Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours von Gampala, Silpa, Shah, Fenil, Zhang, Chi, Rhodes, Steven D., Babb, Olivia, Grimard, Michelle, Wireman, Randall S., Rad, Ellie, Calver, Brian, Bai, Ren-Yuan, Staedtke, Verena, Hulsey, Emily L., Saadatzadeh, M. Reza, Pollok, Karen E., Tong, Yan, Smith, Abbi E., Clapp, D. Wade, Tee, Andrew R., Kelley, Mark R., Fishel, Melissa L.

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Correction: Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours von Gampala, Silpa, Shah, Fenil, Zhang, Chi, Rhodes, Steven D., Babb, Olivia, Grimard, Michelle, Wireman, Randall S., Rad, Ellie, Calver, Brian, Bai, Ren-Yuan, Staedtke, Verena, Hulsey, Emily L., Saadatzadeh, M. Reza, Pollok, Karen E., Tong, Yan, Smith, Abbi E., Clapp, D. Wade, Tee, Andrew R., Kelley, Mark R., Fishel, Melissa L.

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New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types von Gampala, Silpa, Moon, Hye-ran, Wireman, Randall, Peil, Jacqueline, Kiran, Sonia, Mitchell, Dana K., Brewster, Kylee, Mang, Henry, Masters, Andi, Bach, Christine, Smith-Kinnamen, Whitney, Doud, Emma H., Rai, Ratan, Mosley, Amber L., Quinney, Sara K., Clapp, D. Wade, Hamdouchi, Chafiq, Wikel, James, Zhang, Chi, Han, Bumsoo, Georgiadis, Millie M., Kelley, Mark R., Fishel, Melissa L.

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RelA Is an Essential Target for Enhancing Cellular Responses to the DNA Repair/Ref-1 Redox Signaling Protein and Restoring Perturbated Cellular Redox Homeostasis in Mouse PDAC Cell... von Mijit, Mahmut, Wireman, Randall, Armstrong, Lee, Gampala, Silpa, Hassan, Zonera, Schneeweis, Christian, Schneider, Guenter, Zhang, Chi, Fishel, Melissa L, Kelley, Mark R

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ROS associated ER-stress and intracellular Cysteine 65 in Ref-1 is essential for Ref-1 redox function and transcriptional regulation in human PDAC cells von Maihemuti, Mijiti, Gampala, Silpa, Wireman, Randall, Kpenu, Eryam, Georgiadis, Millie, Fishel, Melissa, Kelley, Mark

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Abstract 1452: Deciphering mechanisms of Ref-1 signaling and its inhibition in aggressive tumor-stroma PDAC models von Gampala, Silpa, Chowdhury, Nayela, Babb, Olivia, Caston, Rachel A., Wireman, Randall S., Moon, Hye-ran, Sandusky, George, Hulsey, Emily, Han, Bumsoo, Georgiadis, Millie M., Quinney, Sara K., Masters, Andi R., Wikel, James H., Kelley, Mark R., Fishel, Melissa L.

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Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1 von Trilles, Richard, Beglov, Dmitri, Chen, Qiujia, He, Hongzhen, Wireman, Randall, Reed, April, Chennamadhavuni, Spandan, Panek, James S, Brown, Lauren E, Vajda, Sandor, Porco, John A, Kelley, Mark R, Georgiadis, Millie M

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Combined inhibition of Ref‐1 and STAT3 leads to synergistic tumour inhibition in multiple cancers using 3D and in vivo tumour co‐culture models von Caston, Rachel A., Shah, Fenil, Starcher, Colton L., Wireman, Randall, Babb, Olivia, Grimard, Michelle, McGeown, Jack, Armstrong, Lee, Tong, Yan, Pili, Roberto, Rupert, Joseph, Zimmers, Teresa A., Elmi, Adily N., Pollok, Karen E., Motea, Edward A., Kelley, Mark R., Fishel, Melissa L.

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Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neurons von Georgiadis, Millie M., Chen, Qiujia, Meng, Jingwei, Guo, Chunlu, Wireman, Randall, Reed, April, Vasko, Michael R., Kelley, Mark R.

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Abstract 2366: Inhibition of Ref-1/APE1 redox activity with APX3330 enhances Ref-1/APE1 protein unfolded conformation in human PDAC cells von Mijit, Mahmut, Babb, Olivia, Gampala, Silpa, Wireman, Randall, Georgiadis, Millie M., Fishel, Melissa L., Kelley, Mark R.

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Abstract C129: Development of new increased potency Ref-1/APE1 targeted inhibitors that show promise for clinical applications against solid tumors von Gampala, Silpa, Moon, Hye-Ran, Wireman, Randall, Peil, Jacqueline, Kiran, Sonia, Masters, Andi, Bach, Christine, Smith-Kinnamen, Whitney, Doud, Emma, Rai, Ratan, Mosley, Amber L, Georgiadis, Millie M, Han, Bumsoo, Zhang, Chi, Hamdouchi, Chafiq, Wikel, James, Kelley, Mark R, Fishel, Melissa L

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Phosphorylation site specificity of the Pak-mediated regulation of Raf-1 and cooperativity with Src von King, Alastair J., Wireman, Randall S., Hamilton, Mark, Marshall, Mark S.

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