The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing von Begolo, Daniela, Vincent, Isabel M, Giordani, Federica, Pöhner, Ina, Witty, Michael J, Rowan, Timothy G, Bengaly, Zakaria, Gillingwater, Kirsten, Freund, Yvonne, Wade, Rebecca C, Barrett, Michael P, Clayton, Christine

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Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs von Giordani, Federica, Paape, Daniel, Vincent, Isabel M., Pountain, Andrew W., Fernandez-Cortes, Fernando, Rico, Eva, Zhang, Ning, Morrison, Liam J., Freund, Yvonne, Witty, Michael J., Peter, Rosemary, Edwards, Darren Y., Wilkes, Jonathan M., van der Hooft, Justin J. J., Regnault, Clement, Read, Kevin D., Horn, David, Field, Mark C., Barrett, Michael P.

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Athenaeus describes the most ancient intellectual property von Witty, Michael

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3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential von Younis, Yassir, Douelle, Frederic, Feng, Tzu-Shean, Cabrera, Diego González, Manach, Claire Le, Nchinda, Aloysius T, Duffy, Sandra, White, Karen L, Shackleford, David M, Morizzi, Julia, Mannila, Janne, Katneni, Kasiram, Bhamidipati, Ravi, Zabiulla, K. Mohammed, Joseph, Jayan T, Bashyam, Sridevi, Waterson, David, Witty, Michael J, Hardick, David, Wittlin, Sergio, Avery, Vicky, Charman, Susan A, Chibale, Kelly

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Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum von Le Manach, Claire, Scheurer, Christian, Sax, Sibylle, Schleiferböck, Sarah, Cabrera, Diego Gonzalez, Younis, Yassir, Paquet, Tanya, Street, Leslie, Smith, Peter, Ding, Xavier C, Waterson, David, Witty, Michael J, Leroy, Didier, Chibale, Kelly, Wittlin, Sergio

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Transformation of struvite from wastewater to a hydrogen fuel storage compound ammonia borane von Dingra, Nin, Witty, Michael, Celis, Marie, Boppana, Narendra, Ayudhya, Theppawut

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Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT) von Akama, Tsutomu, Zhang, Yong-Kang, Freund, Yvonne R., Berry, Pamela, Lee, Joanne, Easom, Eric E., Jacobs, Robert T., Plattner, Jacob J., Witty, Michael J., Peter, Rosemary, Rowan, Tim G., Gillingwater, Kirsten, Brun, Reto, Nare, Bakela, Mercer, Luke, Xu, Musheng, Wang, Jiangong, Liang, Hao

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UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria von Brunschwig, Christel, Lawrence, Nina, Taylor, Dale, Abay, Efrem, Njoroge, Mathew, Basarab, Gregory S, Le Manach, Claire, Paquet, Tanya, Cabrera, Diego Gonzàlez, Nchinda, Aloysius T, de Kock, Carmen, Wiesner, Lubbe, Denti, Paolo, Waterson, David, Blasco, Benjamin, Leroy, Didier, Witty, Michael J, Donini, Cristina, Duffy, James, Wittlin, Sergio, White, Karen L, Charman, Susan A, Jiménez-Díaz, Maria Belén, Angulo-Barturen, Iñigo, Herreros, Esperanza, Gamo, Francisco Javier, Rochford, Rosemary, Mancama, Dalu, Coetzer, Theresa L, van der Watt, Mariëtte E, Reader, Janette, Birkholtz, Lyn-Marie, Marsh, Kennan C, Solapure, Suresh M, Burke, John E, McPhail, Jacob A, Vanaerschot, Manu, Fidock, David A, Fish, Paul V, Siegl, Peter, Smith, Dennis A, Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N, Marfurt, Jutta, Silue, Kigbafori D, Street, Leslie J, Chibale, Kelly

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Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis von Smith, Alasdair, Wall, Richard J, Patterson, Stephen, Rowan, Tim, Rico Vidal, Eva, Stojanovski, Laste, Huggett, Margaret, Hampton, Shahienaz E, Thomas, Michael G, Corpas Lopez, Victoriano, Gillingwater, Kirsten, Duke, Jeff, Napier, Grant, Peter, Rose, Vitouley, Hervé S, Harrison, Justin R, Milne, Rachel, Jeacock, Laura, Baker, Nicola, Davis, Susan H, Simeons, Frederick, Riley, Jennifer, Horn, David, Brun, Reto, Zuccotto, Fabio, Witty, Michael J, Wyllie, Susan, Read, Kevin D, Gilbert, Ian H

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Medicinal Chemistry Optimization of Antiplasmodial Imidazopyridazine Hits from High Throughput Screening of a SoftFocus Kinase Library: Part 1 von Le Manach, Claire, Gonzàlez Cabrera, Diego, Douelle, Frederic, Nchinda, Aloysius T, Younis, Yassir, Taylor, Dale, Wiesner, Lubbe, White, Karen L, Ryan, Eileen, March, Corinne, Duffy, Sandra, Avery, Vicky M, Waterson, David, Witty, Michael J, Wittlin, Sergio, Charman, Susan A, Street, Leslie J, Chibale, Kelly

