PD-1 and PD-L1 Expression in NSCLC Indicate a Favorable Prognosis in Defined Subgroups von Schmidt, Lars Henning, Kümmel, Andreas, Görlich, Dennis, Mohr, Michael, Bröckling, Sebastian, Mikesch, Jan Henrik, Grünewald, Inga, Marra, Alessandro, Schultheis, Anne M, Wardelmann, Eva, Müller-Tidow, Carsten, Spieker, Tilmann, Schliemann, Christoph, Berdel, Wolfgang E, Wiewrodt, Rainer, Hartmann, Wolfgang

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SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia von Schneider, Constanze, Oellerich, Thomas, Baldauf, Hanna-Mari, Schwarz, Sarah-Marie, Thomas, Dominique, Flick, Robert, Bohnenberger, Hanibal, Kaderali, Lars, Stegmann, Lena, Cremer, Anjali, Martin, Margarethe, Lohmeyer, Julian, Michaelis, Martin, Hornung, Veit, Schliemann, Christoph, Berdel, Wolfgang E, Hartmann, Wolfgang, Wardelmann, Eva, Comoglio, Federico, Hansmann, Martin-Leo, Yakunin, Alexander F, Geisslinger, Gerd, Ströbel, Philipp, Ferreirós, Nerea, Serve, Hubert, Keppler, Oliver T, Cinatl, Jindrich

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NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas von Meder, Lydia, König, Katharina, Ozretić, Luka, Schultheis, Anne M., Ueckeroth, Frank, Ade, Carsten P., Albus, Kerstin, Boehm, Diana, Rommerscheidt‐Fuss, Ursula, Florin, Alexandra, Buhl, Theresa, Hartmann, Wolfgang, Wolf, Jürgen, Merkelbach‐Bruse, Sabine, Eilers, Martin, Perner, Sven, Heukamp, Lukas C., Buettner, Reinhard

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Prostate specific membrane antigen (PSMA) expression in non-small cell lung cancer von Schmidt, Lars Henning, Heitkötter, Birthe, Schulze, Arik B, Schliemann, Christoph, Steinestel, Konrad, Trautmann, Marcel, Marra, Alessandro, Hillejan, Ludger, Mohr, Michael, Evers, Georg, Wardelmann, Eva, Rahbar, Kambiz, Görlich, Dennis, Lenz, Georg, Berdel, Wolfgang E, Hartmann, Wolfgang, Wiewrodt, Rainer, Huss, Sebastian

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Genomic EWSR1 Fusion Sequence as Highly Sensitive and Dynamic Plasma Tumor Marker in Ewing Sarcoma von Krumbholz, Manuela, Hellberg, Julia, Steif, Benedikt, Bäuerle, Tobias, Gillmann, Clarissa, Fritscher, Torsten, Agaimy, Abbas, Frey, Benjamin, Juengert, Joerg, Wardelmann, Eva, Hartmann, Wolfgang, Juergens, Heribert, Dirksen, Uta, Metzler, Markus

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Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age von Burkhardt, Birgit, Michgehl, Ulf, Rohde, Jonas, Erdmann, Tabea, Berning, Philipp, Reutter, Katrin, Rohde, Marius, Borkhardt, Arndt, Burmeister, Thomas, Dave, Sandeep, Tzankov, Alexandar, Dugas, Martin, Sandmann, Sarah, Fend, Falko, Finger, Jasmin, Mueller, Stephanie, Gökbuget, Nicola, Haferlach, Torsten, Kern, Wolfgang, Hartmann, Wolfgang, Klapper, Wolfram, Oschlies, Ilske, Richter, Julia, Kontny, Udo, Lutz, Mathias, Maecker-Kolhoff, Britta, Ott, German, Rosenwald, Andreas, Siebert, Reiner, von Stackelberg, Arend, Strahm, Brigitte, Woessmann, Wilhelm, Zimmermann, Martin, Zapukhlyak, Myroslav, Grau, Michael, Lenz, Georg

