LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys von Adams, Andrew C, Halstead, Carolyn A, Hansen, Barbara C, Irizarry, Armando R, Martin, Jennifer A, Myers, Sharon R, Reynolds, Vincent L, Smith, Holly W, Wroblewski, Victor J, Kharitonenkov, Alexei

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Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319 von Kharitonenkov, Alexei, Beals, John M, Micanovic, Radmila, Strifler, Beth A, Rathnachalam, Radhakrishnan, Wroblewski, Victor J, Li, Shun, Koester, Anja, Ford, Amy M, Coskun, Tamer, Dunbar, James D, Cheng, Christine C, Frye, Christopher C, Bumol, Thomas F, Moller, David E

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Peripheral and central nervous system distribution of the CGRP neutralizing antibody [125I] galcanezumab in male rats von Johnson, Kirk W, Morin, S Michelle, Wroblewski, Victor J, Johnson, Michael P

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Generation and characterization of ixekizumab, a humanized monoclonal antibody that neutralizes interleukin-17A von Liu, Ling, Lu, Jirong, Allan, Barrett W, Tang, Ying, Tetreault, Jonathan, Chow, Chi-Kin, Barmettler, Barbra, Nelson, James, Bina, Holly, Huang, Lihua, Wroblewski, Victor J, Kikly, Kristine

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Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics von Datta-Mannan, Amita, Thangaraju, Arunkumar, Leung, Donmienne, Tang, Ying, Witcher, Derrick R, Lu, Jirong, Wroblewski, Victor J

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Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications von Theurl, Igor, Aigner, Elmar, Theurl, Milan, Nairz, Manfred, Seifert, Markus, Schroll, Andrea, Sonnweber, Thomas, Eberwein, Lukas, Witcher, Derrick R., Murphy, Anthony T., Wroblewski, Victor J., Wurz, Eva, Datz, Christian, Weiss, Guenter

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The Metabolic State of Diabetic Monkeys Is Regulated by Fibroblast Growth Factor-21 von Kharitonenkov, Alexei, Wroblewski, Victor J, Koester, Anja, Chen, Yun-Fei, Clutinger, Cathleen K, Tigno, Xenia T, Hansen, Barbara C, Shanafelt, Armen B, Etgen, Garret J

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A Modeling and Experimental Investigation of the Effects of Antigen Density, Binding Affinity, and Antigen Expression Ratio on Bispecific Antibody Binding to Cell Surface Targets von Rhoden, John J., Dyas, Gregory L., Wroblewski, Victor J.

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Application of FcRn binding assays to guide mAb development von Datta-Mannan, Amita, Wroblewski, Victor J

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The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies von Datta-Mannan, Amita, Lu, Jirong, Witcher, Derrick R, Leung, Donmienne, Tang, Ying, Wroblewski, Victor J

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Translational Pharmacodynamics of Calcitonin Gene-Related Peptide Monoclonal Antibody LY2951742 in a Capsaicin-Induced Dermal Blood Flow Model von Vermeersch, Steve, Benschop, Robert J, Van Hecken, Anne, Monteith, David, Wroblewski, Victor J, Grayzel, David, de Hoon, Jan, Collins, Emily C

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Aberrant bispecific antibody pharmacokinetics linked to liver sinusoidal endothelium clearance mechanism in cynomolgus monkeys von Datta-Mannan, Amita, Croy, Johnny E, Schirtzinger, Linda, Torgerson, Stacy, Breyer, Matthew, Wroblewski, Victor J

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Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB von Sonnweber, Thomas, Nachbaur, David, Schroll, Andrea, Nairz, Manfred, Seifert, Markus, Demetz, Egon, Haschka, David, Mitterstiller, Anna-Maria, Kleinsasser, Axel, Burtscher, Martin, Trübsbach, Susanne, Murphy, Anthony T, Wroblewski, Victor, Witcher, Derrick R, Mleczko-Sanecka, Katarzyna, Vecchi, Chiara, Muckenthaler, Martina U, Pietrangelo, Antonello, Theurl, Igor, Weiss, Günter

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Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry von Murphy, Anthony T., Witcher, Derrick R., Luan, Peng, Wroblewski, Victor J.

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FGF-21 as a novel metabolic regulator von Kharitonenkov, Alexei, Shiyanova, Tatiyana L, Koester, Anja, Ford, Amy M, Micanovic, Radmila, Galbreath, Elizabeth J, Sandusky, George E, Hammond, Lisa J, Moyers, Julie S, Owens, Rebecca A, Gromada, Jesper, Brozinick, Joseph T, Hawkins, Eric D, Wroblewski, Victor J, Li, De-Shan, Mehrbod, Farrokh, Jaskunas, S Richard, Shanafelt, Armen B

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In Vivo Deamidation Characterization of Monoclonal Antibody by LC/MS/MS von Huang, Lihua, Lu, Jirong, Wroblewski, Victor J, Beals, John M, Riggin, Ralph M

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Monoclonal Antibody Clearance: IMPACT OF MODULATING THE INTERACTION OF IgG WITH THE NEONATAL Fc RECEPTOR von Datta-Mannan, Amita, Witcher, Derrick R, Tang, Ying, Watkins, Jeffry, Wroblewski, Victor J

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Proteolytic cleavage of antigen extends the durability of an anti-PCSK9 monoclonal antibody[S] von Schroeder, Krista M., Beyer, Thomas P., Hansen, Ryan J., Han, Bomie, Pickard, Richard T., Wroblewski, Victor J., Kowala, Mark C., Eacho, Patrick I.

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Distinct mobilization of leukocytes and hematopoietic stem cells by CXCR4 peptide antagonist LY2510924 and monoclonal antibody LY2624587 von Peng, Sheng-Bin, Van Horn, Robert D, Yin, Tinggui, Brown, Robin M, Roell, William C, Obungu, Victor H, Ruegg, Charles, Wroblewski, Victor J, Raddad, Eyas, Stille, John R

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FcRn affinity-pharmacokinetic relationship of five human IgG4 antibodies engineered for improved in vitro FcRn binding properties in cynomolgus monkeys von Datta-Mannan, Amita, Chow, Chi-Kin, Dickinson, Craig, Driver, David, Lu, Jirong, Witcher, Derrick R, Wroblewski, Victor J

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