Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress von Thomas, Anish, Takahashi, Nobuyuki, Rajapakse, Vinodh N., Zhang, Xiaohu, Sun, Yilun, Ceribelli, Michele, Wilson, Kelli M., Zhang, Yang, Beck, Erin, Sciuto, Linda, Nichols, Samantha, Elenbaas, Brian, Puc, Janusz, Dahmen, Heike, Zimmermann, Astrid, Varonin, Jillian, Schultz, Christopher W., Kim, Sehyun, Shimellis, Hirity, Desai, Parth, Klumpp-Thomas, Carleen, Chen, Lu, Travers, Jameson, McKnight, Crystal, Michael, Sam, Itkin, Zina, Lee, Sunmin, Yuno, Akira, Lee, Min-Jung, Redon, Christophe E., Kindrick, Jessica D., Peer, Cody J., Wei, Jun S., Aladjem, Mirit, Figg, William Douglas, Steinberg, Seth M., Trepel, Jane B., Zenke, Frank T., Pommier, Yves, Khan, Javed, Thomas, Craig J.

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Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2 von Chen, Catherine Z., Shinn, Paul, Itkin, Zina, Eastman, Richard T., Bostwick, Robert, Rasmussen, Lynn, Huang, Ruili, Shen, Min, Hu, Xin, Wilson, Kelli M., Brooks, Brianna M., Guo, Hui, Zhao, Tongan, Klump-Thomas, Carleen, Simeonov, Anton, Michael, Samuel G., Lo, Donald C., Hall, Matthew D., Zheng, Wei

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A landscape of response to drug combinations in non-small cell lung cancer von Nair, Nishanth Ulhas, Greninger, Patricia, Zhang, Xiaohu, Friedman, Adam A., Amzallag, Arnaud, Cortez, Eliane, Sahu, Avinash Das, Lee, Joo Sang, Dastur, Anahita, Egan, Regina K., Murchie, Ellen, Ceribelli, Michele, Crowther, Giovanna S., Beck, Erin, McClanaghan, Joseph, Klump-Thomas, Carleen, Boisvert, Jessica L., Damon, Leah J., Wilson, Kelli M., Ho, Jeffrey, Tam, Angela, McKnight, Crystal, Michael, Sam, Itkin, Zina, Garnett, Mathew J., Engelman, Jeffrey A., Haber, Daniel A., Thomas, Craig J., Ruppin, Eytan, Benes, Cyril H.

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Establishment and Biological Characterization of a Panel of Glioblastoma Multiforme (GBM) and GBM Variant Oncosphere Cell Lines von Binder, Zev A, Wilson, Kelli M, Salmasi, Vafi, Orr, Brent A, Eberhart, Charles G, Siu, I-Mei, Lim, Michael, Weingart, Jon D, Quinones-Hinojosa, Alfredo, Bettegowda, Chetan, Kassam, Amin B, Olivi, Alessandro, Brem, Henry, Riggins, Gregory J, Gallia, Gary L

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Multi-Component, Time-Course screening to develop combination cancer therapies based on synergistic toxicity von Ceribelli, Michele, Tosto, Frances Anne, Zhang, Xiaohu, Melani, Christopher J., Roschewski, Mark, Beck, Erin, Klumpp-Thomas, Carleen, Peer, Cody J., Wilson, Kelli M., Chen, Lu, McKnight, Crystal, Michael, Sam, Itkin, Zina, Shinn, Paul, Figg, William D., Wilson, Wyndham H., Staudt, Louis M., Thomas, Craig J.

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Targeting the PI3K/mTOR Pathway Augments CHK1 Inhibitor-Induced Replication Stress and Antitumor Activity in High-Grade Serous Ovarian Cancer von Huang, Tzu-Ting, Brill, Ethan, Nair, Jayakumar R., Zhang, Xiaohu, Wilson, Kelli M., Chen, Lu, Thomas, Craig J., Lee, Jung-Min

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Augmented efficacy of brentuximab vedotin combined with ruxolitinib and/or Navitoclax in a murine model of human Hodgkin’s lymphoma von Ju, Wei, Zhang, Meili, Wilson, Kelli M., Petrus, Michael N., Bamford, Richard N., Zhang, Xiaohu, Guha, Rajarshi, Ferrer, Marc, Thomas, Craig J., Waldmann, Thomas A.

