BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR von Carboni, Joan M, Wittman, Mark, Yang, Zheng, Lee, Francis, Greer, Ann, Hurlburt, Warren, Hillerman, Stephen, Cao, Carolyn, Cantor, Glenn H, Dell-John, Janet, Chen, Cliff, Discenza, Lorell, Menard, Krista, Li, Aixin, Trainor, George, Vyas, Dolatrai, Kramer, Robert, Attar, Ricardo M, Gottardis, Marco M

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Discovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development von Wittman, Mark D, Carboni, Joan M, Yang, Zheng, Lee, Francis Y, Antman, Melissa, Attar, Ricardo, Balimane, Praveen, Chang, Chiehying, Chen, Cliff, Discenza, Lorell, Frennesson, David, Gottardis, Marco M, Greer, Ann, Hurlburt, Warren, Johnson, Walter, Langley, David R, Li, Aixin, Li, Jianqing, Liu, Peiying, Mastalerz, Harold, Mathur, Arvind, Menard, Krista, Patel, Karishma, Sack, John, Sang, Xiaopeng, Saulnier, Mark, Smith, Daniel, Stefanski, Kevin, Trainor, George, Velaparthi, Upender, Zhang, Guifen, Zimmermann, Kurt, Vyas, Dolatrai M

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Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1 von Degnan, Andrew P, Kumi, Godwin K, Allard, Christopher W, Araujo, Erika V, Johnson, Walter L, Zimmermann, Kurt, Pearce, Bradley C, Sheriff, Steven, Futran, Alan, Li, Xin, Locke, Gregory A, You, Dan, Morrison, John, Parrish, Karen E, Stromko, Caitlyn, Murtaza, Anwar, Liu, Jinqi, Johnson, Benjamin M, Vite, Gregory D, Wittman, Mark D

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Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor von You, Dan, Hillerman, Stephen, Locke, Gregory, Chaudhry, Charu, Stromko, Caitlyn, Murtaza, Anwar, Fan, Yi, Koenitzer, Jennifer, Chen, Yali, Briceno, Stephanie, Bhadra, Rajarshi, Duperret, Elizabeth, Gullo-Brown, Johnni, Gao, Chan, Zhao, Dandan, Feder, John, Curtin, Joshua, Degnan, Andrew P, Kumi, Godwin, Wittman, Mark, Johnson, Benjamin M, Parrish, Karen E, Gokulrangan, Giridharan, Morrison, John, Quigley, Michael, Hunt, John T, Salter-Cid, Luisa, Lees, Emma, Sanjuan, Miguel A, Liu, Jinqi

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In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417 von Haluska, Paul, Carboni, Joan M, Loegering, David A, Lee, Francis Y, Wittman, Mark, Saulnier, Mark G, Frennesson, David B, Kalli, Kimberly R, Conover, Cheryl A, Attar, Ricardo M, Kaufmann, Scott H, Gottardis, Marco, Erlichman, Charles

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Imidazole moiety replacements in the 3-(1 H-benzo[d]imidazol-2-yl)pyridin-2(1 H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile von Velaparthi, Upender, Liu, Peiying, Balasubramanian, Balu, Carboni, Joan, Attar, Ricardo, Gottardis, Marco, Li, Aixin, Greer, Ann, Zoeckler, Mary, Wittman, Mark D., Vyas, Dolatrai

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Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2- f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase von Sampognaro, Anthony J., Wittman, Mark D., Carboni, Joan M., Chang, Chiehying, Greer, Ann F., Hurlburt, Warren W., Sack, John S., Vyas, Dolatrai M.

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Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one von VELAPARTHI, Upender, SAULNIER, Mark G, CLARKE, Wendy, ZHENG YANG, MENARD, Krista, LEE, Francis Y, TRAINOR, George, VYAS, Dolatrai, WITTMAN, Mark D, PEIYING LIU, FRENNESSON, David B, ZIMMERMANN, Kurt, CARBONI, Joan M, GOTTARDIS, Marco, AIXIN LI, GREER, Ann

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SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors von Zimmermann, Kurt, Wittman, Mark D., Saulnier, Mark G., Velaparthi, Upender, Sang, Xiaopeng, Frennesson, David B., Struzynski, Charles, Seitz, Steven P., He, Liqi, Carboni, Joan M., Li, Aixin, Greer, Ann F., Gottardis, Marco, Attar, Ricardo M., Yang, Zheng, Balimane, Praveen, Discenza, Lorell N., Lee, Francis Y., Sinz, Michael, Kim, Sean, Vyas, Dolatrai

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Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors von Zimmermann, Kurt, Wittman, Mark D., Saulnier, Mark G., Velaparthi, Upender, Langley, David R., Sang, Xiaopeng, Frennesson, David, Carboni, Joan, Li, Aixin, Greer, Ann, Gottardis, Marco, Attar, Ricardo M., Yang, Zheng, Balimane, Praveen, Discenza, Lorell N., Vyas, Dolatrai

