Efficient Synthesis of Imidazoles from Aldehydes and 1,2-Diketones Using Microwave Irradiation von Wolkenberg, Scott E, Wisnoski, David D, Leister, William H, Wang, Yi, Zhao, Zhijian, Lindsley, Craig W

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General microwave-assisted protocols for the expedient synthesis of quinoxalines and heterocyclic pyrazines von Zhao, Zhijian, Wisnoski, David D, Wolkenberg, Scott E, Leister, William H, Wang, Yi, Lindsley, Craig W

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Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases von Harris, Philip A, Berger, Scott B, Jeong, Jae U, Nagilla, Rakesh, Bandyopadhyay, Deepak, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Dong, Xiaoyang, Eidam, Patrick M, Finger, Joshua N, Hoffman, Sandra J, Kang, James, Kasparcova, Viera, King, Bryan W, Lehr, Ruth, Lan, Yunfeng, Leister, Lara K, Lich, John D, MacDonald, Thomas T, Miller, Nathan A, Ouellette, Michael T, Pao, Christina S, Rahman, Attiq, Reilly, Michael A, Rendina, Alan R, Rivera, Elizabeth J, Schaeffer, Michelle C, Sehon, Clark A, Singhaus, Robert R, Sun, Helen H, Swift, Barbara A, Totoritis, Rachel D, Vossenkämper, Anna, Ward, Paris, Wisnoski, David D, Zhang, Daohua, Marquis, Robert W, Gough, Peter J, Bertin, John

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Discovery of 3-Aryl-4-isoxazolecarboxamides as TGR5 Receptor Agonists von Evans, Karen A, Budzik, Brian W, Ross, Sean A, Wisnoski, David D, Jin, Jian, Rivero, Ralph A, Vimal, Mythily, Szewczyk, George R, Jayawickreme, Channa, Moncol, David L, Rimele, Thomas J, Armour, Susan L, Weaver, Susan P, Griffin, Robert J, Tadepalli, Sarva M, Jeune, Michael R, Shearer, Todd W, Chen, Zibin B, Chen, Lihong, Anderson, Donald L, Becherer, J. David, De Los Frailes, Maite, Colilla, Francisco Javier

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Synthesis and structure–activity relationships of a series of 3-aryl-4-isoxazolecarboxamides as a new class of TGR5 agonists von Budzik, Brian W., Evans, Karen A., Wisnoski, David D., Jin, Jian, Rivero, Ralph A., Szewczyk, George R., Jayawickreme, Channa, Moncol, David L., Yu, Hongshi

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Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase von Harris, Philip A, Faucher, Nicolas, George, Nicolas, Eidam, Patrick M, King, Bryan W, White, Gemma V, Anderson, Niall A, Bandyopadhyay, Deepak, Beal, Allison M, Beneton, Veronique, Berger, Scott B, Campobasso, Nino, Campos, Sebastien, Capriotti, Carol A, Cox, Julie A, Daugan, Alain, Donche, Frederic, Fouchet, Marie-Hélène, Finger, Joshua N, Geddes, Brad, Gough, Peter J, Grondin, Pascal, Hoffman, Bonnie L, Hoffman, Sandra J, Hutchinson, Susan E, Jeong, Jae U, Jigorel, Emilie, Lamoureux, Pauline, Leister, Lara K, Lich, John D, Mahajan, Mukesh K, Meslamani, Jamel, Mosley, Julie E, Nagilla, Rakesh, Nassau, Pamela M, Ng, Sze-Ling, Ouellette, Michael T, Pasikanti, Kishore K, Potvain, Florent, Reilly, Michael A, Rivera, Elizabeth J, Sautet, Stéphane, Schaeffer, Michelle C, Sehon, Clark A, Sun, Helen, Thorpe, James H, Totoritis, Rachel D, Ward, Paris, Wellaway, Natalie, Wisnoski, David D, Woolven, James M, Bertin, John, Marquis, Robert W

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Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Re... von Wu, Zining, Graybill, Todd L, Zeng, Xin, Platchek, Michael, Zhang, Jean, Bodmer, Vera Q, Wisnoski, David D, Deng, Jianghe, Coppo, Frank T, Yao, Gang, Tamburino, Alex, Scavello, Genaro, Franklin, G. Joseph, Mataruse, Sibongile, Bedard, Katie L, Ding, Yun, Chai, Jing, Summerfield, Jennifer, Centrella, Paolo A, Messer, Jeffrey A, Pope, Andrew J, Israel, David I

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Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity von Charnley, Adam K., Convery, Máire A., Lakdawala Shah, Ami, Jones, Emma, Hardwicke, Philip, Bridges, Angela, Ouellette, Michael, Totoritis, Rachel, Schwartz, Benjamin, King, Bryan W., Wisnoski, David D., Kang, James, Eidam, Patrick M., Votta, Bartholomew J., Gough, Peter J., Marquis, Robert W., Bertin, John, Casillas, Linda

