EGFR Phosphorylates Tumor-Derived EGFRvIII Driving STAT3/5 and Progression in Glioblastoma von Fan, Qi-Wen, Cheng, Christine K., Gustafson, W. Clay, Charron, Elizabeth, Zipper, Petra, Wong, Robyn A., Chen, Justin, Lau, Jasmine, Knobbe-Thomsen, Christiane, Weller, Michael, Jura, Natalia, Reifenberger, Guido, Shokat, Kevan M., Weiss, William A.

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A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma von Fan, QiWen, Aksoy, Ozlem, Wong, Robyn A., Ilkhanizadeh, Shirin, Novotny, Chris J., Gustafson, William C., Truong, Albert Yi-Que, Cayanan, Geraldine, Simonds, Erin F., Haas-Kogan, Daphne, Phillips, Joanna J., Nicolaides, Theodore, Okaniwa, Masanori, Shokat, Kevan M., Weiss, William A.

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IL15 Enhances CAR-T Cell Antitumor Activity by Reducing mTORC1 Activity and Preserving Their Stem Cell Memory Phenotype von Alizadeh, Darya, Wong, Robyn A, Yang, Xin, Wang, Dongrui, Pecoraro, Joseph R, Kuo, Cheng-Fu, Aguilar, Brenda, Qi, Yue, Ann, David K, Starr, Renate, Urak, Ryan, Wang, Xiuli, Forman, Stephen J, Brown, Christine E

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IFNγ Is Critical for CAR T Cell-Mediated Myeloid Activation and Induction of Endogenous Immunity von Alizadeh, Darya, Wong, Robyn A, Gholamin, Sharareh, Maker, Madeleine, Aftabizadeh, Maryam, Yang, Xin, Pecoraro, Joseph R, Jeppson, John D, Wang, Dongrui, Aguilar, Brenda, Starr, Renate, Larmonier, Claire B, Larmonier, Nicolas, Chen, Min-Hsuan, Wu, Xiwei, Ribas, Antoni, Badie, Behnam, Forman, Stephen J, Brown, Christine E

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Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial von Brown, Christine E., Hibbard, Jonathan C., Alizadeh, Darya, Blanchard, M. Suzette, Natri, Heini M., Wang, Dongrui, Ostberg, Julie R., Aguilar, Brenda, Wagner, Jamie R., Paul, Jinny A., Starr, Renate, Wong, Robyn A., Chen, Wuyang, Shulkin, Noah, Aftabizadeh, Maryam, Filippov, Aleksandr, Chaudhry, Ammar, Ressler, Julie A., Kilpatrick, Julie, Myers-McNamara, Paige, Chen, Mike, Wang, Leo D., Rockne, Russell C., Georges, Joseph, Portnow, Jana, Barish, Michael E., D’Apuzzo, Massimo, Banovich, Nicholas E., Forman, Stephen J., Badie, Behnam

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STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma von Lau, Jasmine, Ilkhanizadeh, Shirin, Wang, Susan, Miroshnikova, Yekaterina A, Salvatierra, Nicolas A, Wong, Robyn A, Schmidt, Christin, Weaver, Valerie M, Weiss, William A, Persson, Anders I

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Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma von Wong, Robyn A, Luo, Xujun, Lu, Mimi, An, Zhenyi, Haas-Kogan, Daphne A, Phillips, Joanna J, Shokat, Kevan M, Weiss, William A, Fan, Qi Wen

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Evaluation of the Immunomodulatory Effects of Radiation for Chimeric Antigen Receptor T Cell Therapy in Glioblastoma Multiforme von Akhavan, David, Subham, Siddharth, Jeppson, John D, Aguilar, Brenda, Wong, Robyn A, Hibbard, Jonathan C, Hui, Susanta, Wong, Jeffrey Y C, Forman, Stephen J, Alizadeh, Darya, Brown, Christine E

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Author Correction: Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial von Brown, Christine E., Hibbard, Jonathan C., Alizadeh, Darya, Blanchard, M. Suzette, Natri, Heini M., Wang, Dongrui, Ostberg, Julie R., Aguilar, Brenda, Wagner, Jamie R., Paul, Jinny A., Starr, Renate, Wong, Robyn A., Chen, Wuyang, Shulkin, Noah, Aftabizadeh, Maryam, Filippov, Aleksandr, Chaudhry, Ammar, Ressler, Julie A., Kilpatrick, Julie, Myers-McNamara, Paige, Chen, Mike, Wang, Leo D., Rockne, Russell C., Georges, Joseph, Portnow, Jana, Barish, Michael E., D’Apuzzo, Massimo, Banovich, Nicholas E., Forman, Stephen J., Badie, Behnam

