A Structural Basis for Constitutive Activity in the Human CAR/RXRα Heterodimer von Xu, Robert X., Lambert, Millard H., Wisely, Bruce B., Warren, Erin N., Weinert, Emily E., Waitt, Gregory M., Williams, Jon D., Collins, Jon L., Moore, Linda B., Willson, Timothy M., Moore, John T.

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A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer von Xu, Robert X, Lambert, Millard H, Wisely, Bruce B, Warren, Erin N, Weinert, Emily E, Waitt, Gregory M, Williams, Jon D, Collins, Jon L, Moore, Linda B, Willson, Timothy M, Moore, John T

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The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity von Watkins, Ryan E., Wisely, G. Bruce, Moore, Linda B., Collins, Jon L., Lambert, Millard H., Williams, Shawn P., Willson, Timothy M., Kliewer, Steven A., Redinbo, Matthew R.

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St. John's Wort Induces Hepatic Drug Metabolism through Activation of the Pregnane X Receptor von Moore, Linda B., Goodwin, Bryan, Jones, Stacey A., Wisely, G. Bruce, Serabjit-Singh, Cosette J., Willson, Timothy M., Collins, Jon L., Kliewer, Steven A.

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Structural Disorder in the Complex of Human Pregnane X Receptor and the Macrolide Antibiotic Rifampicin von Chrencik, Jill E, Orans, Jillian, Moore, Linda B, Xue, Yu, Peng, Li, Collins, Jon L, Wisely, G. Bruce, Lambert, Millard H, Kliewer, Steven A, Redinbo, Matthew R

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Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene von Akwabi-Ameyaw, Adwoa, Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., Miller, Aaron B., Navas, Frank, Parks, Derek J., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce

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Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064 von Akwabi-Ameyaw, Adwoa, Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Jones, Stacey A., Kaldor, Istvan, Liu, Yaping, Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., III, Frank Navas, Parks, Derek J., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce

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FXR agonist activity of conformationally constrained analogs of GW 4064 von Akwabi-Ameyaw, Adwoa, Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., Navas, Frank, Parks, Derek J., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Bruce Wisely, G.

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Hepatocyte Nuclear Factor 4 Is a Transcription Factor that Constitutively Binds Fatty Acids von Wisely, G.Bruce, Miller, Ann B., Davis, Roderick G., Thornquest, Alan D., Johnson, Robert, Spitzer, Tim, Sefler, Andrea, Shearer, Barry, Moore, John T., Miller, Aaron B., Willson, Timothy M., Williams, Shawn P.

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Conformationally constrained farnesoid X receptor (FXR) agonists: Heteroaryl replacements of the naphthalene von Bass, Jonathan Y., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., Mills, Wendy Y., Navas, Frank, Parks, Derek J., Smalley, Terrence L., Spearing, Paul K., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce

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Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ von Nolte, Robert T., Wisely, G. Bruce, Westin, Stefan, Cobb, Jeffery E., Lambert, Millard H., Kurokawa, Riki, Rosenfeld, Michael G., Willson, Timothy M., Glass, Christopher K., Milburn, Michael V.

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Structural Requirements of Ligands for the Oxysterol Liver X Receptors LXR α and LXRβ von Janowski, Bethany A., Grogan, Michael J., Jones, Stacey A., Wisely, G. Bruce, Kliewer, Steven A., Corey, Elias J., Mangelsdorf, David J.

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Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators von Westin, Stefan, Kurokawa, Riki, Nolte, Robert T., Wisely, G. Bruce, McInerney, Eileen M., Rose, David W., Milburn, Michael V., Rosenfeld, Michael G., Glass, Christopher K.

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Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma von Kliewer, S.A. (Glaxo Wellcome Research and Development, Research Triangle Park, NC.), Sundseth, S.S, Jones, S.A, Brown, P.J, Wisely, G.B, Koble, C.S, Devchand, P, Walhi, W, Willson, T.M, Lenhard, J.M

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Pregnane X Receptor (PXR), Constitutive Androstane Receptor (CAR), and Benzoate X Receptor (BXR) Define Three Pharmacologically Distinct Classes of Nuclear Receptors von Moore, Linda B, Maglich, Jodi M, McKee, David D, Wisely, Bruce, Willson, Timothy M, Kliewer, Steven A, Lambert, Millard H, Moore, John T

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Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064 von Bass, Jonathan Y., Caldwell, Richard D., Caravella, Justin A., Chen, Lihong, Creech, Katrina L., Deaton, David N., Madauss, Kevin P., Marr, Harry B., McFadyen, Robert B., Miller, Aaron B., Parks, Derek J., Todd, Dan, Williams, Shawn P., Wisely, G. Bruce

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Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors von Xu, H.Eric, Lambert, Millard H, Montana, Valerie G, Parks, Derek J, Blanchard, Steven G, Brown, Peter J, Sternbach, Daniel D, Lehmann, Jürgen M, Wisely, G.Bruce, Willson, Timothy M, Kliewer, Steven A, Milburn, Michael V

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2.1 Å Crystal Structure of Human PXR in Complex with the St. John's Wort Compound Hyperforin von Watkins, Ryan E, Maglich, Jodi M, Moore, Linda B, Wisely, G. Bruce, Noble, Schroeder M, Davis-Searles, Paula R, Lambert, Mill H, Kliewer, Steven A, Redinbo, Matthew R

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The Phytoestrogen Coumestrol Is a Naturally Occurring Antagonist of the Human Pregnane X Receptor von Wang, Hongwei, Li, Hao, Moore, Linda B, Johnson, Michael D. L, Maglich, Jodi M, Goodwin, Bryan, Ittoop, Olivia R. R, Wisely, Bruce, Creech, Katrina, Parks, Derek J, Collins, Jon L, Willson, Timothy M, Kalpana, Ganjam V, Venkatesh, Madhukumar, Xie, Wen, Cho, Sool Y, Roboz, John, Redinbo, Matthew, Moore, John T, Mani, Sridhar

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A New Series of Estrogen Receptor Modulators That Display Selectivity for Estrogen Receptor β von Henke, Brad R, Consler, Thomas G, Go, Ning, Hale, Ron L, Hohman, Dana R, Jones, Stacey A, Lu, Amy T, Moore, Linda B, Moore, John T, Orband-Miller, Lisa A, Robinett, R. Graham, Shearin, Jean, Spearing, Paul K, Stewart, Eugene L, Turnbull, Philip S, Weaver, Susan L, Williams, Shawn P, Wisely, G. Bruce, Lambert, Millard H

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