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Identification of a Potential Antimalarial Drug Candidate from a Series of 2‑Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle von Le Manach, Claire, Nchinda, Aloysius T, Paquet, Tanya, Gonzàlez Cabrera, Diego, Younis, Yassir, Han, Ze, Bashyam, Sridevi, Zabiulla, Mohammed, Taylor, Dale, Lawrence, Nina, White, Karen L, Charman, Susan A, Waterson, David, Witty, Michael J, Wittlin, Sergio, Botha, Mariëtte E, Nondaba, Sindisiswe H, Reader, Janette, Birkholtz, Lyn-Marie, Jiménez-Díaz, María Belén, Martínez, María Santos, Ferrer, Santiago, Angulo-Barturen, Iñigo, Meister, Stephan, Antonova-Koch, Yevgeniya, Winzeler, Elizabeth A, Street, Leslie J, Chibale, Kelly

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Novel Orally Active Antimalarial Thiazoles von González Cabrera, Diego, Douelle, Frederic, Feng, Tzu-Shean, Nchinda, Aloysius T, Younis, Yassir, White, Karen L, Wu, Quoc, Ryan, Eileen, Burrows, Jeremy N, Waterson, David, Witty, Michael J, Wittlin, Sergio, Charman, Susan A, Chibale, Kelly

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Medicinal Chemistry Optimization of Antiplasmodial Imidazopyridazine Hits from High Throughput Screening of a SoftFocus Kinase Library: Part 2 von Le Manach, Claire, Paquet, Tanya, Gonzàlez Cabrera, Diego, Younis, Yassir, Taylor, Dale, Wiesner, Lubbe, Lawrence, Nina, Schwager, Sylva, Waterson, David, Witty, Michael J, Wittlin, Sergio, Street, Leslie J, Chibale, Kelly

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Cell-based medicinal chemistry optimization of high throughput screening hits for orally active antimalarials. Part 2: hits from SoftFocus kinase and other libraries von Younis, Yassir, Street, Leslie J, Waterson, David, Witty, Michael J, Chibale, Kelly

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A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum -Infected Mouse Models from Structure–Activity Relationship Studies around the Core... von Le Manach, Claire, Paquet, Tanya, Brunschwig, Christel, Njoroge, Mathew, Han, Ze, Gonzàlez Cabrera, Diego, Bashyam, Sridevi, Dhinakaran, Rajkumar, Taylor, Dale, Reader, Janette, Botha, Mariette, Churchyard, Alisje, Lauterbach, Sonja, Coetzer, Theresa L, Birkholtz, Lyn-Marie, Meister, Stephan, Winzeler, Elizabeth A, Waterson, David, Witty, Michael J, Wittlin, Sergio, Jiménez-Díaz, María-Belén, Santos Martínez, María, Ferrer, Santiago, Angulo-Barturen, Iñigo, Street, Leslie J, Chibale, Kelly

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Mission possible von Hopkins, Andrew L, Witty, Michael J, Nwaka, Solomon

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Structure–Activity-Relationship Studies around the 2‑Amino Group and Pyridine Core of Antimalarial 3,5-Diarylaminopyridines Lead to a Novel Series of Pyrazine Analogues with Oral i... von Younis, Yassir, Douelle, Frederic, González Cabrera, Diego, Le Manach, Claire, Nchinda, Aloysius T, Paquet, Tanya, Street, Leslie J, White, Karen L, Zabiulla, K. Mohammed, Joseph, Jayan T, Bashyam, Sridevi, Waterson, David, Witty, Michael J, Wittlin, Sergio, Charman, Susan A, Chibale, Kelly

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Structure–Activity Relationship Studies of Orally Active Antimalarial 2,4-Diamino-thienopyrimidines von Gonzàlez Cabrera, Diego, Douelle, Frederic, Le Manach, Claire, Han, Ze, Paquet, Tanya, Taylor, Dale, Njoroge, Mathew, Lawrence, Nina, Wiesner, Lubbe, Waterson, David, Witty, Michael J, Wittlin, Sergio, Street, Leslie J, Chibale, Kelly

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Structure–Activity Relationship Studies of Orally Active Antimalarial 3,5-Substituted 2‑Aminopyridines von González Cabrera, Diego, Douelle, Frederic, Younis, Yassir, Feng, Tzu-Shean, Le Manach, Claire, Nchinda, Aloysius T, Street, Leslie J, Scheurer, Christian, Kamber, Jolanda, White, Karen L, Montagnat, Oliver D, Ryan, Eileen, Katneni, Kasiram, Zabiulla, K. Mohammed, Joseph, Jayan T, Bashyam, Sridevi, Waterson, David, Witty, Michael J, Charman, Susan A, Wittlin, Sergio, Chibale, Kelly

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Cell-Based Medicinal Chemistry Optimization of High Throughput Screening Hits for Orally Active Antimalarials. Part 2: Hits from SoftFocus Kinase and other Libraries: Miniperspecti... von Younis, Yassir, Street, Leslie J, Waterson, David, Witty, Michael J, Chibale, Kelly

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