Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis von Yoshimi, Akihide, Lin, Kuan-Ting, Wiseman, Daniel H., Rahman, Mohammad Alinoor, Pastore, Alessandro, Wang, Bo, Lee, Stanley Chun-Wei, Micol, Jean-Baptiste, Zhang, Xiao Jing, de Botton, Stephane, Penard-Lacronique, Virginie, Stein, Eytan M., Cho, Hana, Miles, Rachel E., Inoue, Daichi, Albrecht, Todd R., Somervaille, Tim C. P., Batta, Kiran, Amaral, Fabio, Simeoni, Fabrizio, Wilks, Deepti P., Cargo, Catherine, Intlekofer, Andrew M., Levine, Ross L., Dvinge, Heidi, Bradley, Robert K., Wagner, Eric J., Krainer, Adrian R., Abdel-Wahab, Omar

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Reversible Inhibitors of LSD1 as Therapeutic Agents in Acute Myeloid Leukemia: Clinical Significance and Progress to Date von Mould, Daniel P., McGonagle, Alison E., Wiseman, Daniel H., Williams, Emma L., Jordan, Allan M.

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Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia von Maiques-Diaz, Alba, Spencer, Gary J., Lynch, James T., Ciceri, Filippo, Williams, Emma L., Amaral, Fabio M.R., Wiseman, Daniel H., Harris, William J., Li, Yaoyong, Sahoo, Sudhakar, Hitchin, James R., Mould, Daniel P., Fairweather, Emma E., Waszkowycz, Bohdan, Jordan, Allan M., Smith, Duncan L., Somervaille, Tim C.P.

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Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia von Somerville, Tim D.D., Wiseman, Daniel H., Spencer, Gary J., Huang, Xu, Lynch, James T., Leong, Hui Sun, Williams, Emma L., Cheesman, Edmund, Somervaille, Tim C.P.

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Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia von Simeoni, Fabrizio, Romero-Camarero, Isabel, Camera, Francesco, Amaral, Fabio M.R., Sinclair, Oliver J., Papachristou, Evangelia K., Spencer, Gary J., Lie-A-Ling, Michael, Lacaud, Georges, Wiseman, Daniel H., Carroll, Jason S., Somervaille, Tim C.P.

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A novel syndrome of congenital sideroblastic anemia, B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD) von Wiseman, Daniel H., May, Alison, Jolles, Stephen, Connor, Philip, Powell, Colin, Heeney, Matthew M., Giardina, Patricia J., Klaassen, Robert J., Chakraborty, Pranesh, Geraghty, Michael T., Major-Cook, Nathalie, Kannengiesser, Caroline, Thuret, Isabelle, Thompson, Alexis A., Marques, Laura, Hughes, Stephen, Bonney, Denise K., Bottomley, Sylvia S., Fleming, Mark D., Wynn, Robert F.

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Blast cells surviving acute myeloid leukemia induction therapy are in cycle with a signature of FOXM1 activity von Williams, Mark S, Basma, Naseer J, Amaral, Fabio M R, Wiseman, Daniel H, Somervaille, Tim C P

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Prognostic and therapeutic implications of TP53 expression in chronic myelomonocytic leukemia von Wang, Yu-Hung, Lin, Chien-Chin, Gurashi, Kristian, Yao, Chi-Yuan, Jerez, Andres, Hou, Hsin-An, Chou, Wen-Chien, Tien, Hwei-Fang, Batta, Kiran, Wiseman, Daniel H.

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Targeted nanopore sequencing for the identification of ABCB1 promoter translocations in cancer von Williams, Mark S, Basma, Naseer J, Amaral, Fabio M R, Williams, Gillian, Weightman, John P, Breitwieser, Wolfgang, Nelson, Louisa, Taylor, Stephen S, Wiseman, Daniel H, Somervaille, Tim C P

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The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy von Mosteo, Laura, Storer, Joanna, Batta, Kiran, Searle, Emma J, Duarte, Delfim, Wiseman, Daniel H

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Chronic myelomonocytic leukaemia stem cell transcriptomes anticipate disease morphology and outcome von Wiseman, Daniel H, Baker, Syed M, Dongre, Arundhati V, Gurashi, Kristian, Storer, Joanna A, Somervaille, Tim CP, Batta, Kiran

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Differentiation block in acute myeloid leukemia regulated by intronic sequences of FTO von Camera, Francesco, Romero-Camarero, Isabel, Revell, Bradley H., Amaral, Fabio M.R., Sinclair, Oliver J., Simeoni, Fabrizio, Wiseman, Daniel H., Stojic, Lovorka, Somervaille, Tim C.P.

