Mathieu, Zhang, Yanming, Chou, Alexander J, Dunkel, Ira J, Sanghvi, Rashesh, Shah, Minita, Geiger, Heather, Rahman, Sadia, Felice, Vanessa, Wrzeszczynski, Kazimierz O, Darnell, Robert B, Antonescu, Cristina R, French, Christopher A, Papaemmanuil, Elli, Kung, Andrew L, Shukla, Neerav

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Functional Mutation of SMAC/DIABLO, Encoding a Mitochondrial Proapoptotic Protein, Causes Human Progressive Hearing Loss DFNA64 von Cheng, Jing, Zhu, Yuhua, He, Sudan, Lu, Yanping, Chen, Jing, Han, Bing, Petrillo, Marco, Wrzeszczynski, Kazimierz O., Yang, Shiming, Dai, Pu, Zhai, Suoqiang, Han, Dongyi, Zhang, Michael Q., Li, Wei, Liu, Xuezhong, Li, Huawei, Chen, Zheng-Yi, Yuan, Huijun

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Analytical demands to use whole-genome sequencing in precision oncology von Meggendorfer, Manja, Jobanputra, Vaidehi, Wrzeszczynski, Kazimierz O., Roepman, Paul, de Bruijn, Ewart, Cuppen, Edwin, Buttner, Reinhard, Caldas, Carlos, Grimmond, Sean, Mullighan, Charles G., Elemento, Olivier, Rosenquist, Richard, Schuh, Anna, Haferlach, Torsten

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Clinical interpretation of whole-genome and whole-transcriptome sequencing for precision oncology von Jobanputra, Vaidehi, Wrzeszczynski, Kazimierz O, Buttner, Reinhard, Caldas, Carlos, Cuppen, Edwin, Grimmond, Sean, Haferlach, Torsten, Mullighan, Charles, Schuh, Anna, Elemento, Olivier

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Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductal papillary mucinous neoplasm and ductal adenocarcinoma von Basturk, Olca, Berger, Michael F, Yamaguchi, Hiroshi, Adsay, Volkan, Askan, Gokce, Bhanot, Umesh K, Zehir, Ahmet, Carneiro, Fatima, Hong, Seung-Mo, Zamboni, Giuseppe, Dikoglu, Esra, Jobanputra, Vaidehi, Wrzeszczynski, Kazimierz O, Balci, Serdar, Allen, Peter, Ikari, Naoki, Takeuchi, Shoko, Akagawa, Hiroyuki, Kanno, Atsushi, Shimosegawa, Tooru, Morikawa, Takanori, Motoi, Fuyuhiko, Unno, Michiaki, Higuchi, Ryota, Yamamoto, Masakazu, Shimizu, Kyoko, Furukawa, Toru, Klimstra, David S

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Whole Genome Sequencing-Based Discovery of Structural Variants in Glioblastoma von Wrzeszczynski, Kazimierz O., Felice, Vanessa, Shah, Minita, Rahman, Sadia, Emde, Anne-Katrin, Jobanputra, Vaidehi, O. Frank, Mayu, Darnell, Robert B.

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Analytical Validation of Clinical Whole-Genome and Transcriptome Sequencing of Patient-Derived Tumors for Reporting Targetable Variants in Cancer von Wrzeszczynski, Kazimierz O., Felice, Vanessa, Abhyankar, Avinash, Kozon, Lukasz, Geiger, Heather, Manaa, Dina, London, Ferrah, Robinson, Dino, Fang, Xiaolan, Lin, David, Lamendola-Essel, Michelle F., Khaira, Depinder, Dikoglu, Esra, Emde, Anne-Katrin, Robine, Nicolas, Shah, Minita, Arora, Kanika, Basturk, Olca, Bhanot, Umesh, Kentsis, Alex, Mansukhani, Mahesh M., Bhagat, Govind, Jobanputra, Vaidehi

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RNA Sequencing of Primary Cutaneous and Breast-Implant Associated Anaplastic Large Cell Lymphomas Reveals Infrequent Fusion Transcripts and Upregulation of PI3K/AKT Signaling via N... von Di Napoli, Arianna, Vacca, Davide, Bertolazzi, Giorgio, Lopez, Gianluca, Piane, Maria, Germani, Aldo, Rogges, Evelina, Pepe, Giuseppina, Santanelli Di Pompeo, Fabio, Salgarello, Marzia, Jobanputra, Vaidehi, Hsiao, Susan, Wrzeszczynski, Kazimierz O, Berti, Emilio, Bhagat, Govind