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2-(1 H-Imidazol-4-yl)ethanamine and 2-(1 H-pyrazol-1-yl)ethanamine side chain variants of the IGF-1R inhibitor BMS-536924 von Saulnier, Mark G., Frennesson, David B., Wittman, Mark D., Zimmermann, Kurt, Velaparthi, Upender, Langley, David R., Struzynski, Charles, Sang, Xiaopeng, Carboni, Joan, Li, Aixin, Greer, Ann, Yang, Zheng, Balimane, Praveen, Gottardis, Marco, Attar, Ricardo, Vyas, Dolatrai

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Biochemical and transcriptional profiling to triage additional activities in a series of IGF-1R/IR inhibitors von Ross-Macdonald, Petra, de Silva, Heshani, Patel, Vishal, Truong, Amy, He, Aiqing, Neuhaus, Isaac, Tilford, Charles, Ji, RuiRu, Siemers, Nathan, Greer, Ann, Carboni, Joan, Gottardis, Marco, Menard, Krista, Lee, Frank, Dodier, Marco, Frennesson, David, Sampognaro, Anthony, Saulnier, Mark, Trainor, George, Vyas, Dolatrai, Zimmermann, Kurt, Wittman, Mark

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Synthesis and Antitumor Activity of Novel C-7 Paclitaxel Ethers:  Discovery of BMS-184476 von Altstadt, Thomas J, Fairchild, Craig R, Golik, Jerzy, Johnston, Kathy A, Kadow, John F, Lee, Francis Y, Long, Byron H, Rose, William C, Vyas, Dolatrai M, Wong, Henry, Wu, Mu-Jen, Wittman, Mark D

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Novel 1H -(benzimidazol -2 -yl ) -1H -pyridin -2 -one inhibitors of insulin-like growth factor I (IGF-1R) kinase von WITTMAN, Mark D, BALASUBRAMANIAN, Balu, GOTTARDIS, Marco, CHIEHYING CHANG, JACOBSON, Bruce, SUN, Yax, HANSEL, Steven, ZOECKLER, Mary, VYAS, Dolatrai M, STOFFAN, Karen, VELAPARTHI, Upender, PIEYING LIU, KRISHNANATHAN, Subramaniam, CARBONI, Joan, AIXIN LI, GREER, Ann, ATTAR, Ricardo

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Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor von CARBONI, Joan M, LEE, Adrian V, HURLBURT, Warren, AIXIN LI, SAUJNIER, Mark, VELAPARTHI, Upender, WANG, Cindy, WEN, Mei-Li, WESTHOUSE, Richard A, WINMAN, Mark, ZIMMERMANN, Kurt, RUPNOW, Brent A, HADSELL, Darryl L, WONG, Tai W, ROWLEY, Bruce R, LEE, Francis Y, BOL, David K, CAMUSO, Amy E, GOTTARDIS, Marco, GREER, Ann F, CHING PING HO

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SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia von Moison, Céline, Gracias, Deanne, Schmitt, Julie, Girard, Simon, Spinella, Jean-François, Fortier, Simon, Boivin, Isabel, Mendoza-Sanchez, Rodrigo, Thavonekham, Bounkham, MacRae, Tara, Mayotte, Nadine, Bonneil, Eric, Wittman, Mark, Carmichael, James, Ruel, Réjean, Thibault, Pierre, Hébert, Josée, Marinier, Anne, Sauvageau, Guy

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Discovery of a 1H-Benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity von Wittman, Mark, Carboni, Joan, Attar, Ricardo, Balasubramanian, Balu, Balimane, Praveen, Brassil, Patrick, Beaulieu, Francis, Chang, Chiehying, Clarke, Wendy, Dell, Janet, Eummer, Jeffrey, Frennesson, David, Gottardis, Marco, Greer, Ann, Hansel, Steven, Hurlburt, Warren, Jacobson, Bruce, Krishnananthan, Subramaniam, Lee, Francis Y, Li, Aixin, Lin, Tai-An, Liu, Peiying, Ouellet, Carl, Sang, Xiaopeng, Saulnier, Mark G, Stoffan, Karen, Sun, Yax, Velaparthi, Upender, Wong, Henry, Yang, Zheng, Zimmermann, Kurt, Zoeckler, Mary, Vyas, Dolatrai

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Synthesis and antitumor activity of novel paclitaxel–chlorambucil hybrids von Wittman, Mark D., Kadow, John F., Vyas, Dolatrai M., Lee, Francis L., Rose, William C., Long, Byron H., Fairchild, Craig, Johnston, Kathy

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Studies Related to the Carbohydrate Sectors of Esperamicin and Calicheamicin: Definition of the Stability Limits of the Esperamicin Domain and Fashioning of a Glycosyl Donor from t... von Halcomb, Randall L, Boyer, Serge H, Wittman, Mark D, Olson, Steven H, Denhart, Derek J, Liu, Kevin K. C, Danishefsky, Samuel J

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Synthesis of metabolically blocked paclitaxel analogues von Wittman, Mark D., Altstadt, Thomas J., Fairchild, Craig, Hansel, Stephen, Johnston, Kathy, Kadow, John F., Long, Byron H., Rose, William C., Vyas, Dolatrai M., Wu, Mu-Jen, Zoeckler, Mary E.

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