Abstract A54: Pantoprazole enhances the activity of docetaxel chemotherapy for solid tumors by inhibition of autophagy von TAN, QIAN, Joshua, Anthony, Saggar, Jasdeep K., Man, Yu, Lee, Carol CM, Wouters, Bradly R., Tannock, Ian F.

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Abstract 3829A: Pantoprazole enhances the activity of chemotherapy for solid tumors by inhibition of autophagy von Tan, Qian, Joshua, Anthony, Saggar, Jasdeep, Yu, Man, Lee, Carol M, Koritzinsky, Marianne, Wouters, Bradly R, Tannock, Ian F

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Hypoxia-activated prodrugs: paths forward in the era of personalised medicine von Hunter, Francis W, Wouters, Bradly G, Wilson, William R

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The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress von van Galen, Peter, Kreso, Antonija, Mbong, Nathan, Kent, David G., Fitzmaurice, Timothy, Chambers, Joseph E., Xie, Stephanie, Laurenti, Elisa, Hermans, Karin, Eppert, Kolja, Marciniak, Stefan J., Goodall, Jane C., Green, Anthony R., Wouters, Bradly G., Wienholds, Erno, Dick, John E.

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ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth von Bi, Meixia, Naczki, Christine, Koritzinsky, Marianne, Fels, Diane, Blais, Jaime, Hu, Nianping, Harding, Heather, Novoa, Isabelle, Varia, Mahesh, Raleigh, James, Scheuner, Donalyn, Kaufman, Randal J, Bell, John, Ron, David, Wouters, Bradly G, Koumenis, Constantinos

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Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs von Hunter, Francis W, Young, Richard J, Shalev, Zvi, Vellanki, Ravi N, Wang, Jingli, Gu, Yongchuan, Joshi, Naveen, Sreebhavan, Sreevalsan, Weinreb, Ilan, Goldstein, David P, Moffat, Jason, Ketela, Troy, Brown, Kevin R, Koritzinsky, Marianne, Solomon, Benjamin, Rischin, Danny, Wilson, William R, Wouters, Bradly G

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Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control von Koritzinsky, Marianne, Magagnin, Michaël G, van den Beucken, Twan, Seigneuric, Renaud, Savelkouls, Kim, Dostie, Josée, Pyronnet, Stéphane, Kaufman, Randal J, Weppler, Sherry A, Voncken, Jan Willem, Lambin, Philippe, Koumenis, Constantinos, Sonenberg, Nahum, Wouters, Bradly G

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Pantoprazole Affecting Docetaxel Resistance Pathways via Autophagy (PANDORA): Phase II Trial of High Dose Pantoprazole (Autophagy Inhibitor) with Docetaxel in Metastatic Castration... von Hansen, Aaron R., Tannock, Ian F., Templeton, Arnoud, Chen, Eric, Evans, Andrew, Knox, Jennifer, Prawira, Amy, Sridhar, Srikala S., Tan, Susie, Vera‐Badillo, Francisco, Wang, Lisa, Wouters, Bradly G., Joshua, Anthony M.

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Drug-induced reactive oxygen species (ROS) rely on cell membrane properties to exert anticancer effects von Molavian, Hamid R., Goldman, Aaron, Phipps, Colin J., Kohandel, Mohammad, Wouters, Bradly G., Sengupta, Shiladitya, Sivaloganathan, Sivabal

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Radiobiological Intercomparison of the 160 MeV and 230 MeV Proton Therapy Beams at the Harvard Cyclotron Laboratory and at Massachusetts General Hospital von Wouters, Bradly G., Skarsgard, Lloyd D., Gerweck, Leo E., Carabe-Fernandez, Alejandro, Wong, Michelle, Durand, Ralph E., Nielson, Deanna, Bussiere, Marc R., Wagner, Miles, Biggs, Peter, Paganetti, Harald, Suit, Herman D.

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Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian Cells von Seagroves, Tiffany N., Ryan, Heather E., Lu, Han, Wouters, Bradly G., Knapp, Merrill, Thibault, Pierre, Laderoute, Keith, Johnson, Randall S.