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Identification of targetable BRAF ΔN486_P490 variant by whole-genome sequencing leading to dabrafenib-induced remission of a BRAF -mutant pancreatic adenocarcinoma von Wrzeszczynski, Kazimierz O, Rahman, Sadia, Frank, Mayu O, Arora, Kanika, Shah, Minita, Geiger, Heather, Felice, Vanessa, Manaa, Dina, Dikoglu, Esra, Khaira, Depinder, Chimpiri, A Rao, Michelini, Vanessa V, Jobanputra, Vaidehi, Darnell, Robert B, Powers, Scott, Choi, Minsig

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Metastatic pediatric sclerosing epithelioid fibrosarcoma von Woods, Andrew D, Purohit, Reshma, Mitchell, Laura Crocker, Collier, John R, Collier, Katherine A, Lathara, Melvin, Learned, Katrina, Vaske, Olena, Geiger, Heather, Wrzeszczynski, Kazimierz O, Jobanputra, Vaidehi, Srinivasa, Ganapati, Rudzinski, Erin R, Whelan, Kimberly, Beierle, Elizabeth, Spunt, Sheri L, Keller, Charles, Wadhwa, Aman

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Abstract 4497: NYGC glioblastoma clinical outcomes pilot study: Discovering therapeutic potential in glioblastoma through integrative genomics von Wrzeszczynski, Kazimierz O., Robine, Nicolas, Vacic, Vladimir, Emde, Anne-Katrin, Chen, Bo-Juen, Liao, Will, Arora, Kanika, Shah, Minita, Grabowska, Ewa A., Felice, Vanessa, Dikoglu, Esra, Reeves, Catherine, Frank, Mayu, Jobanputra, Vaidehi, Zody, Michael C., Bloom, Toby, Darnell, Robert B.

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Sequencing and curation strategies for identifying candidate glioblastoma treatments von Frank, Mayu O, Koyama, Takahiko, Rhrissorrakrai, Kahn, Robine, Nicolas, Utro, Filippo, Emde, Anne-Katrin, Chen, Bo-Juen, Arora, Kanika, Shah, Minita, Geiger, Heather, Felice, Vanessa, Dikoglu, Esra, Rahman, Sadia, Fang, Alice, Vacic, Vladimir, Bergmann, Ewa A, Vogel, Julia L Moore, Reeves, Catherine, Khaira, Depinder, Calabro, Anthony, Kim, Duyang, Lamendola-Essel, Michelle F, Esteves, Cecilia, Agius, Phaedra, Stolte, Christian, Boockvar, John, Demopoulos, Alexis, Placantonakis, Dimitris G, Golfinos, John G, Brennan, Cameron, Bruce, Jeffrey, Lassman, Andrew B, Canoll, Peter, Grommes, Christian, Daras, Mariza, Diamond, Eli, Omuro, Antonio, Pentsova, Elena, Orange, Dana E, Harvey, Stephen J, Posner, Jerome B, Michelini, Vanessa V, Jobanputra, Vaidehi, Zody, Michael C, Kelly, John, Parida, Laxmi, Wrzeszczynski, Kazimierz O, Royyuru, Ajay K, Darnell, Robert B

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Comparing sequencing assays and human-machine analyses in actionable genomics for glioblastoma von Wrzeszczynski, Kazimierz O, Frank, Mayu O, Koyama, Takahiko, Rhrissorrakrai, Kahn, Robine, Nicolas, Utro, Filippo, Emde, Anne-Katrin, Chen, Bo-Juen, Arora, Kanika, Shah, Minita, Vacic, Vladimir, Norel, Raquel, Bilal, Erhan, Bergmann, Ewa A, Moore Vogel, Julia L, Bruce, Jeffrey N, Lassman, Andrew B, Canoll, Peter, Grommes, Christian, Harvey, Steve, Parida, Laxmi, Michelini, Vanessa V, Zody, Michael C, Jobanputra, Vaidehi, Royyuru, Ajay K, Darnell, Robert B

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