The history and future of targeting cyclin-dependent kinases in cancer therapy von Asghar, Uzma, Witkiewicz, Agnieszka K., Turner, Nicholas C., Knudsen, Erik S.

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Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine von Briggs, Kimberly J., Koivunen, Peppi, Cao, Shugeng, Backus, Keriann M., Olenchock, Benjamin A., Patel, Hetalben, Zhang, Qing, Signoretti, Sabina, Gerfen, Gary J., Richardson, Andrea L., Witkiewicz, Agnieszka K., Cravatt, Benjamin F., Clardy, Jon, Kaelin, William G.

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Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities von Franco, Jorge, Balaji, Uthra, Freinkman, Elizaveta, Witkiewicz, Agnieszka K., Knudsen, Erik S.

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The Strange Case of CDK4/6 Inhibitors: Mechanisms, Resistance, and Combination Strategies von Knudsen, Erik S., Witkiewicz, Agnieszka K.

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Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets von Witkiewicz, Agnieszka K., McMillan, Elizabeth A., Balaji, Uthra, Baek, GuemHee, Lin, Wan-Chi, Mansour, John, Mollaee, Mehri, Wagner, Kay-Uwe, Koduru, Prasad, Yopp, Adam, Choti, Michael A., Yeo, Charles J., McCue, Peter, White, Michael A., Knudsen, Erik S.

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Retinoblastoma tumor suppressor pathway in breast cancer: prognosis, precision medicine, and therapeutic interventions von Witkiewicz, Agnieszka K, Knudsen, Erik S

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Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunologic Markers von Knudsen, Erik S, Vail, Paris, Balaji, Uthra, Ngo, Hoai, Botros, Ihab W, Makarov, Vladimir, Riaz, Nadeem, Balachandran, Vinod, Leach, Steven, Thompson, Debrah M, Chan, Timothy A, Witkiewicz, Agnieszka K

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MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies von Baek, GuemHee, Tse, Yan F., Hu, Zeping, Cox, Derek, Buboltz, Noah, McCue, Peter, Yeo, Charles J., White, Michael A., DeBerardinis, Ralph J., Knudsen, Erik S., Witkiewicz, Agnieszka K.

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KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism von Vaseva, Angelina V., Blake, Devon R., Gilbert, Thomas S.K., Ng, Serina, Hostetter, Galen, Azam, Salma H., Ozkan-Dagliyan, Irem, Gautam, Prson, Bryant, Kirsten L., Pearce, Kenneth H., Herring, Laura E., Han, Haiyong, Graves, Lee M., Witkiewicz, Agnieszka K., Knudsen, Erik S., Pecot, Chad V., Rashid, Naim, Houghton, Peter J., Wennerberg, Krister, Cox, Adrienne D., Der, Channing J.

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Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer von Witkiewicz, Agnieszka K., Balaji, Uthra, Eslinger, Cody, McMillan, Elizabeth, Conway, William, Posner, Bruce, Mills, Gordon B., O’Reilly, Eileen M., Knudsen, Erik S.

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The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma von Pavlides, Stephanos, Whitaker-Menezes, Diana, Castello-Cros, Remedios, Flomenberg, Neal, Witkiewicz, Agnieszka K., Frank, Philippe G., Casimiro, Mathew C., Wang, Chenguang, Fortina, Paolo, Addya, Sankar, Pestell, Richard G., Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.

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Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine von Knudsen, Erik S, O’Reilly, Eileen M, Brody, Jonathan R, Witkiewicz, Agnieszka K

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Using the "reverse Warburg effect" to identify high-risk breast cancer patients: Stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers von Witkiewicz, Agnieszka K., Whitaker-Menezes, Diana, Dasgupta, Abhijit, Philp, Nancy J., Lin, Zhao, Gandara, Ricardo, Sneddon, Sharon, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.

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Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors von Dean, Jeffry L., McClendon, A. Kathleen, Hickey, Theresa E., Butler, Lisa M., Tilley, Wayne D., Witkiewicz, Agnieszka K., Knudsen, Erik S.

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Targeting the Vulnerability of RB Tumor Suppressor Loss in Triple-Negative Breast Cancer von Witkiewicz, Agnieszka K., Chung, Sejin, Brough, Rachel, Vail, Paris, Franco, Jorge, Lord, Christopher J., Knudsen, Erik S.

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Immunologic and Metabolic Features of Pancreatic Ductal Adenocarcinoma Define Prognostic Subtypes of Disease von Hutcheson, Jack, Balaji, Uthra, Porembka, Matthew R, Wachsmann, Megan B, McCue, Peter A, Knudsen, Erik S, Witkiewicz, Agnieszka K

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Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts von Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E., Lin, Zhao, Ertel, Adam, Flomenberg, Neal, Witkiewicz, Agnieszka K., Birbe, Ruth, Howell, Anthony, Pavlides, Stephanos, Gandara, Ricardo, Pestell, Richard G., Sotgia, Federica, Philp, Nancy J., Lisanti, Michael P

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Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer von Thangavel, Chellappagounder, Dean, Jeffry L, Ertel, Adam, Knudsen, Karen E, Aldaz, C Marcelo, Witkiewicz, Agnieszka K, Clarke, Robert, Knudsen, Erik S

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Cell Cycle and Beyond: Exploiting New RB1 Controlled Mechanisms for Cancer Therapy von Knudsen, Erik S, Pruitt, Steven C, Hershberger, Pamela A, Witkiewicz, Agnieszka K, Goodrich, David W

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An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers von Witkiewicz, Agnieszka K, Dasgupta, Abhijit, Sotgia, Federica, Mercier, Isabelle, Pestell, Richard G, Sabel, Michael, Kleer, Celina G, Brody, Jonathan R, Lisanti, Michael P

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