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Betacellulin drives therapy resistance in glioblastoma von Fan, Qiwen, An, Zhenyi, Wong, Robyn A, Luo, Xujun, Lu, Edbert D, Baldwin, Albert, Mayekar, Manasi K, Haderk, Franziska, Shokat, Kevan M, Bivona, Trever G, Weiss, William A

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Expression Quantitative Trait Loci and Receptor Pharmacology Implicate Arg1 and the GABA-A Receptor as Therapeutic Targets in Neuroblastoma von Hackett, Christopher S., Quigley, David A., Wong, Robyn A., Chen, Justin, Cheng, Christine, Song, Young K., Wei, Jun S., Pawlikowska, Ludmila, Bao, Yun, Goldenberg, David D., Nguyen, Kim, Gustafson, W. Clay, Rallapalli, Sundari K., Cho, Yoon-Jae, Cook, James M., Kozlov, Serguei, Mao, Jian-Hua, Van Dyke, Terry, Kwok, Pui-Yan, Khan, Javed, Balmain, Allan, Fan, QiWen, Weiss, William A.

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IMMU-12. IL13Ra2-CAR T CELLS STIMULATE ENDOGENOUS IMMUNE RESPONSES AGAINST MURINE GLIOBLASTOMAS von Alizadeh, Darya, Wong, Robyn, Pecoraro, Joseph, Yang, Xin, Forman, Stephen, Brown, Christine E

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TMIC-42. CONQUERING SPP1+ MYELOID-DRIVEN RESISTANCE OF GLIOBLASTOMA TO IL13RA2-TARGETED CAR T CELL THERAPY von Gholamin, Sharareh, Natri, Heini M, Zhao, Yuqi, Xu, Shengchao, Aftabizadeh, Maryam, Comin-Anduix, Begonya, Saravanakumar, Supraja, Masia, Christian, Wong, Robyn, Peter, Lance, Chung, Mei-i, Mee, Evan D, Aguilar, Brenda, Starr, Renate, Torrejon, Davis Y, Kalbasi, Anusha, Alizadeh, Darya, Wu, Xiwei, Ribas, Antoni, Forman, Stephen, Badie, Behnam, Banovich, Nicholas E, Brown, Christine E

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Abstract 59: CAR T cell therapy reshapes the tumor microenvironment to promote host antitumor immune repsonses in glioblastoma von Brown, Christine E., Alizadeh, Darya, Jonsson, Vanessa, Hibbard, Jonathan, Yahn, Stephanie, Wong, Robyn A., Yang, Xin, Ng, Rachel, Dullerud, Natalie, Maker, Madeleine, Gholamin, Sharahreh, Starr, Renate, Banovich, Nicholas, Forman, Stephen J., Badie, Behnam

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Glial Progenitors as Targets for Transformation in Glioma von Ilkhanizadeh, Shirin, Lau, Jasmine, Huang, Miller, Foster, Daniel J., Wong, Robyn, Frantz, Aaron, Wang, Susan, Weiss, William A., Persson, Anders I.

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ATPS-94THIRD GENERATION mTOR INHIBITORS IN GLIOBLASTOMA von Fan, QiWen, Wong, Robyn, Novotny, Chris, Okaniwa, Masanori, Nicolaides, Theodore, Shokat, Kevan, Weiss, William

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Abstract IA27: A kinase inhibitor targeted to mTORC1 drives regression in glioblastoma von Fan, QiWen, Aksoy, Ozlem, Wong, Robyn, Ilkhanizadeh, Shirin, Novotny, Chris, Gustafson, William, Tuong, Albert, Cayanan, Geraldine, Simonds, Erin, Haas-Kogan, Daphne, Phillips, Joanna, Nicolaides, Theo, Okaniwa, Masanori, Shokat, Kevan, Weiss, William A.

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STAT3 blockade inhibits a radiation-induced proneural-to-mesenchymal transition in glioma von Lau, Jasmine, Ilkhanizadeh, Shirin, Wang, Susan, Miroshnikova, Yekaterina A., Salvatierra, Nicolas A., Wong, Robyn A., Schmidt, Christin, Weaver, Valerie M., Weiss, William A., Persson, Anders I.

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ET-63TARGETING THE EGFR-STAT-NF-κB AXIS IN GLIOBLASTOMA von Weiss, William, Fan, Qi-Wen, Baldwin, Albert, Wong, Robyn, Shokat, Kevan

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ET-63 TARGETING THE EGFR-STAT-NF- Kappa B AXIS IN GLIOBLASTOMA von Weiss, William, Fan, Qi-Wen, Baldwin, Albert, Wong, Robyn, Shokat, Kevan

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