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Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain von Grunewald, Susanne, Klug, Lillian R, Mühlenberg, Thomas, Lategahn, Jonas, Falkenhorst, Johanna, Town, Ajia, Ehrt, Christiane, Wardelmann, Eva, Hartmann, Wolfgang, Schildhaus, Hans-Ulrich, Treckmann, Juergen, Fletcher, Jonathan A, Jung, Sascha, Czodrowski, Paul, Miller, Stephen, Schmidt-Kittler, Oleg, Rauh, Daniel, Heinrich, Michael C, Bauer, Sebastian

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Activating mutations in the MAP‐kinase pathway define non‐ossifying fibroma of bone von Baumhoer, Daniel, Kovac, Michal, Sperveslage, Jan, Ameline, Baptiste, Strobl, Anna‐Christina, Krause, Arthur, Trautmann, Marcel, Wardelmann, Eva, Nathrath, Michaela, Höller, Sylvia, Hardes, Jendrik, Gosheger, Georg, Krieg, Andreas H, Vieth, Volker, Tirabosco, Roberto, Amary, Fernanda, Flanagan, Adrienne M, Hartmann, Wolfgang

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Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features von Kool, Marcel, Koster, Jan, Bunt, Jens, Hasselt, Nancy E, Lakeman, Arjan, van Sluis, Peter, Troost, Dirk, Meeteren, Netteke Schouten-van, Caron, Huib N, Cloos, Jacqueline, Mrsić, Alan, Ylstra, Bauke, Grajkowska, Wieslawa, Hartmann, Wolfgang, Pietsch, Torsten, Ellison, David, Clifford, Steven C, Versteeg, Rogier

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Novel pathogenic alterations in pediatric and adult desmoid-type fibromatosis – A systematic analysis of 204 cases von Trautmann, Marcel, Rehkämper, Jan, Gevensleben, Heidrun, Becker, Jessica, Wardelmann, Eva, Hartmann, Wolfgang, Grünewald, Inga, Huss, Sebastian

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Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML von Oellerich, Thomas, Schneider, Constanze, Thomas, Dominique, Knecht, Kirsten M., Buzovetsky, Olga, Kaderali, Lars, Schliemann, Christoph, Bohnenberger, Hanibal, Angenendt, Linus, Hartmann, Wolfgang, Wardelmann, Eva, Rothenburger, Tamara, Mohr, Sebastian, Scheich, Sebastian, Comoglio, Federico, Wilke, Anne, Ströbel, Philipp, Serve, Hubert, Michaelis, Martin, Ferreirós, Nerea, Geisslinger, Gerd, Xiong, Yong, Keppler, Oliver T., Cinatl, Jindrich

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Clinicopathological and molecular features of a large cohort of gastrointestinal stromal tumors (GISTs) and review of the literature: BRAF mutations in KIT/PDGFRA wild-type GISTs a... von Huss, Sebastian, Pasternack, Helen, Ihle, Michaela Angelika, Merkelbach-Bruse, Sabine, Heitkötter, Birthe, Hartmann, Wolfgang, Trautmann, Marcel, Gevensleben, Heidrun, Büttner, Reinhard, Schildhaus, Hans-Ulrich, Wardelmann, Eva

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Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes von Musa, Julian, Cidre-Aranaz, Florencia, Aynaud, Marie-Ming, Orth, Martin F., Knott, Maximilian M. L., Mirabeau, Olivier, Mazor, Gal, Varon, Mor, Hölting, Tilman L. B., Grossetête, Sandrine, Gartlgruber, Moritz, Surdez, Didier, Gerke, Julia S., Ohmura, Shunya, Marchetto, Aruna, Dallmayer, Marlene, Baldauf, Michaela C., Stein, Stefanie, Sannino, Giuseppina, Li, Jing, Romero-Pérez, Laura, Westermann, Frank, Hartmann, Wolfgang, Dirksen, Uta, Gymrek, Melissa, Anderson, Nathaniel D., Shlien, Adam, Rotblat, Barak, Kirchner, Thomas, Delattre, Olivier, Grünewald, Thomas G. P.