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Methotrexate-based PROTACs as DHFR-specific chemical probes von Rana, Sandeep, Dranchak, Patricia, Dahlin, Jayme L., Lamy, Laurence, Li, Wenqing, Oliphant, Erin, Shrimp, Jonathan H., Rajacharya, Girish H., Tharakan, Ravi, Holland, David O., Whitten, Apryl S., Wilson, Kelli M., Singh, Pankaj K., Durum, Scott K., Tao, Dingyin, Rai, Ganesha, Inglese, James

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Targeting AML-associated FLT3 mutations with a type I kinase inhibitor von Jones, LaQuita M., Melgar, Katelyn, Bolanos, Lyndsey, Hueneman, Kathleen, Walker, Morgan M., Jiang, Jian-Kang, Wilson, Kelli M., Zhang, Xiaohu, Shen, Jian, Jiang, Fan, Sutter, Patrick, Wang, Amy, Xu, Xin, Tawa, Gregory J., Hoyt, Scott B., Wunderlich, Mark, O'Brien, Eric, Perentesis, John P., Starczynowski, Daniel T., Thomas, Craig J.

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High-throughput and targeted drug screens identify pharmacological candidates against MiT-translocation renal cell carcinoma von Lang, Martin, Schmidt, Laura S, Wilson, Kelli M, Ricketts, Christopher J, Sourbier, Carole, Vocke, Cathy D, Wei, Darmood, Crooks, Daniel R, Yang, Youfeng, Gibbs, Benjamin K, Zhang, Xiaohu, Klumpp-Thomas, Carleen, Chen, Lu, Guha, Rajarshi, Ferrer, Marc, McKnight, Crystal, Itkin, Zina, Wangsa, Darawalee, Wangsa, Danny, James, Amy, Difilippantonio, Simone, Karim, Baktir, Morís, Francisco, Ried, Thomas, Merino, Maria J, Srinivasan, Ramaprasad, Thomas, Craig J, Linehan, W Marston

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Targeting ACE2–RBD Interaction as a Platform for COVID-19 Therapeutics: Development and Drug-Repurposing Screen of an AlphaLISA Proximity Assay von Hanson, Quinlin M, Wilson, Kelli M, Shen, Min, Itkin, Zina, Eastman, Richard T, Shinn, Paul, Hall, Matthew D

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Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma von Yang, Yandan, Bolomsky, Arnold, Oellerich, Thomas, Chen, Ping, Ceribelli, Michele, Häupl, Björn, Wright, George W., Phelan, James D., Huang, Da Wei, Lord, James W., Van Winkle, Callie K., Yu, Xin, Wisniewski, Jan, Wang, James Q., Tosto, Frances A., Beck, Erin, Wilson, Kelli, McKnight, Crystal, Travers, Jameson, Klumpp-Thomas, Carleen, Smith, Grace A., Pittaluga, Stefania, Maric, Irina, Kazandjian, Dickran, Thomas, Craig J., Young, Ryan M.

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Rigosertib Induces Mitotic Arrest and Apoptosis in RAS-Mutated Rhabdomyosarcoma and Neuroblastoma von Kowalczyk, Joshua T., Wan, Xiaolin, Hernandez, Edjay R., Luo, Ruibai, Lyons, Gaelyn C., Wilson, Kelli M., Gallardo, Devorah C., Isanogle, Kristine A., Robinson, Christina M., Mendoza, Arnulfo, Heske, Christine M., Chen, Jinqui-Qiu, Luo, Xiaoling, Kelly, Alexander E., Difilippantinio, Simone, Robey, Robert W., Thomas, Craig J., Sackett, Dan L., Morrison, Deborah K., Randazzo, Paul A., Jenkins, Lisa M. Miller, Yohe, Marielle E.