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Discovery of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 5 from a Series of N-(1,3-Diphenyl-1H- pyrazol-5-yl)benzamides That Potentiate Receptor... von Lindsley, Craig W, Wisnoski, David D, Leister, William H, O'Brien, Julie A, Lemaire, Wei, Williams, David L, Burno, Maryann, Sur, Cyrille, Kinney, Gene G, Pettibone, Doug J, Tiller, Philip R, Smith, Sheri, Duggan, Mark E, Hartman, George D, Conn, P. Jeffrey, Huff, Joel R

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Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M1 positive allosteric modulators von YANG, Feng V, SHIPE, William D, SEAGER, Matthew A, KOEPLINGER, Kenneth A, HARTMAN, George D, LINDSLEY, Craig W, BUNDA, Jaime L, BRAD NOLT, M, WISNOSKI, David D, ZHIJIAN ZHAO, BARROW, James C, RAY, William J, LEI MA, WITTMANN, Marion

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Challenges in the development of mGluR5 positive allosteric modulators: The discovery of CPPHA von Zhao, Zhijian, Wisnoski, David D., O’Brien, Julie A., Lemaire, Wei, Williams, David L., Jacobson, Marlene A., Wittman, Marion, Ha, Sookhee N., Schaffhauser, Herve, Sur, Cyrille, Pettibone, Doug J., Duggan, Mark E., Conn, P. Jeffrey, Hartman, George D., Lindsley, Craig W.

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A ‘one pot’ microwave-mediated synthesis of the basic canthine skeleton: expedient access to unnatural β-carboline alkaloids von Lindsley, Craig W, Wisnoski, David D, Wang, Yi, Leister, William H, Zhao, Zhijian

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Discovery of GlyT1 inhibitors with improved pharmacokinetic properties von Wolkenberg, Scott E., Zhao, Zhijian, Wisnoski, David D., Leister, William H., O’Brien, Julie, Lemaire, Wei, Williams, David L., Jacobson, Marlene A., Sur, Cyrille, Kinney, Gene G., Pettibone, Doug J., Tiller, Philip R., Smith, Sheri, Gibson, Christopher, Ma, Bennett K., Polsky-Fisher, Stacey L., Lindsley, Craig W., Hartman, George D.

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Phenoxyacetic acids as PPARδ partial agonists: Synthesis, optimization, and in vivo efficacy von Evans, Karen A., Shearer, Barry G., Wisnoski, David D., Shi, Dongchuan, Sparks, Steven M., Sternbach, Daniel D., Winegar, Deborah A., Billin, Andrew N., Britt, Christy, Way, James M., Epperly, Andrea H., Leesnitzer, Lisa M., Merrihew, Raymond V., Xu, Robert X., Lambert, Millard H., Jin, Jian

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N ω -Nitro-N ω’ -Substituted Guanidines: A Simple Class of Nitric Oxide Synthase Inhibitors von Guillon, Christophe D., Wisnoski, David D., Saxena, Jaya, Heindel, Ned D., Heck, Diane E., Wolff, Donald J., Laskin, Jeffrey D.

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p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5- d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3- d]pyrimidin-2-ones von Natarajan, Swaminathan R., Wisnoski, David D., Thompson, James E., O’Neill, Edward A., O’Keefe, Stephen J.

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Acetonitrile/water gas-phase reaction products observed by use of atmospheric pressure chemical ionization: adducts formed with sulfonamides von Ross III, Charles W., Coddington, Arthur B., Murphy, Joan S., Wisnoski, David D., Zartman, C. Blair, Ramjit, Harri G.

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Cyclization of unsaturated amides with triflic anhydride and samarium diiodide von McDonald, Chriss E, Galka, Amy M, Green, Ahren I, Keane, Joseph M, Kowalchick, Jennifer E, Micklitsch, Christopher M, Wisnoski, David D

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Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M 1 positive allosteric modulators von Yang, Feng V., Shipe, William D., Bunda, Jaime L., Nolt, M. Brad, Wisnoski, David D., Zhao, Zhijian, Barrow, James C., Ray, William J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Hartman, George D., Lindsley, Craig W.

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Difference in mGluR5 Interaction between Positive Allosteric Modulators from Two Structural Classes von WILLIAMS JR, DAVID L., O'BRIEN, JULIE A., LEMAIRE, WEI, CHEN, TSING-BAU, CHANG, RAYMOND S. L., JACOBSON, MARLENE A., HA, SOOKHEE N., WISNOSKI, DAVID D., LINDSLEY, CRAIG W., SUR, CYRILLE, DUGGAN, MARK E., PETTIBONE, DOUGLAS J., CONN, P. JEFFREY

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