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SS18-SSX-Dependent YAP/TAZ Signaling in Synovial Sarcoma von Isfort, Ilka, Cyra, Magdalene, Elges, Sandra, Kailayangiri, Sareetha, Altvater, Bianca, Rossig, Claudia, Steinestel, Konrad, Grünewald, Inga, Huss, Sebastian, Eßeling, Eva, Mikesch, Jan-Henrik, Hafner, Susanne, Simmet, Thomas, Wozniak, Agnieszka, Schöffski, Patrick, Larsson, Olle, Wardelmann, Eva, Trautmann, Marcel, Hartmann, Wolfgang

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FUS-DDIT3 Fusion Protein-Driven IGF-IR Signaling is a Therapeutic Target in Myxoid Liposarcoma von Trautmann, Marcel, Menzel, Jasmin, Bertling, Christian, Cyra, Magdalene, Isfort, Ilka, Steinestel, Konrad, Elges, Sandra, Grünewald, Inga, Altvater, Bianca, Rossig, Claudia, Fröhling, Stefan, Hafner, Susanne, Simmet, Thomas, Åman, Pierre, Wardelmann, Eva, Huss, Sebastian, Hartmann, Wolfgang

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Ganglioside SSEA-4 in Ewing sarcoma marks a tumor cell population with aggressive features and is a potential cell-surface immune target von Jamitzky, Silke, Altvater, Bianca, Krekeler, Carolin, Hoen, Laura, Brandes, Caroline, Ebbinghaus, Julia, Richter, Lisa, Kosel, Lisa, Ochs, Laurin, Farwick, Nicole, Urban, Katja, Kluge, Lena, Bücker, Lara, Görlich, Dennis, Johnston, Ian C. D., Pfeifer, Rita, Hartmann, Wolfgang, Rossig, Claudia, Kailayangiri, Sareetha

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Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma von Ohmura, Shunya, Marchetto, Aruna, Orth, Martin F, Li, Jing, Jabar, Susanne, Ranft, Andreas, Vinca, Endrit, Ceranski, Katharina, Carreño-Gonzalez, Martha J, Romero-Pérez, Laura, Wehweck, Fabienne S, Musa, Julian, Bestvater, Felix, Knott, Maximilian M L, Hölting, Tilman L B, Hartmann, Wolfgang, Dirksen, Uta, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G P

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Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer von Li, Jing, Ohmura, Shunya, Marchetto, Aruna, Orth, Martin F., Imle, Roland, Dallmayer, Marlene, Musa, Julian, Knott, Maximilian M. L., Hölting, Tilman L. B., Stein, Stefanie, Funk, Cornelius M., Sastre, Ana, Alonso, Javier, Bestvater, Felix, Kasan, Merve, Romero-Pérez, Laura, Hartmann, Wolfgang, Ranft, Andreas, Banito, Ana, Dirksen, Uta, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G. P.

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Prevalence of the Hippo Effectors YAP1/TAZ in Tumors of Soft Tissue and Bone von Isfort, Ilka, Elges, Sandra, Cyra, Magdalene, Berthold, Ruth, Renner, Marcus, Mechtersheimer, Gunhild, Åman, Pierre, Larsson, Olle, Ratner, Nancy, Hafner, Susanne, Simmet, Thomas, Schliemann, Christoph, Rossig, Claudia, Dirksen, Uta, Grünewald, Inga, Wardelmann, Eva, Huss, Sebastian, Hartmann, Wolfgang, Trautmann, Marcel

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Potential therapeutic impact of CD13 expression in non-small cell lung cancer von Schmidt, Lars Henning, Brand, Caroline, Stucke-Ring, Janine, Schliemann, Christoph, Kessler, Torsten, Harrach, Saliha, Mohr, Michael, Görlich, Dennis, Marra, Alessandro, Hillejan, Ludger, Müller-Tidow, Carsten, Lenz, Georg, Wardelmann, Eva, Wiewrodt, Rainer, Berdel, Wolfgang E, Schwöppe, Christian, Hartmann, Wolfgang

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