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mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer von Kumari, Anju, Gesumaria, Lisa, Liu, Yan-Jin, Hughitt, V Keith, Zhang, Xiaohu, Ceribelli, Michele, Wilson, Kelli M, Klumpp-Thomas, Carleen, Chen, Lu, McKnight, Crystal, Itkin, Zina, Thomas, Craig J, Mock, Beverly A, Schrump, David S, Chen, Haobin

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Publisher Correction: Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma von Yang, Yandan, Bolomsky, Arnold, Oellerich, Thomas, Chen, Ping, Ceribelli, Michele, Häupl, Björn, Wright, George W., Phelan, James D., Huang, Da Wei, Lord, James W., Van Winkle, Callie K., Yu, Xin, Wisniewski, Jan, Wang, James Q., Tosto, Frances A., Beck, Erin, Wilson, Kelli, McKnight, Crystal, Travers, Jameson, Klumpp-Thomas, Carleen, Smith, Grace A., Pittaluga, Stefania, Maric, Irina, Kazandjian, Dickran, Thomas, Craig J., Young, Ryan M.

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High-throughput approaches to uncover synergistic drug combinations in leukemia von Chory, Emma J., Wang, Meng, Ceribelli, Michele, Michalowska, Aleksandra M, Golas, Stefan, Beck, Erin, Klumpp-Thomas, Carleen, Chen, Lu, McKnight, Crystal, Itkin, Zina, Wilson, Kelli M., Holland, David, Divakaran, Sanjay, Bradner, James, Khan, Javed, Gryder, Berkley E., Thomas, Craig J., Stanton, Benjamin Z.

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Anxiolytic Drug FGIN-1-27 Ameliorates Autoimmunity by Metabolic Reprogramming of Pathogenic Th17 Cells von Singh, Anju, Dashnyam, Myagmarjav, Chim, Bryan, Escobar, Thelma M., Dulcey, Andrés E., Hu, Xin, Wilson, Kelli M., Koganti, Prasanthi P., Spinner, Camille A., Xu, Xin, Jadhav, Ajit, Southall, Noel, Marugan, Juan, Selvaraj, Vimal, Lazarevic, Vanja, Muljo, Stefan A., Ferrer, Marc

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Inhibition of HSP 90 is associated with potent anti-tumor activity in Papillary Renal Cell Carcinoma von Pahwa, Roma, Dubhashi, Janhavi, Singh, Anand, Jailwala, Parthav, Lobanov, Alexei, Thomas, Craig J, Ceribelli, Michele, Wilson, Kelli, Ricketts, Christopher J, Vocke, Cathy D, Wells, Catherine, Bottaro, Donald P, Linehan, W. Marston, Neckers, Len, Srinivasan, Ramaprasad

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Overcoming Acquired Epigenetic Resistance to BTK Inhibitors von Shaffer, 3rd, Arthur L, Phelan, James D, Wang, James Q, Huang, DaWei, Wright, George W, Kasbekar, Monica, Choi, Jaewoo, Young, Ryan M, Webster, Daniel E, Yang, Yandan, Zhao, Hong, Yu, Xin, Xu, Weihong, Roulland, Sandrine, Ceribelli, Michele, Zhang, Xiaohu, Wilson, Kelli M, Chen, Lu, McKnight, Crystal, Klumpp-Thomas, Carleen, Thomas, Craig J, Häupl, Björn, Oellerich, Thomas, Rae, Zachary, Kelly, Michael C, Ahn, Inhye E, Sun, Clare, Gaglione, Erika M, Wilson, Wyndham H, Wiestner, Adrian, Staudt, Louis M

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High-Throughput Screening for Drug Combinations von Shinn, Paul, Chen, Lu, Ferrer, Marc, Itkin, Zina, Klumpp-Thomas, Carleen, McKnight, Crystal, Michael, Sam, Mierzwa, Tim, Thomas, Craig, Wilson, Kelli, Guha, Rajarshi

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