Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7 von Jaeger, Kathrin, Bruenle, Steffen, Weinert, Tobias, Guba, Wolfgang, Muehle, Jonas, Miyazaki, Takuya, Weber, Martin, Furrer, Antonia, Haenggi, Noemi, Tetaz, Tim, Huang, Chia-Ying, Mattle, Daniel, Vonach, Jean-Marie, Gast, Alain, Kuglstatter, Andreas, Rudolph, Markus G., Nogly, Przemyslaw, Benz, Joerg, Dawson, Roger J.P., Standfuss, Joerg

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Torsion Angle Preferences in Druglike Chemical Space: A Comprehensive Guide von Schärfer, Christin, Schulz-Gasch, Tanja, Ehrlich, Hans-Christian, Guba, Wolfgang, Rarey, Matthias, Stahl, Martin

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VolSurf: a new tool for the pharmacokinetic optimization of lead compounds von Cruciani, Gabriele, Pastor, Manuel, Guba, Wolfgang

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Selective Cannabinoid 2 Receptor Agonists as Potential Therapeutic Drugs for the Treatment of Endotoxin-Induced Uveitis von Porter, Richard Frederick, Szczesniak, Anna-Maria, Toguri, James Thomas, Gebremeskel, Simon, Johnston, Brent, Lehmann, Christian, Fingerle, Jürgen, Rothenhäusler, Benno, Perret, Camille, Rogers-Evans, Mark, Kimbara, Atsushi, Nettekoven, Matthias, Guba, Wolfgang, Grether, Uwe, Ullmer, Christoph, Kelly, Melanie E M

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Development of a membrane-based Gi-CASE biosensor assay for profiling compounds at cannabinoid receptors von Scott-Dennis, Morgan, Rafani, Fikri A., Yi, Yicheng, Perera, Themiya, Harwood, Clare R., Guba, Wolfgang, Rufer, Arne C., Grether, Uwe, Veprintsev, Dmitry B., Sykes, David A.

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Tritium Labeling of Neuromedin S by Conjugation with [3H]N‑Succinimidyl Propionate von Edelmann, Martin R., Erny, Johannes, Guba, Wolfgang, Hierl, Markus

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TFD: Torsion Fingerprints As a New Measure To Compare Small Molecule Conformations von Schulz-Gasch, Tanja, Schärfer, Christin, Guba, Wolfgang, Rarey, Matthias

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RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal m... von Grether, Uwe, Foxton, Richard H, Gruener, Sabine, Korn, Claudia, Kimbara, Atsushi, Osterwald, Anja, Zirwes, Elisabeth, Uhles, Sabine, Thoele, Janina, Colé, Nadine, Rogers-Evans, Mark, Röver, Stephan, Nettekoven, Matthias, Martin, Rainer E, Adam, Jean-Michel, Fingerle, Jürgen, Bissantz, Caterina, Guba, Wolfgang, Alker, André, Szczesniak, Anna M, Porter, Ross F, Toguri, Tom J, Revelant, Franco, Poirier, Agnès, Perret, Camille, Winther, Lotte, Caruso, Antonello, Fezza, Filomena, Maccarrone, Mauro, Kelly, Melanie E M, Fauser, Sascha, Ullmer, Christoph

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BACE1 inhibitors: A head group scan on a series of amides von Woltering, Thomas J., Wostl, Wolfgang, Hilpert, Hans, Rogers-Evans, Mark, Pinard, Emmanuel, Mayweg, Alexander, Göbel, Martin, Banner, David W., Benz, Jörg, Travagli, Massimiliano, Pollastrini, Martina, Marconi, Guido, Gabellieri, Emanuele, Guba, Wolfgang, Mauser, Harald, Andreini, Matteo, Jacobsen, Helmut, Power, Eoin, Narquizian, Robert

