The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell von Lee, Jeong Han, Perez-Flores, Maria C., Park, Seojin, Kim, Hyo Jeong, Chen, Yingying, Kang, Mincheol, Kersigo, Jennifer, Choi, Jinsil, Thai, Phung N., Woltz, Ryan L., Perez-Flores, Dolores Columba, Perkins, Guy, Sihn, Choong-Ryoul, Trinh, Pauline, Zhang, Xiao-Dong, Sirish, Padmini, Dong, Yao, Feng, Wayne Wei, Pessah, Isaac N., Dixon, Rose E., Sokolowski, Bernd, Fritzsch, Bernd, Chiamvimonvat, Nipavan, Yamoah, Ebenezer N.

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Functional interaction with filamin A and intracellular Ca2+enhance the surface membrane expression of a small-conductance Ca2+-activated K+(SK2) channel von Rafizadeh, Sassan, Zhang, Zheng, Woltz, Ryan L., Kim, Hyo Jeong, Myers, Richard E., Lu, Ling, Tuteja, Dipika, Singapuri, Anil, Bigdeli, Amir Ali Ziaei, Harchache, Sana Ben, Knowlton, Anne A., Yarov-Yarovoy, Vladimir, Yamoah, Ebenezer N., Chiamvimonvat, Nipavan

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Gating Properties of Mutant Sodium Channels and Responses to Sodium Current Inhibitors Predict Mexiletine-Sensitive Mutations of Long QT Syndrome 3 von Li, Gang, Woltz, Ryan L, Wang, Cheng-Yu, Ren, Lu, He, Pei-Xin, Yu, Shan-Dong, Liu, Xue-Qin, Yarov-Yarovoy, Vladimir, Hu, Dan, Chiamvimonvat, Nipavan, Wu, Lin

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Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains von Ren, Lu, Thai, Phung N, Gopireddy, Raghavender Reddy, Timofeyev, Valeriy, Ledford, Hannah A, Woltz, Ryan L, Park, Seojin, Puglisi, Jose L, Moreno, Claudia M, Santana, Luis Fernando, Conti, Alana C, Kotlikoff, Michael I, Xiang, Yang Kevin, Yarov-Yarovoy, Vladimir, Zaccolo, Manuela, Zhang, Xiao-Dong, Yamoah, Ebenezer N, Navedo, Manuel F, Chiamvimonvat, Nipavan

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Atomistic mechanisms of the regulation of small-conductance Ca2+-activated K+ channel (SK2) by PIP2 von Woltz, Ryan L, Zheng, Yang, Choi, Woori, Ngo, Khoa, Trinh, Pauline, Ren, Lu, Thai, Phung N, Harris, Brandon J, Han, Yanxiao, Rouen, Kyle C, Mateos, Diego Lopez, Jian, Zhong, Chen-Izu, Ye, Dickson, Eamonn J, Yamoah, Ebenezer N, Yarov-Yarovoy, Vladimir, Vorobyov, Igor, Zhang, Xiao-Dong, Chiamvimonvat, Nipavan

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A double-stranded RNA platform is required for the interaction between a host restriction factor and the NS1 protein of influenza A virus von Chen, Guifang, Ma, Li-Chung, Wang, Shanshan, Woltz, Ryan L, Grasso, Emily M, Montelione, Gaetano T, Krug, Robert M

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Regulation of Gene Transcription by Voltage-gated L-type Calcium Channel, Cav1.3 von Lu, Ling, Sirish, Padmini, Zhang, Zheng, Woltz, Ryan L., Li, Ning, Timofeyev, Valeriy, Knowlton, Anne A., Zhang, Xiao-Dong, Yamoah, Ebenezer N., Chiamvimonvat, Nipavan

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Methods for stable multimeric molecular dynamics simulation and modeling of cardiac SK2 channel function von Woltz, Ryan L., Chiamvimonvat, Nipavan, Yarov-Yarovoy, Vladimir, DeMarco, Kevin, Srivatsa, Adith, Vorobyov, Igor V., Lopez Mateos, Diego, Nguyen, Phuong T., Harris, Brandon J., Ngo, Khoa, Zhang, Xiao-Dong

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Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation von Ledford, Hannah A., Park, Seojin, Muir, Duncan, Woltz, Ryan L., Ren, Lu, Nguyen, Phuong T., Sirish, Padmini, Wang, Wenying, Sihn, Choong-Ryoul, George, Alfred L., Knollmann, Björn C., Yamoah, Ebenezer N., Yarov-Yarovoy, Vladimir, Zhang, Xiao-Dong, Chiamvimonvat, Nipavan