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NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4 von Jain, Pallavi, Dvorkin-Gheva, Anna, Mollen, Erik, Malbeteau, Lucie, Xie, Michael, Jessa, Fatima, Dhavarasa, Piriththiv, Chung, Stephen, Brown, Kevin R, Jang, Gun Ho, Vora, Parth, Notta, Faiyaz, Moffat, Jason, Hedley, David, Boutros, Paul C, Wouters, Bradly G, Koritzinsky, Marianne

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Time Between the First Day of Chemotherapy and the Last Day of Chest Radiation Is the Most Important Predictor of Survival in Limited-Disease Small-Cell Lung Cancer von DE RUYSSCHER, Dirk, PIJIS-JOHANNESMA, Madelon, VANSTEENKISTE, Johan, LAMBIN, Philippe, BENTZEN, Søren M, MINKEN, André, WANDERS, Rinus, LUTGENS, Ludy, HOCHSTENBAG, Monique, BOERSMA, Liesbeth, WOUTERS, Bradly, LAMMERING, Guido

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CHCHD2 Is Coamplified with EGFR in NSCLC and Regulates Mitochondrial Function and Cell Migration von Wei, Yuhong, Vellanki, Ravi N, Coyaud, Étienne, Ignatchenko, Vladimir, Li, Lei, Krieger, Jonathan R, Taylor, Paul, Tong, Jiefei, Pham, Nhu-An, Liu, Geoffrey, Raught, Brian, Wouters, Bradly G, Kislinger, Thomas, Tsao, Ming Sound, Moran, Michael F

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Functional CRISPR and shRNA Screens Identify Involvement of Mitochondrial Electron Transport in the Activation of Evofosfamide von Hunter, Francis W., Devaux, Jules B.L., Meng, Fanying, Hong, Cho Rong, Khan, Aziza, Tsai, Peter, Ketela, Troy W., Sharma, Indumati, Kakadia, Purvi M., Marastoni, Stefano, Shalev, Zvi, Hickey, Anthony J.R., Print, Cristin G., Bohlander, Stefan K., Hart, Charles P., Wouters, Bradly G., Wilson, William R.

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Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR von Belmont, Peter J, Jiang, Ping, McKee, Trevor D, Xie, Tao, Isaacson, Jason, Baryla, Nicole E, Roper, Jatin, Sinnamon, Mark J, Lee, Nathan V, Kan, Julie L C, Guicherit, Oivin, Wouters, Bradly G, O'Brien, Catherine A, Shields, David, Olson, Peter, VanArsdale, Todd, Weinrich, Scott L, Rejto, Paul, Christensen, James G, Fantin, Valeria R, Hung, Kenneth E, Martin, Eric S

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Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma von Jamieson, Stephen Mf, Tsai, Peter, Kondratyev, Maria K, Budhani, Pratha, Liu, Arthur, Senzer, Neil N, Chiorean, E Gabriela, Jalal, Shadia I, Nemunaitis, John J, Kee, Dennis, Shome, Avik, Wong, Way W, Li, Dan, Poonawala-Lohani, Nooriyah, Kakadia, Purvi M, Knowlton, Nicholas S, Lynch, Courtney Rh, Hong, Cho R, Lee, Tet Woo, Grénman, Reidar A, Caporiccio, Laura, McKee, Trevor D, Zaidi, Mark, Butt, Sehrish, Macann, Andrew Mj, McIvor, Nicholas P, Chaplin, John M, Hicks, Kevin O, Bohlander, Stefan K, Wouters, Bradly G, Hart, Charles P, Print, Cristin G, Wilson, William R, Curran, Michael A, Hunter, Francis W

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The hypoxic proteome is influenced by gene-specific changes in mRNA translation von Koritzinsky, Marianne, Seigneuric, Renaud, Magagnin, Michaël G., Beucken, Twan van den, Lambin, Philippe, Wouters, Bradly G.

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Impact of supervised gene signatures of early hypoxia on patient survival von Seigneuric, Renaud, Starmans, Maud H.W, Fung, Glenn, Krishnapuram, Balaji, Nuyten, Dimitry S.A, van Erk, Arie, Magagnin, Michael G, Rouschop, Kasper M, Krishnan, Sriram, Rao, R. Bharat, Evelo, Chris T.A, Begg, Adrian C, Wouters, Bradly G, Lambin, Philippe

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Plasma citrulline concentration: A surrogate end point for radiation-induced mucosal atrophy of the small bowel. A feasibility study in 23 patients von Lutgens, Ludy C.H.W., Deutz, Nicolaas, Granzier-Peeters, Marlies, Beets-Tan, Regina, De Ruysscher, Dirk, Gueulette, John, Cleutjens, Jack, Berger, Martijn, Wouters, Bradly, von Meyenfeldt, Maarten, Lambin, Philippe

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