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Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2‑Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl‑1H‑imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523... von Jaeschke, Georg, Kolczewski, Sabine, Spooren, Will, Vieira, Eric, Bitter-Stoll, Nadia, Boissin, Patrick, Borroni, Edilio, Büttelmann, Bernd, Ceccarelli, Simona, Clemann, Nicole, David, Beatrice, Funk, Christoph, Guba, Wolfgang, Harrison, Anthony, Hartung, Thomas, Honer, Michael, Huwyler, Jörg, Kuratli, Martin, Niederhauser, Urs, Pähler, Axel, Peters, Jens-Uwe, Petersen, Ann, Prinssen, Eric, Ricci, Antonio, Rueher, Daniel, Rueher, Marianne, Schneider, Manfred, Spurr, Paul, Stoll, Theodor, Tännler, Daniel, Wichmann, Jürgen, Porter, Richard H, Wettstein, Joseph G, Lindemann, Lothar

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6‑Alkoxy-5-aryl-3-pyridinecarboxamides, a New Series of Bioavailable Cannabinoid Receptor Type 1 (CB1) Antagonists Including Peripherally Selective Compounds von Röver, Stephan, Andjelkovic, Mirjana, Bénardeau, Agnès, Chaput, Evelyne, Guba, Wolfgang, Hebeisen, Paul, Mohr, Susanne, Nettekoven, Matthias, Obst, Ulrike, Richter, Wolfgang F, Ullmer, Christoph, Waldmeier, Pius, Wright, Matthew B

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Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists von Kosar, Miroslav, Sarott, Roman C., Sykes, David A., Viray, Alexander E. G., Vitale, Rosa Maria, Tomašević, Nataša, Li, Xiaoting, Ganzoni, Rudolf L. Z., Kicin, Bilal, Reichert, Lisa, Patej, Kacper J., Gómez-Bouzó, Uxía, Guba, Wolfgang, McCormick, Peter J., Hua, Tian, Gruber, Christian W., Veprintsev, Dmitry B., Frank, James A., Grether, Uwe, Carreira, Erick M.

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Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries von Roche, Olivier, Schneider, Petra, Zuegge, Jochen, Guba, Wolfgang, Kansy, Manfred, Alanine, Alexander, Bleicher, Konrad, Danel, Franck, Gutknecht, Eva-Maria, Rogers-Evans, Mark, Neidhart, Werner, Stalder, Henri, Dillon, Michael, Sjögren, Eric, Fotouhi, Nader, Gillespie, Paul, Goodnow, Robert, Harris, William, Jones, Phil, Taniguchi, Mikio, Tsujii, Shinji, von der Saal, Wolfgang, Zimmermann, Gerd, Schneider, Gisbert

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Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport von Ruderisch, Nadine, Schlatter, Daniel, Kuglstatter, Andreas, Guba, Wolfgang, Huber, Sylwia, Cusulin, Carlo, Benz, Jörg, Rufer, Arne Christian, Hoernschemeyer, Joerg, Schweitzer, Christophe, Bülau, Tina, Gärtner, Achim, Hoffmann, Eike, Niewoehner, Jens, Patsch, Christoph, Baumann, Karlheinz, Loetscher, Hansruedi, Kitas, Eric, Freskgård, Per-Ola

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Machine Learning and Computational Chemistry for the Endocannabinoid System von Atz, Kenneth, Guba, Wolfgang, Grether, Uwe, Schneider, Gisbert

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Cross-project HTS-datamining von Guba, Wolfgang, Stoffler, Daniel

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Using macromolecular phasing and refinement techniques for a small molecule gyrase inhibitor von Rudolph, Markus G., Guba, Wolfgang, Xuefei, Tan, Xu, Bruce

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The Torsion Library: Semiautomated Improvement of Torsion Rules with SMARTScompare von Penner, Patrick, Guba, Wolfgang, Schmidt, Robert, Meyder, Agnes, Stahl, Martin, Rarey, Matthias

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Structural insights into the inhibition of glycine reuptake von Shahsavar, Azadeh, Stohler, Peter, Bourenkov, Gleb, Zimmermann, Iwan, Siegrist, Martin, Guba, Wolfgang, Pinard, Emmanuel, Sinning, Steffen, Seeger, Markus A., Schneider, Thomas R., Dawson, Roger J. P., Nissen, Poul

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Discovery of an Orally Active Non-Peptide Fibrinogen Receptor Antagonist Based on the Hydantoin Scaffold von Stilz, Hans Ulrich, Guba, Wolfgang, Jablonka, Bernd, Just, Melitta, Klingler, Otmar, König, Wolfgang, Wehner, Volkmar, Zoller, Gerhard

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