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Adenylyl Cyclase Subtype–Specific Compartmentalization: Differential Regulation of L-Type Ca2+ Current in Ventricular Myocytes von Timofeyev, Valeriy, Myers, Richard E, Kim, Hyo Jeong, Woltz, Ryan L, Sirish, Padmini, Heiserman, James P, Li, Ning, Singapuri, Anil, Tang, Tong, Yarov-Yarovoy, Vladimir, Yamoah, Ebenezer N, Hammond, H Kirk, Chiamvimonvat, Nipavan

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Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ Channels von Sihn, Choong-Ryoul, Kim, Hyo Jeong, Woltz, Ryan L., Yarov-Yarovoy, Vladimir, Yang, Pei-Chi, Xu, Jun, Clancy, Colleen E., Zhang, Xiao-Dong, Chiamvimonvat, Nipavan, Yamoah, Ebenezer N.

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Influence of the selectivity filter serine and threonine residues on the stability and conductivity of human small-conductance calcium-activated potassium channels von Choi, Woori, Woltz, Ryan L., Vorobyov, Igor V., Chiamvimonvat, Nipavan

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PO-01-175 INTEGRATING MOLECULAR MODELING WITH PIP2 BINDING OF KIR2.1 CHANNELS: IMPACT OF CLINICAL KCNJ2 MUTATIONS von Munawar, Saba, Anderson, Corey L., Reilly, Louise, Woltz, Ryan L., Chiamvimonvat, Nipavan, Eckhardt, Lee

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MD simulation identifies a novel and direct mechanism for PIP2 activation of SK2 von Woltz, Ryan L., Choi, Woori, Ngo, Khoa, Harris, Brandon J., Han, Yanxiao, Rouen, Kyle, Trinh, Pauline, Yamoah, Ebenezer N., Mateos, Diego Lopez, Yarov-Yarovoy, Vladimir, Vorobyov, Igor V., Zhang, Xiao-Dong, Chiamvimonvat, Nipavan

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Developing a stable full atom molecular dynamics model starting from a cyro-EM structure of a K+ channel bound to regulatory protein and varying PIP2 concentrations to understand r... von Woltz, Ryan L., Srivatsa, Adith, DeMarco, Kevin, Lopez Mateos, Diego, Nguyen, Phuong T., Zhang, Xiao-Dong, Vorobyov, Igor V., Yarov-Yarovoy, Vladimir, Chiamvimonvat, Nipavan

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Mechanisms of Cardiac Arrhythmias and Sudden Cardiac Death in Human Calmodulinopathy von Woltz, Ryan L., Ledford, Hannah A., Sirish, Padmini, Muir, Duncan, Smith, Wen, Zhang, Xiao-Dong, Yarov-Yarovoy, Vladimir, Chiamvimonvat, Nipavan

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The Use of Enhanced Sampling Molecular Dynamics (ES-MD) to Determine PIP2 Binding in SK2-Calmodulin Complex von Woltz, Ryan L., Srivatsa, Adith, Nguyen, Phuong T., DeMarco, Kevin, Zhang, Xiao-Dong, Vorobyov, Igor V., Yarov-Yarovoy, Vladimir, Chiamvimonvat, Nipavan

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Molecular Dynamic Simulations Suggest Novel PIP2 Binding Sites for SK2 Channel Regulation von Srivatsa, Adith V., Woltz, Ryan L., Nguyen, Phuong T., DeMarco, Kevin, Zhang, Xiao-Dong, Vorobyov, Igor V., Yarov-Yarovoy, Vladimir, Chiamvimonvat, Nipavan

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Abstract 17319: Distinct Effects of Human Calmodulinopathy on the Function of Small Conductance Ca 2+ -Activated K + (SK) Channels von Ledford, Hannah A, Park, Seojin, Muir, Duncan, Smith, Wen, Woltz, Ryan L, Sihn, Choong-Ryoul, Sirish, Padmini, Yamoah, Ebenezer N, Yarov-Yarovoy, Vladimir, Zhang, Xiao-Dong, Chiamvimonvat, Nipavan

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Functional Microdomain of Adenylyl Cyclase Isoform 1 Contributes to Sinoatrial Node Automaticity via β-Adrenergic Receptor Pathway von Ren, Lu, Thai, Phung N., Gopireddy, Raghavender R., Timofeyev, Valeriy, Ledford, Hannah A., Woltz, Ryan L., Park, Seojin, Moreno, Claudia M., Santana, Luis F., Conti, Alana C., Xiang, Yang K., Yarov-Yarovoy, Vladimir, Yamoah, Ebenezer N., Navedo, Manuel F., Chiamvimonvat, Nipavan

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