Histone Deacetylase Inhibitors von Miller, Thomas A, Witter, David J, Belvedere, Sandro

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Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor von Elwood, Fiona, Witter, David J, Piesvaux, Jennifer, Kraybill, Brian, Bays, Nathan, Alpert, Carla, Goldenblatt, Peter, Qu, Yujie, Ivanovska, Irena, Lee, Hyun-Hee, Chiu, Chi-Sung, Tang, Hao, Scott, Mark E, Deshmukh, Sujal V, Zielstorff, Mark, Byford, Alan, Chakravarthy, Kalyan, Dorosh, Lauren, Rivkin, Alexey, Klappenbach, Joel, Pan, Bo-Sheng, Kariv, Ilona, Dinsmore, Christopher, Slipetz, Deborah, Dandliker, Peter J

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Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2) von Witter, David J., Harrington, Paul, Wilson, Kevin J., Chenard, Melissa, Fleming, Judith C., Haines, Brian, Kral, Astrid M., Secrist, J. Paul, Miller, Thomas A.

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Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2) von Methot, Joey L., Chakravarty, Prasun K., Chenard, Melissa, Close, Joshua, Cruz, Jonathan C., Dahlberg, William K., Fleming, Judith, Hamblett, Christopher L., Hamill, Julie E., Harrington, Paul, Harsch, Andreas, Heidebrecht, Richard, Hughes, Bethany, Jung, Joon, Kenific, Candia M., Kral, Astrid M., Meinke, Peter T., Middleton, Richard E., Ozerova, Nicole, Sloman, David L., Stanton, Matthew G., Szewczak, Alexander A., Tyagarajan, Sriram, Witter, David J., Paul Secrist, J., Miller, Thomas A.

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A Divergent Approach to the Synthesis of 3-Substituted-2-pyrazolines: Suzuki Cross-Coupling of 3-Sulfonyloxy-2-pyrazolines von Grimm, Jonathan B, Wilson, Kevin J, Witter, David J

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Lovastatin Nonaketide Synthase Catalyzes an Intramolecular Diels−Alder Reaction of a Substrate Analogue von Auclair, Karine, Sutherland, Andrew, Kennedy, Jonathan, Witter, David J, Van den Heever, Johan P, Hutchinson, C. Richard, Vederas, John C

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A New Strategy for the Synthesis of Benzylic Sulfonamides:  Palladium-Catalyzed Arylation and Sulfonamide Metathesis von Grimm, Jonathan B, Katcher, Matthew H, Witter, David J, Northrup, Alan B

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Aminosuberoyl hydroxamic acids (ASHAs): A potent new class of HDAC inhibitors von Belvedere, Sandro, Witter, David J., Yan, Jiaming, Secrist, J. Paul, Richon, Victoria, Miller, Thomas A.

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Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor von Methot, Joey L, Hoffman, Dawn Mampreian, Witter, David J, Stanton, Matthew G, Harrington, Paul, Hamblett, Christopher, Siliphaivanh, Phieng, Wilson, Kevin, Hubbs, Jed, Heidebrecht, Richard, Kral, Astrid M, Ozerova, Nicole, Fleming, Judith C, Wang, Hongmei, Szewczak, Alexander A, Middleton, Richard E, Hughes, Bethany, Cruz, Jonathan C, Haines, Brian B, Chenard, Melissa, Kenific, Candia M, Harsch, Andreas, Secrist, J. Paul, Miller, Thomas A

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Benzo[b]thiophene-based histone deacetylase inhibitors von Witter, David J., Belvedere, Sandro, Chen, Liqiang, Secrist, J. Paul, Mosley, Ralph T., Miller, Thomas A.

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Health status of individuals with mild stroke von DUNCAN, P. W, SAMSA, G. P, WEINBERGER, M, GOLDSTEIN, L. B, BONITO, A, WITTER, D. M, ENARSON, C, MATCHAR, D

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Design of novel histone deacetylase inhibitors von Siliphaivanh, Phieng, Harrington, Paul, Witter, David J., Otte, Karin, Tempest, Paul, Kattar, Sam, Kral, Astrid M., Fleming, Judith C., Deshmukh, Sujal V., Harsch, Andreas, Secrist, Paul J., Miller, Thomas A.