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Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils von Huerga Encabo, Hector, Aramburu, Iker Valle, Garcia-Albornoz, Manuel, Piganeau, Marion, Wood, Henry, Song, Anna, Ferrelli, Alessandra, Sharma, Aneesh, Minutti, Carlos M., Domart, Marie-Charlotte, Papazoglou, Despoina, Gurashi, Kristian, Llorian Sopena, Miriam, Goldstone, Robert, Fallesen, Todd, Wang, Qian, Ariza-McNaughton, Linda, Wiseman, Daniel H., Batta, Kiran, Gupta, Rajeev, Papayannopoulos, Venizelos, Bonnet, Dominique

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Multi-omic analysis of chronic myelomonocytic leukemia monocytes reveals metabolic and immune dysregulation leading to altered macrophage polarization von Addinsell, Hasse M, Cant, Rachel, Hull, Nathan J, Wang, Yu-Hung, Somervaille, Tim C P, Wiseman, Daniel H, Batta, Kiran

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SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications von Singh, Shalini, Ahmed, Doaa, Dolatshad, Hamid, Tatwavedi, Dharamveer, Schulze, Ulrike, Sanchi, Andrea, Ryley, Sarah, Dhir, Ashish, Carpenter, Lee, Watt, Suzanne M., Roberts, David J., Abdel-Aal, Amal M., Sayed, Sohair K., Mohamed, Somaia A., Schuh, Anna, Vyas, Paresh, Killick, Sally, Kotini, Andriana G., Papapetrou, Eirini P., Wiseman, Daniel H., Pellagatti, Andrea, Boultwood, Jacqueline

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Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies von Nicosia, Luciano, Spencer, Gary J, Brooks, Nigel, Amaral, Fabio M R, Basma, Naseer J, Chadwick, John A, Revell, Bradley, Wingelhofer, Bettina, Maiques-Diaz, Alba, Sinclair, Oliver, Camera, Francesco, Ciceri, Filippo, Wiseman, Daniel H, Pegg, Neil, West, Will, Knurowski, Tomasz, Frese, Kris, Clegg, Karen, Campbell, Victoria L, Cavet, James, Copland, Mhairi, Searle, Emma, Somervaille, Tim C P

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Divergent clonal evolution of blastic plasmacytoid dendritic cell neoplasm and chronic myelomonocytic leukemia from a shared TET2-mutated origin von Batta, Kiran, Bossenbroek, Hasse M., Pemmaraju, Naveen, Wilks, Deepti P., Chasty, Richard, Dennis, Mike, Milne, Paul, Collin, Matthew, Beird, Hannah C., Taylor, Justin, Patnaik, Mrinal M., Cargo, Catherine A., Somervaille, Tim C. P., Wiseman, Daniel H.

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Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths von Cortés-López, Mariela, Chamely, Paulina, Hawkins, Allegra G., Stanley, Robert F., Swett, Ariel D., Ganesan, Saravanan, Mouhieddine, Tarek H., Dai, Xiaoguang, Kluegel, Lloyd, Chen, Celine, Batta, Kiran, Furer, Nili, Vedula, Rahul S., Beaulaurier, John, Drong, Alexander W., Hickey, Scott, Dusaj, Neville, Mullokandov, Gavriel, Stasiw, Adam M., Su, Jiayu, Chaligné, Ronan, Juul, Sissel, Harrington, Eoghan, Knowles, David A., Potenski, Catherine J., Wiseman, Daniel H., Tanay, Amos, Shlush, Liran, Lindsley, Robert C., Ghobrial, Irene M., Taylor, Justin, Abdel-Wahab, Omar, Gaiti, Federico, Landau, Dan A.

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Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD) von Chakraborty, Pranesh K., Schmitz-Abe, Klaus, Kennedy, Erin K., Mamady, Hapsatou, Naas, Turaya, Durie, Danielle, Campagna, Dean R., Lau, Ashley, Sendamarai, Anoop K., Wiseman, Daniel H., May, Alison, Jolles, Stephen, Connor, Philip, Powell, Colin, Heeney, Matthew M., Giardina, Patricia-Jane, Klaassen, Robert J., Kannengiesser, Caroline, Thuret, Isabelle, Thompson, Alexis A., Marques, Laura, Hughes, Stephen, Bonney, Denise K., Bottomley, Sylvia S., Wynn, Robert F., Laxer, Ronald M., Minniti, Caterina P., Moppett, John, Bordon, Victoria, Geraghty, Michael, Joyce, Paul B.M., Markianos, Kyriacos, Rudner, Adam D., Holcik, Martin, Fleming, Mark D.

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Synergistic effect of concurrent high molecular risk mutations and lower JAK2 mutant variant allele frequencies on prognosis in patients with myelofibrosis-insights from a multicen... von Wang, Yu-Hung, Wei, Chao-Hung, Lin, Chien-Chin, Gurnari, Carmelo, Awada, Hussein, Benajiba, Lina, Daltro de Oliveira, Rafael, Soret-Dulphy, Juliette, Cassinat, Bruno, Zucenka, Andrius, Mosquera Orgueira, Adrián, Yuan, Chang-Tsu, Lee, Sze-Hwei, Yao, Chi-Yuan, Gurashi, Kristian, Hou, Hsin-An, Batta, Kiran, Pérez Encinas, Manuel Mateo, Chou, Wen-Chien, Maciejewski, Jaroslaw P, Wiseman, Daniel H, Kiladjian, Jean-Jacques, Tien, Hwei-Fang

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