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Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2) von HEIDEBRECHT, Richard W, CHENARD, Melissa, KRAL, Astrid M, MIDDLETON, Richard E, MUSHTI, Chandrasekhar, OZEROVA, Nicole, SZEWCZAK, Alexander A, HONGMEI WANG, WILSON, Kevin, WITTER, David J, SECRIST, J. Paul, MILLER, Thomas A, CLOSE, Joshua, DAHLBERG, William K, FLEMING, Judith, GRIMM, Jonathan B, HAMILL, Julie E, HARSCH, Andreas, HAINES, Brian B, HUGHES, Bethany

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Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors von Morris, Erick J, Jha, Sharda, Restaino, Clifford R, Dayananth, Priya, Zhu, Hugh, Cooper, Alan, Carr, Donna, Deng, Yongi, Jin, Weihong, Black, Stuart, Long, Brian, Liu, Jenny, Dinunzio, Edward, Windsor, William, Zhang, Rumin, Zhao, Shuxia, Angagaw, Minilik H, Pinheiro, Elaine M, Desai, Jagdish, Xiao, Li, Shipps, Gerald, Hruza, Alan, Wang, James, Kelly, Joe, Paliwal, Sunil, Gao, Xiaolei, Babu, Boga Sobhana, Zhu, Liang, Daublain, Pierre, Zhang, Ling, Lutterbach, Bart A, Pelletier, Marc R, Philippar, Ulrike, Siliphaivanh, Phieng, Witter, David, Kirschmeier, Paul, Bishop, W Robert, Hicklin, Daniel, Gilliland, D Gary, Jayaraman, Lata, Zawel, Leigh, Fawell, Stephen, Samatar, Ahmed A

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Phenylglycine and phenylalanine derivatives as potent and selective HDAC1 inhibitors (SHI-1) von Wilson, Kevin J, Witter, David J, Grimm, Jonathan B, Siliphaivanh, Phieng, Otte, Karin M, Kral, Astrid M, Fleming, Judith C, Harsch, Andreas, Hamill, Julie E, Cruz, Jonathan C, Chenard, Melissa, Szewczak, Alexander A, Middleton, Richard E, Hughes, Bethany L, Dahlberg, William K, Secrist, J Paul, Miller, Thomas A

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Development of a Flexible and Robust Synthesis of Tetrahydrofuro[3,4‑b]furan Nucleoside Analogues von Candito, David A, Ye, Yingchun, Quiroz, Ryan V, Reutershan, Michael H, Witter, David, Gadamsetty, Surendra B, Li, Hongming, Saurí, Josep, Schneider, Sebastian E, Lam, Yu-hong, Palte, Rachel L

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The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer von Quiroz, Ryan V, Reutershan, Michael H, Schneider, Sebastian E, Sloman, David, Lacey, Brian M, Swalm, Brooke M, Yeung, Charles S, Gibeau, Craig, Spellman, Daniel S, Rankic, Danica A, Chen, Dapeng, Witter, David, Linn, Doug, Munsell, Erik, Feng, Guo, Xu, Haiyan, Hughes, Jonathan M. E, Lim, Jongwon, Saurí, Josep, Geddes, Kristin, Wan, Murray, Mansueto, My Sam, Follmer, Nicole E, Fier, Patrick S, Siliphaivanh, Phieng, Daublain, Pierre, Palte, Rachel L, Hayes, Robert P, Lee, Sandra, Kawamura, Shuhei, Silverman, Steven, Sanyal, Sulagna, Henderson, Timothy J, Ye, Yingchun, Gao, Yuanwei, Nicholson, Benjamin, Machacek, Michelle R

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Phase (Ph) 1/2a study of CLN-081 in patients (pts) with NSCLC with EGFR exon 20 insertion mutations (Ins20) von Yu, Helena Alexandra, Tan, Daniel Shao-Weng, Smit, Egbert F., Spira, Alexander I., Soo, Ross A., Nguyen, Danny, Lee, Victor Ho-Fun, Yang, James Chih-Hsin, Velcheti, Vamsidhar, Wrangle, John M., Socinski, Mark A., Koczywas, Marianna, Witter, David, Page, Asher, Zawel, Leigh, Janik, John Edward, Piotrowska, Zofia

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Putative Diels−Alder-Catalyzed Cyclization during the Biosynthesis of Lovastatin von Witter, David J, Vederas, John C

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Safety and activity of CLN-081 (TAS6417) in NSCLC with EGFR Exon 20 insertion mutations (Ins20) von Piotrowska, Zofia, Yu, Helena Alexandra, Yang, James Chih-Hsin, Koczywas, Marianna, Smit, Egbert F., Tan, Daniel Shao-Weng, Lee, Victor Ho-Fun, Soo, Ross A., Wrangle, John M., Spira, Alexander I., Velcheti, Vamsidhar, Socinski, Mark A., Page, Asher, Witter, David, Zawel, Leigh, Wigginton, Jon M., Clancy, Myles Steven, Nguyen, Danny

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